JP2014525449A5 - - Google Patents

Download PDF

Info

Publication number
JP2014525449A5
JP2014525449A5 JP2014528539A JP2014528539A JP2014525449A5 JP 2014525449 A5 JP2014525449 A5 JP 2014525449A5 JP 2014528539 A JP2014528539 A JP 2014528539A JP 2014528539 A JP2014528539 A JP 2014528539A JP 2014525449 A5 JP2014525449 A5 JP 2014525449A5
Authority
JP
Japan
Prior art keywords
compound
formulation
dmso
kit
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014528539A
Other languages
English (en)
Japanese (ja)
Other versions
JP6038921B2 (ja
JP2014525449A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/052816 external-priority patent/WO2013033176A1/en
Publication of JP2014525449A publication Critical patent/JP2014525449A/ja
Publication of JP2014525449A5 publication Critical patent/JP2014525449A5/ja
Application granted granted Critical
Publication of JP6038921B2 publication Critical patent/JP6038921B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014528539A 2011-08-30 2012-08-29 デシタビン誘導体製剤 Expired - Fee Related JP6038921B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161529081P 2011-08-30 2011-08-30
US61/529,081 2011-08-30
PCT/US2012/052816 WO2013033176A1 (en) 2011-08-30 2012-08-29 Decitabine derivative formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016214862A Division JP6257734B2 (ja) 2011-08-30 2016-11-02 デシタビン誘導体製剤

Publications (3)

Publication Number Publication Date
JP2014525449A JP2014525449A (ja) 2014-09-29
JP2014525449A5 true JP2014525449A5 (enExample) 2015-10-29
JP6038921B2 JP6038921B2 (ja) 2016-12-07

Family

ID=46875963

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014528539A Expired - Fee Related JP6038921B2 (ja) 2011-08-30 2012-08-29 デシタビン誘導体製剤
JP2016214862A Expired - Fee Related JP6257734B2 (ja) 2011-08-30 2016-11-02 デシタビン誘導体製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016214862A Expired - Fee Related JP6257734B2 (ja) 2011-08-30 2016-11-02 デシタビン誘導体製剤

Country Status (25)

Country Link
US (4) US9381207B2 (enExample)
EP (2) EP2750768B1 (enExample)
JP (2) JP6038921B2 (enExample)
KR (1) KR102004559B1 (enExample)
CN (2) CN108635367B (enExample)
AU (2) AU2012302051B2 (enExample)
BR (1) BR112014004779B1 (enExample)
CA (1) CA2845585C (enExample)
CO (1) CO6950470A2 (enExample)
CY (1) CY1122168T1 (enExample)
DK (1) DK2750768T3 (enExample)
ES (1) ES2702495T3 (enExample)
HU (1) HUE042327T2 (enExample)
IL (2) IL231209A0 (enExample)
LT (1) LT2750768T (enExample)
MX (1) MX359314B (enExample)
MY (2) MY186676A (enExample)
PH (2) PH12014500477A1 (enExample)
PL (1) PL2750768T3 (enExample)
PT (1) PT2750768T (enExample)
RU (1) RU2605289C2 (enExample)
SG (1) SG2014013395A (enExample)
UA (1) UA116528C2 (enExample)
WO (1) WO2013033176A1 (enExample)
ZA (1) ZA201701083B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE
PL2750768T3 (pl) 2011-08-30 2019-05-31 Astex Pharmaceuticals Inc Formulacje pochodnej decytabiny
RU2708246C2 (ru) * 2013-03-01 2019-12-05 Астекс Фармасьютикалз, Инк. Комбинации лекарственных средств
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
HK1254645A1 (zh) * 2015-07-02 2019-07-26 Otsuka Pharmaceutical Co., Ltd. 冻乾药物组合物
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
EP3661522A2 (en) 2017-08-03 2020-06-10 Otsuka Pharmaceutical Co., Ltd. Drug compound and purification methods thereof
CA3211506A1 (en) 2018-02-07 2019-08-15 Lovelace Biomedical Research Institute Inhalable dry powder cytidine analogue composition and method of use as a treatment for cancer
KR102785135B1 (ko) 2018-06-11 2025-03-21 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 눈 질환을 치료하는 탈메틸화
KR102834624B1 (ko) * 2019-10-18 2025-07-15 후지필름 와코 준야쿠 가부시키가이샤 포스포아미다이트 활성화제
US20220096507A1 (en) * 2020-07-01 2022-03-31 Sandoz Ag Parenteral Pharmaceutical Composition Comprising Azacitidine or Decitabine in DMSO

