CY1108474T1 - Ανοσοθεραπευτικοι συνδυασμοι για την αγωγη των ογκων - Google Patents
Ανοσοθεραπευτικοι συνδυασμοι για την αγωγη των ογκωνInfo
- Publication number
- CY1108474T1 CY1108474T1 CY20081101242T CY081101242T CY1108474T1 CY 1108474 T1 CY1108474 T1 CY 1108474T1 CY 20081101242 T CY20081101242 T CY 20081101242T CY 081101242 T CY081101242 T CY 081101242T CY 1108474 T1 CY1108474 T1 CY 1108474T1
- Authority
- CY
- Cyprus
- Prior art keywords
- receptors
- immunotherapeutic
- treatment
- ligands
- patients
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 abstract 5
- 108020003175 receptors Proteins 0.000 abstract 5
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 238000009098 adjuvant therapy Methods 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000004565 tumor cell growth Effects 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001104—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00113—Growth factors
- A61K39/001131—Epidermal growth factor [EGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00113—Growth factors
- A61K39/001134—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με το πεδίο της ανοσολογίας, περισσότερο δε ειδικότερα με την ανοσοθεραπεία του καρκίνου, ειδικότερα δε με την χρήση ανοσοθεραπευτικών συνδυασμών και με μεθόδους αγωγής για την πρόληψη της ανάπτυξης των κυττάρων των όγκων και/ή την απαλοιφή των εν λόγω κυττάρων. Οι μέθοδοι που αποκαλύπτονται και δημοσιοποιούνται ως αναφορά σύμφωνα με την εφεύρεση βασίζονται στην αναστολή των υποδοχέων πρωτεϊνών κινάσης σε κατάλοιπα τυροσίνης (RTK) και με τους προσδέτες για τους εν λόγω υποδοχείς. Η εφεύρεση περιγράφει ανοσοθεραπευτικούς συνδυασμούς οι οποίοι αναστέλλουν τους υποδοχείς RTK και/ή τους προσδέτες αυτών μέσω συνδυασμού ενεργής και/ή παθητικής ανοσοθεραπείας έναντι των εν λόγω υποδοχέων. Οι μέθοδοι που αποκαλύπτονται και δημοσιοποιούνται ως αναφορά μπορούν να χρησιμοποιηθούν σε ασθενείς με διαφορετικές κλινικές καταστάσεις όγκων επιθηλιακής προέλευσης οι οποίες υπερ-εκφράζουν τους εν λόγω υποδοχείς. Ο ενεργός και παθητικός ανοσοθεραπευτικός συνδυασμός μπορεί να χρησιμοποιηθεί ταυτόχρονα ή επαγωγικά εξαρτώμενου του εάν η θεραπευτική μέθοδος πρόκειται να χρησιμοποιηθεί σε ασθενείς με μία προχωρημένη κατάσταση πάθησης ή ως ανοσοενισχυτική θεραπεία.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20000287A CU22979A1 (es) | 2000-12-08 | 2000-12-08 | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
EP01999388A EP1350521B1 (en) | 2000-12-08 | 2001-12-06 | Immunotherapeutic combinations for the treatment of tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108474T1 true CY1108474T1 (el) | 2014-04-09 |
Family
ID=40261022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101242T CY1108474T1 (el) | 2000-12-08 | 2008-11-03 | Ανοσοθεραπευτικοι συνδυασμοι για την αγωγη των ογκων |
Country Status (26)
Country | Link |
---|---|
US (2) | US20020160014A1 (el) |
EP (2) | EP2005996A3 (el) |
JP (2) | JP2005519023A (el) |
KR (1) | KR20030064416A (el) |
CN (1) | CN1326566C (el) |
AR (1) | AR031641A1 (el) |
AT (1) | ATE403438T1 (el) |
AU (2) | AU2152102A (el) |
BR (1) | BR0116010A (el) |
CA (1) | CA2431199C (el) |
CU (1) | CU22979A1 (el) |
CY (1) | CY1108474T1 (el) |
DE (1) | DE60135248D1 (el) |
DK (1) | DK1350521T3 (el) |
EA (1) | EA007381B1 (el) |
ES (1) | ES2311036T3 (el) |
HK (1) | HK1073244A1 (el) |
MX (1) | MXPA03005030A (el) |
MY (1) | MY138833A (el) |
NZ (1) | NZ526284A (el) |
PE (1) | PE20020695A1 (el) |
PT (1) | PT1350521E (el) |
SI (1) | SI1350521T1 (el) |
UY (1) | UY27058A1 (el) |
WO (1) | WO2002045747A1 (el) |
ZA (1) | ZA200304415B (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7507724B2 (en) * | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
EP1493445A1 (en) * | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
CU23297A1 (es) * | 2004-11-16 | 2008-07-24 | Ct De Inmunologa A Molecular | Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer |
