CN102675460B - 抗肿瘤坏死因子α的人源化抗体 - Google Patents

抗肿瘤坏死因子α的人源化抗体 Download PDF

Info

Publication number
CN102675460B
CN102675460B CN201210026698.5A CN201210026698A CN102675460B CN 102675460 B CN102675460 B CN 102675460B CN 201210026698 A CN201210026698 A CN 201210026698A CN 102675460 B CN102675460 B CN 102675460B
Authority
CN
China
Prior art keywords
antibody
chain variable
variable region
region sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201210026698.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN102675460A (zh
Inventor
朱保国
陶德胜
孙乃超
金宜慧
刘瑞贤
周若芸
李强
彭育才
张经纬
胡振湘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd
Original Assignee
ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46757361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102675460(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd filed Critical ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd
Priority to CN201210026698.5A priority Critical patent/CN102675460B/zh
Priority to RU2013139480/10A priority patent/RU2549700C1/ru
Priority to KR1020137025433A priority patent/KR101576559B1/ko
Priority to JP2013516997A priority patent/JP6054864B2/ja
Priority to PCT/CN2012/071079 priority patent/WO2012116595A1/zh
Priority to NZ615477A priority patent/NZ615477B2/en
Priority to BR112013021860-6A priority patent/BR112013021860A2/pt
Priority to AU2012222738A priority patent/AU2012222738B2/en
Priority to EP12752672.1A priority patent/EP2682405A4/en
Priority to CA2827799A priority patent/CA2827799C/en
Priority to US13/405,144 priority patent/US8658171B2/en
Priority to ARP120100640A priority patent/AR085501A1/es
Publication of CN102675460A publication Critical patent/CN102675460A/zh
Priority to JP2015134436A priority patent/JP2016006052A/ja
Publication of CN102675460B publication Critical patent/CN102675460B/zh
Application granted granted Critical
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201210026698.5A 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体 Expired - Fee Related CN102675460B (zh)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CN201210026698.5A CN102675460B (zh) 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体
EP12752672.1A EP2682405A4 (en) 2011-02-28 2012-02-13 THROUGH THE TUMOR NECROSIS FACTOR HUMANIZED ANTIBODY
KR1020137025433A KR101576559B1 (ko) 2011-02-28 2012-02-13 종양 괴사인자―α 인간화 항체
JP2013516997A JP6054864B2 (ja) 2011-02-28 2012-02-13 抗腫瘍壊死因子αヒト化抗体
PCT/CN2012/071079 WO2012116595A1 (zh) 2011-02-28 2012-02-13 抗肿瘤坏死因子α的人源化抗体
NZ615477A NZ615477B2 (en) 2011-02-28 2012-02-13 Tumor necrosis factor-? humanized antibody
BR112013021860-6A BR112013021860A2 (pt) 2011-02-28 2012-02-13 anticorpo anti-tnfalpha humanizado
AU2012222738A AU2012222738B2 (en) 2011-02-28 2012-02-13 Tumor necrosis factor-a humanized antibody
RU2013139480/10A RU2549700C1 (ru) 2011-02-28 2012-02-13 ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ TNFα
CA2827799A CA2827799C (en) 2011-02-28 2012-02-13 Tumor necrosis factor-a humanized antibody
US13/405,144 US8658171B2 (en) 2011-02-28 2012-02-24 Humanized anti-TNFα antibodies
ARP120100640A AR085501A1 (es) 2011-02-28 2012-02-28 ANTICUERPO ANTI-TNF a HUMANIZADO
JP2015134436A JP2016006052A (ja) 2011-02-28 2015-07-03 抗腫瘍壊死因子αヒト化抗体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201110048505.1 2011-02-28
CN201110048505 2011-02-28
CN2011100485051 2011-02-28
CN201210026698.5A CN102675460B (zh) 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体

Publications (2)

Publication Number Publication Date
CN102675460A CN102675460A (zh) 2012-09-19
CN102675460B true CN102675460B (zh) 2015-08-19

