JP2008526991A5 - - Google Patents
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- Publication number
- JP2008526991A5 JP2008526991A5 JP2007551416A JP2007551416A JP2008526991A5 JP 2008526991 A5 JP2008526991 A5 JP 2008526991A5 JP 2007551416 A JP2007551416 A JP 2007551416A JP 2007551416 A JP2007551416 A JP 2007551416A JP 2008526991 A5 JP2008526991 A5 JP 2008526991A5
- Authority
- JP
- Japan
- Prior art keywords
- bendamustine
- formulation
- concentration
- amount
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 81
- 229960002707 bendamustine Drugs 0.000 claims 77
- 229960001215 bendamustine hydrochloride Drugs 0.000 claims 48
- ZHSKUOZOLHMKEA-UHFFFAOYSA-N 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 ZHSKUOZOLHMKEA-UHFFFAOYSA-N 0.000 claims 45
- 238000000034 method Methods 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 29
- 238000009472 formulation Methods 0.000 claims 26
- 239000012931 lyophilized formulation Substances 0.000 claims 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical group CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 16
- 238000004108 freeze drying Methods 0.000 claims 13
- 239000003960 organic solvent Substances 0.000 claims 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- 239000000047 product Substances 0.000 claims 9
- 238000001035 drying Methods 0.000 claims 8
- 239000006185 dispersion Substances 0.000 claims 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 239000007857 degradation product Substances 0.000 claims 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 5
- 229930195725 Mannitol Natural products 0.000 claims 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 5
- 239000008176 lyophilized powder Substances 0.000 claims 5
- 235000010355 mannitol Nutrition 0.000 claims 5
- 239000000594 mannitol Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000000087 stabilizing effect Effects 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 229940034982 antineoplastic agent Drugs 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 238000013475 authorization Methods 0.000 claims 3
- GVLZDNWNOBSNEN-UHFFFAOYSA-N ethyl 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoate Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(=O)OCC)=NC2=C1 GVLZDNWNOBSNEN-UHFFFAOYSA-N 0.000 claims 3
- 239000012467 final product Substances 0.000 claims 3
- 229960004592 isopropanol Drugs 0.000 claims 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 238000000354 decomposition reaction Methods 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960004926 chlorobutanol Drugs 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940088679 drug related substance Drugs 0.000 claims 1
- VBZWSGALLODQNC-UHFFFAOYSA-N hexafluoroacetone Chemical compound FC(F)(F)C(=O)C(F)(F)F VBZWSGALLODQNC-UHFFFAOYSA-N 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- HOQADATXFBOEGG-UHFFFAOYSA-N isofenphos Chemical compound CCOP(=S)(NC(C)C)OC1=CC=CC=C1C(=O)OC(C)C HOQADATXFBOEGG-UHFFFAOYSA-N 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- OCDRLZFZBHZTKQ-NMUBGGKPSA-N onetine Chemical compound C[C@@H](O)[C@@]1(O)C[C@@H](C)[C@@](C)(O)C(=O)OC\C2=C\CN(C)CC[C@@H](OC1=O)C2=O OCDRLZFZBHZTKQ-NMUBGGKPSA-N 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64435405P | 2005-01-14 | 2005-01-14 | |
| US11/330,868 US8436190B2 (en) | 2005-01-14 | 2006-01-12 | Bendamustine pharmaceutical compositions |
| PCT/US2006/001308 WO2006076620A2 (en) | 2005-01-14 | 2006-01-13 | Bendamustine pharmaceutical compositions for lyophilisation |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012231760A Division JP5688195B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
| JP2012231759A Division JP5726833B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526991A JP2008526991A (ja) | 2008-07-24 |
