JP2012521191A5 - - Google Patents

Info

Publication number

JP2012521191A5

JP2012521191A5 JP2011551173A JP2011551173A JP2012521191A5 JP 2012521191 A5 JP2012521191 A5 JP 2012521191A5 JP 2011551173 A JP2011551173 A JP 2011551173A JP 2011551173 A JP2011551173 A JP 2011551173A JP 2012521191 A5 JP2012521191 A5 JP 2012521191A5

Authority

JP

Japan

Prior art keywords

seq

antibody

sequence provided

heavy chain

light chain

Prior art date

2010-02-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000003042 antagnostic effect Effects 0.000 claims 12
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 7
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 7
• 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 6
• 102000050320 human TNFRSF4 Human genes 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 208000035475 disorder Diseases 0.000 claims 5
• 230000001575 pathological effect Effects 0.000 claims 5
• 108020001507 fusion proteins Proteins 0.000 claims 4
• 102000037865 fusion proteins Human genes 0.000 claims 4
• 229920000642 polymer Polymers 0.000 claims 4
• 108060003951 Immunoglobulin Proteins 0.000 claims 3
• 125000003277 amino group Chemical group 0.000 claims 3
• 102000018358 immunoglobulin Human genes 0.000 claims 3
• 229920001427 mPEG Polymers 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 238000010367 cloning Methods 0.000 claims 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
• 239000012636 effector Substances 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 239000013599 cloning vector Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000003472 neutralizing effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920002859 polyalkenylene Polymers 0.000 claims 1
• 229920001281 polyalkylene Polymers 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1