JP2004504063A5 - - Google Patents
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- Publication number
- JP2004504063A5 JP2004504063A5 JP2002514175A JP2002514175A JP2004504063A5 JP 2004504063 A5 JP2004504063 A5 JP 2004504063A5 JP 2002514175 A JP2002514175 A JP 2002514175A JP 2002514175 A JP2002514175 A JP 2002514175A JP 2004504063 A5 JP2004504063 A5 JP 2004504063A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- polypeptide
- mutation
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 102000004042 Fibroblast Growth Factor-23 Human genes 0.000 description 4
- 108090000569 Fibroblast Growth Factor-23 Proteins 0.000 description 4
- 230000035772 mutation Effects 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21913700P | 2000-07-19 | 2000-07-19 | |
| PCT/US2001/021738 WO2002008271A1 (en) | 2000-07-19 | 2001-07-10 | Novel fibroblast growth factor (fgf23) and methods for use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008025528A Division JP2008194039A (ja) | 2000-07-19 | 2008-02-05 | 新規線維芽細胞増殖因子（ｆｇｆ２３）および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004504063A JP2004504063A (ja) | 2004-02-12 |
| JP2004504063A5 true JP2004504063A5 (enExample) | 2008-03-27 |
Family
ID=22818027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002514175A Pending JP2004504063A (ja) | 2000-07-19 | 2001-07-10 | 新規線維芽細胞増殖因子（ｆｇｆ２３）および使用方法 |
| JP2008025528A Pending JP2008194039A (ja) | 2000-07-19 | 2008-02-05 | 新規線維芽細胞増殖因子（ｆｇｆ２３）および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008025528A Pending JP2008194039A (ja) | 2000-07-19 | 2008-02-05 | 新規線維芽細胞増殖因子（ｆｇｆ２３）および使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7223563B2 (enExample) |
| EP (2) | EP1303536B1 (enExample) |
| JP (2) | JP2004504063A (enExample) |
| KR (2) | KR20090036151A (enExample) |
| CN (1) | CN1446227B (enExample) |
| AT (1) | ATE461213T1 (enExample) |
| AU (2) | AU7332301A (enExample) |
| CA (1) | CA2418215A1 (enExample) |
| DE (1) | DE60141582D1 (enExample) |
| ES (1) | ES2340662T3 (enExample) |
| WO (1) | WO2002008271A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20060160181A1 (en) * | 2000-02-15 | 2006-07-20 | Amgen Inc. | Fibroblast Growth Factor-23 molecules and uses thereof |
| EP1261638A2 (en) * | 2000-03-08 | 2002-12-04 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| ES2344679T3 (es) * | 2000-08-11 | 2010-09-03 | Kyowa Hakko Kirin Co., Ltd. | Polipeptidos que controlan el metabolismo del acido fosforico, el metabolismo del calcio, el metabolismo de la calcificacion y de la vitamina d y moleculas de adn que los codifican. |
| US7226749B2 (en) | 2000-12-05 | 2007-06-05 | Zahradnik Richard J | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 |
| US6838264B2 (en) | 2000-12-05 | 2005-01-04 | Immutopics, Inc. | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 |
| RU2003123108A (ru) * | 2000-12-26 | 2005-02-27 | Чугаи Сейяку Кабусики Кайся (Jp) | Мутантные формы человеческого белка fgf23, снижающие содержание фосфора в крови |
| US20040171825A1 (en) * | 2001-04-26 | 2004-09-02 | Lydie Bougueleret | Human fibroblast growth factor-related compositions |
| ATE441666T1 (de) | 2001-12-28 | 2009-09-15 | Kyowa Hakko Kirin Co Ltd | Antikírper gegen den fibroblastenwachstumsfaktor 23 |
| US7094551B2 (en) | 2002-09-17 | 2006-08-22 | Zahradnik Richard J | Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23 |
| JP5118851B2 (ja) * | 2003-11-07 | 2013-01-16 | ノバルティス アーゲー | 線維芽細胞増殖因子フラグメントの使用 |
