BR0116010A - Kit imunoterapêutico para o tratamento de tumores - Google Patents
Kit imunoterapêutico para o tratamento de tumoresInfo
- Publication number
- BR0116010A BR0116010A BR0116010-9A BR0116010A BR0116010A BR 0116010 A BR0116010 A BR 0116010A BR 0116010 A BR0116010 A BR 0116010A BR 0116010 A BR0116010 A BR 0116010A
- Authority
- BR
- Brazil
- Prior art keywords
- tyrosine kinase
- receptor
- kinase activity
- kit
- tumors
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 abstract 8
- 108020003175 receptors Proteins 0.000 abstract 8
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 6
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 6
- 230000000694 effects Effects 0.000 abstract 6
- 239000003446 ligand Substances 0.000 abstract 3
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000011360 adjunctive therapy Methods 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002900 effect on cell Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000004565 tumor cell growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001104—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00113—Growth factors
- A61K39/001131—Epidermal growth factor [EGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00113—Growth factors
- A61K39/001134—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"KIT IMUNOTERAPêUTICO PARA O TRATAMENTO DE TUMORES". A presente invenção relaciona-se com o campo da imunologia e, mais especificamente, com a imunoterapia do câncer, particularmente com um kit imunoterapêutico para impedir o crescimento de células de tumor e/ou eliminar referidas células. O kit da invenção é útil para o tratamento de tumores, que tem efeito sobre células cujo crescimento é dependente do sistema de receptores com atividadede tirosina quinase, caracterizado pelo fato de que compreende os componentes A, B, C e D que são usados simultaneamente ou seq³encialmente nas combinações de A+C; ou A+D; ou B+C; ou 8+D; ou C+D, em que A, B, C e D são:A. um anticorpo contra um receptor de atividade de tirosina quinase;B. um anticorpo contra o(s) ligando(s) do receptor de atividade de tirosina quinase; C.-uma vacina cujo princípio ativo é um receptor de atividade de tirosina quinase, que induz anticorpos contra referido receptor de atividade de tirosina quinase; D.-uma vacina cujo princípio é o(s) ligando(s) de um receptor de atividade de tirosina quinase, que induz anticorpos contra referidos ligando(s) do receptor de atividade de tirosina quinase. O kit proporciona o meio de realizar combinação terapêutica de imunoterapia passiva e ativa. Os procedimentos referenciados podem ser aplicados em diferentes estágios clinicos com tumores de origem epitelial que sobre-expressam esses receptores. A combinação de terapia passiva e ativa pode ser simultânea ou seq³encial independentemente de se o procedimento terapêutico vai ser usado em pacientes com doença avançada ou como terapia adjuvante.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20000287A CU22979A1 (es) | 2000-12-08 | 2000-12-08 | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
| PCT/CU2001/000012 WO2002045747A1 (es) | 2000-12-08 | 2001-12-06 | Combinaciones inmunoterapeuticas para el tratamiento de tumores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0116010A true BR0116010A (pt) | 2004-01-06 |
Family
ID=40261022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0116010-9A BR0116010A (pt) | 2000-12-08 | 2001-12-06 | Kit imunoterapêutico para o tratamento de tumores |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20020160014A1 (pt) |
| EP (2) | EP2005996A3 (pt) |
| JP (2) | JP2005519023A (pt) |
| KR (1) | KR20030064416A (pt) |
| CN (1) | CN1326566C (pt) |
| AR (1) | AR031641A1 (pt) |
| AT (1) | ATE403438T1 (pt) |
| AU (2) | AU2002221521B2 (pt) |
| BR (1) | BR0116010A (pt) |
| CA (1) | CA2431199C (pt) |
| CU (1) | CU22979A1 (pt) |
| CY (1) | CY1108474T1 (pt) |
| DE (1) | DE60135248D1 (pt) |
| DK (1) | DK1350521T3 (pt) |
| EA (1) | EA007381B1 (pt) |
| ES (1) | ES2311036T3 (pt) |
| HK (1) | HK1073244A1 (pt) |
| MX (1) | MXPA03005030A (pt) |
| MY (1) | MY138833A (pt) |
| NZ (1) | NZ526284A (pt) |
| PE (1) | PE20020695A1 (pt) |
| PT (1) | PT1350521E (pt) |
| SI (1) | SI1350521T1 (pt) |
| UY (1) | UY27058A1 (pt) |
| WO (1) | WO2002045747A1 (pt) |
| ZA (1) | ZA200304415B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507724B2 (en) | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| EP1493445A1 (en) * | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
| CU23297A1 (es) * | 2004-11-16 | 2008-07-24 | Ct De Inmunologa A Molecular | Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer |
| US8323644B2 (en) * | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
| CA2665528C (en) | 2006-10-12 | 2018-01-23 | The University Of Tokyo | Diagnosis and treatment of cancer using anti-ereg antibody |
