JP2011510654A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011510654A5 JP2011510654A5 JP2010545017A JP2010545017A JP2011510654A5 JP 2011510654 A5 JP2011510654 A5 JP 2011510654A5 JP 2010545017 A JP2010545017 A JP 2010545017A JP 2010545017 A JP2010545017 A JP 2010545017A JP 2011510654 A5 JP2011510654 A5 JP 2011510654A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hybridoma
- antigen
- fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 8
- 210000004408 hybridoma Anatomy 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102100027207 CD27 antigen Human genes 0.000 claims 3
- 108010029697 CD40 Ligand Proteins 0.000 claims 3
- 102100032937 CD40 ligand Human genes 0.000 claims 3
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108030001720 Bontoxilysin Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6258408P | 2008-01-28 | 2008-01-28 | |
| PCT/US2009/000562 WO2009105150A2 (en) | 2008-01-28 | 2009-01-28 | Method of making hybrid cells that express useful antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015009809A Division JP5923186B2 (ja) | 2008-01-28 | 2015-01-21 | 有用な抗体を発現する雑種細胞の作成方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011510654A JP2011510654A (ja) | 2011-04-07 |
| JP2011510654A5 true JP2011510654A5 (enExample) | 2012-03-15 |
Family
ID=40986086
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545017A Pending JP2011510654A (ja) | 2008-01-28 | 2009-01-28 | 有用な抗体を発現する雑種細胞の作成方法 |
| JP2015009809A Active JP5923186B2 (ja) | 2008-01-28 | 2015-01-21 | 有用な抗体を発現する雑種細胞の作成方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015009809A Active JP5923186B2 (ja) | 2008-01-28 | 2015-01-21 | 有用な抗体を発現する雑種細胞の作成方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8999707B2 (enExample) |
| EP (1) | EP2242836B1 (enExample) |
| JP (2) | JP2011510654A (enExample) |
| WO (1) | WO2009105150A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563874B2 (en) | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| EP2134749B1 (en) | 2007-03-22 | 2013-11-06 | The Regents of the University of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| WO2009131605A2 (en) * | 2008-01-28 | 2009-10-29 | Thomas Jefferson University | Fusion partner cell line for preparation of hybrid cells expressing human antibodies |
| WO2010003529A1 (en) * | 2008-06-16 | 2010-01-14 | University Of Zurich | Method of providing immunoglobulin secreting b lymphocytes and human antibodies |
| US9000131B2 (en) | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| US8821879B2 (en) | 2009-09-04 | 2014-09-02 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
| EP2473191B1 (en) * | 2009-09-04 | 2017-08-23 | XOMA Technology Ltd. | Antibody coformulations |
| DK2400298T3 (da) * | 2010-05-28 | 2013-09-02 | Hoffmann La Roche | Enkelt B-celle-dyrkningsfremgangsmåde og specifik antistoffremstilling |
| WO2012047427A2 (en) | 2010-08-31 | 2012-04-12 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| PT2646466T (pt) * | 2010-12-02 | 2017-06-07 | Aimm Therapeutics Bv | Meios e métodos para produzir anticorpos de alta afinidade |
| WO2013000982A1 (en) | 2011-06-27 | 2013-01-03 | Vivalis | Method for screening cells |
| CN103946236B (zh) * | 2011-11-23 | 2018-02-16 | 弗·哈夫曼-拉罗切有限公司 | 表达cd40l的哺乳动物细胞及其用途 |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| WO2014138733A2 (en) * | 2013-03-08 | 2014-09-12 | Dessain Scott K | Compositions and methods for making human antibodies |
| US20160014600A1 (en) * | 2014-07-10 | 2016-01-14 | Bank Of America Corporation | Identification of Potential Improper Transaction |
| US20160253708A1 (en) * | 2015-02-26 | 2016-09-01 | Dropbox, Inc. | Method and system for efficiently serving upsell content based on complex user archetypes |