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133858A (en) * 1954-03-24 1964-05-19 Abbott Lab Stable thiobarbituric acid solution
CH527207A (de) 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
DE2105468A1 (en) 1970-04-23 1971-11-18 Czeskoslovenska akademie ved, Prag; VtnKarstedt, E., Dipl.-Ing. Dr., Pat-Anw., 4200 Oberhausen 1-glycosyl-5-aza-cytosines prepn
US5157120A (en) 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4855304A (en) 1985-01-10 1989-08-08 Repligen Corporation Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
JPS61176523A (ja) 1985-01-30 1986-08-08 Teruhiko Beppu 制癌剤
GB8612826D0 (en) 1986-05-27 1986-07-02 Boots Co Plc Insecticidal compositions
DE3712786A1 (de) 1987-04-15 1988-11-03 Merck Patent Gmbh Verfahren und mittel zur bestimmung von nucleinsaeuren
CS269077B1 (cs) 1987-10-01 1990-04-11 Piskala Alois Způsob přípravy 5-azacytosinů
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en) 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US4904770A (en) 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US5324831A (en) 1988-04-06 1994-06-28 The United States Of America As Represented By The Secretary Of Health And Human Services Phosphoramidite reagent for chemical synthesis of modified DNA
PT93772A (pt) 1989-04-17 1991-01-08 Searle & Co Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
WO1993001202A1 (en) 1991-07-05 1993-01-21 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
IL103311A0 (en) 1991-10-07 1993-03-15 Univ Johns Hopkins Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers
JPH05219974A (ja) 1992-02-13 1993-08-31 Mitsui Petrochem Ind Ltd トロパンアルカロイドの製造方法
JPH05246891A (ja) * 1992-03-09 1993-09-24 Kobayashi Seiyaku Kogyo Kk 安定な抗膵炎用注射液
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
AU6081294A (en) 1993-05-14 1994-12-12 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
GB9311252D0 (en) 1993-06-01 1993-07-21 Hafslund Nycomed As Cell growth regualtors
AU1061395A (en) 1993-11-30 1995-06-19 Mcgill University Inhibition of dna methyltransferase
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
US5856090A (en) 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
US20030104576A1 (en) 1994-10-07 2003-06-05 Jonathan W. Nyce Dna construct, composition, formulations & methods for making the construct & for modulating expression
CA2221411A1 (en) 1995-05-19 1996-11-21 Phytera, Inc. Manipulation of plant cell and tissue cultures
EP0852463B1 (en) 1995-06-06 2008-09-03 Case Western Reserve University Myogenic differentiation of human mesenchymal stem cells
US6136791A (en) 1995-12-22 2000-10-24 East Carolina University Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression
CZ120699A3 (cs) 1996-10-16 1999-09-15 Icn Pharmaceuticals, Inc. Monocyklická L-nukleosidová analoga a jejich využití
US6423692B2 (en) 1997-04-24 2002-07-23 Dana-Farber Cancer Institute, Inc. Method of enhancing the effectiveness of DCK phosphorylated molecules
US6153383A (en) 1997-12-09 2000-11-28 Verdine; Gregory L. Synthetic transcriptional modulators and uses thereof
JP4768121B2 (ja) 1998-02-05 2011-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Mageファミリーからの腫瘍関連抗原及びそれらをコードする核酸配列、融合タンパク質の及びワクチン接種のための組成物の調製のための使用
WO2000023112A1 (en) 1998-10-19 2000-04-27 Methylgene, Inc. Modulation of gene expression by combination therapy
EP3553085A1 (en) 1998-12-23 2019-10-16 Pfizer Inc Human momoclonal antibodies to ctla-4
WO2000040269A2 (en) 1999-01-05 2000-07-13 Lee Clarence C Pharmaceutical compositions for treatment of diseased tissues
WO2000062075A1 (en) 1999-04-13 2000-10-19 Rutgers, The State University Of New Jersey Ubiquitin cross-reactive protein as a prognostic marker for tumor cell chemosensitivity
US6599912B1 (en) 1999-06-03 2003-07-29 Jessie L. -S. Au Methods and compositions for modulating cell proliferation and cell death
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
