JP2004502409A5 - - Google Patents
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- JP2004502409A5 JP2004502409A5 JP2001580185A JP2001580185A JP2004502409A5 JP 2004502409 A5 JP2004502409 A5 JP 2004502409A5 JP 2001580185 A JP2001580185 A JP 2001580185A JP 2001580185 A JP2001580185 A JP 2001580185A JP 2004502409 A5 JP2004502409 A5 JP 2004502409A5
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- Prior art keywords
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- 125000000539 amino acid group Chemical group 0.000 claims 38
- 239000002773 nucleotide Substances 0.000 claims 32
- 125000003729 nucleotide group Chemical group 0.000 claims 32
- 108060003951 Immunoglobulin Proteins 0.000 claims 24
- 102000018358 immunoglobulin Human genes 0.000 claims 24
- 241000588724 Escherichia coli Species 0.000 claims 22
- 241000620209 Escherichia coli DH5[alpha] Species 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 15
- 210000004408 hybridoma Anatomy 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 3
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims 2
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims 2
- 102000012960 Immunoglobulin kappa-Chains Human genes 0.000 claims 2
- 108010090227 Immunoglobulin kappa-Chains Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 101100495352 Candida albicans CDR4 gene Proteins 0.000 claims 1
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims 1
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20134400P | 2000-05-02 | 2000-05-02 | |
| PCT/US2001/014151 WO2001083560A1 (en) | 2000-05-02 | 2001-05-02 | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005113535A Division JP3892466B2 (ja) | 2000-05-02 | 2005-04-11 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2006315093A Division JP2007091749A (ja) | 2000-05-02 | 2006-11-22 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502409A JP2004502409A (ja) | 2004-01-29 |
| JP2004502409A5 true JP2004502409A5 (enExample) | 2007-02-01 |
| JP4156238B2 JP4156238B2 (ja) | 2008-09-24 |
Family
ID=22745456
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001580185A Expired - Lifetime JP4156238B2 (ja) | 2000-05-02 | 2001-05-02 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターについて選択的な抗体、およびそれらの使用 |
| JP2005113535A Expired - Lifetime JP3892466B2 (ja) | 2000-05-02 | 2005-04-11 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2006315093A Pending JP2007091749A (ja) | 2000-05-02 | 2006-11-22 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2008194948A Expired - Lifetime JP4575975B2 (ja) | 2000-05-02 | 2008-07-29 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005113535A Expired - Lifetime JP3892466B2 (ja) | 2000-05-02 | 2005-04-11 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2006315093A Pending JP2007091749A (ja) | 2000-05-02 | 2006-11-22 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
| JP2008194948A Expired - Lifetime JP4575975B2 (ja) | 2000-05-02 | 2008-07-29 | 腫瘍壊死因子関連アポトーシス誘導性リガンドレセプターに対して選択的な抗体およびそれらの用途 |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US7244429B2 (enExample) |
| EP (4) | EP2065400B1 (enExample) |
| JP (4) | JP4156238B2 (enExample) |
| KR (2) | KR20060092292A (enExample) |
| CN (2) | CN100497388C (enExample) |
| AT (1) | ATE426615T1 (enExample) |
| AU (2) | AU5936601A (enExample) |
| BG (3) | BG109275A (enExample) |
| BR (1) | BR0110547A (enExample) |
| CA (1) | CA2407965C (enExample) |
| CY (1) | CY1109179T1 (enExample) |
| CZ (2) | CZ306996B6 (enExample) |
| DE (1) | DE60138097D1 (enExample) |
| DK (1) | DK1287035T3 (enExample) |
| EE (1) | EE05548B1 (enExample) |
| ES (1) | ES2323448T3 (enExample) |
| HU (2) | HU230399B1 (enExample) |
| IL (1) | IL152605A0 (enExample) |
| MX (1) | MXPA02010823A (enExample) |
| NO (2) | NO329843B1 (enExample) |
| NZ (1) | NZ522881A (enExample) |
| PL (1) | PL211733B1 (enExample) |
| PT (1) | PT1287035E (enExample) |
| RU (1) | RU2298013C2 (enExample) |