| AU2017218415B2 (en) | 2016-02-10 | 2024-05-02 | Rutgers, The State University Of New Jersey | Novel anti-LAM and anti-PIM6/LAM monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
| WO2018112407A1 (en) | 2016-12-15 | 2018-06-21 | Duke University | Antibodies and methods for depleting regulatory b10 cells and use in combination with immune checkpoint inhibitors |
| SG11202103411RA (en) | 2018-10-02 | 2021-04-29 | Immunome Inc | Antibodies targeting epn1 |
| WO2022150809A1 (en) | 2021-01-05 | 2022-07-14 | Immunome, Inc. | Antibody cocktail against sars-cov-2 spike protein |
| CN114350606A (zh) * | 2022-01-05 | 2022-04-15 | 上海药明生物医药有限公司 | 一种富集大鼠浆细胞及建立浆细胞杂交瘤的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3150991B2 (ja) * | 1991-04-10 | 2001-03-26 | 協和醗酵工業株式会社 | ハイブリドーマの製造法 |
| US6541225B1 (en) | 2000-01-26 | 2003-04-01 | Raven Biotechnologies, Inc. | Methods and compositions for generating human monoclonal antibodies |
| WO2003052082A2 (en) | 2001-12-18 | 2003-06-26 | Whitehead Institute For Biomedical Research | Fusion partner cells and uses thereof |
| EP1692276B1 (en) | 2003-11-19 | 2010-07-21 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method of inducing memory b cell development and terminal differentiation |
| ATE505535T1 (de) | 2005-08-23 | 2011-04-15 | Iq Corp | Verfahren zur herstellung stabiler b-lymphozyten |
| WO2009131605A2 (en) * | 2008-01-28 | 2009-10-29 | Thomas Jefferson University | Fusion partner cell line for preparation of hybrid cells expressing human antibodies |
-
2009
- 2009-01-28 EP EP09713631.1A patent/EP2242836B1/en active Active
- 2009-01-28 JP JP2010545017A patent/JP2011510654A/ja active Pending
- 2009-01-28 WO PCT/US2009/000562 patent/WO2009105150A2/en not_active Ceased
- 2009-01-28 US US12/864,889 patent/US8999707B2/en active Active
-
2015
- 2015-01-21 JP JP2015009809A patent/JP5923186B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011510654A5 (enExample) | ||
| JP2022177090A5 (enExample) | ||
| RU2020120539A (ru) | Композиции для ингибирования masp-2-зависимой активации комплемента | |
| JP2011526785A5 (enExample) | ||
| HRP20191697T1 (hr) | Vezujuće molekule za bcma i cd3 | |
| JP2020534830A5 (enExample) | ||
| RU2012142230A (ru) | Антитела против csf-1r человека и их применение | |
| RU2012147638A (ru) | Антитела против растворимого st-2 человека и способы анализа | |
| HRP20131215T1 (hr) | Antagonistiäśka humana monoklonska protutijela specifiäśna za humane slabe epitope | |
| JP2020504101A5 (enExample) | ||
| IL273196B1 (en) | Claudin 6 antibodies and methods of cancer treatment | |
| JP2015508056A5 (enExample) | ||
| RU2012142231A (ru) | Антитела против csf-1r человека и их применение | |
| RU2008129111A (ru) | Антитела к ox40l и способы их применения | |
| RU2014103784A (ru) | Антитело, блокирующее agr2, и его применение | |
| NZ603226A (en) | Anti-c5a antibodies and methods for using the antibodies | |
| KR20210100654A (ko) | Cd3 항체 및 그의 약제학적 용도 | |
| RU2009126766A (ru) | Антитела человека к дельта-подобному лиганду-4 человека | |
| RU2013142600A (ru) | Белки, связывающие специфический мембранный антиген простаты, и соответствующие композиции и способы | |
| JP2011527899A5 (enExample) | ||
| NZ597067A (en) | Monoclonal antibodies expressed by ATCC PTA-4621 for the treatment of cancer | |
| RU2009111884A (ru) | Последовательности вариабельных областей моноклональных антител против il-31 и способы использования | |
| JP2012523848A5 (enExample) | ||
| FI3561057T3 (fi) | Anti-cd3-vasta-aine ja vasta-ainetta sisältäviä molekyylejä | |
| RU2012137380A (ru) | Моноклональные антитела к cd44, предназначенные для применения при лечении плоскоклеточной карциномы головы и шеи |