JP2010514459A5 - - Google Patents
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- Publication number
- JP2010514459A5 JP2010514459A5 JP2009544928A JP2009544928A JP2010514459A5 JP 2010514459 A5 JP2010514459 A5 JP 2010514459A5 JP 2009544928 A JP2009544928 A JP 2009544928A JP 2009544928 A JP2009544928 A JP 2009544928A JP 2010514459 A5 JP2010514459 A5 JP 2010514459A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 5
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 40
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 25
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 claims 4
- 231100000655 enterotoxin Toxicity 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88327107P | 2007-01-03 | 2007-01-03 | |
| US60/883,271 | 2007-01-03 | ||
| US88840507P | 2007-02-06 | 2007-02-06 | |
| US60/888,405 | 2007-02-06 | ||
| PCT/US2008/000104 WO2008085878A2 (en) | 2007-01-03 | 2008-01-03 | High affinity antibodies that neutralize staphylcoccus enterotoxin b |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013126119A Division JP5881646B2 (ja) | 2007-01-03 | 2013-06-14 | ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514459A JP2010514459A (ja) | 2010-05-06 |
| JP2010514459A5 true JP2010514459A5 (enExample) | 2011-02-24 |
| JP5412293B2 JP5412293B2 (ja) | 2014-02-12 |
Family
ID=39529113
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544928A Active JP5412293B2 (ja) | 2007-01-03 | 2008-01-03 | ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 |
| JP2013126119A Active JP5881646B2 (ja) | 2007-01-03 | 2013-06-14 | ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 |
| JP2016017809A Active JP6195946B2 (ja) | 2007-01-03 | 2016-02-02 | ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013126119A Active JP5881646B2 (ja) | 2007-01-03 | 2013-06-14 | ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 |
| JP2016017809A Active JP6195946B2 (ja) | 2007-01-03 | 2016-02-02 | ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US8236932B2 (enExample) |
| EP (2) | EP3138852A1 (enExample) |
| JP (3) | JP5412293B2 (enExample) |
| AU (1) | AU2008205376B2 (enExample) |
| CA (2) | CA2924155C (enExample) |
| DK (1) | DK2109622T3 (enExample) |
| ES (1) | ES2619943T3 (enExample) |
| PL (1) | PL2109622T3 (enExample) |
| WO (1) | WO2008085878A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236932B2 (en) | 2007-01-03 | 2012-08-07 | Morphotek, Inc. | High affinity antibodies that neutralize Staphylococcus enterotoxin B |
| WO2010030182A2 (en) * | 2008-09-10 | 2010-03-18 | Bac Ip B.V. | Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases |
| WO2013089877A2 (en) * | 2011-09-27 | 2013-06-20 | Albert Einstein College Of Medicine Of Yeshiva University | Adjuvant therapy for staphylococcal infection with enterotoxin specific mabs |
| SG10201608341XA (en) * | 2011-11-23 | 2016-11-29 | Hoffmann La Roche | Cd40l expressing mammalian cells and their use |
| US20160039914A1 (en) * | 2013-03-14 | 2016-02-11 | Albert Einstein College Of Medicine Of Yeshiva University | Humanized antibodies specific for staphylococcal enterotoxin b |
| US10995152B2 (en) | 2016-10-26 | 2021-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