| CU23652A1 (es) * | 2007-06-29 | 2011-05-27 | Centro Inmunologia Molecular | Composición vacunal homogénea para el tratamiento del cáncer y su método de obtención |
| JP5420568B2 (ja) | 2008-01-17 | 2014-02-19 | アイアールエム・リミテッド・ライアビリティ・カンパニー | 改良された抗ＴｒｋＢ抗体 |
| EP2436397B1 (en) | 2009-05-29 | 2017-05-10 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition containing antagonist of egf family ligand as component |
| WO2012018260A1 (en) * | 2010-08-05 | 2012-02-09 | Universiteit Utrecht Holding B.V. | Epidermal growth factor receptor targeted immune therapy |
| TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
| CA3053239A1 (en) * | 2017-02-17 | 2018-08-23 | George Todaro | Use of tgf alpha for the treatment of diseases and disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| JPH01221326A (ja) * | 1988-02-29 | 1989-09-04 | Toyo Jozo Co Ltd | 悪性腫瘍細胞障害剤 |
| US5705157A (en) * | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
| EP0586002B1 (en) | 1992-08-18 | 2000-01-19 | CENTRO de IMMUNOLOGIA MOLECULAR | Monoclonal antibodies recognizing the epidermal growth factor receptor, cells and methods for their production and compositions containing them |
| CA2261433A1 (en) | 1993-12-09 | 1995-06-10 | Belinda Sanchez Ramirez | Composition comprising autologous epidermal growth factor |
| EP0657175B1 (en) * | 1993-12-09 | 2005-03-02 | Centro de Inmunologia Molecular | Vaccine comprising human autologous epidermal growth factor and use thereof |
| CU22615A1 (es) * | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| BR9811264A (pt) * | 1997-05-12 | 2000-07-18 | Aphton Corp | Composições imunogênicas ao receptor de gastrina/cck-b e métodos para o tratamento de tumores |
| US20030219380A1 (en) * | 1997-11-07 | 2003-11-27 | Annie Fong | Method of determining an efficacious dose of a drug |
| JP2002514573A (ja) * | 1998-05-08 | 2002-05-21 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 能動的なワクチン接種のための組成物および方法 |
| JP2002515511A (ja) * | 1998-05-15 | 2002-05-28 | イムクローン システムズ インコーポレイティド | 放射線及び成長因子レセプター・チロシン・キナーゼのインヒビターを使用するヒト腫瘍の治療 |
| US6498181B1 (en) * | 1999-01-06 | 2002-12-24 | Maxim Pharmaceuticals | Synergistic tumorcidal response induced by histamine |
| EP1303533A2 (en) * | 2000-05-05 | 2003-04-23 | Aphton Corporation | Chimeric peptide immunogens, their preparation and use |
| CU23077A1 (es) * | 2000-12-06 | 2005-08-17 | Centro Inmunologia Molecular | Composicion vacunal que contiene factor de crecimiento transformante (tgf-alfa). su uso en la terapia de enfermedades malignas |
-
2000
- 2000-12-08 CU CU20000287A patent/CU22979A1/es unknown
-
2001
- 2001-11-29 PE PE2001001203A patent/PE20020695A1/es not_active Application Discontinuation
- 2001-12-05 MY MYPI20015556A patent/MY138833A/en unknown
- 2001-12-06 AU AU2002221521A patent/AU2002221521B2/en not_active Ceased
- 2001-12-06 EP EP08161862A patent/EP2005996A3/en not_active Withdrawn
- 2001-12-06 AU AU2152102A patent/AU2152102A/xx active Pending
- 2001-12-06 CN CNB018216854A patent/CN1326566C/zh not_active Expired - Fee Related
- 2001-12-06 JP JP2002547530A patent/JP2005519023A/ja active Pending
- 2001-12-06 CA CA2431199A patent/CA2431199C/en not_active Expired - Fee Related
- 2001-12-06 DE DE60135248T patent/DE60135248D1/de not_active Expired - Lifetime
- 2001-12-06 DK DK01999388T patent/DK1350521T3/da active
- 2001-12-06 PT PT01999388T patent/PT1350521E/pt unknown
- 2001-12-06 UY UY27058A patent/UY27058A1/es unknown
- 2001-12-06 SI SI200130873T patent/SI1350521T1/sl unknown
- 2001-12-06 ES ES01999388T patent/ES2311036T3/es not_active Expired - Lifetime
- 2001-12-06 AT AT01999388T patent/ATE403438T1/de active
- 2001-12-06 KR KR10-2003-7007630A patent/KR20030064416A/ko active Search and Examination
- 2001-12-06 WO PCT/CU2001/000012 patent/WO2002045747A1/es active IP Right Grant
- 2001-12-06 EP EP01999388A patent/EP1350521B1/en not_active Expired - Lifetime
- 2001-12-06 BR BR0116010-9A patent/BR0116010A/pt not_active IP Right Cessation
- 2001-12-06 NZ NZ526284A patent/NZ526284A/en not_active IP Right Cessation
- 2001-12-06 MX MXPA03005030A patent/MXPA03005030A/es active IP Right Grant
- 2001-12-06 EA EA200300646A patent/EA007381B1/ru not_active IP Right Cessation
- 2001-12-07 AR ARP010105686A patent/AR031641A1/es not_active Application Discontinuation
- 2001-12-07 US US10/005,341 patent/US20020160014A1/en not_active Abandoned
-
2003
- 2003-06-05 ZA ZA200304415A patent/ZA200304415B/en unknown
-
2005
- 2005-07-11 HK HK05105840A patent/HK1073244A1/xx not_active IP Right Cessation
-
2006
- 2006-04-20 US US11/407,103 patent/US7744871B2/en not_active Expired - Lifetime
-
2008
- 2008-11-03 CY CY20081101242T patent/CY1108474T1/el unknown
-
2010
- 2010-03-23 JP JP2010066088A patent/JP2010150286A/ja not_active Abandoned
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