US8323644B2 (en) * | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
MX2009003738A (es) * | 2006-10-12 | 2009-07-17 | Forerunner Pharma Res Co Ltd | Diagnóstico y tratamiento de cáncer usando anticuerpo anti-ereg. |
CU23652A1 (es) * | 2007-06-29 | 2011-05-27 | Centro Inmunologia Molecular | Composición vacunal homogénea para el tratamiento del cáncer y su método de obtención |
KR101290503B1 (ko) | 2008-01-17 | 2013-07-26 | 아이알엠 엘엘씨 | 개선된 항-trkb 항체 |
JP5808052B2 (ja) | 2009-05-29 | 2015-11-10 | 中外製薬株式会社 | Egfファミリーリガンドのアンタゴニストを成分とする医薬組成物 |
WO2012018260A1 (en) * | 2010-08-05 | 2012-02-09 | Universiteit Utrecht Holding B.V. | Epidermal growth factor receptor targeted immune therapy |
TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
EP3583113A4 (en) * | 2017-02-17 | 2020-08-26 | George Todaro | USE OF TGF-ALPHA FOR TREATMENT OF DISEASES AND DISORDERS |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
JPH01221326A (ja) * | 1988-02-29 | 1989-09-04 | Toyo Jozo Co Ltd | 悪性腫瘍細胞障害剤 |
US5705157A (en) * | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
EP0586002B1 (en) * | 1992-08-18 | 2000-01-19 | CENTRO de IMMUNOLOGIA MOLECULAR | Monoclonal antibodies recognizing the epidermal growth factor receptor, cells and methods for their production and compositions containing them |
CA2137639C (en) * | 1993-12-09 | 1999-01-26 | Agustin B. L. Davila | Vaccine composition comprising autologous epidermal growth factor or a fragment or a derivate thereof having anti-tumor activity and use thereof in the therapy of malignant diseases |
CA2261433A1 (en) * | 1993-12-09 | 1995-06-10 | Belinda Sanchez Ramirez | Composition comprising autologous epidermal growth factor |
CU22615A1 (es) * | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
DE69827621T9 (de) * | 1997-05-12 | 2007-06-06 | Aphton Corp., Woodland | Immunogene zusammensetzungen gegen den cck-b-gastrin-rezeptor und verfahren zur behandlung von tumoren |
US20030219380A1 (en) * | 1997-11-07 | 2003-11-27 | Annie Fong | Method of determining an efficacious dose of a drug |
EP1075184A4 (en) * | 1998-05-08 | 2002-01-30 | Sloan Kettering Inst Cancer | ACTIVE VACCINATION COMPOSITIONS AND METHODS |
KR20010071271A (ko) * | 1998-05-15 | 2001-07-28 | 존 비. 랜디스 | 방사선 및 성장 인자 수용체 티로신 키나아제 억제제에의한 사람 종양의 치료법 |
US6498181B1 (en) * | 1999-01-06 | 2002-12-24 | Maxim Pharmaceuticals | Synergistic tumorcidal response induced by histamine |
AU2001259452A1 (en) * | 2000-05-05 | 2001-11-20 | Aphton Corporation | Chimeric peptide immunogens their preparation and use |
CU23077A1 (es) * | 2000-12-06 | 2005-08-17 | Centro Inmunologia Molecular | Composicion vacunal que contiene factor de crecimiento transformante (tgf-alfa). su uso en la terapia de enfermedades malignas |
-
2000
- 2000-12-08 CU CU20000287A patent/CU22979A1/es unknown
-
2001
- 2001-11-29 PE PE2001001203A patent/PE20020695A1/es not_active Application Discontinuation
- 2001-12-05 MY MYPI20015556A patent/MY138833A/en unknown
- 2001-12-06 KR KR10-2003-7007630A patent/KR20030064416A/ko active Search and Examination
- 2001-12-06 CA CA2431199A patent/CA2431199C/en not_active Expired - Fee Related
- 2001-12-06 EA EA200300646A patent/EA007381B1/ru not_active IP Right Cessation
- 2001-12-06 DK DK01999388T patent/DK1350521T3/da active
- 2001-12-06 PT PT01999388T patent/PT1350521E/pt unknown
- 2001-12-06 WO PCT/CU2001/000012 patent/WO2002045747A1/es active IP Right Grant
- 2001-12-06 AU AU2152102A patent/AU2152102A/xx active Pending
- 2001-12-06 DE DE60135248T patent/DE60135248D1/de not_active Expired - Lifetime
- 2001-12-06 AU AU2002221521A patent/AU2002221521B2/en not_active Ceased
- 2001-12-06 ES ES01999388T patent/ES2311036T3/es not_active Expired - Lifetime
- 2001-12-06 CN CNB018216854A patent/CN1326566C/zh not_active Expired - Fee Related
- 2001-12-06 JP JP2002547530A patent/JP2005519023A/ja active Pending
- 2001-12-06 AT AT01999388T patent/ATE403438T1/de active
- 2001-12-06 EP EP08161862A patent/EP2005996A3/en not_active Withdrawn
