JP2020037555A5 - - Google Patents
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- JP2020037555A5 JP2020037555A5 JP2019187271A JP2019187271A JP2020037555A5 JP 2020037555 A5 JP2020037555 A5 JP 2020037555A5 JP 2019187271 A JP2019187271 A JP 2019187271A JP 2019187271 A JP2019187271 A JP 2019187271A JP 2020037555 A5 JP2020037555 A5 JP 2020037555A5
- Authority
- JP
- Japan
- Prior art keywords
- cdr
- seq
- sequence shown
- light chain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161535532P | 2011-09-16 | 2011-09-16 | |
| US61/535,532 | 2011-09-16 | ||
| US201261638731P | 2012-04-26 | 2012-04-26 | |
| US61/638,731 | 2012-04-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017104698A Division JP6603685B2 (ja) | 2011-09-16 | 2017-05-26 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020037555A JP2020037555A (ja) | 2020-03-12 |
| JP2020037555A5 true JP2020037555A5 (enExample) | 2020-08-06 |
Family
ID=46881094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530307A Expired - Fee Related JP6152107B2 (ja) | 2011-09-16 | 2012-09-10 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
| JP2017104698A Expired - Fee Related JP6603685B2 (ja) | 2011-09-16 | 2017-05-26 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
| JP2019187271A Ceased JP2020037555A (ja) | 2011-09-16 | 2019-10-11 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530307A Expired - Fee Related JP6152107B2 (ja) | 2011-09-16 | 2012-09-10 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
| JP2017104698A Expired - Fee Related JP6603685B2 (ja) | 2011-09-16 | 2017-05-26 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10752676B2 (enExample) |
| EP (2) | EP3617227A3 (enExample) |
| JP (3) | JP6152107B2 (enExample) |
| KR (1) | KR20140063825A (enExample) |
| CN (2) | CN108424449A (enExample) |
| AU (1) | AU2012307157B2 (enExample) |
| BR (1) | BR112014006175B1 (enExample) |
| CA (1) | CA2848611A1 (enExample) |
| CL (1) | CL2014000491A1 (enExample) |
| CO (1) | CO6930310A2 (enExample) |
| CY (1) | CY1121673T1 (enExample) |
| DK (1) | DK2758432T3 (enExample) |
| EA (1) | EA032475B1 (enExample) |
| EC (1) | ECSP14013316A (enExample) |
| ES (1) | ES2729278T3 (enExample) |
| HK (1) | HK1199463A1 (enExample) |
| HR (1) | HRP20190917T1 (enExample) |
| HU (1) | HUE043661T2 (enExample) |
| IL (1) | IL231167A0 (enExample) |
| LT (1) | LT2758432T (enExample) |
| MX (1) | MX2014002769A (enExample) |
| PE (1) | PE20141547A1 (enExample) |
| PH (1) | PH12014500456A1 (enExample) |
| PL (1) | PL2758432T3 (enExample) |
| PT (1) | PT2758432T (enExample) |
| SG (2) | SG10201701055WA (enExample) |
| SI (1) | SI2758432T1 (enExample) |
| TN (1) | TN2014000101A1 (enExample) |
| WO (1) | WO2013038156A1 (enExample) |
| ZA (1) | ZA201402760B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014006175B1 (pt) * | 2011-09-16 | 2020-02-11 | Ucb Pharma S.A. | Anticorpos capazes de neutralisar as exotoxinas principais tcda e tcdb de clostridium difficile |
| JP2016501877A (ja) * | 2012-11-28 | 2016-01-21 | シーエヌジェー ホールディングス，インコーポレイテッド | クロストリジウム・ディフィシルに対する抗体 |
| CN105451762A (zh) * | 2013-04-22 | 2016-03-30 | 俄克拉荷马州大学评议会 | 艰难梭菌疫苗及使用方法 |
| CA2939969A1 (en) * | 2014-02-18 | 2015-08-27 | The Hospital For Sick Children | Compositions and methods for treating or preventing clostridium infection |
| US9717711B2 (en) | 2014-06-16 | 2017-08-01 | The Lauridsen Group | Methods and compositions for treating Clostridium difficile associated disease |
| WO2016178773A1 (en) * | 2015-04-06 | 2016-11-10 | Saureus, Inc. | System and method for detecting clostridium difficile toxins |
| EP3283103A4 (en) * | 2015-04-15 | 2018-12-05 | Medimmune, LLC | Methods for treating clostridium difficile infection and associated disease |
| AU2016282334B2 (en) | 2015-06-24 | 2022-07-21 | F. Hoffmann-La Roche Ag | Anti-transferrin receptor antibodies with tailored affinity |