| TW (1) | TWI318983B (enExample) |
| WO (1) | WO2001083560A1 (enExample) |
| ZA (1) | ZA200209230B (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7528239B1 (en) | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| JP4330180B2 (ja) | 1997-03-17 | 2009-09-16 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 死ドメイン含有レセプター5 |
| EP1196191A4 (en) * | 1999-05-04 | 2004-03-24 | Human Genome Sciences Inc | DEATH DOMAIN CONTAINING RECEPTOR 5 |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US7115717B2 (en) | 2001-05-18 | 2006-10-03 | Kirin Beer Kabushiki Kaisha | Anti-TRAIL-R antibodies |
| US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
| US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| NZ529359A (en) | 2001-05-25 | 2007-04-27 | Human Genome Sciences Inc | Antibodies that immunospecifically bind to a TR4 polypeptide or polypeptide fragment or variant of TR4 and their use in a medicament for treating cancer |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| KR100866117B1 (ko) | 2001-10-19 | 2008-10-31 | 바스큘라 바이오제닉스 리미티드 | 혈관형성의 표적화 억제조절 및 항암 치료를 위한폴리뉴클레오타이드 작제물, 약학적 조성물 및 방법 |
| ATE491019T1 (de) * | 2001-11-01 | 2010-12-15 | Uab Research Foundation | Kombinationen aus anti-dr5-antikörpern und anti- dr4-antikörpern und weiteren therapeutischen agentien |
| ES2357225T3 (es) * | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
| EP1465925A4 (en) * | 2001-12-20 | 2006-02-08 | Human Genome Sciences Inc | "ANTIBODIES THAT IMMUNE SPECIFICALLY TO TRAIL RECEPTORS" |
| US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
| DE10210427A1 (de) * | 2002-03-09 | 2003-10-09 | Hans Konrad Mueller-Hermelink | Humaner monoklonaler Antikörper |
| AU2003249533A1 (en) * | 2002-07-04 | 2004-01-23 | Oncomab Gmbh | Neoplasm specific antibodies and uses thereof |
| AU2008201431B2 (en) * | 2002-11-27 | 2011-11-24 | Irm, Llc | Methods and compositions for inducing Apoptosis in cancer cells |
| DE60334247D1 (de) * | 2002-11-27 | 2010-10-28 | Irm Llc | Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen |
| DE10311248A1 (de) | 2003-03-14 | 2004-09-30 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper |
| EP1531162A1 (en) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Adenocarcinoma specific antibody SAM-6, and uses thereof |
| DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
| CA2560742A1 (en) * | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| CN100427505C (zh) * | 2004-08-19 | 2008-10-22 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体(ad5-10)及其制法与用途 |
| AU2005316193B2 (en) * | 2004-12-13 | 2012-05-17 | Cephalon Australia (Vic) Pty Ltd | Osteoprotegerin variant proteins |
| AU2006210838B2 (en) | 2005-02-02 | 2011-10-20 | The Uab Research Foundation | Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists |
| US8029783B2 (en) * | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| JP5004154B2 (ja) * | 2005-04-06 | 2012-08-22 | 一般財団法人化学及血清療法研究所 | 組換え抗ボツリヌス神経毒素抗体 |
| EP1907001B1 (en) | 2005-06-17 | 2015-07-15 | Merck Sharp & Dohme Corp. | Ilt3 binding molecules and uses therefor |
| PE20071101A1 (es) * | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| CN101300273B (zh) * | 2005-08-31 | 2013-05-22 | 安姆根有限公司 | Trail受体2多肽和抗体 |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CN101605887B (zh) | 2006-05-16 | 2012-09-05 | 协和发酵麒麟株式会社 | 蛋白的高分泌生产方法 |
| AU2007345745C1 (en) * | 2006-06-19 | 2013-05-23 | Merck Sharp & Dohme Corp. | ILT3 binding molecules and uses therefor |
| KR100847010B1 (ko) * | 2006-07-05 | 2008-07-17 | 아주대학교산학협력단 | 세포사멸 수용체 5 (dr5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물 |
| KR100804126B1 (ko) | 2007-02-09 | 2008-02-19 | 아주대학교산학협력단 | 종양 괴사 인자―관련 세포사멸―유도 리간드의 수용체에특이적으로 결합하는 1가의 인간 단일클론 항체 및 그의항원결합 단편 |
| WO2008154439A1 (en) * | 2007-06-08 | 2008-12-18 | Irm Llc | Methods and compositions for inducing apoptosis in cancer cells |
