ES2619943T3 - Anticuerpos de alta afinidad que neutralizan la enterotoxina B estafilocócica - Google Patents
Anticuerpos de alta afinidad que neutralizan la enterotoxina B estafilocócica Download PDFInfo
- Publication number
- ES2619943T3 ES2619943T3 ES08712978.9T ES08712978T ES2619943T3 ES 2619943 T3 ES2619943 T3 ES 2619943T3 ES 08712978 T ES08712978 T ES 08712978T ES 2619943 T3 ES2619943 T3 ES 2619943T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- acid sequence
- seq
- light chain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88327107P | 2007-01-03 | 2007-01-03 | |
| US883271P | 2007-01-03 | ||
| US88840507P | 2007-02-06 | 2007-02-06 | |
| US888405P | 2007-02-06 | ||
| PCT/US2008/000104 WO2008085878A2 (en) | 2007-01-03 | 2008-01-03 | High affinity antibodies that neutralize staphylcoccus enterotoxin b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2619943T3 true ES2619943T3 (es) | 2017-06-27 |
Family
ID=39529113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08712978.9T Active ES2619943T3 (es) | 2007-01-03 | 2008-01-03 | Anticuerpos de alta afinidad que neutralizan la enterotoxina B estafilocócica |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US8236932B2 (enExample) |
| EP (2) | EP3138852A1 (enExample) |
| JP (3) | JP5412293B2 (enExample) |
| AU (1) | AU2008205376B2 (enExample) |
| CA (2) | CA2674382C (enExample) |
| DK (1) | DK2109622T3 (enExample) |
| ES (1) | ES2619943T3 (enExample) |
| PL (1) | PL2109622T3 (enExample) |
| WO (1) | WO2008085878A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2109622T3 (pl) * | 2007-01-03 | 2017-06-30 | Morphotek, Inc. | Przeciwciała o wysokim powinowactwie neutralizujące gronkowcową enterotoksynę B |
| EP2328929A2 (en) * | 2008-09-10 | 2011-06-08 | Bac Ip B.V. | Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases |
| WO2013089877A2 (en) * | 2011-09-27 | 2013-06-20 | Albert Einstein College Of Medicine Of Yeshiva University | Adjuvant therapy for staphylococcal infection with enterotoxin specific mabs |
| KR102069394B1 (ko) * | 2011-11-23 | 2020-01-22 | 에프. 호프만-라 로슈 아게 | Ｃｄ40ｌ 발현 포유류 세포 및 그의 용도 |
| WO2014160121A1 (en) * | 2013-03-14 | 2014-10-02 | Albert Einstein College Of Medicine Of Yeshiva University | Humanized antibodies specific for staphylococcal enterotoxin b |
| PL3532497T3 (pl) | 2016-10-26 | 2024-11-04 | The Board Of Trustees Of The Leland Stanford Junior University | Zmodyfikowane regiony zawiasowe immunoglobuliny dla zmniejszania hemaglutynacji |
| CN110662770A (zh) * | 2016-11-23 | 2020-01-07 | 比奥维拉迪维治疗股份有限公司 | 结合凝血因子ix和凝血因子x的双特异性抗体 |
| KR102124258B1 (ko) * | 2018-10-19 | 2020-06-26 | 대한민국(관리부서 질병관리본부장) | 신속 면역크로마토그래피법을 이용한 황색 포도알균 장독소 b 진단·탐지 키트 및 이를 위한 특이항체와 항체생산세포주 |
| JP7716399B2 (ja) * | 2019-11-01 | 2025-07-31 | ブイオーアール バイオファーマ インコーポレーテッド | 抗－ｃｄ４５抗体及びそのコンジュゲート |
| KR102274759B1 (ko) * | 2020-01-16 | 2021-07-09 | 대한민국(질병관리청장) | 황색포도알균 장독소 b에 특이적인 항체 및 이의 용도 |
| CN119101153B (zh) * | 2024-04-30 | 2025-07-08 | 中国人民解放军军事科学院军事医学研究院 | 一种葡萄球菌肠毒素b纳米抗体及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2574089A (en) | 1948-06-08 | 1951-11-06 | Cochran Jacqueline | Luggage case having a removable lining |
| US4854432A (en) | 1988-07-06 | 1989-08-08 | American Tourister, Inc. | Suitcase having removable divider with clothing pockets |
| US6713610B1 (en) * | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| WO1996001065A1 (en) | 1994-07-06 | 1996-01-18 | Truckin' Movers Corporation | Convertible carrying case and work platform |