DK1212422T3 (da) 1999-08-24 2007-07-02 Medarex Inc Humane CTLA-4-antistoffer og anvendelserne deraf
JP2001163776A (ja) * 1999-09-30 2001-06-19 Nisshin Oil Mills Ltd:The 安定化された液剤
WO2001029235A2 (en) 1999-10-18 2001-04-26 Emory University Tms1 compositions and methods of use
AU2001247444A1 (en) 2000-03-15 2001-09-24 University Of Massachusetts Erbeta-mediated gene expression
ATE461453T1 (de) 2000-09-08 2010-04-15 Seoul Nat Univ Ind Foundation Nukleinsäuresequenz und protein, das eine rolle bei der zellulären alterung spielt
JP2004536026A (ja) * 2000-11-28 2004-12-02 トランスフォーム ファーマシューティカルズ,インコーポレーティッド. パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤
WO2002053138A2 (en) 2001-01-02 2002-07-11 Elisabeth Shanahan-Prendergast Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens
DZ3487A1 (fr) 2001-01-22 2002-07-25 Merck Sharp & Dohme Derives de nucleoside comme inhibiteurs de l'arn polymerase virale d'arn-dependant
JP2002223753A (ja) 2001-01-30 2002-08-13 Hitachi Ltd 薬物応答解析用オリゴヌクレオチドアレイ
CA2436340A1 (en) 2001-02-05 2002-10-03 Innoventus Project Ab Histidine-rich glycoprotein
US6613753B2 (en) 2001-02-21 2003-09-02 Supergen, Inc. Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation
AU2002252183A1 (en) 2001-03-06 2002-09-19 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
US20060194275A1 (en) 2001-04-13 2006-08-31 Incyte Corporation Transporter and ion channels
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
EP1383504A1 (en) 2001-04-26 2004-01-28 Control Delivery Systems, Inc. Sustained release drug delivery system containing codrugs
US20030148973A1 (en) 2001-05-23 2003-08-07 Peter Emtage MAGE-A1 peptides for treating or preventing cancer
JP2004536596A (ja) 2001-06-08 2004-12-09 ユー.エス. ジェノミクス, インコーポレイテッド メチル化状態に基づいて核酸を分析するための方法および生成物
JP2002370939A (ja) 2001-06-12 2002-12-24 Taisho Pharmaceut Co Ltd 育毛剤
US20030045497A1 (en) 2001-07-27 2003-03-06 Geneinvent Bbl Ab Methylation resistant vectors
SE0102627L (sv) 2001-07-27 2002-11-19 Geneinvent Bbl Ab Vektorer motståndskraftiga mot metylering
WO2003012085A1 (en) 2001-07-30 2003-02-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Antigen presenting cells, method for their preparation and their use for cancer vaccines
PT2177223E (pt) 2001-09-05 2012-05-23 Chemgenex Pharmaceuticals Ltd Tratamento da leucemia mielóide crónica, resistente ou intolerante ao sti571, envolvendo a homoharringtonina isoladamente ou em combinação com outros agentes
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
IN2014DN10834A (enExample) 2001-09-17 2015-09-04 Psivida Inc
CA2461227C (en) 2001-09-24 2012-05-15 Jessie L.-S Au Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
EP1452592A4 (en) 2001-11-08 2006-02-15 Japan Science & Tech Agency TRANSPOSONGENE FROM RICE
WO2003043631A2 (en) 2001-11-23 2003-05-30 Chugai Seiyaku Kabushiki Kaisha Method for identification of tumor targeting enzymes
DE60234115D1 (de) 2001-11-29 2009-12-03 Dandrit Biotech As Pharmazeutische zusammensetzung zur auslösung einer immunantwort bei einem menschen oder einem tier
WO2003046190A1 (de) 2001-11-30 2003-06-05 Medigene Aktiengesellschaft Optimierte herstellung von viralen, von parvoviren abgeleiteten vektoren in verpackungs- und produktionszellen durch hsv-infektion oder behandlung mit inhibitoren der dna-methylierung
GB0201498D0 (en) 2002-01-23 2002-03-13 Biotech Res Ventures Pte Ltd Materials and methods for treating cancer
US20030147813A1 (en) 2002-02-07 2003-08-07 John Lyons Method for treating chronic myelogenous leukemia
US6998391B2 (en) 2002-02-07 2006-02-14 Supergen.Inc. Method for treating diseases associated with abnormal kinase activity
WO2003076660A1 (en) 2002-03-13 2003-09-18 F.Hoffmann-La Roche Ag Method for selecting drug sensitivity-determining factors and method for predicting drug sensitivity using the selected factors
JP2003310293A (ja) 2002-04-26 2003-11-05 Mitsui Chemicals Inc ヌクレオシド化合物の製造法
