KR20090036151A - 신규 섬유아세포 성장 인자 (fgf23) 및 그의 이용 방법 - Google Patents
신규 섬유아세포 성장 인자 (fgf23) 및 그의 이용 방법 Download PDFInfo
- Publication number
- KR20090036151A KR20090036151A KR1020097006051A KR20097006051A KR20090036151A KR 20090036151 A KR20090036151 A KR 20090036151A KR 1020097006051 A KR1020097006051 A KR 1020097006051A KR 20097006051 A KR20097006051 A KR 20097006051A KR 20090036151 A KR20090036151 A KR 20090036151A
- Authority
- KR
- South Korea
- Prior art keywords
- fgf23
- leu
- gly
- arg
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Obesity (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21913700P | 2000-07-19 | 2000-07-19 | |
| US60/219,137 | 2000-07-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037000821A Division KR100924183B1 (ko) | 2000-07-19 | 2003-01-18 | 신규 섬유아세포 성장 인자 (fgf23) 및 그의 이용 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20090036151A true KR20090036151A (ko) | 2009-04-13 |
Family
ID=22818027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097006051A Ceased KR20090036151A (ko) | 2000-07-19 | 2001-07-10 | 신규 섬유아세포 성장 인자 (fgf23) 및 그의 이용 방법 |
| KR1020037000821A Expired - Lifetime KR100924183B1 (ko) | 2000-07-19 | 2003-01-18 | 신규 섬유아세포 성장 인자 (fgf23) 및 그의 이용 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037000821A Expired - Lifetime KR100924183B1 (ko) | 2000-07-19 | 2003-01-18 | 신규 섬유아세포 성장 인자 (fgf23) 및 그의 이용 방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7223563B2 (enExample) |
| EP (2) | EP1303536B1 (enExample) |
| JP (2) | JP2004504063A (enExample) |
| KR (2) | KR20090036151A (enExample) |
| CN (1) | CN1446227B (enExample) |
| AT (1) | ATE461213T1 (enExample) |
| AU (2) | AU2001273323B2 (enExample) |
| CA (1) | CA2418215A1 (enExample) |
| DE (1) | DE60141582D1 (enExample) |
| ES (1) | ES2340662T3 (enExample) |
| WO (1) | WO2002008271A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20060160181A1 (en) * | 2000-02-15 | 2006-07-20 | Amgen Inc. | Fibroblast Growth Factor-23 molecules and uses thereof |
| EP1261638A2 (en) * | 2000-03-08 | 2002-12-04 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| CN100387713C (zh) * | 2000-08-11 | 2008-05-14 | 麒麟医药株式会社 | 调节磷酸代谢,钙代谢,钙化和维生素d代谢的多肽及其编码dna |
| US7226749B2 (en) | 2000-12-05 | 2007-06-05 | Zahradnik Richard J | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 |
| US6838264B2 (en) | 2000-12-05 | 2005-01-04 | Immutopics, Inc. | Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 |
| KR20030074678A (ko) * | 2000-12-26 | 2003-09-19 | 추가이 세이야쿠 가부시키가이샤 | 혈중 인농도를 저하시키는 인간 fgf23 단백질 변이체 |
| CN1602355A (zh) * | 2001-04-26 | 2005-03-30 | 杰诺瓦有限公司 | 与人成纤维细胞生长因子有关的组合物 |
| CA2471656C (en) | 2001-12-28 | 2012-07-31 | Kirin Beer Kabushiki Kaisha | Antibody against fibroblast growth factor-23 |
| US7094551B2 (en) | 2002-09-17 | 2006-08-22 | Zahradnik Richard J | Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23 |
| JP5118851B2 (ja) * | 2003-11-07 | 2013-01-16 | ノバルティス アーゲー | 線維芽細胞増殖因子フラグメントの使用 |
| WO2005108607A1 (en) * | 2004-05-09 | 2005-11-17 | Technion Research & Development Foundation Ltd. | Compositions and methods for treating disorders associated with abnormal phosphate metabolism |
| IL161886A0 (en) * | 2004-05-09 | 2005-11-20 | Technion Res & Dev Foundation | Development of inducers of udp-n-acetyl-alphad-galactosamine: polypeptide n-acetylgalactosami-nyltransferase 3(ppgantase |
| BRPI0612974A2 (pt) * | 2005-04-18 | 2010-12-14 | Clearplay Inc | produto de programa de computador, sinal de dados de computador incorporado em uma mÍdia de transmissço, mÉtodo para associar uma apresentaÇço de multimÍdia com informaÇÕes de filtro de conteédo e reprodutor de multimÍdia |
| KR100760525B1 (ko) * | 2006-04-13 | 2007-10-04 | 김재만 | 병원성 미생물의 무증폭 다중 정량 검출킷트 및 검출방법 |