Family

ID=46757361

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201210026698.5A Expired - Fee Related CN102675460B (zh) 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体

Country Status (11)

Country Link
US (1) US8658171B2 (enExample)
EP (1) EP2682405A4 (enExample)
JP (2) JP6054864B2 (enExample)
KR (1) KR101576559B1 (enExample)
CN (1) CN102675460B (enExample)
AR (1) AR085501A1 (enExample)
AU (1) AU2012222738B2 (enExample)
BR (1) BR112013021860A2 (enExample)
CA (1) CA2827799C (enExample)
RU (1) RU2549700C1 (enExample)
WO (1) WO2012116595A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103217489B (zh) 2013-01-15 2016-03-09 珠海市丽珠单抗生物技术有限公司 一种测定蛋白纯化工艺过程中样品的糖基化和末端修饰情况的方法
WO2015190439A1 (ja) * 2014-06-09 2015-12-17 株式会社カネカ 抗体に結合する低分子化合物のスクリーニング方法
IL261793B2 (en) * 2016-03-17 2025-04-01 Numab Therapeutics AG ANTI-TNFALPHA ANTIBODIES AND THEIR FUNCTIONAL PARTS
CN106279413A (zh) * 2016-08-30 2017-01-04 苏州普罗达生物科技有限公司 抗肿瘤坏死因子抗体多肽及应用
CN111153994B (zh) * 2019-12-31 2021-10-15 武汉班科生物技术股份有限公司 人肿瘤坏死因子的人源单克隆抗体
CN115819575B (zh) * 2022-08-24 2023-06-27 武汉爱博泰克生物科技有限公司 针对人肿瘤坏死因子-α的单克隆抗体
CN115710314B (zh) * 2022-09-14 2025-10-28 江苏睿源生物技术有限公司 用于检测肿瘤坏死因子-α的抗体组合及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4193302T1 (de) * 1990-12-21 1993-02-18 Celltech Ltd Rekombinanter antikoerper spezifisch fuer tnf-(alpha)
CN1649624A (zh) * 2002-04-26 2005-08-03 艾博特生物技术有限公司 TNFα抗体及另外一种药物的用途
CN101177453A (zh) * 2006-11-07 2008-05-14 旭华（上海）生物研发中心有限公司 抗人肿瘤坏死因子α的重组嵌合抗体

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4818679A (en) 1985-02-19 1989-04-04 The Trustees Of Columbia University In The City Of New York Method for recovering mutant cells
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
DE07012626T1 (de) 1991-03-18 2010-01-21 New York University Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
UA81743C2 (uk) * 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
AU2002351957B2 (en) 2001-11-12 2009-09-03 Merck Patent Gmbh Modified anti-TNF alpha antibody
CN1225479C (zh) * 2002-12-23 2005-11-02 马菁 肿瘤坏死因子抗体，其制备方法以及药物组合物
CN1255536C (zh) 2003-11-13 2006-05-10 中国人民解放军第四军医大学 高亲和力抗肿瘤坏死因子单克隆抗体的可变区基因及其制备
KR100772800B1 (ko) 2003-11-17 2007-11-01 주식회사유한양행 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자
CA2577133A1 (en) * 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
CN101111521B (zh) * 2004-12-29 2011-08-24 株式会社柳韩洋行 肿瘤坏死因子-α特异性人源化抗体
EP2545938A1 (en) * 2007-08-03 2013-01-16 Abbott Biotherapeutics Corp. Therapeutic use of anti-tweak receptor antibodies
EP2050764A1 (en) * 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
PT2242773T (pt) * 2008-02-11 2017-09-15 Cure Tech Ltd Anticorpos monoclonais para o tratamento de tumores

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4193302T1 (de) * 1990-12-21 1993-02-18 Celltech Ltd Rekombinanter antikoerper spezifisch fuer tnf-(alpha)
CN1649624A (zh) * 2002-04-26 2005-08-03 艾博特生物技术有限公司 TNFα抗体及另外一种药物的用途
CN101177453A (zh) * 2006-11-07 2008-05-14 旭华（上海）生物研发中心有限公司 抗人肿瘤坏死因子α的重组嵌合抗体

