MA33122B1 - Molecules d'anticorps ayant une specificite pour ox40 humain - Google Patents

Molecules d'anticorps ayant une specificite pour ox40 humain

Info

Publication number
MA33122B1
MA33122B1 MA34167A MA34167A MA33122B1 MA 33122 B1 MA33122 B1 MA 33122B1 MA 34167 A MA34167 A MA 34167A MA 34167 A MA34167 A MA 34167A MA 33122 B1 MA33122 B1 MA 33122B1
Authority
MA
Morocco
Prior art keywords
antibody molecules
human
quality
specificity
producing
Prior art date
Application number
MA34167A
Other languages
Arabic (ar)
English (en)
Inventor
Alastair David Griffiths Lawson
Andrew Malcolm Nesbitt
Andrew George Popplewell
Stephen Graham Shaw
Diana Shpektor
Yi Zhang
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42634416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33122(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of MA33122B1 publication Critical patent/MA33122B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)

Abstract

L'invention porte sur des molécules d'anticorps ayant une spécificité pour des déterminants antigéniques de OX40 humain, sur des utilisations thérapeutiques des molécules d'anticorps et sur des procédés de production desdites molécules d'anticorps.
MA34167A 2009-02-17 2010-02-17 Molecules d'anticorps ayant une specificite pour ox40 humain MA33122B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15303809P 2009-02-17 2009-02-17
PCT/US2010/024377 WO2010096418A2 (fr) 2009-02-17 2010-02-17 Molécules d'anticorps ayant une spécificité pour ox40 humain

Publications (1)

Publication Number Publication Date
MA33122B1 true MA33122B1 (fr) 2012-03-01

Family

ID=42634416

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34167A MA33122B1 (fr) 2009-02-17 2010-02-17 Molecules d'anticorps ayant une specificite pour ox40 humain

Country Status (35)

Country Link
US (3) US8614295B2 (fr)
EP (1) EP2398498B1 (fr)
JP (2) JP5782385B2 (fr)
KR (1) KR101761929B1 (fr)
CN (1) CN102741287B (fr)
AR (1) AR075504A1 (fr)
AU (1) AU2010216152B2 (fr)
BR (1) BRPI1008692B8 (fr)
CA (1) CA2751477C (fr)
CL (1) CL2011001994A1 (fr)
CO (1) CO6410312A2 (fr)
CY (1) CY1121431T1 (fr)
DK (1) DK2398498T3 (fr)
EA (1) EA037792B1 (fr)
ES (1) ES2699716T3 (fr)
HK (1) HK1177470A1 (fr)
HR (1) HRP20181932T1 (fr)
HU (1) HUE042114T2 (fr)
IL (1) IL214282A (fr)
LT (1) LT2398498T (fr)
MA (1) MA33122B1 (fr)
MX (1) MX2011008697A (fr)
MY (1) MY157473A (fr)
NZ (1) NZ594315A (fr)
PE (1) PE20120211A1 (fr)
PL (1) PL2398498T3 (fr)
PT (1) PT2398498T (fr)
SG (3) SG10201505038TA (fr)
SI (1) SI2398498T1 (fr)
TN (1) TN2011000374A1 (fr)
TW (1) TWI476281B (fr)
UA (1) UA107341C2 (fr)
UY (1) UY32451A (fr)
WO (1) WO2010096418A2 (fr)
ZA (1) ZA201105500B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1008692B8 (pt) 2009-02-17 2021-05-25 Ucb Biopharma Sprl anticorpo antagonista tendo especificidade para ox40 humano, sequência de dna isolado, vetor de clonagem ou de expressão, célula hospedeira, processo para a produção do referido anticorpo, composição farmacêutica, uso do 5 referido anticorpo e proteína de fusão
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
ES2630328T3 (es) 2010-08-23 2017-08-21 Board Of Regents, The University Of Texas System Anticuerpos anti-OX40 y procedimientos de uso de los mismos
EP2655409A4 (fr) 2010-12-22 2015-07-01 Univ Leland Stanford Junior Super-agonistes et antagonistes de l'interleukine-2
JP6261499B2 (ja) * 2011-07-11 2018-01-17 グレンマーク ファーマシューティカルズ， エセ．アー． Ｏｘ４０と結合する抗体およびその使用
CA2845810C (fr) * 2011-08-23 2017-03-28 Board Of Regents, The University Of Texas System Anticorps anti-ox40 et leurs procedes d'utilisation
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
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