JP2016006052A5 - - Google Patents

Info

Publication number

JP2016006052A5

JP2016006052A5 JP2015134436A JP2015134436A JP2016006052A5 JP 2016006052 A5 JP2016006052 A5 JP 2016006052A5 JP 2015134436 A JP2015134436 A JP 2015134436A JP 2015134436 A JP2015134436 A JP 2015134436A JP 2016006052 A5 JP2016006052 A5 JP 2016006052A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

acid sequence

substitution

sequence shown

Prior art date

2015-07-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 30
• 238000006467 substitution reaction Methods 0.000 claims 16
• 150000001413 amino acids Chemical class 0.000 claims 12
• 206010054094 Tumour necrosis Diseases 0.000 claims 8
• 230000000259 anti-tumor effect Effects 0.000 claims 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 208000030507 AIDS Diseases 0.000 claims 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 241000701022 Cytomegalovirus Species 0.000 claims 1
• 150000008575 L-amino acids Chemical group 0.000 claims 1
• 206010027202 Meningitis bacterial Diseases 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 206010000269 abscess Diseases 0.000 claims 1
• 201000009904 bacterial meningitis Diseases 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000005980 lung dysfunction Effects 0.000 claims 1
• 201000004792 malaria Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 239000012634 fragment Substances 0.000 description 1