JP2010524466A5 - - Google Patents
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- Publication number
- JP2010524466A5 JP2010524466A5 JP2010504124A JP2010504124A JP2010524466A5 JP 2010524466 A5 JP2010524466 A5 JP 2010524466A5 JP 2010504124 A JP2010504124 A JP 2010504124A JP 2010504124 A JP2010504124 A JP 2010504124A JP 2010524466 A5 JP2010524466 A5 JP 2010524466A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- cancer
- antibody
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 101000692457 Mus musculus Platelet-derived growth factor receptor beta Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92397907P | 2007-04-17 | 2007-04-17 | |
| US60/923,979 | 2007-04-17 | ||
| PCT/US2008/005137 WO2008130704A2 (en) | 2007-04-17 | 2008-04-17 | PDGFRβ-SPECIFIC INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524466A JP2010524466A (ja) | 2010-07-22 |
| JP2010524466A5 true JP2010524466A5 (enExample) | 2010-10-21 |
| JP5209702B2 JP5209702B2 (ja) | 2013-06-12 |
Family
ID=39837443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504124A Expired - Fee Related JP5209702B2 (ja) | 2007-04-17 | 2008-04-17 | PDGFRβ特異的インヒビター |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7740850B2 (enExample) |
| EP (1) | EP2139921A2 (enExample) |
| JP (1) | JP5209702B2 (enExample) |
| KR (1) | KR101136262B1 (enExample) |
| CN (1) | CN101707882A (enExample) |
| AU (1) | AU2008242444B2 (enExample) |
| BR (1) | BRPI0810374A2 (enExample) |
| CA (1) | CA2682390A1 (enExample) |
| EA (1) | EA019595B1 (enExample) |
| IL (1) | IL200779A0 (enExample) |
| MX (1) | MX2009011226A (enExample) |
| NZ (1) | NZ579734A (enExample) |
| UA (1) | UA99608C2 (enExample) |
| WO (1) | WO2008130704A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2274008T3 (pl) | 2008-03-27 | 2014-07-31 | Zymogenetics Inc | Kompozycje i sposoby hamowania PDGFRbeta i VEGF-A |
| US20120231537A1 (en) * | 2008-04-30 | 2012-09-13 | Gradalis, Inc. | Highly Pure Plasmid DNA Preparations |
| CN102171341A (zh) * | 2008-04-30 | 2011-08-31 | 格兰达利斯有限公司 | 高纯度质粒dna制备物及其制备方法 |
| US20110305672A1 (en) | 2008-07-25 | 2011-12-15 | University Of Georgia Research Foundation, Inc. | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME |
| WO2010069913A1 (en) | 2008-12-16 | 2010-06-24 | Novartis Ag | Yeast display systems |
| TW201102068A (en) * | 2009-06-02 | 2011-01-16 | Novartis Ag | Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms |
| AU2010299756A1 (en) * | 2009-09-28 | 2012-04-19 | Medizinische Universitat Wien | PDGFRbeta inhibitors for use in the treatment of T-cell lymphoma |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| ES2873375T3 (es) * | 2011-03-15 | 2021-11-03 | X Body Inc | Métodos de cribado de anticuerpos |
| CN102250249A (zh) * | 2011-06-18 | 2011-11-23 | 常州亚当生物技术有限公司 | 一种抗VEGF/PDGFRbeta双特异性抗体及其应用 |
| EP2748197A2 (en) | 2011-08-26 | 2014-07-02 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
| CA2857721C (en) * | 2011-12-05 | 2022-05-31 | X-Body, Inc. | Pdgf receptor beta binding polypeptides |
| TWI613215B (zh) | 2012-02-22 | 2018-02-01 | 再生元醫藥公司 | 抗-大-內皮素-1(big-et-1)抗體及其用途 |
| JO3405B1 (ar) * | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
| TW201444872A (zh) | 2013-03-06 | 2014-12-01 | Merrimack Pharmaceuticals Inc | 抗C-MET串聯Fc雙特異性抗體 |
| JP6463361B2 (ja) | 2013-09-08 | 2019-01-30 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | 第viii因子両性イオンポリマーコンジュゲート |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
| KR102127408B1 (ko) * | 2014-01-29 | 2020-06-29 | 삼성전자주식회사 | 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| US20180044672A1 (en) | 2015-03-20 | 2018-02-15 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Pericyte Long Non-Coding RNAs |
| WO2017106609A2 (en) * | 2015-12-16 | 2017-06-22 | Kadmon Corporation, Llc. | Pdgfr beta antibody |
| AU2016369557B2 (en) | 2015-12-16 | 2022-10-20 | Regeneron Pharmaceuticals, Inc. | Compositions and methods of manufacturing protein microparticles |
| NZ744185A (en) | 2015-12-30 | 2025-09-26 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
| TW201803905A (zh) | 2016-06-20 | 2018-02-01 | 克馬伯有限公司 | 用於免疫腫瘤學之多重專一性抗體 |