| JP2008526991A5 true JP2008526991A5 (enExample) | 2009-10-15 |
Family
ID=36678237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551416A Pending JP2008526991A (ja) | 2005-01-14 | 2006-01-13 | ベンダムスチン製薬学的組成物 |
| JP2012231759A Active JP5726833B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
| JP2012231760A Active JP5688195B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012231759A Active JP5726833B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
| JP2012231760A Active JP5688195B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (9) | US8436190B2 (enExample) |
| EP (2) | EP2574334A1 (enExample) |
| JP (3) | JP2008526991A (enExample) |
| KR (4) | KR101918188B1 (enExample) |
| CN (1) | CN102078305B (enExample) |
| AR (1) | AR052877A1 (enExample) |
| AU (1) | AU2006204817B2 (enExample) |
| BR (1) | BRPI0606332A2 (enExample) |
| CA (1) | CA2593582A1 (enExample) |
| EA (1) | EA013324B1 (enExample) |
| ES (1) | ES2405611T3 (enExample) |
| IL (1) | IL184394A0 (enExample) |
| MX (1) | MX2007008562A (enExample) |
| MY (1) | MY157661A (enExample) |
| NO (1) | NO343659B1 (enExample) |
| NZ (1) | NZ556435A (enExample) |
| SG (1) | SG158870A1 (enExample) |
| TW (1) | TWI380830B (enExample) |
| WO (1) | WO2006076620A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| PT1912675E (pt) | 2005-07-25 | 2014-05-09 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
| US20090082416A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched bendamustine |
| EP2219605B1 (en) * | 2007-10-09 | 2015-08-19 | US Worldmeds LLC | Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents |
| AR072777A1 (es) * | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| RS51975B (sr) * | 2008-04-11 | 2012-02-29 | Emergent Product Development Seattle Llc. | Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom |
| EP2889029A1 (en) * | 2008-09-25 | 2015-07-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
| JP2012508749A (ja) * | 2008-11-13 | 2012-04-12 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | 多発性骨髄腫治療のためのベンダムスチン、ドキソルビシンおよびボルテゾミブの併用 |
| BRPI0922806B8 (pt) * | 2008-12-03 | 2021-05-25 | Astellas Deutschland Gmbh | composição farmacêutica oral compreendendo bendamustina |
| UA107186C2 (xx) * | 2008-12-03 | 2014-12-10 | Тверді форми дозування бендамустину | |
| NZ594010A (en) * | 2009-01-15 | 2013-08-30 | Cephalon Inc | Novel forms of bendamustine free base |
| ME02254B (me) | 2009-01-23 | 2015-12-31 | Euro Celtique Sa | Derivati hidroksamske kiseline |
| AU2010217297A1 (en) | 2009-02-25 | 2011-10-20 | Supratek Pharma, Inc. | Bendamustine cyclopolysaccharide compositions |
| CN102413816A (zh) * | 2009-04-28 | 2012-04-11 | 赛福伦公司 | 苯达莫司汀的口服制剂 |
| WO2010144675A1 (en) | 2009-06-10 | 2010-12-16 | Plus Chemicals Sa | Polymorphs of bendamustine hcl and processes for preparation thereof |
| US20110015245A1 (en) * | 2009-07-20 | 2011-01-20 | Valery Alakhov | Bendamustine amphiphilic cationic compositions |
| US8389558B2 (en) * | 2009-07-20 | 2013-03-05 | Supratek Pharma Inc. | Bendamustine amphiphilic anionic compositions |
| DK3158991T3 (da) * | 2010-01-28 | 2021-06-14 | Eagle Pharmaceuticals Inc | Formuleringer af bendamustin |
| WO2011103150A2 (en) * | 2010-02-18 | 2011-08-25 | Cephalon, Inc. | Lyophilized preparations of bendamustine |
| JO3659B1 (ar) * | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| EA031793B1 (ru) * | 2010-06-02 | 2019-02-28 | Астеллас Дойчланд Гмбх | Пероральные лекарственные формы бендамустина |
| EP2593144A1 (en) * | 2010-07-13 | 2013-05-22 | Cephalon, Inc. | Improved methods for the sterilization of bendamustine |
| US8383663B2 (en) | 2010-07-19 | 2013-02-26 | Supratek Pharma Inc. | Bendamustine anionic-catioinic cyclopolysaccharide compositions |
