JP2020037555A5 - - Google Patents
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- JP2020037555A5 JP2020037555A5 JP2019187271A JP2019187271A JP2020037555A5 JP 2020037555 A5 JP2020037555 A5 JP 2020037555A5 JP 2019187271 A JP2019187271 A JP 2019187271A JP 2019187271 A JP2019187271 A JP 2019187271A JP 2020037555 A5 JP2020037555 A5 JP 2020037555A5
- Authority
- JP
- Japan
- Prior art keywords
- cdr
- seq
- sequence shown
- light chain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000003796 beauty Effects 0.000 claims 4
- 208000037384 Clostridium Infections Diseases 0.000 claims 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 1
- 206010054236 Clostridium difficile infection Diseases 0.000 claims 1
- 108010059993 Vancomycin Proteins 0.000 claims 1
- 229960002227 clindamycin Drugs 0.000 claims 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960000282 metronidazole Drugs 0.000 claims 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
- 229960003165 vancomycin Drugs 0.000 claims 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161535532P | 2011-09-16 | 2011-09-16 | |
| US61/535,532 | 2011-09-16 | ||
| US201261638731P | 2012-04-26 | 2012-04-26 | |
| US61/638,731 | 2012-04-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017104698A Division JP6603685B2 (ja) | 2011-09-16 | 2017-05-26 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020037555A JP2020037555A (ja) | 2020-03-12 |
| JP2020037555A5 true JP2020037555A5 (enExample) | 2020-08-06 |
Family
ID=46881094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530307A Expired - Fee Related JP6152107B2 (ja) | 2011-09-16 | 2012-09-10 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
| JP2017104698A Expired - Fee Related JP6603685B2 (ja) | 2011-09-16 | 2017-05-26 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
| JP2019187271A Ceased JP2020037555A (ja) | 2011-09-16 | 2019-10-11 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530307A Expired - Fee Related JP6152107B2 (ja) | 2011-09-16 | 2012-09-10 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
| JP2017104698A Expired - Fee Related JP6603685B2 (ja) | 2011-09-16 | 2017-05-26 | クロストリジウム・ディフィシレの主要な外毒素ＴｃｄＡ及びＴｃｄＢに対する中和抗体 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10752676B2 (enExample) |
| EP (2) | EP3617227A3 (enExample) |
| JP (3) | JP6152107B2 (enExample) |
| KR (1) | KR20140063825A (enExample) |
| CN (2) | CN108424449A (enExample) |
| AU (1) | AU2012307157B2 (enExample) |
| BR (1) | BR112014006175B1 (enExample) |
| CA (1) | CA2848611A1 (enExample) |
| CL (1) | CL2014000491A1 (enExample) |
| CO (1) | CO6930310A2 (enExample) |
| CY (1) | CY1121673T1 (enExample) |
| DK (1) | DK2758432T3 (enExample) |
| EA (1) | EA032475B1 (enExample) |
| EC (1) | ECSP14013316A (enExample) |
| ES (1) | ES2729278T3 (enExample) |
| HK (1) | HK1199463A1 (enExample) |
| HR (1) | HRP20190917T1 (enExample) |
| HU (1) | HUE043661T2 (enExample) |
| IL (1) | IL231167A0 (enExample) |
| LT (1) | LT2758432T (enExample) |
| MX (1) | MX2014002769A (enExample) |
| PE (1) | PE20141547A1 (enExample) |
| PH (1) | PH12014500456A1 (enExample) |
| PL (1) | PL2758432T3 (enExample) |
| PT (1) | PT2758432T (enExample) |
| SG (2) | SG10201701055WA (enExample) |
| SI (1) | SI2758432T1 (enExample) |
| TN (1) | TN2014000101A1 (enExample) |
| WO (1) | WO2013038156A1 (enExample) |
| ZA (1) | ZA201402760B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014006175B1 (pt) * | 2011-09-16 | 2020-02-11 | Ucb Pharma S.A. | Anticorpos capazes de neutralisar as exotoxinas principais tcda e tcdb de clostridium difficile |
| WO2014085749A2 (en) * | 2012-11-28 | 2014-06-05 | Cnj Holdings, Inc. | Antibodies against clostridium difficile |
| CN105451762A (zh) * | 2013-04-22 | 2016-03-30 | 俄克拉荷马州大学评议会 | 艰难梭菌疫苗及使用方法 |
