JP2011504501A5 - - Google Patents

Info

Publication number

JP2011504501A5

JP2011504501A5 JP2010534969A JP2010534969A JP2011504501A5 JP 2011504501 A5 JP2011504501 A5 JP 2011504501A5 JP 2010534969 A JP2010534969 A JP 2010534969A JP 2010534969 A JP2010534969 A JP 2010534969A JP 2011504501 A5 JP2011504501 A5 JP 2011504501A5

Authority

JP

Japan

Prior art keywords

seq

nos

cdr sequences

cdr

antibody

Prior art date

2008-11-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102100024952 Protein CBFA2T1 Human genes 0.000 claims 107
• 239000012634 fragment Substances 0.000 claims 26
• 101100366217 Gallus gallus SOSTDC1 gene Proteins 0.000 claims 15
• 102100022432 Sclerostin domain-containing protein 1 Human genes 0.000 claims 15
• 229920001184 polypeptide Polymers 0.000 claims 13
• 102000004196 processed proteins & peptides Human genes 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
• 125000000539 amino acid group Chemical group 0.000 claims 7
• 230000002401 inhibitory effect Effects 0.000 claims 5
• 101000825071 Homo sapiens Sclerostin domain-containing protein 1 Proteins 0.000 claims 4
• 102000057897 human SOSTDC1 Human genes 0.000 claims 4
• 206010016654 Fibrosis Diseases 0.000 claims 3
• 230000004761 fibrosis Effects 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 201000001474 proteinuria Diseases 0.000 claims 3
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
• 102000004264 Osteopontin Human genes 0.000 claims 2
• 108010081689 Osteopontin Proteins 0.000 claims 2
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
• 239000004473 Threonine Substances 0.000 claims 2
• 229940024606 amino acid Drugs 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 230000000903 blocking effect Effects 0.000 claims 2
• 238000000423 cell based assay Methods 0.000 claims 2
• 230000037319 collagen production Effects 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000002163 immunogen Effects 0.000 claims 2
• 229960000310 isoleucine Drugs 0.000 claims 2
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
• 239000003550 marker Substances 0.000 claims 2
• 210000000651 myofibroblast Anatomy 0.000 claims 2
• 230000007170 pathology Effects 0.000 claims 2
• 238000013424 sirius red staining Methods 0.000 claims 2
• 208000037816 tissue injury Diseases 0.000 claims 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
• 102100027211 Albumin Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 102100029880 Glycodelin Human genes 0.000 claims 1
• 101000585553 Homo sapiens Glycodelin Proteins 0.000 claims 1
• 208000019693 Lung disease Diseases 0.000 claims 1
• 102000004338 Transferrin Human genes 0.000 claims 1
• 108090000901 Transferrin Proteins 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 239000012581 transferrin Substances 0.000 claims 1