JP2004504063A5 - - Google Patents

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Publication number
JP2004504063A5
JP2004504063A5 JP2002514175A JP2002514175A JP2004504063A5 JP 2004504063 A5 JP2004504063 A5 JP 2004504063A5 JP 2002514175 A JP2002514175 A JP 2002514175A JP 2002514175 A JP2002514175 A JP 2002514175A JP 2004504063 A5 JP2004504063 A5 JP 2004504063A5
Authority
JP
Japan
Prior art keywords
antibody
seq
polypeptide
mutation
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002514175A
Other languages
English (en)
Japanese (ja)
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JP2004504063A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/021738 external-priority patent/WO2002008271A1/en
Publication of JP2004504063A publication Critical patent/JP2004504063A/ja
Publication of JP2004504063A5 publication Critical patent/JP2004504063A5/ja
Pending legal-status Critical Current

Links

JP2002514175A 2000-07-19 2001-07-10 新規線維芽細胞増殖因子(fgf23)および使用方法 Pending JP2004504063A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21913700P 2000-07-19 2000-07-19
PCT/US2001/021738 WO2002008271A1 (en) 2000-07-19 2001-07-10 Novel fibroblast growth factor (fgf23) and methods for use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008025528A Division JP2008194039A (ja) 2000-07-19 2008-02-05 新規線維芽細胞増殖因子(fgf23)および使用方法

Publications (2)

Publication Number Publication Date
JP2004504063A JP2004504063A (ja) 2004-02-12
JP2004504063A5 true JP2004504063A5 (enExample) 2008-03-27

Family

ID=22818027

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002514175A Pending JP2004504063A (ja) 2000-07-19 2001-07-10 新規線維芽細胞増殖因子(fgf23)および使用方法
JP2008025528A Pending JP2008194039A (ja) 2000-07-19 2008-02-05 新規線維芽細胞増殖因子(fgf23)および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008025528A Pending JP2008194039A (ja) 2000-07-19 2008-02-05 新規線維芽細胞増殖因子(fgf23)および使用方法

Country Status (11)

Country Link
US (5) US7223563B2 (enExample)
EP (2) EP1303536B1 (enExample)
JP (2) JP2004504063A (enExample)
KR (2) KR20090036151A (enExample)
CN (1) CN1446227B (enExample)
AT (1) ATE461213T1 (enExample)
AU (2) AU2001273323B2 (enExample)
CA (1) CA2418215A1 (enExample)
DE (1) DE60141582D1 (enExample)
ES (1) ES2340662T3 (enExample)
WO (1) WO2002008271A1 (enExample)

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US6838264B2 (en) 2000-12-05 2005-01-04 Immutopics, Inc. Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
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CN1602355A (zh) * 2001-04-26 2005-03-30 杰诺瓦有限公司 与人成纤维细胞生长因子有关的组合物
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WO2008089936A1 (en) * 2007-01-22 2008-07-31 Medizinische Universität Innsbruck Novel markers for chronic kidney disease
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WO2009091556A2 (en) * 2008-01-17 2009-07-23 The General Hospital Corporation Diagnostic methods and kits using fibroblast growth factor-23
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
MX2010011959A (es) * 2008-04-29 2010-11-30 Novartis Ag Metodos para monitorear la modulacion de la actividad de cinasa del receptor del factor de crecimiento de fibroblastos y uso de dichos metodos.
US8889621B2 (en) 2009-10-30 2014-11-18 New York University Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia
US20110195077A1 (en) 2010-01-29 2011-08-11 Novartis Ag Methods and compositions using fgf23 fusion ppolypeptides
JP5865838B2 (ja) 2010-08-31 2016-02-17 協和メデックス株式会社 線維芽細胞増殖因子−23の測定方法及び測定試薬
WO2012055096A1 (zh) * 2010-10-27 2012-05-03 温州医学院生物与天然药物开发中心有限公司 抗fgf-23抗体的制备方法及用途
US20140294820A1 (en) 2011-06-24 2014-10-02 University Of Miami Fibroblast growth factor receptor inhibition for the treatment of disease
WO2013006486A2 (en) 2011-07-01 2013-01-10 Ngm Biopharmaceuticals, Inc. Compositions, uses and methods for treatment of metabolic disorders and diseases
WO2013027191A1 (en) 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
WO2014085365A2 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
IL292303A (en) 2012-12-27 2022-06-01 Ngm Biopharmaceuticals Inc Methods for modulating bile acid homeostatsis and treatment of bile acid disorders and disease
WO2014130659A1 (en) 2013-02-22 2014-08-28 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
WO2015040497A2 (en) * 2013-09-20 2015-03-26 Lonza Ltd Methods for nuclear reprogramming of cells
SG11201602870YA (en) 2013-10-28 2016-05-30 Ngm Biopharmaceuticals Inc Cancer models and associated methods
PL3097122T3 (pl) 2014-01-24 2020-10-19 Ngm Biopharmaceuticals, Inc. Przeciwciała wiążące domenę 2 beta klotho oraz sposoby ich stosowania
JP2017517272A (ja) 2014-03-28 2017-06-29 ニューヨーク・ユニバーシティ Fgf23融合タンパク質
WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
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EP3227319B1 (en) 2014-12-04 2019-11-27 Novartis AG Methods and compositions using klotho variant polypeptides
CN105699664A (zh) * 2015-04-13 2016-06-22 陈柏龄 Fgf23检测试剂盒及其制备方法
WO2016210350A1 (en) * 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
AU2016353988B2 (en) 2015-11-09 2019-09-26 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders
WO2018039557A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
CA3058306A1 (en) * 2017-03-28 2018-10-04 Ajinomoto Co., Inc. Additive for undifferentiation maintaining medium
EP3633373B1 (en) 2017-05-31 2025-02-19 Hitachi Chemical Diagnostics Systems Co., Ltd. Measurement method for fibroblast growth factor 23, measurement reagent, and measurement kit
WO2020047475A1 (en) * 2018-08-30 2020-03-05 The Uab Research Foundation Drug screening for fgf23-fgfr4 inhibitors
JP2022527790A (ja) * 2019-03-29 2022-06-06 アターガ,エルエルシー 抗fgf23抗体分子
KR20210153069A (ko) * 2019-04-19 2021-12-16 제네똥 섬유아세포 성장 인자 23 관련 저인산혈증성 질환의 유전자 요법

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WO2002076467A1 (en) * 2001-03-22 2002-10-03 Genzyme Corporation Compositions and methods to regulate bone and mineral metabolism

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