JP2013514992A5 - - Google Patents

Info

Publication number

JP2013514992A5

JP2013514992A5 JP2012544884A JP2012544884A JP2013514992A5 JP 2013514992 A5 JP2013514992 A5 JP 2013514992A5 JP 2012544884 A JP2012544884 A JP 2012544884A JP 2012544884 A JP2012544884 A JP 2012544884A JP 2013514992 A5 JP2013514992 A5 JP 2013514992A5

Authority

JP

Japan

Prior art keywords

seq

sequences

nos

antibody

fragment

Prior art date

2010-12-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000012634 fragment Substances 0.000 claims 15
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
• 229940024606 amino acid Drugs 0.000 claims 12
• 235000001014 amino acid Nutrition 0.000 claims 12
• 150000001413 amino acids Chemical class 0.000 claims 12
• 101100366217 Gallus gallus SOSTDC1 gene Proteins 0.000 claims 8
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
• 102100022432 Sclerostin domain-containing protein 1 Human genes 0.000 claims 8
• 101000825071 Homo sapiens Sclerostin domain-containing protein 1 Proteins 0.000 claims 6
• 102000057897 human SOSTDC1 Human genes 0.000 claims 6
• 239000004471 Glycine Substances 0.000 claims 4
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 4
• 208000017169 kidney disease Diseases 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 201000001474 proteinuria Diseases 0.000 claims 3
• 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
• 102000004264 Osteopontin Human genes 0.000 claims 2
• 108010081689 Osteopontin Proteins 0.000 claims 2
• 238000000423 cell based assay Methods 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 230000037319 collagen production Effects 0.000 claims 2
• 229940109239 creatinine Drugs 0.000 claims 2
• 208000033679 diabetic kidney disease Diseases 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000002163 immunogen Effects 0.000 claims 2
• 239000003550 marker Substances 0.000 claims 2
• 210000000651 myofibroblast Anatomy 0.000 claims 2
• 238000013424 sirius red staining Methods 0.000 claims 2
• 230000000451 tissue damage Effects 0.000 claims 2
• 231100000827 tissue damage Toxicity 0.000 claims 2
• 102000009027 Albumins Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 239000004475 Arginine Substances 0.000 claims 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 102100029880 Glycodelin Human genes 0.000 claims 1
• 208000034706 Graft dysfunction Diseases 0.000 claims 1
• 101000585553 Homo sapiens Glycodelin Proteins 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 102000004338 Transferrin Human genes 0.000 claims 1
• 108090000901 Transferrin Proteins 0.000 claims 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 229960001230 asparagine Drugs 0.000 claims 1
• 235000009582 asparagine Nutrition 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000029142 excretion Effects 0.000 claims 1
• 230000004761 fibrosis Effects 0.000 claims 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
• 230000001631 hypertensive effect Effects 0.000 claims 1
• 229960000310 isoleucine Drugs 0.000 claims 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
• 230000003907 kidney function Effects 0.000 claims 1
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 239000012581 transferrin Substances 0.000 claims 1