| IL161886A0 (en) * | 2004-05-09 | 2005-11-20 | Technion Res & Dev Foundation | Development of inducers of udp-n-acetyl-alphad-galactosamine: polypeptide n-acetylgalactosami-nyltransferase 3(ppgantase |
| WO2005108607A1 (en) * | 2004-05-09 | 2005-11-17 | Technion Research & Development Foundation Ltd. | Compositions and methods for treating disorders associated with abnormal phosphate metabolism |
| US20060236220A1 (en) * | 2005-04-18 | 2006-10-19 | Clearplay, Inc. | Apparatus, System and Method for Associating One or More Filter Files with a Particular Multimedia Presentation |
| KR100760525B1 (ko) * | 2006-04-13 | 2007-10-04 | 김재만 | 병원성 미생물의 무증폭 다중 정량 검출킷트 및 검출방법 |
| US8012694B2 (en) | 2006-09-14 | 2011-09-06 | Immutopics, Inc. | Assay for the detection of phosphorylated PTH |
| EP2468888B1 (en) * | 2007-01-22 | 2018-04-11 | Medizinische Universität Innsbruck | Novel markers for chronic kidney disease |
| US7883705B2 (en) | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| US20110183434A1 (en) * | 2008-01-17 | 2011-07-28 | Myles Wolf | Diagnostic methods and kits using fibroblast growth factor-23 |
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| MX342553B (es) * | 2008-04-29 | 2016-10-04 | Novartis Ag | Metodos para monitorear la modulacion de la actividad de cinasa del receptor del factor de crecimiento de fibroblastos y uso de dichos metodos. |
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| US20110195077A1 (en) | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
| WO2012029837A1 (ja) | 2010-08-31 | 2012-03-08 | 協和メデックス株式会社 | 線維芽細胞増殖因子－２３の測定方法及び測定試薬 |
| WO2012055096A1 (zh) * | 2010-10-27 | 2012-05-03 | 温州医学院生物与天然药物开发中心有限公司 | 抗fgf-23抗体的制备方法及用途 |
| EP2723391B1 (en) | 2011-06-24 | 2018-06-13 | University of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| WO2013027191A1 (en) | 2011-08-25 | 2013-02-28 | Novartis Ag | Methods and compositions using fgf23 fusion polypeptides |
| US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| SG10202100667SA (en) | 2012-12-27 | 2021-02-25 | Ngm Biopharmaceuticals Inc | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2014130659A1 (en) | 2013-02-22 | 2014-08-28 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| CA2924735C (en) | 2013-09-20 | 2023-02-28 | Lonza Ltd | Methods for nuclear reprogramming of cells |
| EP3062881B1 (en) | 2013-10-28 | 2019-10-02 | NGM Biopharmaceuticals, Inc. | Cancer models and associated methods |
| NZ722377A (en) | 2014-01-24 | 2022-09-30 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| CA2943361A1 (en) | 2014-03-28 | 2015-10-01 | New York University | Fgf23 fusion proteins |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| LT3151859T (lt) | 2014-06-09 | 2021-03-25 | Ultragenyx Pharmaceutical Inc. | Veiksminga ir efektyvi serumo fosfatų kontrolė optimaliam kaulų formavimosi užtikrinimui |
| US10456449B2 (en) | 2014-06-16 | 2019-10-29 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| CN107108711B (zh) | 2014-10-23 | 2021-11-23 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CA2969307A1 (en) | 2014-12-04 | 2016-06-09 | Novartis Ag | Methods and compositions using klotho variant polypeptides |
| CN105699664A (zh) * | 2015-04-13 | 2016-06-22 | 陈柏龄 | Fgf23检测试剂盒及其制备方法 |
| EP3313996A1 (en) | 2015-06-25 | 2018-05-02 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| WO2017083276A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| EP3503882A4 (en) | 2016-08-26 | 2020-07-29 | NGM Biopharmaceuticals, Inc. | METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS |
