JP2008511291A5 - - Google Patents
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- JP2008511291A5 JP2008511291A5 JP2007523885A JP2007523885A JP2008511291A5 JP 2008511291 A5 JP2008511291 A5 JP 2008511291A5 JP 2007523885 A JP2007523885 A JP 2007523885A JP 2007523885 A JP2007523885 A JP 2007523885A JP 2008511291 A5 JP2008511291 A5 JP 2008511291A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- region
- seq
- set forth
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000001413 amino acids Chemical group 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 6
- 229910052720 vanadium Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 230000004988 N-glycosylation Effects 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- -1 serine amino acid Chemical class 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59249404P | 2004-07-30 | 2004-07-30 | |
| US60/592,494 | 2004-07-30 | ||
| US65319705P | 2005-02-14 | 2005-02-14 | |
| US60/653,197 | 2005-02-14 | ||
| US67609305P | 2005-04-29 | 2005-04-29 | |
| US60/676,093 | 2005-04-29 | ||
| PCT/US2005/027295 WO2006036291A2 (en) | 2004-07-30 | 2005-08-01 | Antibodies directed against amyloid-beta peptide and methods using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012127432A Division JP2012197292A (ja) | 2004-07-30 | 2012-06-04 | アミロイド−ベータ・ペプチドに対して向けられる抗体、および該抗体を用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511291A JP2008511291A (ja) | 2008-04-17 |
| JP2008511291A5 true JP2008511291A5 (enExample) | 2008-09-18 |
| JP5042828B2 JP5042828B2 (ja) | 2012-10-03 |
Family
ID=36010949
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007523885A Expired - Fee Related JP5042828B2 (ja) | 2004-07-30 | 2005-08-01 | アミロイド−ベータ・ペプチドに対して向けられる抗体、および該抗体を用いる方法 |
| JP2012127432A Withdrawn JP2012197292A (ja) | 2004-07-30 | 2012-06-04 | アミロイド−ベータ・ペプチドに対して向けられる抗体、および該抗体を用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012127432A Withdrawn JP2012197292A (ja) | 2004-07-30 | 2012-06-04 | アミロイド−ベータ・ペプチドに対して向けられる抗体、および該抗体を用いる方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US7807165B2 (enExample) |
| EP (2) | EP1781704A2 (enExample) |
| JP (2) | JP5042828B2 (enExample) |
| KR (2) | KR20070040824A (enExample) |
| AP (1) | AP2007003890A0 (enExample) |
| AU (2) | AU2005290250A1 (enExample) |
| BR (1) | BRPI0513959A (enExample) |
| CA (1) | CA2575663C (enExample) |
| EA (1) | EA016357B1 (enExample) |
| GE (1) | GEP20115195B (enExample) |
| IL (1) | IL180364A (enExample) |
| MA (1) | MA28757B1 (enExample) |
| MX (1) | MX2007000998A (enExample) |
| NI (1) | NI200700021A (enExample) |
| NO (1) | NO20066058L (enExample) |
| NZ (1) | NZ552480A (enExample) |
| SG (1) | SG190665A1 (enExample) |
| TN (1) | TNSN07031A1 (enExample) |
| TW (1) | TWI355389B (enExample) |
| WO (1) | WO2006036291A2 (enExample) |
Families Citing this family (164)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
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| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| MXPA05003621A (es) * | 2002-10-09 | 2005-10-19 | Rinat Neuroscience Corp | Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos. |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| PL378571A1 (pl) * | 2003-02-01 | 2006-05-02 | Neuralab Limited | Czynna immunizacja dla wytworzenia przeciwciał przeciw rozpuszczalnemu A-ß |
| MX2007000998A (es) * | 2004-07-30 | 2007-07-11 | Rinat Neuroscience Corp | Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos. |
| AR052051A1 (es) * | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
| US8420093B2 (en) | 2005-02-14 | 2013-04-16 | Merck Sharp & Dohme Corp. | Anti-ADDL monoclonal antibody and use thereof |
| US7731962B2 (en) | 2005-02-14 | 2010-06-08 | Merck & Co., Inc. | Anti-ADDL monoclonal antibody and use thereof |
| UY29504A1 (es) * | 2005-04-29 | 2006-10-31 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos. |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
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- 2005-08-01 US US11/195,207 patent/US7807165B2/en not_active Expired - Fee Related
- 2005-08-01 EP EP05778628A patent/EP1781704A2/en not_active Withdrawn
- 2005-08-01 GE GEAP20059836A patent/GEP20115195B/en unknown
- 2005-08-01 US US11/194,989 patent/US7927594B2/en not_active Expired - Fee Related
- 2005-08-01 AU AU2005290250A patent/AU2005290250A1/en not_active Abandoned
- 2005-08-01 KR KR1020077004986A patent/KR20070040824A/ko not_active Ceased
- 2005-08-01 WO PCT/US2005/027295 patent/WO2006036291A2/en not_active Ceased
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