BR0213846A - métodos de induzir seletivamente a apoptose nas células alvo que expressam dr5, de inibir a proliferação de células alvo que expressam dr5 e de tratar um paciente tendo uma doença inflamatória ou doença autoimune, e, composição - Google Patents

métodos de induzir seletivamente a apoptose nas células alvo que expressam dr5, de inibir a proliferação de células alvo que expressam dr5 e de tratar um paciente tendo uma doença inflamatória ou doença autoimune, e, composição

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Publication number
BR0213846A
BR0213846A BRPI0213846-8A BR0213846A BR0213846A BR 0213846 A BR0213846 A BR 0213846A BR 0213846 A BR0213846 A BR 0213846A BR 0213846 A BR0213846 A BR 0213846A
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BR
Brazil
Prior art keywords
target cells
expressing target
methods
patient
treating
Prior art date
Application number
BRPI0213846-8A
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English (en)
Other versions
BRPI0213846B8 (pt
BRPI0213846B1 (pt
Inventor
Tong Zhou
Kimihisa Ichikawa
Robert P Kimberly
William J Koopman
Jun Oshumi
Albert F Lobuglio
Donald J Buchsbaum
Original Assignee
Uab Research Foundation
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Publication date
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Publication of BR0213846A publication Critical patent/BR0213846A/pt
Publication of BRPI0213846B1 publication Critical patent/BRPI0213846B1/pt
Publication of BRPI0213846B8 publication Critical patent/BRPI0213846B8/pt

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

"MéTODOS DE INDUZIR SELETIVAMENTE A APOPTOSE NAS CéLULAS ALVO QUE EXPRESSAM DR5, DE INIBIR A PROLIFERAçãO DE CéLULAS ALVO QUE EXPRESSAM DR5 E DE TRATAR UM PACIENTE TENDO UMA DOENçA INFLAMATóRIA OU DOENçA AUTOIMUNE, E, COMPOSIçãO". Um anticorpo da invenção interage com a DR5 humana ou com a DR4 humana para produzir efeitos agonísticos ou antagonísticos a jusante do receptor incluindo a inibição da proliferação celular e apoptose. Métodos e usos para os anticorpos, opcionalmente em combinação com vários agentes terapêuticos, são detalhados, incluindo o tratamento de doença relacionada com a apoptose e tratamento do desenvolvimento celular desregulado.
BRPI0213846A 2001-11-01 2002-10-25 composição que compreende um anticorpo que liga especificamente uma dr5 do receptor de trail e um ou mais agentes terapêuticos BRPI0213846B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34640201P 2001-11-01 2001-11-01
US60/346402 2001-11-01
US39147802P 2002-06-24 2002-06-24
US60/391478 2002-06-24
PCT/US2002/034420 WO2003038043A2 (en) 2001-11-01 2002-10-25 Combinations of dr5 antibody and other therapeutic agents

Publications (3)

Publication Number Publication Date
BR0213846A true BR0213846A (pt) 2006-11-21
BRPI0213846B1 BRPI0213846B1 (pt) 2019-10-15
BRPI0213846B8 BRPI0213846B8 (pt) 2021-05-25

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BRPI0213846A BRPI0213846B8 (pt) 2001-11-01 2002-10-25 composição que compreende um anticorpo que liga especificamente uma dr5 do receptor de trail e um ou mais agentes terapêuticos

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KR (1) KR20040081422A (pt)
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AT (1) ATE491019T1 (pt)
AU (1) AU2002360307B2 (pt)
BR (1) BRPI0213846B8 (pt)
CA (1) CA2465314C (pt)
CO (1) CO5650175A2 (pt)
DE (1) DE60238560D1 (pt)
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RU (1) RU2313368C2 (pt)
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ZA (1) ZA200403573B (pt)

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TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
JP3665316B2 (ja) 2001-05-18 2005-06-29 麒麟麦酒株式会社 抗ｔｒａｉｌ−ｒ抗体
CA2451680C (en) 2001-07-03 2011-04-19 Genentech, Inc. Human dr4 antibodies and uses thereof
MXPA04003514A (es) 2001-10-19 2004-07-23 Vascular Biogenics Ltd Construcciones de polinucleotidos, composiciones farmaceuticas y metodos para reducir la regulacion dirigida de angionesis y terapia anticancer.
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