| WO2018080812A1 (en) | 2016-10-30 | 2018-05-03 | Henlix, Inc. | Anti-pd-l1 antibodies and variants |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| US11440951B2 (en) | 2017-03-13 | 2022-09-13 | The Government Of The United States, As Represented By The Secretary Of The Army | Therapeutic antibodies to Marburg virus |
| CN109021104B (zh) * | 2017-06-12 | 2022-08-12 | 上海睿智化学研究有限公司 | 一种抗人血小板衍生生长因子β受体的抗体及其应用 |
| US11795221B2 (en) | 2018-02-28 | 2023-10-24 | WuXi Biologics Ireland Limited | Monoclonal antibody against human LAG-3, method for preparing the same, and use thereof |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| DE102018204828A1 (de) | 2018-03-29 | 2019-10-02 | Ford Global Technologies, Llc | Verhinderung von Glatteis durch Abwasser von Kraftfahrzeugen |
| WO2020029860A1 (zh) | 2018-08-09 | 2020-02-13 | 北京智仁美博生物科技有限公司 | 针对狂犬病病毒的双特异性抗体及其用途 |
| KR102199383B1 (ko) * | 2018-10-05 | 2021-01-06 | 서울대학교산학협력단 | Pdgf 수용체에 대한 항체 및 이의 용도 |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US20240174755A1 (en) * | 2020-02-07 | 2024-05-30 | Biorion Technologies B.V. | Platelet derived growth factor receptor (pdgfr) antibodies, conjugates, compositions, and uses thereof |
| TW202506733A (zh) | 2023-06-12 | 2025-02-16 | 美商安進公司 | 淋巴毒素β受體促效劑結合蛋白 |
| CN118440214B (zh) * | 2024-04-02 | 2025-01-28 | 山东大学 | 一种靶向PDGFRβ的嵌合抗原受体、CAR-T细胞及应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1992013867A1 (en) | 1991-01-31 | 1992-08-20 | Cor Therapeutics, Inc. | Domains of extracellular region of human platelet derived growth factor receptor polypeptides |
| US20020009443A1 (en) * | 1991-12-02 | 2002-01-24 | Vanitha Ramakrishman | Inhibitory immunoglobulin polypeptides to human pdgf beta receptor |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5817310A (en) | 1991-12-02 | 1998-10-06 | Cor Therapeutics, Inc. | Inhibitory immunoglobulin polypeptides to human PDGF beta receptor |
| US5620687A (en) | 1993-02-25 | 1997-04-15 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors |
| US5976534A (en) | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
| US5882644A (en) | 1996-03-22 | 1999-03-16 | Protein Design Labs, Inc. | Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof |
| US6259971B1 (en) * | 1997-06-30 | 2001-07-10 | Compaq Computer Corporation | Portable fuel-cell-powered system with ultrasonic atomization of H2O by-product |
| US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| CA2409991A1 (en) | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| JP3881624B2 (ja) * | 2000-09-22 | 2007-02-14 | シーメンス アクチエンゲゼルシヤフト | 燃料電池からの媒体の放出の監視方法と燃料電池設備 |
| EP1313161A1 (en) * | 2001-11-15 | 2003-05-21 | Ballard Power Systems AG | Fuel cell system and method for operating the same |
| US7582726B2 (en) * | 2003-11-10 | 2009-09-01 | Ghc Research Development Corporation | VEGF receptor antagonists |
| WO2006020258A2 (en) | 2004-07-17 | 2006-02-23 | Imclone Systems Incorporated | Novel tetravalent bispecific antibody |
| WO2008011216A2 (en) | 2006-05-16 | 2008-01-24 | Pro-Pharmaceuticals, Inc. | Galactose-pronged polysaccharides in a formulation for antifibrotic therapies |
-
2008
- 2008-04-17 BR BRPI0810374-7A2A patent/BRPI0810374A2/pt not_active IP Right Cessation
- 2008-04-17 JP JP2010504124A patent/JP5209702B2/ja not_active Expired - Fee Related
- 2008-04-17 MX MX2009011226A patent/MX2009011226A/es active IP Right Grant
- 2008-04-17 NZ NZ579734A patent/NZ579734A/en not_active IP Right Cessation
- 2008-04-17 CN CN200880012257A patent/CN101707882A/zh active Pending
- 2008-04-17 WO PCT/US2008/005137 patent/WO2008130704A2/en not_active Ceased
- 2008-04-17 UA UAA200910244A patent/UA99608C2/ru unknown
- 2008-04-17 EP EP08743156A patent/EP2139921A2/en not_active Withdrawn
- 2008-04-17 AU AU2008242444A patent/AU2008242444B2/en not_active Ceased
- 2008-04-17 CA CA002682390A patent/CA2682390A1/en not_active Abandoned
- 2008-04-17 US US12/148,482 patent/US7740850B2/en not_active Expired - Fee Related
- 2008-04-17 EA EA200970953A patent/EA019595B1/ru not_active IP Right Cessation
- 2008-04-17 KR KR1020097021652A patent/KR101136262B1/ko not_active Expired - Fee Related
- 2008-06-25 US US12/674,350 patent/US20110207005A1/en not_active Abandoned
-
2009
- 2009-09-07 IL IL200779A patent/IL200779A0/en unknown
-
2010
- 2010-04-21 US US12/764,121 patent/US20100221267A1/en not_active Abandoned
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