CN102675460B - 抗肿瘤坏死因子α的人源化抗体 - Google Patents

抗肿瘤坏死因子α的人源化抗体 Download PDF

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Publication number
CN102675460B
CN102675460B CN201210026698.5A CN201210026698A CN102675460B CN 102675460 B CN102675460 B CN 102675460B CN 201210026698 A CN201210026698 A CN 201210026698A CN 102675460 B CN102675460 B CN 102675460B
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antibody
seq
tumor necrosis
chain variable
amino acid
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Chinese (zh)
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CN102675460A (zh
Inventor
朱保国
陶德胜
孙乃超
金宜慧
刘瑞贤
周若芸
李强
彭育才
张经纬
胡振湘
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ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd
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ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd
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Application filed by ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd filed Critical ZHUHAI LIZHU SHEET RESISTANCE TO BIOTECHNOLOGY CO Ltd
Priority to CN201210026698.5A priority Critical patent/CN102675460B/zh
Priority to NZ615477A priority patent/NZ615477B2/en
Priority to AU2012222738A priority patent/AU2012222738B2/en
Priority to RU2013139480/10A priority patent/RU2549700C1/ru
Priority to CA2827799A priority patent/CA2827799C/en
Priority to EP12752672.1A priority patent/EP2682405A4/en
Priority to JP2013516997A priority patent/JP6054864B2/ja
Priority to KR1020137025433A priority patent/KR101576559B1/ko
Priority to BR112013021860-6A priority patent/BR112013021860A2/pt
Priority to PCT/CN2012/071079 priority patent/WO2012116595A1/zh
Priority to US13/405,144 priority patent/US8658171B2/en
Priority to ARP120100640A priority patent/AR085501A1/es
Publication of CN102675460A publication Critical patent/CN102675460A/zh
Priority to JP2015134436A priority patent/JP2016006052A/ja
Publication of CN102675460B publication Critical patent/CN102675460B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201210026698.5A 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体 Active CN102675460B (zh)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CN201210026698.5A CN102675460B (zh) 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体
BR112013021860-6A BR112013021860A2 (pt) 2011-02-28 2012-02-13 anticorpo anti-tnfalpha humanizado
AU2012222738A AU2012222738B2 (en) 2011-02-28 2012-02-13 Tumor necrosis factor-a humanized antibody
RU2013139480/10A RU2549700C1 (ru) 2011-02-28 2012-02-13 ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ TNFα
CA2827799A CA2827799C (en) 2011-02-28 2012-02-13 Tumor necrosis factor-a humanized antibody
EP12752672.1A EP2682405A4 (en) 2011-02-28 2012-02-13 THROUGH THE TUMOR NECROSIS FACTOR HUMANIZED ANTIBODY
JP2013516997A JP6054864B2 (ja) 2011-02-28 2012-02-13 抗腫瘍壊死因子αヒト化抗体
KR1020137025433A KR101576559B1 (ko) 2011-02-28 2012-02-13 종양 괴사인자―α 인간화 항체
NZ615477A NZ615477B2 (en) 2011-02-28 2012-02-13 Tumor necrosis factor-? humanized antibody
PCT/CN2012/071079 WO2012116595A1 (zh) 2011-02-28 2012-02-13 抗肿瘤坏死因子α的人源化抗体
US13/405,144 US8658171B2 (en) 2011-02-28 2012-02-24 Humanized anti-TNFα antibodies
ARP120100640A AR085501A1 (es) 2011-02-28 2012-02-28 ANTICUERPO ANTI-TNF a HUMANIZADO
JP2015134436A JP2016006052A (ja) 2011-02-28 2015-07-03 抗腫瘍壊死因子αヒト化抗体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201110048505.1 2011-02-28
CN2011100485051 2011-02-28
CN201110048505 2011-02-28
CN201210026698.5A CN102675460B (zh) 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体

Publications (2)

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CN102675460A CN102675460A (zh) 2012-09-19
CN102675460B true CN102675460B (zh) 2015-08-19

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CN201210026698.5A Active CN102675460B (zh) 2011-02-28 2012-02-07 抗肿瘤坏死因子α的人源化抗体

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EP (1) EP2682405A4 (enExample)
JP (2) JP6054864B2 (enExample)
KR (1) KR101576559B1 (enExample)
CN (1) CN102675460B (enExample)
AR (1) AR085501A1 (enExample)
AU (1) AU2012222738B2 (enExample)
BR (1) BR112013021860A2 (enExample)
CA (1) CA2827799C (enExample)
RU (1) RU2549700C1 (enExample)
WO (1) WO2012116595A1 (enExample)

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CN103217489B (zh) 2013-01-15 2016-03-09 珠海市丽珠单抗生物技术有限公司 一种测定蛋白纯化工艺过程中样品的糖基化和末端修饰情况的方法
WO2015190439A1 (ja) * 2014-06-09 2015-12-17 株式会社カネカ 抗体に結合する低分子化合物のスクリーニング方法
CN109153718B (zh) * 2016-03-17 2022-02-08 努玛治疗有限公司 抗TNFα抗体及其功能片段
CN106279413A (zh) * 2016-08-30 2017-01-04 苏州普罗达生物科技有限公司 抗肿瘤坏死因子抗体多肽及应用
CN111153994B (zh) * 2019-12-31 2021-10-15 武汉班科生物技术股份有限公司 人肿瘤坏死因子的人源单克隆抗体
CN115819575B (zh) * 2022-08-24 2023-06-27 武汉爱博泰克生物科技有限公司 针对人肿瘤坏死因子-α的单克隆抗体
CN115710314B (zh) * 2022-09-14 2025-10-28 江苏睿源生物技术有限公司 用于检测肿瘤坏死因子-α的抗体组合及其应用

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DE4193302T1 (de) * 1990-12-21 1993-02-18 Celltech Ltd Rekombinanter antikoerper spezifisch fuer tnf-(alpha)
CN1649624A (zh) * 2002-04-26 2005-08-03 艾博特生物技术有限公司 TNFα抗体及另外一种药物的用途
CN101177453A (zh) * 2006-11-07 2008-05-14 旭华（上海）生物研发中心有限公司 抗人肿瘤坏死因子α的重组嵌合抗体

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DE4193302T1 (de) * 1990-12-21 1993-02-18 Celltech Ltd Rekombinanter antikoerper spezifisch fuer tnf-(alpha)
CN1649624A (zh) * 2002-04-26 2005-08-03 艾博特生物技术有限公司 TNFα抗体及另外一种药物的用途
CN101177453A (zh) * 2006-11-07 2008-05-14 旭华（上海）生物研发中心有限公司 抗人肿瘤坏死因子α的重组嵌合抗体

Also Published As

Publication number Publication date
AR085501A1 (es) 2013-10-09
JP6054864B2 (ja) 2016-12-27
KR101576559B1 (ko) 2015-12-10
JP2013539354A (ja) 2013-10-24
EP2682405A1 (en) 2014-01-08
KR20130133272A (ko) 2013-12-06
EP2682405A4 (en) 2015-06-24
WO2012116595A1 (zh) 2012-09-07
AU2012222738A1 (en) 2013-08-22
AU2012222738B2 (en) 2016-05-26
CA2827799C (en) 2017-03-21
BR112013021860A2 (pt) 2018-09-11
JP2016006052A (ja) 2016-01-14
RU2013139480A (ru) 2015-04-10
CN102675460A (zh) 2012-09-19
RU2549700C1 (ru) 2015-04-27
CA2827799A1 (en) 2012-09-07
NZ615477A (en) 2015-11-27

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