| US6036697A (en) | 1998-07-09 | 2000-03-14 | Scimed Life Systems, Inc. | Balloon catheter with balloon inflation at distal end of balloon |
| WO2000020598A1 (en) | 1998-10-07 | 2000-04-13 | The Rockefeller University | Peptides useful for reducing symptoms of toxic shock syndrome and septic shock |
| AU2003210060B2 (en) | 2002-03-22 | 2010-02-25 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| BR0313638A (pt) | 2002-08-21 | 2005-06-21 | Merck Patent Ges Mit Berschron | Epìtopos de células t na enterotoxina b em estafilococos |
| WO2005023853A1 (ja) * | 2003-09-05 | 2005-03-17 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | プロテアーゼ耐性ｓｅｂ改変体およびそれを含むワクチン |
| EP2395026B1 (en) * | 2005-02-08 | 2018-01-24 | The Chemo-Sero-Therapeutic Research Institute | Method for improving antibody |
| CN103351435B (zh) | 2006-06-06 | 2015-08-19 | 克鲁塞尔荷兰公司 | 具有杀灭葡萄球菌活性的人结合分子及其应用 |
| PL2109622T3 (pl) * | 2007-01-03 | 2017-06-30 | Morphotek, Inc. | Przeciwciała o wysokim powinowactwie neutralizujące gronkowcową enterotoksynę B |
-
2008
- 2008-01-03 PL PL08712978T patent/PL2109622T3/pl unknown
- 2008-01-03 AU AU2008205376A patent/AU2008205376B2/en active Active
- 2008-01-03 EP EP16192106.9A patent/EP3138852A1/en not_active Withdrawn
- 2008-01-03 EP EP08712978.9A patent/EP2109622B1/en active Active
- 2008-01-03 DK DK08712978.9T patent/DK2109622T3/en active
- 2008-01-03 JP JP2009544928A patent/JP5412293B2/ja active Active
- 2008-01-03 CA CA2674382A patent/CA2674382C/en active Active
- 2008-01-03 CA CA2924155A patent/CA2924155C/en active Active
- 2008-01-03 ES ES08712978.9T patent/ES2619943T3/es active Active
- 2008-01-03 WO PCT/US2008/000104 patent/WO2008085878A2/en not_active Ceased
- 2008-01-03 US US11/969,097 patent/US8236932B2/en active Active
-
2012
- 2012-07-02 US US13/540,330 patent/US8889846B2/en active Active
-
2013
- 2013-06-14 JP JP2013126119A patent/JP5881646B2/ja active Active
- 2013-07-16 US US13/943,060 patent/US8895704B2/en active Active
-
2014
- 2014-10-15 US US14/515,146 patent/US9359428B2/en active Active
-
2016
- 2016-02-02 JP JP2016017809A patent/JP6195946B2/ja active Active
- 2016-05-02 US US15/144,334 patent/US9868780B2/en active Active
-
2017
- 2017-12-12 US US15/839,403 patent/US10364284B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5881646B2 (ja) | 2016-03-09 |
| US20170121396A1 (en) | 2017-05-04 |
| US8895704B2 (en) | 2014-11-25 |
| US9359428B2 (en) | 2016-06-07 |
| US20130183314A1 (en) | 2013-07-18 |
| AU2008205376A1 (en) | 2008-07-17 |
| EP3138852A1 (en) | 2017-03-08 |
| AU2008205376B2 (en) | 2012-07-12 |
| JP2010514459A (ja) | 2010-05-06 |
| US20140072553A1 (en) | 2014-03-13 |
| US10364284B2 (en) | 2019-07-30 |
| US20120171223A1 (en) | 2012-07-05 |
| EP2109622A2 (en) | 2009-10-21 |
| US20150050276A1 (en) | 2015-02-19 |
| EP2109622B1 (en) | 2016-11-09 |
| CA2674382A1 (en) | 2008-07-17 |
| PL2109622T3 (pl) | 2017-06-30 |
| US20180094048A1 (en) | 2018-04-05 |
| JP2013216673A (ja) | 2013-10-24 |
| WO2008085878A3 (en) | 2009-02-26 |
| CA2924155A1 (en) | 2008-07-17 |
| CA2924155C (en) | 2020-02-11 |
| CA2674382C (en) | 2016-05-31 |
| JP2016146824A (ja) | 2016-08-18 |
| DK2109622T3 (en) | 2017-02-13 |
| JP5412293B2 (ja) | 2014-02-12 |
| US9868780B2 (en) | 2018-01-16 |
| JP6195946B2 (ja) | 2017-09-13 |
| WO2008085878A2 (en) | 2008-07-17 |
| US8889846B2 (en) | 2014-11-18 |
| US8236932B2 (en) | 2012-08-07 |
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