| EP3344276B1 (en) | 2015-09-03 | 2020-04-22 | The Board of Regents of the University of Oklahoma | Peptide inhibitors of clostridium difficile tcdb toxin |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| MX2018003822A (es) | 2015-10-02 | 2018-06-22 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso. |
| USD864160S1 (en) | 2016-12-06 | 2019-10-22 | Samsung Electronics Co., Ltd. | Audio device |
| BR112019012203A2 (pt) * | 2016-12-14 | 2019-11-12 | Beijing Genomics Inst At Shenzhen | marcadores genéticos humanos associados à resposta para tratamentos que têm como alvo a toxina b de clostridium difficile |
| CN110607314B (zh) * | 2019-10-31 | 2022-09-23 | 四川农业大学 | 一种TcdB RBD基因、重组RBD蛋白和应用 |
| CN111763263A (zh) * | 2020-07-09 | 2020-10-13 | 宁夏医科大学 | 一种艰难梭菌抗原及多克隆抗体的制备方法和检测试剂盒 |
| CN112500484B (zh) * | 2021-01-29 | 2021-06-08 | 迈杰转化医学研究(苏州)有限公司 | 一种抗trop2抗体及其应用 |
| CN121379975B (zh) * | 2025-12-25 | 2026-04-17 | 天津一瑞生物科技股份有限公司 | 抗TcdB毒素杂交瘤细胞株、单克隆抗体及应用 |
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| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
| GB9113120D0 (en) | 1991-06-18 | 1991-08-07 | Kodak Ltd | Photographic processing apparatus |
| GB9120467D0 (en) | 1991-09-26 | 1991-11-06 | Celltech Ltd | Anti-hmfg antibodies and process for their production |
| JP3723231B2 (ja) | 1991-12-23 | 2005-12-07 | ディミナコ アクチェンゲゼルシャフト | アジュバント |
| DE69313134T2 (de) | 1992-06-25 | 1998-02-26 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| KR100310510B1 (ko) | 1993-03-23 | 2002-07-04 | 장 스테판느 | 3-0-탈아세틸화모노포스포릴지질a를함유하는백신조성물 |
| PT729473E (pt) | 1993-11-17 | 2001-02-28 | Deutsche Om Arzneimittel Gmbh | Dissacaridos de glucosamina metodo para a sua preparacao composicao farmaceutica contendo os mesmos e sua utilizacao |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| FR2716640B1 (fr) | 1994-02-28 | 1996-05-03 | Procedes Machines Speciales | Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion. |
| AU713040B2 (en) | 1994-07-15 | 1999-11-18 | University Of Iowa Research Foundation, The | Immunomodulatory oligonucleotides |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| GB9620795D0 (en) | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| WO1998016247A1 (en) | 1996-10-11 | 1998-04-23 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| GB9711990D0 (en) | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
| AU734180B2 (en) | 1997-08-29 | 2001-06-07 | Antigenics Llc | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
| EP1279401B1 (en) | 1997-09-05 | 2008-01-09 | GlaxoSmithKline Biologicals S.A. | Oil in water emulsions containing saponins |
| GB9718901D0 (en) | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| AU2003299527A1 (en) * | 2002-06-17 | 2004-06-07 | Jimmy D. Ballard | Mutant of clostridium difficile toxin b and methods of use |
| ATE544354T1 (de) * | 2002-11-26 | 2012-02-15 | Univ Chicago | Vermeidung und behandlung von mikrobenübertragenen epithelerkrankungen |
| WO2004051268A1 (en) | 2002-12-03 | 2004-06-17 | Celltech R & D Limited | Assay for identifying antibody producing cells |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| PT1644412E (pt) | 2003-07-01 | 2015-12-23 | Ucb Biopharma Sprl | Fragmentos de anticorpos fab modificados |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| ES2366626T3 (es) * | 2004-02-06 | 2011-10-24 | University Of Massachusetts | Anticuerpos contra toxinas de clostridium difficile y usos de los mismos. |
| GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| CA2592015A1 (en) | 2004-12-27 | 2006-07-06 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| EP1830635B1 (en) | 2004-12-27 | 2015-10-28 | Huntsman Corporation Australia Pty Limited | Reduced foam dispersions and formulations therefor |
| CN101500581B (zh) * | 2006-06-08 | 2013-10-30 | 科内尔研究基金会 | 编码艰难梭菌毒素a和毒素b受体结合域的密码子优化dna分子及其使用方法 |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| EP2535350B1 (en) * | 2007-09-26 | 2018-01-24 | UCB Biopharma SPRL | Dual specificity antibody fusions |
| EP2271366A4 (en) * | 2008-02-28 | 2012-06-20 | 3M Innovative Properties Co | ANTIBODIES DIFFICULT CLOSTRIDIUM SPORES AND USES THEREOF |