Also Published As

Publication number Publication date
KR20130133272A (ko) 2013-12-06
US8658171B2 (en) 2014-02-25
WO2012116595A1 (zh) 2012-09-07
NZ615477A (en) 2015-11-27
JP2016006052A (ja) 2016-01-14
JP6054864B2 (ja) 2016-12-27
RU2013139480A (ru) 2015-04-10
JP2013539354A (ja) 2013-10-24
CN102675460A (zh) 2012-09-19
EP2682405A4 (en) 2015-06-24
AU2012222738B2 (en) 2016-05-26
AU2012222738A1 (en) 2013-08-22
KR101576559B1 (ko) 2015-12-10
AR085501A1 (es) 2013-10-09
RU2549700C1 (ru) 2015-04-27
CA2827799C (en) 2017-03-21
CA2827799A1 (en) 2012-09-07
US20120219547A1 (en) 2012-08-30
EP2682405A1 (en) 2014-01-08
BR112013021860A2 (pt) 2018-09-11

Similar Documents

Publication Publication Date Title
US10899837B2 (en) B7-H3 antibody, antigen-binding fragment thereof and medical use thereof
JP2023065375A (ja) 胸腺間質性リンパ球性新生因子に結合することができる抗原結合タンパク質
TWI391401B (zh) 人類化之抗-因子ｄ抗體及其用途
CN102482349B (zh) 抗vegf抗体和其用途
CA3098374A1 (en) Optimized anti-tl1a antibodies
CN108473568A (zh) 对TNF-α、IL-17A和IL-17F具有特异性的多特异性抗体分子
WO2011084714A2 (en) STABILIZED ANTI-TNF-ALPHA scFv MOLECULES OR ANTI-TWEAK scFv MOLECULES AND USES THEREOF
JP6054864B2 (ja) 抗腫瘍壊死因子αヒト化抗体
CN104903348A (zh) 抗vegf抗体及其用途
WO2004041863A2 (en) Single domain antibodies directed against interferon- gamma and uses therefor
JP2012510295A (ja) グアニル酸シクラーゼ受容体に対する抗体
WO2018050027A1 (zh) 一种能够特异性地结合pd-1的抗体及其功能片段
TW201915023A (zh) Ｉｌ－６ｒ抗體、其抗原結合片段及醫藥用途
CN107428838A (zh) 结合tfpi的新型抗体以及包含所述抗体的组合物
WO2022143550A1 (zh) 间皮素结合分子及其应用
TW201333034A (zh) 新穎抗人類ｃｔｇｆ抗體
EP4013785A1 (en) Complement c2 binding proteins and uses thereof
CN104558175B (zh) 抗人vegf的重组嵌合抗体及其制备方法和用途
CN115594762A (zh) 一种铁蛋白重链抗体及其用途
KR20250050855A (ko) Igf1r 항체
WO2022268178A1 (zh) 人表皮生长因子受体结合分子及其应用
JP7676356B2 (ja) 新規ｂｓｓｌ抗体
HK1175486A1 (zh) 抗肿瘤坏死因子α的人源化抗体
HK1175486B (en) HUMANIZED ANTI-TNFα ANTIBODY
NZ615477B2 (en) Tumor necrosis factor-? humanized antibody

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1175486

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1175486

Country of ref document: HK

DD01 Delivery of document by public notice

Addressee: Zhao Wudi

Document name: Notice of acceptance of a petition for invalidation

DD01 Delivery of document by public notice
PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of invention: Anti tumor necrosis factor a Humanized antibodies

Effective date of registration: 20231215

Granted publication date: 20150819

Pledgee: CITIC Bank Zhuhai Branch

Pledgor: LIVZON MABPHARM Inc.

Registration number: Y2023980072292

PE01 Entry into force of the registration of the contract for pledge of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150819

CF01 Termination of patent right due to non-payment of annual fee