JP2003527861A5 - - Google Patents

Info

Publication number

JP2003527861A5

JP2003527861A5 JP2001569367A JP2001569367A JP2003527861A5 JP 2003527861 A5 JP2003527861 A5 JP 2003527861A5 JP 2001569367 A JP2001569367 A JP 2001569367A JP 2001569367 A JP2001569367 A JP 2001569367A JP 2003527861 A5 JP2003527861 A5 JP 2003527861A5

Authority

JP

Japan

Prior art keywords

seq

antibody

sequence

cdr

variable domain

Prior art date

2001-03-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 10
• 125000003275 alpha amino acid group Chemical group 0.000 description 8
• 150000007523 nucleic acids Chemical class 0.000 description 8
• 102000039446 nucleic acids Human genes 0.000 description 8
• 108020004707 nucleic acids Proteins 0.000 description 8
• 238000000034 method Methods 0.000 description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
• 239000000203 mixture Substances 0.000 description 4
• 208000035475 disorder Diseases 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 2
• 208000007536 Thrombosis Diseases 0.000 description 2
• 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
• 201000000028 adult respiratory distress syndrome Diseases 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 206010003178 Arterial thrombosis Diseases 0.000 description 1
• 206010003210 Arteriosclerosis Diseases 0.000 description 1
• 206010053567 Coagulopathies Diseases 0.000 description 1
• 208000001953 Hypotension Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 206010040070 Septic Shock Diseases 0.000 description 1
• 208000006011 Stroke Diseases 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
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• 208000011775 arteriosclerosis disease Diseases 0.000 description 1
• 208000015294 blood coagulation disease Diseases 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
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• 238000005345 coagulation Methods 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
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