| US8012694B2 (en) | 2006-09-14 | 2011-09-06 | Immutopics, Inc. | Assay for the detection of phosphorylated PTH |
| WO2008089936A1 (en) * | 2007-01-22 | 2008-07-31 | Medizinische Universität Innsbruck | Novel markers for chronic kidney disease |
| US7883705B2 (en) * | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| WO2009091556A2 (en) * | 2008-01-17 | 2009-07-23 | The General Hospital Corporation | Diagnostic methods and kits using fibroblast growth factor-23 |
| US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| MX2010011959A (es) * | 2008-04-29 | 2010-11-30 | Novartis Ag | Metodos para monitorear la modulacion de la actividad de cinasa del receptor del factor de crecimiento de fibroblastos y uso de dichos metodos. |
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| US20110195077A1 (en) | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
| JP5865838B2 (ja) | 2010-08-31 | 2016-02-17 | 協和メデックス株式会社 | 線維芽細胞増殖因子−23の測定方法及び測定試薬 |
| WO2012055096A1 (zh) * | 2010-10-27 | 2012-05-03 | 温州医学院生物与天然药物开发中心有限公司 | 抗fgf-23抗体的制备方法及用途 |
| US20140294820A1 (en) | 2011-06-24 | 2014-10-02 | University Of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| WO2013027191A1 (en) | 2011-08-25 | 2013-02-28 | Novartis Ag | Methods and compositions using fgf23 fusion polypeptides |
| US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| WO2014085365A2 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| IL292303A (en) | 2012-12-27 | 2022-06-01 | Ngm Biopharmaceuticals Inc | Methods for modulating bile acid homeostatsis and treatment of bile acid disorders and disease |
| WO2014130659A1 (en) | 2013-02-22 | 2014-08-28 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| WO2015040497A2 (en) * | 2013-09-20 | 2015-03-26 | Lonza Ltd | Methods for nuclear reprogramming of cells |
| SG11201602870YA (en) | 2013-10-28 | 2016-05-30 | Ngm Biopharmaceuticals Inc | Cancer models and associated methods |
| PL3097122T3 (pl) | 2014-01-24 | 2020-10-19 | Ngm Biopharmaceuticals, Inc. | Przeciwciała wiążące domenę 2 beta klotho oraz sposoby ich stosowania |
| JP2017517272A (ja) | 2014-03-28 | 2017-06-29 | ニューヨーク・ユニバーシティ | Fgf23融合タンパク質 |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| EP3845245B1 (en) | 2014-06-09 | 2025-06-25 | Ultragenyx Pharmaceutical Inc. | The effective and efficient control of serum phosphate for optimal bone formation |
| WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016065106A1 (en) | 2014-10-23 | 2016-04-28 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| EP3227319B1 (en) | 2014-12-04 | 2019-11-27 | Novartis AG | Methods and compositions using klotho variant polypeptides |
| CN105699664A (zh) * | 2015-04-13 | 2016-06-22 | 陈柏龄 | Fgf23检测试剂盒及其制备方法 |
| WO2016210350A1 (en) * | 2015-06-25 | 2016-12-29 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| AU2016353988B2 (en) | 2015-11-09 | 2019-09-26 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| WO2018039557A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CA3058306A1 (en) * | 2017-03-28 | 2018-10-04 | Ajinomoto Co., Inc. | Additive for undifferentiation maintaining medium |
| EP3633373B1 (en) | 2017-05-31 | 2025-02-19 | Hitachi Chemical Diagnostics Systems Co., Ltd. | Measurement method for fibroblast growth factor 23, measurement reagent, and measurement kit |
| WO2020047475A1 (en) * | 2018-08-30 | 2020-03-05 | The Uab Research Foundation | Drug screening for fgf23-fgfr4 inhibitors |
| JP2022527790A (ja) * | 2019-03-29 | 2022-06-06 | アターガ,エルエルシー | 抗fgf23抗体分子 |
| KR20210153069A (ko) * | 2019-04-19 | 2021-12-16 | 제네똥 | 섬유아세포 성장 인자 23 관련 저인산혈증성 질환의 유전자 요법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| WO1994017810A1 (en) | 1993-02-12 | 1994-08-18 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| EP0708658A4 (en) | 1993-04-16 | 1997-05-21 | Wistar Inst | RECOMBINANT CYTOMEGALOVIRUS VACCINE |