| JP7181534B2 (ja) * | 2017-03-28 | 2022-12-01 | 味の素株式会社 | 未分化維持培地添加剤 |
| JP7296875B2 (ja) | 2017-05-31 | 2023-06-23 | ミナリスメディカル株式会社 | 線維芽細胞増殖因子－２３の測定方法、測定試薬及び測定キット |
| WO2020047475A1 (en) * | 2018-08-30 | 2020-03-05 | The Uab Research Foundation | Drug screening for fgf23-fgfr4 inhibitors |
| PH12021552414A1 (en) * | 2019-03-29 | 2022-07-25 | Atarga Llc | Anti fgf23 antibody |
| KR20210153069A (ko) * | 2019-04-19 | 2021-12-16 | 제네똥 | 섬유아세포 성장 인자 23 관련 저인산혈증성 질환의 유전자 요법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| WO1994017810A1 (en) | 1993-02-12 | 1994-08-18 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| CA2160583A1 (en) | 1993-04-16 | 1994-10-27 | Stanley A. Plotkin | Recombinant cytomegalovirus vaccine |
| US5693775A (en) * | 1995-05-12 | 1997-12-02 | The Johns Hopkins University School Of Medicine | Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use |
| US20020102604A1 (en) * | 1999-12-08 | 2002-08-01 | Milne Edwards Jean-Baptiste Dumas | Full-length human cDNAs encoding potentially secreted proteins |
| JP2004522402A (ja) | 1999-06-02 | 2004-07-29 | ジェネンテック・インコーポレーテッド | 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸 |
| EP1686134A3 (en) * | 1999-12-01 | 2006-08-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2396401A1 (en) | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Novel fgf homolog zfgf12 |
| WO2001060850A1 (en) | 2000-02-14 | 2001-08-23 | Smithkline Beecham Corporation | Novel compounds |
| JP2005508131A (ja) * | 2000-02-15 | 2005-03-31 | アムジェン インコーポレイテッド | 線維芽細胞成長因子−２３分子およびその使用 |
| EP1261638A2 (en) * | 2000-03-08 | 2002-12-04 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| WO2002076467A1 (en) * | 2001-03-22 | 2002-10-03 | Genzyme Corporation | Compositions and methods to regulate bone and mineral metabolism |
-
2001
- 2001-07-10 ES ES01952590T patent/ES2340662T3/es not_active Expired - Lifetime
- 2001-07-10 JP JP2002514175A patent/JP2004504063A/ja active Pending
- 2001-07-10 US US09/901,938 patent/US7223563B2/en not_active Expired - Lifetime
- 2001-07-10 AT AT01952590T patent/ATE461213T1/de not_active IP Right Cessation
- 2001-07-10 KR KR1020097006051A patent/KR20090036151A/ko not_active Ceased
- 2001-07-10 CN CN018140572A patent/CN1446227B/zh not_active Expired - Lifetime
- 2001-07-10 CA CA002418215A patent/CA2418215A1/en not_active Abandoned
- 2001-07-10 DE DE60141582T patent/DE60141582D1/de not_active Expired - Lifetime
- 2001-07-10 WO PCT/US2001/021738 patent/WO2002008271A1/en not_active Ceased
- 2001-07-10 AU AU7332301A patent/AU7332301A/xx active Pending
- 2001-07-10 EP EP01952590A patent/EP1303536B1/en not_active Expired - Lifetime
- 2001-07-10 EP EP10001442A patent/EP2184296A1/en not_active Withdrawn
- 2001-07-10 AU AU2001273323A patent/AU2001273323B2/en not_active Expired
-
2003
- 2003-01-18 KR KR1020037000821A patent/KR100924183B1/ko not_active Expired - Lifetime
- 2003-03-04 US US10/379,334 patent/US7314618B2/en not_active Expired - Lifetime
-
2007
- 2007-11-07 US US11/983,190 patent/US7947810B2/en not_active Expired - Fee Related
- 2007-11-07 US US11/983,137 patent/US7745406B2/en not_active Expired - Fee Related
-
2008
- 2008-02-05 JP JP2008025528A patent/JP2008194039A/ja active Pending
-
2011
- 2011-04-11 US US13/084,203 patent/US8586317B2/en not_active Expired - Fee Related
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