| WO2009020093A1 (ja) * | 2007-08-09 | 2009-02-12 | Daiichi Sankyo Company, Limited | デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム |
| WO2009057813A1 (ja) | 2007-10-31 | 2009-05-07 | National Institute Of Advanced Industrial Science And Technology | タンパク質の高分泌生産方法 |
| WO2010047509A2 (ko) * | 2008-10-24 | 2010-04-29 | 아주대학교 산학협력단 | 친화도와 안정성이 향상된 항 dr5 항체, 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| JP2013505944A (ja) * | 2009-09-24 | 2013-02-21 | シアトル ジェネティックス, インコーポレイテッド | Dr5リガンド薬物結合体 |
| WO2011049350A2 (ko) * | 2009-10-19 | 2011-04-28 | 한올바이오파마주식회사 | 변형된 인간 종양 괴사 인자 수용체-1 폴리펩티드 또는 그의 절편 및 그의 제조방법 |
| CA2780130A1 (en) | 2009-11-05 | 2011-05-12 | The Uab Research Foundation | Treating basal-like genotype cancers |
| US9238069B2 (en) | 2009-12-16 | 2016-01-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of sensitizing cancer cells to the cytotoxic effects of death receptor ligands in cancer treatment |
| US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| KR20120140658A (ko) | 2010-02-12 | 2012-12-31 | 파마사이언스 인크. | Iap bir 도메인 결합 화합물 |
| US8703712B2 (en) | 2010-03-18 | 2014-04-22 | The Uab Research Foundation | Targeting cancer stem cells with DR5 agonists |
| SG189456A1 (en) * | 2010-10-29 | 2013-05-31 | Daiichi Sankyo Co Ltd | Novel anti-dr5 antibody |
| DK2686020T3 (en) | 2011-03-17 | 2017-05-01 | Univ Birmingham | REDIRECTED IMMUNTERY |
| US20140178398A1 (en) * | 2011-05-03 | 2014-06-26 | Genentech, Inc | Vascular disruption agents and uses thereof |
| ES2723885T3 (es) | 2012-07-19 | 2019-09-03 | Daiichi Sankyo Co Ltd | Anticuerpos anti-Siglec-15 |
| CN116574185A (zh) * | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
| CN103074425B (zh) * | 2012-12-29 | 2014-01-01 | 深圳市第三人民医院 | Cd263基因的用途 |
| US10035847B2 (en) | 2013-10-02 | 2018-07-31 | The Rockefeller University | Amyloid protofibril antibodies and methods of use thereof |
| CN104710533A (zh) * | 2013-12-12 | 2015-06-17 | 中国科学院深圳先进技术研究院 | sDR5-Fc融合蛋白及其用途 |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| RU2017129236A (ru) | 2015-01-26 | 2019-03-07 | Макродженикс, Инк. | Мультивалентные молекулы, содержащие dr5-связывающие домены |
| CN105061604B (zh) * | 2015-08-19 | 2018-03-16 | 河南大学 | sDR5‑Fc融合蛋白突变体及其应用 |
| CN109195626B (zh) | 2015-10-30 | 2022-09-13 | 银河生物技术有限责任公司 | 结合死亡受体4和死亡受体5的抗体 |
| US20190202926A1 (en) | 2015-12-01 | 2019-07-04 | Genmab B.V. | Anti-death receptor antibodies and methods of use thereof |
| CN106924735A (zh) * | 2015-12-29 | 2017-07-07 | 上海交通大学医学院附属瑞金医院 | 多巴胺1类受体激动剂在制备肿瘤治疗药物中的用途 |
| US10849912B2 (en) | 2016-02-09 | 2020-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment |
| JP6966176B2 (ja) | 2016-03-01 | 2021-11-10 | イサム リサーチ ディベロップメント カンパニー オブ ザ ヘブルー ユニバーシティ オブ エルサレム エルティーディー. | ヒトポリオウイルス受容体(pvr)に特異的な抗体 |
| KR101926166B1 (ko) * | 2016-05-24 | 2018-12-06 | 재단법인 아산사회복지재단 | 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법 |
| WO2018138297A1 (en) | 2017-01-27 | 2018-08-02 | Kymab Limited | Anti-opg antibodies |
| KR101926834B1 (ko) | 2017-03-21 | 2018-12-07 | 동아에스티 주식회사 | 항-dr5 항체 및 그의 용도 |
| CN111328335A (zh) | 2017-06-07 | 2020-06-23 | 根马布私人有限公司 | 基于突变igg六聚体的治疗性抗体 |
| KR101951025B1 (ko) | 2017-08-17 | 2019-02-21 | 서울대학교산학협력단 | 세포사멸 수용체 저해제를 유효성분으로 포함하는 cx3cl1 케모카인 과발현으로 인한 질환 예방 또는 치료용 조성물 |
| CA3073414A1 (en) * | 2017-09-22 | 2019-03-28 | Immunogen, Inc. | Separation of triple-light chain antibodies using cation exchange chromatography |
| WO2019100194A1 (zh) * | 2017-11-21 | 2019-05-31 | 深圳先进技术研究院 | 抗dr5的抗体及其制备方法和应用 |
| WO2019100193A1 (zh) * | 2017-11-21 | 2019-05-31 | 深圳先进技术研究院 | 抗dr5的抗体及其制备方法和应用 |
| CN108251443A (zh) * | 2018-01-23 | 2018-07-06 | 深圳市人民医院 | 一种tnfrsf10c重组质粒、制备方法及其应用 |
| WO2019173499A1 (en) | 2018-03-06 | 2019-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 17-beta-hydroxywithanolides and use thereof in treating cancer |
| CN117003874A (zh) | 2018-03-20 | 2023-11-07 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