| EP2667868A4 (en) * | 2011-01-25 | 2014-12-10 | Reddys Lab Ltd Dr | Benda MUSTIN FORMULATIONS |
| DK2672986T3 (da) * | 2011-02-09 | 2020-06-08 | Glaxosmithkline Llc | Frysetørrede formuleringer |
| MX363465B (es) | 2011-02-18 | 2019-03-25 | Kythera Biopharmaceuticals Inc | Tratamiento de la grasa submental. |
| CN103917231B (zh) * | 2011-09-13 | 2016-09-28 | 药品循环有限责任公司 | 组蛋白脱乙酰酶抑制剂与苯达莫司汀的联合制剂及其用途 |
| CN104011029B (zh) | 2011-09-26 | 2016-06-08 | 费森尤斯卡比肿瘤学有限公司 | 一种制备盐酸苯达莫司汀的改进方法 |
| WO2013102920A1 (en) | 2011-11-18 | 2013-07-11 | Astron Research Limited | Stable lyophilized formulation of bendamustine |
| WO2013112762A1 (en) * | 2012-01-24 | 2013-08-01 | Innopharma, Inc. | Bendamustine compositions and methods therefore |
| TWI573792B (zh) * | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| US9872873B2 (en) | 2012-02-06 | 2018-01-23 | Fresenius Kabi Oncology Limited | Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis |
| US20130210879A1 (en) * | 2012-02-14 | 2013-08-15 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| HUE064884T2 (hu) * | 2012-03-20 | 2024-04-28 | Eagle Pharmaceuticals Inc | Bendamusztin kiszerelések |
| ES2943668T3 (es) | 2012-03-20 | 2023-06-15 | Eagle Pharmaceuticals Inc | Composiciones líquidas de bendamustina para su uso en un método para tratar afecciones que responden a la bendamustina en pacientes que requieren volúmenes reducidos para administración |
| WO2013148919A1 (en) | 2012-03-30 | 2013-10-03 | The Regents Of The University Of Colorado, A Body Corporate | Treatment of multiple myeloma |
| US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| US9801859B2 (en) * | 2012-09-18 | 2017-10-31 | Innopharma Licensing, Llc | Bendamustine formulations |
| CA2890462A1 (en) | 2012-11-12 | 2014-05-15 | Ignyta, Inc. | Bendamustine derivatives and methods of using same |
| DK2732811T3 (en) | 2012-11-19 | 2016-03-21 | Oncotec Pharma Produktion Gmbh | A process for preparing a freeze-dried composition |
| CN103860482B (zh) * | 2012-12-12 | 2016-08-24 | 海口市制药厂有限公司 | 一种盐酸苯达莫司汀冻干粉针剂的制备方法、其产品及用途 |
| CN103040769A (zh) * | 2013-02-05 | 2013-04-17 | 南京碧迪可医药科技有限公司 | 一种稳定的诺卡沙星粉针冻干剂 |
| EP2958554B1 (en) | 2013-02-19 | 2018-06-06 | Synthon BV | Stable compositions of bendamustine |
| WO2014170769A2 (en) * | 2013-04-15 | 2014-10-23 | Shilpa Medicare Limited | Bendamustine lyophilized pharmaceutical compositions |
| ITMI20131013A1 (it) | 2013-06-19 | 2014-12-20 | Chemi Spa | Formulazioni liofilizzate di bendamustina cloridrato |
| JP2016153374A (ja) * | 2013-06-25 | 2016-08-25 | シンバイオ製薬株式会社 | 炎症性疾患を治療又は予防するための医薬組成物 |
| CN103351347A (zh) * | 2013-07-29 | 2013-10-16 | 东南大学 | 盐酸苯达莫司汀杂质dce的制备方法 |
| WO2015031198A2 (en) | 2013-08-27 | 2015-03-05 | Voudouris Vasilios | Bendamustine pharmaceutical compositions |
| US20150087681A1 (en) * | 2013-09-25 | 2015-03-26 | Pranav Patel | Bendamustine HCL Stable Lyophilized Formulations |
| US20160235717A1 (en) * | 2013-10-11 | 2016-08-18 | Luitpold Pharmaceuticals, Inc. | Bendamustine pharmaceutical compositions |
| WO2015104720A2 (en) * | 2014-01-13 | 2015-07-16 | Hetero Research Foundation | Parenteral compositions of bendamustine |
| US9320730B2 (en) | 2014-03-13 | 2016-04-26 | Vasilios Voudouris | Bendamustine solid dispersions and continuous infusion |
| US20150320774A1 (en) | 2014-05-09 | 2015-11-12 | AuroMedics Pharma LLC | Formulations of cyclophosphamide liquid concentrate |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| EP2985038A1 (en) | 2014-08-12 | 2016-02-17 | Azad Pharma AG | Lyophilized API preparation |
| US10342769B2 (en) | 2014-11-14 | 2019-07-09 | Navinta Iii Inc | Carmustine pharmaceutical composition |
| US9603930B2 (en) | 2014-12-04 | 2017-03-28 | Navinta, Llc | Liquid bendamustine formulation |