BR122019027966B8 (pt) 2002-05-02 2021-07-27 Wyeth Corp conjugado monomérico de derivado de caliqueamicina/anti-corpo anti-cd22 e uso dos mesmos
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
AU2003251483A1 (en) 2002-06-05 2003-12-22 Case Western Reserve University Methods and compositions for detecting cancers
EP1556010A4 (en) 2002-10-31 2007-12-05 Supergen Inc PHARMACEUTICAL FORMULATIONS; WHICH ARE ADDRESSED TO CERTAIN REGIONS OF THE STOMACH-DARM TRAKTS
US20050037992A1 (en) 2003-07-22 2005-02-17 John Lyons Composition and method for treating neurological disorders
US20050059682A1 (en) 2003-09-12 2005-03-17 Supergen, Inc., A Delaware Corporation Compositions and methods for treatment of cancer
WO2005033278A2 (en) 2003-09-30 2005-04-14 Ludwig Institute For Cancer Research In vivo efficacy of ny-eso-1 plus iscom
US7846436B2 (en) 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds
US20050266012A1 (en) 2004-05-26 2005-12-01 Jean-Marie Andrieu Compositions comprising demethylating agents as enhancers of immunotherapy for the treatment of chronic infections and neoplastic diseases and methods for treating the same
US20060014949A1 (en) 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
US20060063735A1 (en) 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20060069060A1 (en) 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
CA2586844A1 (en) 2004-11-04 2006-05-11 Pfizer Products Inc. Ctla-4 antibody and aromatase inhibitor or combination treatment for breast cancer
US20060128653A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of decitabine
US20060128654A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
US20060159694A1 (en) 2004-12-29 2006-07-20 Chih-Sheng Chiang Combinations of tumor-associated antigens in compositions for various types of cancers
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
KR101498834B1 (ko) 2005-05-09 2015-03-05 오노 야꾸힝 고교 가부시키가이샤 예정 사멸 인자 1(pd-1)에 대한 인간 모노클로날 항체, 및 항-pd-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법
HRP20080053A2 (hr) 2005-07-01 2009-08-31 Medarex Ljudska monoklonska protutijela na ligand 1 za programiranu smrt stanice (pd-l1)
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US20070117776A1 (en) 2005-11-04 2007-05-24 John Lyons Low Dose Therapy Of DNA Methylation Inhibitors
US20070105792A1 (en) 2005-11-04 2007-05-10 Dimartino Jorge F Administration Of DNA Methylation Inhibitors For Treating Epigenetic Diseases
CN101637444B (zh) * 2006-03-17 2012-08-15 山东蓝金生物工程有限公司 含吉西他滨的抗癌药物缓释注射剂
EP2026805A1 (en) * 2006-05-08 2009-02-25 Astex Therapeutics Limited Pharmaceutical combinations of diazole derivatives for cancer treatment
US8003324B2 (en) * 2007-10-18 2011-08-23 U.S. Department Of Veterans Affairs Modulation of sodium channels by nicotinamide adenine dinucleotide
CN101570553B (zh) * 2008-05-04 2012-03-28 上海医药工业研究院 一种2-脱氧-d-核糖的衍生物及其制备方法和用途
CN101361718B (zh) 2008-09-26 2013-08-28 深圳万乐药业有限公司 稳定的地西他滨冻干制剂的制备方法
CN101787046B (zh) * 2010-02-11 2012-12-26 福建南方制药股份有限公司 地西他滨的中间体化合物的制备方法
GB201006096D0 (en) 2010-04-13 2010-05-26 Alligator Bioscience Ab Novel compositions and uses thereof
MX349622B (es) 2010-09-08 2017-08-07 Halozyme Inc Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.
CN101966157B (zh) * 2010-10-14 2013-08-14 苏州特瑞药业有限公司 一种地西他滨缓释微球及其制备方法
KR20140029446A (ko) 2011-04-15 2014-03-10 컴퓨젠 엘티디. 면역 관련 장애 및 암의 치료를 위한 폴리펩티드 및 폴리뉴클레오티드, 및 이들의 용도
PL2750768T3 (pl) * 2011-08-30 2019-05-31 Astex Pharmaceuticals Inc Formulacje pochodnej decytabiny
US9872873B2 (en) 2012-02-06 2018-01-23 Fresenius Kabi Oncology Limited Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis
RU2708246C2 (ru) 2013-03-01 2019-12-05 Астекс Фармасьютикалз, Инк. Комбинации лекарственных средств
HK1254645A1 (zh) 2015-07-02 2019-07-26 Otsuka Pharmaceutical Co., Ltd. 冻乾药物组合物
EP3661522A2 (en) 2017-08-03 2020-06-10 Otsuka Pharmaceutical Co., Ltd. Drug compound and purification methods thereof