| KR20180005753A (ko) * | 2008-06-25 | 2018-01-16 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체 |
| US10407513B2 (en) | 2008-09-26 | 2019-09-10 | Ucb Biopharma Sprl | Biological products |
| US8709428B2 (en) * | 2009-02-20 | 2014-04-29 | Health Protection Agency | Antibodies to Clostridium difficile toxins |
| AU2011239470B2 (en) * | 2010-04-15 | 2015-09-10 | Progenics Pharmaceuticals, Inc. | Antibodies for the treatment of Clostridium difficile-associated infection and disease |
| CA2815888C (en) * | 2010-10-25 | 2020-06-30 | National Research Council Of Canada | Clostridium difficile-specific antibodies and uses thereof |
| US9815889B2 (en) * | 2011-08-02 | 2017-11-14 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Antibodies for prevention and treatment of diseases caused by clostridium difficile |
| BR112014006175B1 (pt) * | 2011-09-16 | 2020-02-11 | Ucb Pharma S.A. | Anticorpos capazes de neutralisar as exotoxinas principais tcda e tcdb de clostridium difficile |
| UA112203C2 (uk) * | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| WO2014061783A1 (ja) * | 2012-10-19 | 2014-04-24 | 株式会社イーベック | クロストリジウム・ディフィシルの毒素に特異的なヒト抗体もしくはその抗原結合性断片 |
| GB201411320D0 (en) * | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
| GB201411420D0 (en) * | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
| US9107906B1 (en) * | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
-
2012
- 2012-09-10 BR BR112014006175-0A patent/BR112014006175B1/pt not_active IP Right Cessation
- 2012-09-10 HU HUE12761789A patent/HUE043661T2/hu unknown
- 2012-09-10 ES ES12761789T patent/ES2729278T3/es active Active
- 2012-09-10 SG SG10201701055WA patent/SG10201701055WA/en unknown
- 2012-09-10 CN CN201810242539.6A patent/CN108424449A/zh active Pending
- 2012-09-10 EA EA201400345A patent/EA032475B1/ru not_active IP Right Cessation
- 2012-09-10 US US14/344,637 patent/US10752676B2/en not_active Expired - Fee Related
- 2012-09-10 SG SG11201400193SA patent/SG11201400193SA/en unknown
- 2012-09-10 AU AU2012307157A patent/AU2012307157B2/en not_active Expired - Fee Related
- 2012-09-10 HR HRP20190917TT patent/HRP20190917T1/hr unknown
- 2012-09-10 LT LTEP12761789.2T patent/LT2758432T/lt unknown
- 2012-09-10 PH PH1/2014/500456A patent/PH12014500456A1/en unknown
- 2012-09-10 EP EP19160911.4A patent/EP3617227A3/en not_active Withdrawn
- 2012-09-10 MX MX2014002769A patent/MX2014002769A/es unknown
- 2012-09-10 JP JP2014530307A patent/JP6152107B2/ja not_active Expired - Fee Related
- 2012-09-10 EP EP12761789.2A patent/EP2758432B1/en active Active
- 2012-09-10 KR KR1020147010064A patent/KR20140063825A/ko not_active Withdrawn
- 2012-09-10 PL PL12761789T patent/PL2758432T3/pl unknown
- 2012-09-10 CA CA2848611A patent/CA2848611A1/en not_active Abandoned
- 2012-09-10 HK HK14113105.9A patent/HK1199463A1/xx unknown
- 2012-09-10 SI SI201231613T patent/SI2758432T1/sl unknown
- 2012-09-10 PE PE2014000353A patent/PE20141547A1/es not_active Application Discontinuation
- 2012-09-10 DK DK12761789.2T patent/DK2758432T3/da active
- 2012-09-10 PT PT12761789T patent/PT2758432T/pt unknown
- 2012-09-10 CN CN201280049537.6A patent/CN103958544B/zh not_active Expired - Fee Related
- 2012-09-10 WO PCT/GB2012/052222 patent/WO2013038156A1/en not_active Ceased
-
2014
- 2014-02-26 IL IL231167A patent/IL231167A0/en unknown
- 2014-02-27 CL CL2014000491A patent/CL2014000491A1/es unknown
- 2014-03-07 TN TNP2014000101A patent/TN2014000101A1/en unknown
- 2014-04-15 ZA ZA2014/02760A patent/ZA201402760B/en unknown
- 2014-04-15 CO CO14082286A patent/CO6930310A2/es unknown
- 2014-04-16 EC ECSP14013316 patent/ECSP14013316A/es unknown
-
2017
- 2017-05-26 JP JP2017104698A patent/JP6603685B2/ja not_active Expired - Fee Related
-
2019
- 2019-06-05 CY CY20191100596T patent/CY1121673T1/el unknown
- 2019-10-11 JP JP2019187271A patent/JP2020037555A/ja not_active Ceased
-
2020
- 2020-07-02 US US16/919,576 patent/US20200377578A1/en not_active Abandoned
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