| US9926345B2 (en) | 2014-02-18 | 2018-03-27 | The Hospital For Sick Children | Compositions and methods for treating or preventing Clostridium infection |
| US9717711B2 (en) | 2014-06-16 | 2017-08-01 | The Lauridsen Group | Methods and compositions for treating Clostridium difficile associated disease |
| WO2016178773A1 (en) * | 2015-04-06 | 2016-11-10 | Saureus, Inc. | System and method for detecting clostridium difficile toxins |
| EP3283103A4 (en) * | 2015-04-15 | 2018-12-05 | Medimmune, LLC | Methods for treating clostridium difficile infection and associated disease |
| UA127809C2 (uk) | 2015-06-24 | 2024-01-10 | Ф. Хоффманн-Ля Рош Аг | Антитіло до рецептора трансферину зі спеціально підібраною афінністю |
| WO2017040885A1 (en) | 2015-09-03 | 2017-03-09 | The Board Of Regents Of The University Of Oklahoma | Peptide inhibitors of clostridium difficile tcdb toxin |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| KR20250052494A (ko) | 2015-10-02 | 2025-04-18 | 에프. 호프만-라 로슈 아게 | 이중특이성 항-인간 cd20/인간 트랜스페린 수용체 항체 및 사용 방법 |
| USD864160S1 (en) | 2016-12-06 | 2019-10-22 | Samsung Electronics Co., Ltd. | Audio device |
| WO2018111662A1 (en) * | 2016-12-14 | 2018-06-21 | Merck Sharp & Dohme Corp. | Human genetic markers associated with response to treatments that target clostridium difficile toxin b |
| CN110607314B (zh) * | 2019-10-31 | 2022-09-23 | 四川农业大学 | 一种TcdB RBD基因、重组RBD蛋白和应用 |
| CN111763263A (zh) * | 2020-07-09 | 2020-10-13 | 宁夏医科大学 | 一种艰难梭菌抗原及多克隆抗体的制备方法和检测试剂盒 |
| CN112500484B (zh) * | 2021-01-29 | 2021-06-08 | 迈杰转化医学研究(苏州)有限公司 | 一种抗trop2抗体及其应用 |
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| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
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| GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
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| UA40597C2 (uk) | 1992-06-25 | 2001-08-15 | Смітклайн Бічем Байолоджікалс С.А. | Вакцинна композиція,спосіб лікування ссавців, що страждають або сприйнятливі до інфекції, спосіб лікування ссавців, що страждають на рак, спосіб одержання вакцинної композиції, композиція ад'ювантів |
| EP1175912A1 (en) | 1993-03-23 | 2002-01-30 | SmithKline Beecham Biologics SA | Vaccine compositions containing 3-O deacylated monophosphoryl lipid A |
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| FR2716640B1 (fr) | 1994-02-28 | 1996-05-03 | Procedes Machines Speciales | Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion. |
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| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
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| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| GB9711990D0 (en) | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
| EP1009429B1 (en) | 1997-08-29 | 2009-07-08 | Antigenics Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
| DE69815692T2 (de) | 1997-09-05 | 2004-04-29 | Glaxosmithkline Biologicals S.A. | Öl in wasser emulsionen mit saponinen |
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| WO2004041857A2 (en) * | 2002-06-17 | 2004-05-21 | Ballard Jimmy D | Mutant of clostridium difficile toxin b and methods of use |
| JP5271475B2 (ja) * | 2002-11-26 | 2013-08-21 | ザ ユニヴァーシティー オヴ シカゴ | 微生物媒介上皮疾患の予防及び治療のための材料並びに方法 |
| AU2003285578B2 (en) | 2002-12-03 | 2010-07-15 | Ucb Pharma S.A. | Assay for identifying antibody producing cells |
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| DK1644412T4 (en) | 2003-07-01 | 2018-11-12 | Ucb Biopharma Sprl | MODIFIED ANTIBODY-FAB FRAGMENTS |
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| HRP20110599T1 (hr) | 2004-02-06 | 2011-10-31 | University Of Massachusetts | Antitijela protiv toksina clostridium difficile i njihove primjene |
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| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| US9433206B2 (en) | 2004-12-27 | 2016-09-06 | Huntsman Corporation Australia Pty Limited | Reduced foam dispersions and formulations therefor |