| US5693775A (en) * | 1995-05-12 | 1997-12-02 | The Johns Hopkins University School Of Medicine | Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use |
| AU3774300A (en) | 1999-06-02 | 2000-12-18 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1666494A1 (en) * | 1999-12-01 | 2006-06-07 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2382165A1 (en) | 1999-12-08 | 2001-06-14 | Genset S.A. | Full-length human cdnas encoding potentially secreted proteins |
| AU2759201A (en) | 2000-01-05 | 2001-07-16 | Zymogenetics Inc. | Novel fgf homolog zfgf12 |
| WO2001060850A1 (en) | 2000-02-14 | 2001-08-23 | Smithkline Beecham Corporation | Novel compounds |
| EP1257645A2 (en) * | 2000-02-15 | 2002-11-20 | Amgen Inc. | Fibroblast growth factor-23 molecules and uses thereof |
| EP1261638A2 (en) * | 2000-03-08 | 2002-12-04 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| WO2002076467A1 (en) * | 2001-03-22 | 2002-10-03 | Genzyme Corporation | Compositions and methods to regulate bone and mineral metabolism |
-
2001
- 2001-07-10 US US09/901,938 patent/US7223563B2/en not_active Expired - Lifetime
- 2001-07-10 EP EP01952590A patent/EP1303536B1/en not_active Expired - Lifetime
- 2001-07-10 DE DE60141582T patent/DE60141582D1/de not_active Expired - Lifetime
- 2001-07-10 ES ES01952590T patent/ES2340662T3/es not_active Expired - Lifetime
- 2001-07-10 JP JP2002514175A patent/JP2004504063A/ja active Pending
- 2001-07-10 CA CA002418215A patent/CA2418215A1/en not_active Abandoned
- 2001-07-10 EP EP10001442A patent/EP2184296A1/en not_active Withdrawn
- 2001-07-10 AU AU2001273323A patent/AU2001273323B2/en not_active Expired
- 2001-07-10 WO PCT/US2001/021738 patent/WO2002008271A1/en not_active Ceased
- 2001-07-10 AU AU7332301A patent/AU7332301A/xx active Pending
- 2001-07-10 CN CN018140572A patent/CN1446227B/zh not_active Expired - Lifetime
- 2001-07-10 KR KR1020097006051A patent/KR20090036151A/ko not_active Ceased
- 2001-07-10 AT AT01952590T patent/ATE461213T1/de not_active IP Right Cessation
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2003
- 2003-01-18 KR KR1020037000821A patent/KR100924183B1/ko not_active Expired - Lifetime
- 2003-03-04 US US10/379,334 patent/US7314618B2/en not_active Expired - Lifetime
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2007
- 2007-11-07 US US11/983,190 patent/US7947810B2/en not_active Expired - Fee Related
- 2007-11-07 US US11/983,137 patent/US7745406B2/en not_active Expired - Fee Related
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2008
- 2008-02-05 JP JP2008025528A patent/JP2008194039A/ja active Pending
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2011
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Also Published As
| Publication number | Publication date |
|---|---|
| US8586317B2 (en) | 2013-11-19 |
| WO2002008271A1 (en) | 2002-01-31 |
| KR100924183B1 (ko) | 2009-10-28 |
| AU2001273323B2 (en) | 2005-11-10 |
| JP2008194039A (ja) | 2008-08-28 |
| US7314618B2 (en) | 2008-01-01 |
| US20020156001A1 (en) | 2002-10-24 |
| CA2418215A1 (en) | 2002-01-31 |
| EP1303536A1 (en) | 2003-04-23 |
| US20080241946A1 (en) | 2008-10-02 |
| US20120064544A1 (en) | 2012-03-15 |
| US7223563B2 (en) | 2007-05-29 |
| US20030181379A1 (en) | 2003-09-25 |
| DE60141582D1 (de) | 2010-04-29 |
| AU7332301A (en) | 2002-02-05 |
| ATE461213T1 (de) | 2010-04-15 |
| JP2004504063A (ja) | 2004-02-12 |
| US7745406B2 (en) | 2010-06-29 |
| EP1303536A4 (en) | 2005-01-05 |
| US20090311792A1 (en) | 2009-12-17 |
| CN1446227A (zh) | 2003-10-01 |
| CN1446227B (zh) | 2011-10-05 |
| EP1303536B1 (en) | 2010-03-17 |
| US7947810B2 (en) | 2011-05-24 |
| ES2340662T3 (es) | 2010-06-08 |
| KR20030029111A (ko) | 2003-04-11 |
| EP2184296A1 (en) | 2010-05-12 |
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