BR0110547A - Anticorpo purificado, métodos para induzir seletivamente morte celular em células alvo e para tratar um indivìduo com cancer e que tem uma doença inflamatória ou doença autoimune, processos para inibir proliferação de células alvo, para tratar um indivìduo com uma doença relacionada a apoptose, para produzir um anticorpo humanizado e para aumentar nìveis de nfkb em uma célula, composição, uso de um anticorpo , ácido nucleico isolado, vetor, célula cultivada, polipeptìdio purificado, e, kit comercial para induzir apoptose - Google Patents

Anticorpo purificado, métodos para induzir seletivamente morte celular em células alvo e para tratar um indivìduo com cancer e que tem uma doença inflamatória ou doença autoimune, processos para inibir proliferação de células alvo, para tratar um indivìduo com uma doença relacionada a apoptose, para produzir um anticorpo humanizado e para aumentar nìveis de nfkb em uma célula, composição, uso de um anticorpo , ácido nucleico isolado, vetor, célula cultivada, polipeptìdio purificado, e, kit comercial para induzir apoptose

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Publication number
BR0110547A
BR0110547A BR0110547-7A BR0110547A BR0110547A BR 0110547 A BR0110547 A BR 0110547A BR 0110547 A BR0110547 A BR 0110547A BR 0110547 A BR0110547 A BR 0110547A
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Brazil
Prior art keywords
cell
antibody
methods
treating
individual
Prior art date
Application number
BR0110547-7A
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English (en)
Inventor
Tong Zhou
Kimihisa Ichikawa
Robert P Kimberly
William J Koopman
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Uab Research Foundation
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Publication date
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Publication of BR0110547A publication Critical patent/BR0110547A/pt

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

"ANTICORPO PURIFICADO, MéTODOS PARA INDUZIR SELETIVAMENTE MORTE CELULAR EM CéLULAS ALVO E PARA TRATAR UM INDIVìDUO COM CANCER E QUE TEM UMA DOENçA INFLAMATóRIA OU DOENçA AUTOIMUNE, PROCESSOS PARA IMBIR PROLIFERAçãO DE CéLULAS ALVO, PARA TRATAR UM INDIVìDUO COM UMA DOENçA RELACIONADA A APOPTOSE, PARA PRODUZIR UM ANTICORPO HUMANO E PARA AUMENTAR NìVEIS DE NFkB EM UMA CéLULA, COMPOSIçãO, USO DE UM ANTICORPO, áCIDO NUCLEICO ISOLADO, VETOR, CéLULA CULTIVADA, POLIPEPTìDIO PURIFICADO, E, KIT COMERCIAL PARA INDUZIR APOPTOSE". Um anticorpo da invenção interage com DR5 humano para produzir efeitos agonísticos e antagonísticos a jusante do receptor incluindo inibição de proliferação celular e apoptose. Elucidou-se seq³ências de ácido nucléico e seq³ências de aminoácidos de anticorpos anti-DR5 e gerou-se vetores e células contendo e expressando estas seq³ências. Detalha-se métodos e usos para os anticorpos, incluindo tratamento de doença relacionada com apoptose e tratamento de crescimento desregulado de células.
BR0110547-7A 2000-05-02 2001-05-02 Anticorpo purificado, métodos para induzir seletivamente morte celular em células alvo e para tratar um indivìduo com cancer e que tem uma doença inflamatória ou doença autoimune, processos para inibir proliferação de células alvo, para tratar um indivìduo com uma doença relacionada a apoptose, para produzir um anticorpo humanizado e para aumentar nìveis de nfkb em uma célula, composição, uso de um anticorpo , ácido nucleico isolado, vetor, célula cultivada, polipeptìdio purificado, e, kit comercial para induzir apoptose BR0110547A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20134400P 2000-05-02 2000-05-02
PCT/US2001/014151 WO2001083560A1 (en) 2000-05-02 2001-05-02 An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof

Publications (1)

Publication Number Publication Date
BR0110547A true BR0110547A (pt) 2004-06-22

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BR0110547-7A BR0110547A (pt) 2000-05-02 2001-05-02 Anticorpo purificado, métodos para induzir seletivamente morte celular em células alvo e para tratar um indivìduo com cancer e que tem uma doença inflamatória ou doença autoimune, processos para inibir proliferação de células alvo, para tratar um indivìduo com uma doença relacionada a apoptose, para produzir um anticorpo humanizado e para aumentar nìveis de nfkb em uma célula, composição, uso de um anticorpo , ácido nucleico isolado, vetor, célula cultivada, polipeptìdio purificado, e, kit comercial para induzir apoptose

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US (6) US7244429B2 (pt)
EP (4) EP2065401B1 (pt)
JP (4) JP4156238B2 (pt)
KR (2) KR20060092292A (pt)
CN (2) CN101585881B (pt)
AT (1) ATE426615T1 (pt)
AU (2) AU5936601A (pt)
BG (3) BG65929B1 (pt)
BR (1) BR0110547A (pt)
CA (1) CA2407965C (pt)
CY (1) CY1109179T1 (pt)
CZ (2) CZ304614B6 (pt)
DE (1) DE60138097D1 (pt)
DK (1) DK1287035T3 (pt)
EE (1) EE05548B1 (pt)
ES (1) ES2323448T3 (pt)
HK (3) HK1050372A1 (pt)
HU (2) HU229417B1 (pt)
IL (1) IL152605A0 (pt)
MX (1) MXPA02010823A (pt)
NO (2) NO329843B1 (pt)
NZ (1) NZ522881A (pt)
PL (1) PL211733B1 (pt)
PT (1) PT1287035E (pt)
RU (1) RU2298013C2 (pt)
TW (1) TWI318983B (pt)
WO (1) WO2001083560A1 (pt)
ZA (1) ZA200209230B (pt)

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