- 2001-12-06 NZ NZ526284A patent/NZ526284A/en not_active IP Right Cessation
- 2001-12-06 EP EP01999388A patent/EP1350521B1/en not_active Expired - Lifetime
- 2001-12-06 MX MXPA03005030A patent/MXPA03005030A/es active IP Right Grant
- 2001-12-06 SI SI200130873T patent/SI1350521T1/sl unknown
- 2001-12-06 BR BR0116010-9A patent/BR0116010A/pt not_active IP Right Cessation
- 2001-12-06 UY UY27058A patent/UY27058A1/es unknown
- 2001-12-07 AR ARP010105686A patent/AR031641A1/es not_active Application Discontinuation
- 2001-12-07 US US10/005,341 patent/US20020160014A1/en not_active Abandoned
-
2003
- 2003-06-05 ZA ZA200304415A patent/ZA200304415B/en unknown
-
2005
- 2005-07-11 HK HK05105840A patent/HK1073244A1/xx not_active IP Right Cessation
-
2006
- 2006-04-20 US US11/407,103 patent/US7744871B2/en not_active Expired - Lifetime
-
2008
- 2008-11-03 CY CY20081101242T patent/CY1108474T1/el unknown
-
2010
- 2010-03-23 JP JP2010066088A patent/JP2010150286A/ja not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1108474T1 (el) | Ανοσοθεραπευτικοι συνδυασμοι για την αγωγη των ογκων | |
CY1123535T1 (el) | Υποκαταστατο θεραπευτικο τελικο σημειο για βασιζομενη σε anti-ctla-4 ανοσοθεραπεια ασθενειας | |
CY1120070T1 (el) | Μεθοδοi θεραπευτικης αγωγης με τη χρηση συζευγματων αντισωματος εναντι-erbb-μεϋτανσινοειδους | |
CY1113260T1 (el) | ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΚΑΡΚΙΝΟΥ ME TO ANTI-ErbB2 ΑΝΑΣΥΝΔΥΑΣΜΕΝΟ ΑΝΘΡΩΠΟΠΟΙΗΜΕΝΟ ΜΟΝΟΚΛΩΝΙΚΟ ΑΝΤΙΣΩΜΑ 2C4 (rhuMab 2C4) | |
WO2005062972A3 (en) | Treatment of cancer with novel anti-il 13 monoclonal antibodies | |
WO2008077077A3 (en) | Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors | |
NO331072B1 (no) | Sammensetning som omfatter et angiogenese inhiberende middel og et anti tumor-immunoterapeutisk middel samt anvendelser av det samme. | |
CY1110256T1 (el) | Διαμεμβρανικο αντιγονο λεκτινης τυπου c εκφραζομενο σε καρκινο στον προστατη ανθρωπου και χρησεις αυτου | |
CY1108765T1 (el) | ΑΓΩΓΗ ME ΑΝΤΙΣΩΜΑΤΑ ANTI-ErbB2 | |
CY1109421T1 (el) | ΔΟΣΕΙΣ ΓΙΑ ΑΓΩΓΗ ΜΕ ΑΝΤΙΣΩΜΑΤΑ ΑΝΤΙ-ErbB2 | |
BRPI0509177A (pt) | uso de anticorpos anti-alfa5beta1 para inibir a proliferação de células cancerìgenas | |
CY1110874T1 (el) | Μεθοδοι θεραπειας για συμπαγεις ογκους που εκφραζουν to cd40 αντιγονο κυτταρικης επιφανειας | |
CY1115407T1 (el) | Θοριο-227 για χρηση στην ακτινοθεραπεια ασθενειων των μαλακων ιστων | |
EA201071422A1 (ru) | Способы лечения заболеваний, связанных с мейотическим кинезином | |
ATE419516T1 (de) | Monoklonale antikörper und zelloberflächenantigene zum nachweis und zur behandlung von kleinzelligem lungenkrebs (sclc) | |
DK0939809T3 (da) | TIE-2 receptor-ligand (TIE ligand-4) og dens anvendelse | |
CY1111522T1 (el) | 84p2a9: ειδικη σε προστατη και ορχεις πρωτεϊνη που εκφραζεται σε υψηλο βαθμο στον προστατικο καρκινο | |
CY1109029T1 (el) | Νουκλεϊνικο οξυ και αντιστοιχη πρωτεϊνη ονομαζομενη 85p1b3 χρησιμα στην αγωγη και τον εντοπισμο του καρκινου | |
DE69927286D1 (de) | Verwendung von humanen prostatazellinien zur behandlung von prostatakrebs | |
DE60123138D1 (de) | Verwendung von progesteronrezeptorhemmern zur behandlung von steroid-resistentem brustkrebs | |
EA200701071A1 (ru) | Иммунотерапевтические композиции для получения аутоантител, способных предотвращать связывание интерлейкина-2 со своим рецептором и их использование в лечении рака | |
DE60212415D1 (de) | Die verwendung von einer 4-pyridylmethylphtalazine enthaltenden kombination zur behandlung von tumoren | |
Agaugue et al. | The high expression of NKG2D ligands on tumor and the lack of surface expression on healthy tissues provides a strong rationale to support NKG2D-based therapeutic approaches for cancer | |
小野博史 et al. | The Drug Uptake in the Tumor When the Mild-Hyperthermia Treatment in Combination with the Chemotherapy in vivo. | |
Gan et al. | Humanized knock-in mouse models for evaluating in vivo efficacy of immune-oncology drugs targeting stimulatory immune checkpoint molecules |