BR0213846A - métodos de induzir seletivamente a apoptose nas células alvo que expressam dr5, de inibir a proliferação de células alvo que expressam dr5 e de tratar um paciente tendo uma doença inflamatória ou doença autoimune, e, composição - Google Patents
métodos de induzir seletivamente a apoptose nas células alvo que expressam dr5, de inibir a proliferação de células alvo que expressam dr5 e de tratar um paciente tendo uma doença inflamatória ou doença autoimune, e, composiçãoInfo
- Publication number
- BR0213846A BR0213846A BRPI0213846-8A BR0213846A BR0213846A BR 0213846 A BR0213846 A BR 0213846A BR 0213846 A BR0213846 A BR 0213846A BR 0213846 A BR0213846 A BR 0213846A
- Authority
- BR
- Brazil
- Prior art keywords
- target cells
- expressing target
- methods
- patient
- treating
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 230000006907 apoptotic process Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 abstract 3
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 208000034615 apoptosis-related disease Diseases 0.000 abstract 1
- 230000011712 cell development Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000053594 human TNFRSF10B Human genes 0.000 abstract 1
- 230000006654 negative regulation of apoptotic process Effects 0.000 abstract 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- Hematology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
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- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
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Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34640201P | 2001-11-01 | 2001-11-01 | |
US60/346402 | 2001-11-01 | ||
US39147802P | 2002-06-24 | 2002-06-24 | |
US60/391478 | 2002-06-24 | ||
PCT/US2002/034420 WO2003038043A2 (en) | 2001-11-01 | 2002-10-25 | Combinations of dr5 antibody and other therapeutic agents |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0213846A true BR0213846A (pt) | 2006-11-21 |
BRPI0213846B1 BRPI0213846B1 (pt) | 2019-10-15 |
BRPI0213846B8 BRPI0213846B8 (pt) | 2021-05-25 |
Family
ID=26994839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0213846A BRPI0213846B8 (pt) | 2001-11-01 | 2002-10-25 | composição que compreende um anticorpo que liga especificamente uma dr5 do receptor de trail e um ou mais agentes terapêuticos |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1506285B1 (pt) |
JP (1) | JP4663232B2 (pt) |
KR (1) | KR20040081422A (pt) |
CN (1) | CN100506277C (pt) |
AT (1) | ATE491019T1 (pt) |
AU (1) | AU2002360307B2 (pt) |
BR (1) | BRPI0213846B8 (pt) |
CA (1) | CA2465314C (pt) |
CO (1) | CO5650175A2 (pt) |
DE (1) | DE60238560D1 (pt) |
HK (1) | HK1068914A1 (pt) |
HU (1) | HU230378B1 (pt) |
IL (2) | IL161686A0 (pt) |
MX (1) | MXPA04004184A (pt) |
NO (1) | NO333828B1 (pt) |
NZ (2) | NZ533164A (pt) |
PL (1) | PL216750B1 (pt) |
RO (1) | RO123525B1 (pt) |
RU (1) | RU2313368C2 (pt) |
WO (1) | WO2003038043A2 (pt) |
ZA (1) | ZA200403573B (pt) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
JP3665316B2 (ja) | 2001-05-18 | 2005-06-29 | 麒麟麦酒株式会社 | 抗trail−r抗体 |
CA2451680C (en) | 2001-07-03 | 2011-04-19 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
MXPA04003514A (es) | 2001-10-19 | 2004-07-23 | Vascular Biogenics Ltd | Construcciones de polinucleotidos, composiciones farmaceuticas y metodos para reducir la regulacion dirigida de angionesis y terapia anticancer. |
PT1576179E (pt) * | 2002-11-27 | 2010-12-21 | Irm Llc | Métodos e composições para a indução de apoptose em células cancerosas |
AU2008201431B2 (en) * | 2002-11-27 | 2011-11-24 | Irm, Llc | Methods and compositions for inducing Apoptosis in cancer cells |
US20060228331A1 (en) | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
CA2542662A1 (en) * | 2003-10-17 | 2005-04-28 | Novo Nordisk A/S | Pharmaceutical combinations comprising il-21 |
KR20070010046A (ko) * | 2004-04-06 | 2007-01-19 | 제넨테크, 인크. | Dr5 항체 및 그의 용도 |
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