| KR20210105890A (ko) | 2018-12-17 | 2021-08-27 | 레비토프 리미티드 | 트윈 면역 세포 인게이저 |
| US20240382499A1 (en) | 2021-01-15 | 2024-11-21 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US6433147B1 (en) * | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
| EP1012274B2 (en) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l) |
| US6072047A (en) * | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US6313269B1 (en) * | 1997-03-14 | 2001-11-06 | Smithkline Beecham Corporation | Tumor necrosis factor related receptor, TR6 |
| JP4330180B2 (ja) * | 1997-03-17 | 2009-09-16 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 死ドメイン含有レセプター5 |
| US6872568B1 (en) * | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| IL123888A0 (en) | 1997-04-01 | 1998-10-30 | Sankyo Co | Anti-fas antibodies |
| EP1007562A4 (en) | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR |
| US6342369B1 (en) * | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| ATE516354T1 (de) | 1997-05-15 | 2011-07-15 | Genentech Inc | Apo-2-rezeptor |
| WO1999002653A1 (en) | 1997-07-11 | 1999-01-21 | Trustees Of The University Of Pennsylvania | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
| IL133920A0 (en) * | 1997-07-15 | 2001-04-30 | Immunex Corp | Trail receptor |
| EP0934421A1 (en) | 1997-08-06 | 1999-08-11 | Laboratorio Medinfar-Produtos Farmaceuticos LDA. | DNA INTEGRATION INTO "MYCOBACTERIUM spp." GENOME BY TRANS-COMPLEMENTATION USING A SITE-SPECIFIC INTEGRATION SYSTEM |
| WO1999009365A1 (de) * | 1997-08-13 | 1999-02-25 | Ufe Solar Gmbh | Sorptionsspeicher, anordnung und verfahren zur speicherung von wärme |
| WO1999009165A1 (en) * | 1997-08-15 | 1999-02-25 | Idun Pharmaceuticals, Inc. | Trail receptors, nucleic acids encoding the same, and methods of use thereof |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| EP1012282B1 (en) | 1997-09-12 | 2007-04-18 | Biogen Idec MA Inc. | Cysteine rich receptors-train |
| US7105640B2 (en) * | 1997-10-17 | 2006-09-12 | Genentech, Inc. | Anti-pro792 antibodies |
| US20040120947A1 (en) | 1998-01-26 | 2004-06-24 | Genentech, Inc. | DR4 antibodies and uses thereof |
| CA2318405C (en) | 1998-01-26 | 2014-01-07 | Genentech, Inc. | Antibodies to death receptor 4(dr4) and uses thereof |
| US6252050B1 (en) * | 1998-06-12 | 2001-06-26 | Genentech, Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
| ES2421720T3 (es) * | 1999-04-12 | 2013-09-05 | Genentech Inc | Homólogos del factor de necrosis tumoral y ácidos nucleicos que los codifican |
| EP1196191A4 (en) | 1999-05-04 | 2004-03-24 | Human Genome Sciences Inc | DEATH DOMAIN CONTAINING RECEPTOR 5 |
| AU4984300A (en) | 1999-05-06 | 2000-11-21 | Vishva M Dixit | Death domain containing receptor 4 |
| DK1181319T3 (da) | 1999-05-28 | 2009-08-17 | Genentech Inc | Kimære DR4-antistoffer og anvendelser deraf |
| AU5596500A (en) | 1999-06-09 | 2000-12-28 | Genentech Inc. | Apo-2l receptor agonist and cpt-11 synergism |
| US6294546B1 (en) | 1999-08-30 | 2001-09-25 | The Broad Of Trustees Of The Leland Stanford Junior University | Uses of diterpenoid triepoxides as an anti-proliferative agent |
| CA2384762A1 (en) | 1999-09-15 | 2001-03-22 | Genentech, Inc. | Apo-2 receptor antibodies |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| US7476383B2 (en) * | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| AU2001297702A1 (en) | 2000-11-08 | 2002-10-15 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| US6965023B2 (en) * | 2000-11-17 | 2005-11-15 | The Burnham Institute | Death domain proteins |
| CA2451680C (en) | 2001-07-03 | 2011-04-19 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
| ES2357225T3 (es) | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
| ATE491019T1 (de) | 2001-11-01 | 2010-12-15 | Uab Research Foundation | Kombinationen aus anti-dr5-antikörpern und anti- dr4-antikörpern und weiteren therapeutischen agentien |
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