| MX2019005772A (es) * | 2016-11-23 | 2019-10-02 | Bioverativ Therapeutics Inc | Anticuerpos mono y biespecíficos que se unen al factor de coagulación ix y al factor de coagulación x. |
| KR102124258B1 (ko) * | 2018-10-19 | 2020-06-26 | 대한민국(관리부서 질병관리본부장) | 신속 면역크로마토그래피법을 이용한 황색 포도알균 장독소 b 진단·탐지 키트 및 이를 위한 특이항체와 항체생산세포주 |
| JP7716399B2 (ja) * | 2019-11-01 | 2025-07-31 | ブイオーアール バイオファーマ インコーポレーテッド | 抗－ｃｄ４５抗体及びそのコンジュゲート |
| KR102274759B1 (ko) * | 2020-01-16 | 2021-07-09 | 대한민국(질병관리청장) | 황색포도알균 장독소 b에 특이적인 항체 및 이의 용도 |
| CN119101153B (zh) * | 2024-04-30 | 2025-07-08 | 中国人民解放军军事科学院军事医学研究院 | 一种葡萄球菌肠毒素b纳米抗体及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2574089A (en) | 1948-06-08 | 1951-11-06 | Cochran Jacqueline | Luggage case having a removable lining |
| US4854432A (en) | 1988-07-06 | 1989-08-08 | American Tourister, Inc. | Suitcase having removable divider with clothing pockets |
| US6713610B1 (en) * | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| CA2194450A1 (en) | 1994-07-06 | 1996-01-18 | Truckin' Movers Corporation | Convertible carrying case and work platform |
| US6036697A (en) | 1998-07-09 | 2000-03-14 | Scimed Life Systems, Inc. | Balloon catheter with balloon inflation at distal end of balloon |
| WO2000020598A1 (en) | 1998-10-07 | 2000-04-13 | The Rockefeller University | Peptides useful for reducing symptoms of toxic shock syndrome and septic shock |
| US8420353B2 (en) | 2002-03-22 | 2013-04-16 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| CA2496242A1 (en) | 2002-08-21 | 2004-03-04 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | T-cell epitopes in staphylococcal enterotoxin b |
| JP4571586B2 (ja) * | 2003-09-05 | 2010-10-27 | 一般財団法人化学及血清療法研究所 | プロテアーゼ耐性ｓｅｂ改変体およびそれを含むワクチン |
| CN101155832B (zh) * | 2005-02-08 | 2013-02-06 | 一般财团法人化学及血清疗法研究所 | 抗体的改良方法 |
| EA018030B1 (ru) * | 2006-06-06 | 2013-05-30 | Круселл Холланд Б.В. | Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения |
| US8236932B2 (en) * | 2007-01-03 | 2012-08-07 | Morphotek, Inc. | High affinity antibodies that neutralize Staphylococcus enterotoxin B |
-
2008
- 2008-01-03 US US11/969,097 patent/US8236932B2/en active Active
- 2008-01-03 WO PCT/US2008/000104 patent/WO2008085878A2/en not_active Ceased
- 2008-01-03 DK DK08712978.9T patent/DK2109622T3/en active
- 2008-01-03 AU AU2008205376A patent/AU2008205376B2/en active Active
- 2008-01-03 PL PL08712978T patent/PL2109622T3/pl unknown
- 2008-01-03 JP JP2009544928A patent/JP5412293B2/ja active Active
- 2008-01-03 CA CA2924155A patent/CA2924155C/en active Active
- 2008-01-03 CA CA2674382A patent/CA2674382C/en active Active
- 2008-01-03 EP EP16192106.9A patent/EP3138852A1/en not_active Withdrawn
- 2008-01-03 EP EP08712978.9A patent/EP2109622B1/en active Active
- 2008-01-03 ES ES08712978.9T patent/ES2619943T3/es active Active
-
2012
- 2012-07-02 US US13/540,330 patent/US8889846B2/en active Active
-
2013
- 2013-06-14 JP JP2013126119A patent/JP5881646B2/ja active Active
- 2013-07-16 US US13/943,060 patent/US8895704B2/en active Active
-
2014
- 2014-10-15 US US14/515,146 patent/US9359428B2/en active Active
-
2016
- 2016-02-02 JP JP2016017809A patent/JP6195946B2/ja active Active
- 2016-05-02 US US15/144,334 patent/US9868780B2/en active Active
-
2017
- 2017-12-12 US US15/839,403 patent/US10364284B2/en active Active
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