Similar Documents

Publication Publication Date Title
JP2014525449A5 (enExample)
CN1169525C (zh) 紫杉烷的药物制剂
JP7562125B2 (ja) 疾患の治療方法
TWI384984B (zh) 抗癌口服藥學組成物
JP2018109005A (ja) ベンダムスチン製剤
RU2014112108A (ru) Составы с производными децитабина
JP2017511360A5 (enExample)
JP2013542247A5 (enExample)
JP2013542264A5 (enExample)
CN1612737A (zh) 铂衍生物药物制剂
JP2015535243A5 (enExample)
WO2016059590A1 (en) Stable injectable composition of small molecule drugs and process for its preparation
CN106456654A (zh) 环磷酰胺液体浓缩制剂
FI3511004T3 (fi) Yhdistelmävalmisteita syövän hoitoon
JP6505114B2 (ja) 抗酸化剤を含有しない薬学組成物およびその製造方法
RU2017132330A (ru) Соли производного хиназолина и способ их получения
JP2019513828A5 (enExample)
CN104507467A (zh) 含紫杉烷系活性成分的液体组合物、其制造方法及液体制剂
JP2019516765A5 (enExample)
RU2018142381A (ru) Фармацевтический препарат
RU2018130097A (ru) Лечение экземы кистей
WO2016008289A1 (zh) 一种盐酸伊立替康纳米脂束制剂及其制备方法
WO2014165829A3 (en) Nanoparticle formulations
RU2018114922A (ru) Лечение очаговой алопеции
JP2022500350A (ja) 安定したアザシチジン含有医薬組成物の製造方法