| CA2592015A1 (en) | 2004-12-27 | 2006-07-06 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| CN101500581B (zh) * | 2006-06-08 | 2013-10-30 | 科内尔研究基金会 | 编码艰难梭菌毒素a和毒素b受体结合域的密码子优化dna分子及其使用方法 |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| EP2195341B1 (en) * | 2007-09-26 | 2017-03-22 | UCB Biopharma SPRL | Dual specificity antibody fusions |
| KR20100126760A (ko) * | 2008-02-28 | 2010-12-02 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 클로스트리듐 디피실레 포자에 대한 항체 및 그 용도 |
| MX347972B (es) * | 2008-06-25 | 2017-05-22 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles que inhiben el vegf. |
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| BR112014006175B1 (pt) * | 2011-09-16 | 2020-02-11 | Ucb Pharma S.A. | Anticorpos capazes de neutralisar as exotoxinas principais tcda e tcdb de clostridium difficile |
| UA112203C2 (uk) * | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
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| GB201411320D0 (en) * | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
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| US9107906B1 (en) * | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
-
2012
- 2012-09-10 BR BR112014006175-0A patent/BR112014006175B1/pt not_active IP Right Cessation
- 2012-09-10 EP EP19160911.4A patent/EP3617227A3/en not_active Withdrawn
- 2012-09-10 PL PL12761789T patent/PL2758432T3/pl unknown
- 2012-09-10 US US14/344,637 patent/US10752676B2/en not_active Expired - Fee Related
- 2012-09-10 CN CN201810242539.6A patent/CN108424449A/zh active Pending
- 2012-09-10 SG SG10201701055WA patent/SG10201701055WA/en unknown
- 2012-09-10 PH PH1/2014/500456A patent/PH12014500456A1/en unknown
- 2012-09-10 CN CN201280049537.6A patent/CN103958544B/zh not_active Expired - Fee Related
- 2012-09-10 PE PE2014000353A patent/PE20141547A1/es not_active Application Discontinuation
- 2012-09-10 AU AU2012307157A patent/AU2012307157B2/en not_active Expired - Fee Related
- 2012-09-10 HK HK14113105.9A patent/HK1199463A1/xx unknown
- 2012-09-10 JP JP2014530307A patent/JP6152107B2/ja not_active Expired - Fee Related
- 2012-09-10 SI SI201231613T patent/SI2758432T1/sl unknown
- 2012-09-10 EP EP12761789.2A patent/EP2758432B1/en active Active
- 2012-09-10 ES ES12761789T patent/ES2729278T3/es active Active
- 2012-09-10 DK DK12761789.2T patent/DK2758432T3/da active
- 2012-09-10 MX MX2014002769A patent/MX2014002769A/es unknown
- 2012-09-10 HR HRP20190917TT patent/HRP20190917T1/hr unknown
- 2012-09-10 HU HUE12761789A patent/HUE043661T2/hu unknown
- 2012-09-10 EA EA201400345A patent/EA032475B1/ru not_active IP Right Cessation
- 2012-09-10 KR KR1020147010064A patent/KR20140063825A/ko not_active Withdrawn
- 2012-09-10 CA CA2848611A patent/CA2848611A1/en not_active Abandoned
- 2012-09-10 LT LTEP12761789.2T patent/LT2758432T/lt unknown
- 2012-09-10 SG SG11201400193SA patent/SG11201400193SA/en unknown
- 2012-09-10 PT PT12761789T patent/PT2758432T/pt unknown
- 2012-09-10 WO PCT/GB2012/052222 patent/WO2013038156A1/en not_active Ceased
-
2014
- 2014-02-26 IL IL231167A patent/IL231167A0/en unknown
- 2014-02-27 CL CL2014000491A patent/CL2014000491A1/es unknown
- 2014-03-07 TN TNP2014000101A patent/TN2014000101A1/en unknown
- 2014-04-15 ZA ZA2014/02760A patent/ZA201402760B/en unknown
- 2014-04-15 CO CO14082286A patent/CO6930310A2/es unknown
- 2014-04-16 EC ECSP14013316 patent/ECSP14013316A/es unknown
-
2017
- 2017-05-26 JP JP2017104698A patent/JP6603685B2/ja not_active Expired - Fee Related
-
2019
- 2019-06-05 CY CY20191100596T patent/CY1121673T1/el unknown
- 2019-10-11 JP JP2019187271A patent/JP2020037555A/ja not_active Ceased
-
2020
- 2020-07-02 US US16/919,576 patent/US20200377578A1/en not_active Abandoned
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