| US20170119794A1 (en) * | 2015-11-04 | 2017-05-04 | Kythera Biopharmaceuticals, Inc. | Treatments of accumulated fat with deoxycholic acid and salts thereof |
| US11826466B2 (en) | 2016-08-31 | 2023-11-28 | Navinta, Llc | Bendamustine solution formulations |
| US10905677B2 (en) | 2016-08-31 | 2021-02-02 | Navinta, Llc | Bendamustine solution formulations |
| WO2018068832A1 (en) | 2016-10-11 | 2018-04-19 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| US10688222B2 (en) | 2016-11-21 | 2020-06-23 | Warsaw Orthopedic, Inc. | Lyophilized moldable implants containing an oxysterol |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
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| US12246007B2 (en) | 2018-08-17 | 2025-03-11 | Hospira Australia Pty Ltd | Liquid bendamustine pharmaceutical compositions |
| US11730815B2 (en) | 2018-11-26 | 2023-08-22 | Good Health, Llc | Stable liquid pharmaceutical compositions comprising bendamustine |
| EP3897626B1 (en) | 2018-12-18 | 2025-09-10 | Mundipharma International Corporation Limited | Tinostamustine for treating multiple myeloma |
| US11406598B2 (en) | 2019-09-20 | 2022-08-09 | Nivagen Pharmaceuticals, Inc. | Lyophilized compositions of phenobarbital sodium salt |
| CN110638765A (zh) * | 2019-11-08 | 2020-01-03 | 江苏食品药品职业技术学院 | 一种卡莫司汀冻干工艺 |
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-
2006
- 2006-01-12 US US11/330,868 patent/US8436190B2/en active Active
- 2006-01-13 JP JP2007551416A patent/JP2008526991A/ja active Pending
- 2006-01-13 KR KR1020177022494A patent/KR101918188B1/ko active Active
- 2006-01-13 ES ES06718390T patent/ES2405611T3/es active Active
- 2006-01-13 CA CA002593582A patent/CA2593582A1/en not_active Abandoned
- 2006-01-13 NZ NZ556435A patent/NZ556435A/en unknown
- 2006-01-13 AR ARP060100158A patent/AR052877A1/es not_active Application Discontinuation
- 2006-01-13 BR BRPI0606332-2A patent/BRPI0606332A2/pt not_active Application Discontinuation
- 2006-01-13 EP EP12191786A patent/EP2574334A1/en not_active Withdrawn
- 2006-01-13 CN CN201010621759.3A patent/CN102078305B/zh active Active
- 2006-01-13 WO PCT/US2006/001308 patent/WO2006076620A2/en not_active Ceased
- 2006-01-13 MX MX2007008562A patent/MX2007008562A/es active IP Right Grant
- 2006-01-13 EA EA200701511A patent/EA013324B1/ru unknown
- 2006-01-13 SG SG201000184-0A patent/SG158870A1/en unknown
- 2006-01-13 AU AU2006204817A patent/AU2006204817B2/en active Active
- 2006-01-13 TW TW095101383A patent/TWI380830B/zh active
- 2006-01-13 KR KR1020187014177A patent/KR20180056804A/ko not_active Ceased
- 2006-01-13 KR KR1020167021645A patent/KR20160098530A/ko not_active Ceased
- 2006-01-13 KR KR1020077018503A patent/KR101648495B1/ko active Active
- 2006-01-13 MY MYPI20060159A patent/MY157661A/en unknown
- 2006-01-13 EP EP06718390A patent/EP1863452B1/en not_active Revoked
-
2007
- 2007-07-03 IL IL184394A patent/IL184394A0/en active IP Right Review Request
- 2007-07-18 NO NO20073722A patent/NO343659B1/no unknown
-
2012
- 2012-10-18 US US13/654,898 patent/US8461350B2/en active Active
- 2012-10-19 JP JP2012231759A patent/JP5726833B2/ja active Active
- 2012-10-19 JP JP2012231760A patent/JP5688195B2/ja active Active
- 2012-12-19 US US13/719,409 patent/US8895756B2/en active Active
- 2012-12-19 US US13/719,379 patent/US8609863B2/en active Active
-
2013
- 2013-08-19 US US13/969,724 patent/US8791270B2/en active Active
-
2014
- 2014-01-31 US US14/169,961 patent/US20140148490A1/en not_active Abandoned
-
2015
- 2015-09-04 US US14/845,564 patent/US20150374671A1/en not_active Abandoned
-
2018
- 2018-06-19 US US16/012,417 patent/US20180296534A1/en not_active Abandoned
-
2019
- 2019-11-26 US US16/695,624 patent/US20200237726A1/en not_active Abandoned
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