JP2003521219A5 - - Google Patents
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- Publication number
- JP2003521219A5 JP2003521219A5 JP2000525563A JP2000525563A JP2003521219A5 JP 2003521219 A5 JP2003521219 A5 JP 2003521219A5 JP 2000525563 A JP2000525563 A JP 2000525563A JP 2000525563 A JP2000525563 A JP 2000525563A JP 2003521219 A5 JP2003521219 A5 JP 2003521219A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- shiga toxin
- variable region
- seq
- humanized monoclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010079723 Shiga Toxin Proteins 0.000 description 19
- 239000012634 fragment Substances 0.000 description 10
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000013604 expression vector Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6863597P | 1997-12-23 | 1997-12-23 | |
| US60/068,635 | 1997-12-23 | ||
| US09/215,163 US20030170248A1 (en) | 1997-12-23 | 1998-12-18 | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| US09/215,163 | 1998-12-18 | ||
| PCT/US1998/027267 WO1999032645A1 (en) | 1997-12-23 | 1998-12-22 | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003521219A JP2003521219A (ja) | 2003-07-15 |
| JP2003521219A5 true JP2003521219A5 (enExample) | 2006-01-05 |
| JP4450505B2 JP4450505B2 (ja) | 2010-04-14 |
Family
ID=26749187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525563A Expired - Fee Related JP4450505B2 (ja) | 1997-12-23 | 1998-12-22 | 志賀毒素誘発性疾患を防御するヒト化モノクローナル抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US20030170248A1 (enExample) |
| EP (1) | EP1042492B1 (enExample) |
| JP (1) | JP4450505B2 (enExample) |
| AT (1) | ATE449856T1 (enExample) |
| AU (1) | AU764091B2 (enExample) |
| CA (1) | CA2316411C (enExample) |
| DE (1) | DE69841331D1 (enExample) |
| DK (1) | DK1042492T3 (enExample) |
| ES (1) | ES2339618T3 (enExample) |
| PT (1) | PT1042492E (enExample) |
| WO (1) | WO1999032645A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| DK1079856T3 (da) | 1998-05-20 | 2006-12-04 | Teijin Ltd | Humaniserede antistoffer til genkendelse af verotoxin II samt cellelinie til produktion af samme |
| US6858211B1 (en) * | 1998-07-20 | 2005-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccines against Escherichia coli O157 infection |
| CA2439402A1 (en) * | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
| US6875433B2 (en) * | 2002-08-23 | 2005-04-05 | The United States Of America As Represented By The Secretary Of The Army | Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein |
| CA2434668A1 (en) | 2003-07-04 | 2005-01-04 | Laurence Mulard | Novel approach to design glycopeptides based on o-specific polysaccharide of shigella flexneri serotype 2a |
| CN100441689C (zh) * | 2006-01-20 | 2008-12-10 | 中国人民解放军第三军医大学 | 抗ehec o157志贺样毒素ⅱa亚单位单克隆抗体5f3轻、重链可变区基因及应用 |
| AU2007240614B2 (en) * | 2006-04-20 | 2013-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated | Methods and compositions based on Shiga toxin type 1 protein |
| AU2007254950A1 (en) | 2006-05-31 | 2007-12-13 | Thallion Pharmaceuticals Incorporated | Methods, compositions, and kits for treating Shiga toxin associated conditions |
| US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| EP2172481B1 (en) * | 2008-10-06 | 2014-10-29 | Novoplant GmbH | Proteolytically stable antibody formats |
| US8969529B2 (en) * | 2009-01-23 | 2015-03-03 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
| RU2732155C1 (ru) * | 2019-09-24 | 2020-09-11 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Гуманизированное антитело или его антигенсвязывающий фрагмент (Fab) против шига-токсинов первого и/или второго типов (варианты), композиция для лечения токсических состояний, вызванных энтерогеморрагической кишечной палочкой, содержащая указанные антитела и/или Fab |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5164298A (en) * | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US5747272A (en) * | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
| US5968894A (en) * | 1994-02-22 | 1999-10-19 | Lingwood; Clifford A. | Verotoxin pharmaceutical compositions and medical treatments therewith |
| WO1998020903A1 (en) | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
| US20020160005A1 (en) * | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
| US7910096B2 (en) * | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| DE602004032143D1 (de) * | 2003-07-21 | 2011-05-19 | Intervet Int Bv | Hybrid-toxine mit shiga-artigen toxin-untereinheiten, verbunden mit escherichia coli wärmeinstabilen enterotoxin-untereinheiten und vakzine daraus |
| CA2555306A1 (en) * | 2004-02-06 | 2005-08-18 | Nymox Corporation | Humanized antibody |
| EP1991565B1 (en) * | 2006-02-16 | 2015-01-21 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Shiga toxoid chimeric proteins |
| AU2007240614B2 (en) * | 2006-04-20 | 2013-09-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine Incorporated | Methods and compositions based on Shiga toxin type 1 protein |
| US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
-
1998
- 1998-12-18 US US09/215,163 patent/US20030170248A1/en not_active Abandoned
- 1998-12-22 DE DE69841331T patent/DE69841331D1/de not_active Expired - Lifetime
- 1998-12-22 EP EP98965434A patent/EP1042492B1/en not_active Expired - Lifetime
- 1998-12-22 CA CA002316411A patent/CA2316411C/en not_active Expired - Lifetime
- 1998-12-22 DK DK98965434.8T patent/DK1042492T3/da active
- 1998-12-22 AU AU20902/99A patent/AU764091B2/en not_active Expired
- 1998-12-22 WO PCT/US1998/027267 patent/WO1999032645A1/en not_active Ceased
- 1998-12-22 PT PT98965434T patent/PT1042492E/pt unknown
- 1998-12-22 JP JP2000525563A patent/JP4450505B2/ja not_active Expired - Fee Related
- 1998-12-22 AT AT98965434T patent/ATE449856T1/de active
- 1998-12-22 ES ES98965434T patent/ES2339618T3/es not_active Expired - Lifetime
-
2006
- 2006-06-20 US US11/471,420 patent/US20070160607A1/en not_active Abandoned
- 2006-06-20 US US11/471,369 patent/US20070003560A1/en not_active Abandoned
-
2009
- 2009-08-06 US US12/536,940 patent/US20100189715A1/en not_active Abandoned
- 2009-12-28 US US12/647,845 patent/US20100166753A1/en not_active Abandoned
-
2013
- 2013-09-25 US US14/036,835 patent/US20140135481A1/en not_active Abandoned
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