DK2758432T3 - Neutraliserende antistoffer mod hovedtoksinerne TcdA og TcdB fra Clostridium difficile - Google Patents

Neutraliserende antistoffer mod hovedtoksinerne TcdA og TcdB fra Clostridium difficile Download PDF

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Publication number
DK2758432T3
DK2758432T3 DK12761789.2T DK12761789T DK2758432T3 DK 2758432 T3 DK2758432 T3 DK 2758432T3 DK 12761789 T DK12761789 T DK 12761789T DK 2758432 T3 DK2758432 T3 DK 2758432T3
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Denmark
Prior art keywords
tcdb
neutralizing antibodies
clostridium difficile
toxins tcda
main toxins
Prior art date
Application number
DK12761789.2T
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Danish (da)
English (en)
Inventor
David Paul Humphreys
Daniel John Lightwood
Kerry Louise Tyson
David Edward Ormonde Knight
Karine Jeannine Madeleine Hervé
Joanne Elizabeth Compson
Matthew Jon Timothy Page
Andrew Charles Payne
Nicola Louise Fisher
Brendon Mackenzie
Matthew Cox
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Ucb Biopharma Sprl
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Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
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Publication of DK2758432T3 publication Critical patent/DK2758432T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91097—Hexosyltransferases (general) (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK12761789.2T 2011-09-16 2012-09-10 Neutraliserende antistoffer mod hovedtoksinerne TcdA og TcdB fra Clostridium difficile DK2758432T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535532P 2011-09-16 2011-09-16
US201261638731P 2012-04-26 2012-04-26
PCT/GB2012/052222 WO2013038156A1 (en) 2011-09-16 2012-09-10 Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile

Publications (1)

Publication Number Publication Date
DK2758432T3 true DK2758432T3 (da) 2019-06-03

Family

ID=46881094

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12761789.2T DK2758432T3 (da) 2011-09-16 2012-09-10 Neutraliserende antistoffer mod hovedtoksinerne TcdA og TcdB fra Clostridium difficile

Country Status (30)

Country Link
US (2) US10752676B2 (enExample)
EP (2) EP2758432B1 (enExample)
JP (3) JP6152107B2 (enExample)
KR (1) KR20140063825A (enExample)
CN (2) CN108424449A (enExample)
AU (1) AU2012307157B2 (enExample)
BR (1) BR112014006175B1 (enExample)
CA (1) CA2848611A1 (enExample)
CL (1) CL2014000491A1 (enExample)
CO (1) CO6930310A2 (enExample)
CY (1) CY1121673T1 (enExample)
DK (1) DK2758432T3 (enExample)
EA (1) EA032475B1 (enExample)
EC (1) ECSP14013316A (enExample)
ES (1) ES2729278T3 (enExample)
HK (1) HK1199463A1 (enExample)
HR (1) HRP20190917T1 (enExample)
HU (1) HUE043661T2 (enExample)
IL (1) IL231167A0 (enExample)
LT (1) LT2758432T (enExample)
MX (1) MX2014002769A (enExample)
PE (1) PE20141547A1 (enExample)
PH (1) PH12014500456A1 (enExample)
PL (1) PL2758432T3 (enExample)
PT (1) PT2758432T (enExample)
SG (2) SG10201701055WA (enExample)
SI (1) SI2758432T1 (enExample)
TN (1) TN2014000101A1 (enExample)
WO (1) WO2013038156A1 (enExample)
ZA (1) ZA201402760B (enExample)

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SG11201400193SA (en) 2014-05-29
PT2758432T (pt) 2019-06-14
JP2020037555A (ja) 2020-03-12
CA2848611A1 (en) 2013-03-21
AU2012307157A1 (en) 2014-04-24
CL2014000491A1 (es) 2014-12-26
IL231167A0 (en) 2014-04-30
CN103958544A (zh) 2014-07-30
ECSP14013316A (es) 2014-08-29
PE20141547A1 (es) 2014-10-25
TN2014000101A1 (en) 2015-07-01
CN108424449A (zh) 2018-08-21
HK1199463A1 (en) 2015-07-03
BR112014006175B1 (pt) 2020-02-11
LT2758432T (lt) 2019-06-10
JP6152107B2 (ja) 2017-06-21
EP3617227A3 (en) 2020-06-03
PL2758432T3 (pl) 2019-08-30
PH12014500456A1 (en) 2014-04-14
US20140348844A1 (en) 2014-11-27
AU2012307157B2 (en) 2017-08-03
HRP20190917T1 (hr) 2019-07-26
ES2729278T3 (es) 2019-10-31
BR112014006175A2 (pt) 2017-04-04
CO6930310A2 (es) 2014-04-28
EP3617227A2 (en) 2020-03-04
JP2015501286A (ja) 2015-01-15
CY1121673T1 (el) 2020-07-31
KR20140063825A (ko) 2014-05-27
US10752676B2 (en) 2020-08-25
CN103958544B (zh) 2018-04-24
EA032475B1 (ru) 2019-06-28
JP6603685B2 (ja) 2019-11-06
US20200377578A1 (en) 2020-12-03
ZA201402760B (en) 2016-03-30
SG10201701055WA (en) 2017-03-30
JP2017149773A (ja) 2017-08-31
MX2014002769A (es) 2014-06-11
EA201400345A1 (ru) 2014-09-30
EP2758432B1 (en) 2019-03-06
EP2758432A1 (en) 2014-07-30
NZ623293A (en) 2016-05-27
HUE043661T2 (hu) 2019-08-28
WO2013038156A1 (en) 2013-03-21
SI2758432T1 (sl) 2019-07-31

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