ATE449856T1 - Humanisierte monoklonale antikörper die schützen gegen shigatoxininduzierte krankheiten - Google Patents
Humanisierte monoklonale antikörper die schützen gegen shigatoxininduzierte krankheitenInfo
- Publication number
- ATE449856T1 ATE449856T1 AT98965434T AT98965434T ATE449856T1 AT E449856 T1 ATE449856 T1 AT E449856T1 AT 98965434 T AT98965434 T AT 98965434T AT 98965434 T AT98965434 T AT 98965434T AT E449856 T1 ATE449856 T1 AT E449856T1
- Authority
- AT
- Austria
- Prior art keywords
- humanized monoclonal
- monoclonal antibodies
- present
- induced diseases
- shigatoxin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6863597P | 1997-12-23 | 1997-12-23 | |
US09/215,163 US20030170248A1 (en) | 1997-12-23 | 1998-12-18 | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
PCT/US1998/027267 WO1999032645A1 (en) | 1997-12-23 | 1998-12-22 | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE449856T1 true ATE449856T1 (de) | 2009-12-15 |
Family
ID=26749187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98965434T ATE449856T1 (de) | 1997-12-23 | 1998-12-22 | Humanisierte monoklonale antikörper die schützen gegen shigatoxininduzierte krankheiten |
Country Status (11)
Country | Link |
---|---|
US (6) | US20030170248A1 (de) |
EP (1) | EP1042492B1 (de) |
JP (1) | JP4450505B2 (de) |
AT (1) | ATE449856T1 (de) |
AU (1) | AU764091B2 (de) |
CA (1) | CA2316411C (de) |
DE (1) | DE69841331D1 (de) |
DK (1) | DK1042492T3 (de) |
ES (1) | ES2339618T3 (de) |
PT (1) | PT1042492E (de) |
WO (1) | WO1999032645A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
US7846435B1 (en) | 1998-05-20 | 2010-12-07 | Teijin Limited | Humanized antibodies that recognize Verotoxin II and cell line producing same |
US6858211B1 (en) | 1998-07-20 | 2005-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccines against Escherichia coli O157 infection |
US7101663B2 (en) * | 2001-03-02 | 2006-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | PCR method |
US6875433B2 (en) * | 2002-08-23 | 2005-04-05 | The United States Of America As Represented By The Secretary Of The Army | Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein |
CA2434668A1 (en) | 2003-07-04 | 2005-01-04 | Laurence Mulard | Novel approach to design glycopeptides based on o-specific polysaccharide of shigella flexneri serotype 2a |
CN100441689C (zh) * | 2006-01-20 | 2008-12-10 | 中国人民解放军第三军医大学 | 抗ehec o157志贺样毒素ⅱa亚单位单克隆抗体5f3轻、重链可变区基因及应用 |
JP2009536818A (ja) * | 2006-04-20 | 2009-10-22 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒性1型タンパク質に基づく方法および組成物 |
US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
AU2007254950A1 (en) * | 2006-05-31 | 2007-12-13 | Thallion Pharmaceuticals Incorporated | Methods, compositions, and kits for treating Shiga toxin associated conditions |
EP2172481B1 (de) * | 2008-10-06 | 2014-10-29 | Novoplant GmbH | Proteolytisch stabile Antikörperformate |
JP5773886B2 (ja) | 2009-01-23 | 2015-09-02 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒素タイプ2タンパク質に基づいた方法と組成物 |
RU2732155C1 (ru) * | 2019-09-24 | 2020-09-11 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Гуманизированное антитело или его антигенсвязывающий фрагмент (Fab) против шига-токсинов первого и/или второго типов (варианты), композиция для лечения токсических состояний, вызванных энтерогеморрагической кишечной палочкой, содержащая указанные антитела и/или Fab |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5164298A (en) * | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
AU669124B2 (en) * | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
US5747272A (en) * | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
US5968894A (en) * | 1994-02-22 | 1999-10-19 | Lingwood; Clifford A. | Verotoxin pharmaceutical compositions and medical treatments therewith |
US7910096B2 (en) * | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
US20020160005A1 (en) * | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
WO1998020903A1 (en) * | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
WO2005011733A1 (en) * | 2003-07-21 | 2005-02-10 | Akzo Nobel N.V. | Hybrid toxins comprising shiga-like toxin subunits fused to escherichia coli heat labile enterotoxin subunits and vaccines thereof |
CN1965082A (zh) * | 2004-02-06 | 2007-05-16 | 尼莫克斯股份有限公司 | 人源化抗体 |
CA2642451C (en) * | 2006-02-16 | 2016-12-20 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Shiga toxoid chimeric proteins |
JP2009536818A (ja) * | 2006-04-20 | 2009-10-22 | ザ ヘンリー エム. ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 志賀毒性1型タンパク質に基づく方法および組成物 |
US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
-
1998
- 1998-12-18 US US09/215,163 patent/US20030170248A1/en not_active Abandoned
- 1998-12-22 CA CA002316411A patent/CA2316411C/en not_active Expired - Lifetime
- 1998-12-22 DE DE69841331T patent/DE69841331D1/de not_active Expired - Lifetime
- 1998-12-22 EP EP98965434A patent/EP1042492B1/de not_active Expired - Lifetime
- 1998-12-22 DK DK98965434.8T patent/DK1042492T3/da active
- 1998-12-22 AU AU20902/99A patent/AU764091B2/en not_active Expired
- 1998-12-22 AT AT98965434T patent/ATE449856T1/de active
- 1998-12-22 ES ES98965434T patent/ES2339618T3/es not_active Expired - Lifetime
- 1998-12-22 PT PT98965434T patent/PT1042492E/pt unknown
- 1998-12-22 WO PCT/US1998/027267 patent/WO1999032645A1/en active IP Right Grant
- 1998-12-22 JP JP2000525563A patent/JP4450505B2/ja not_active Expired - Fee Related
-
2006
- 2006-06-20 US US11/471,369 patent/US20070003560A1/en not_active Abandoned
- 2006-06-20 US US11/471,420 patent/US20070160607A1/en not_active Abandoned
-
2009
- 2009-08-06 US US12/536,940 patent/US20100189715A1/en not_active Abandoned
- 2009-12-28 US US12/647,845 patent/US20100166753A1/en not_active Abandoned
-
2013
- 2013-09-25 US US14/036,835 patent/US20140135481A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1999032645A1 (en) | 1999-07-01 |
ES2339618T3 (es) | 2010-05-21 |
AU764091B2 (en) | 2003-08-07 |
US20100189715A1 (en) | 2010-07-29 |
PT1042492E (pt) | 2010-01-08 |
CA2316411A1 (en) | 1999-07-01 |
DE69841331D1 (de) | 2010-01-07 |
EP1042492A1 (de) | 2000-10-11 |
US20100166753A1 (en) | 2010-07-01 |
US20070160607A1 (en) | 2007-07-12 |
CA2316411C (en) | 2009-02-17 |
EP1042492B1 (de) | 2009-11-25 |
AU2090299A (en) | 1999-07-12 |
US20070003560A1 (en) | 2007-01-04 |
JP4450505B2 (ja) | 2010-04-14 |
DK1042492T3 (da) | 2010-01-18 |
US20030170248A1 (en) | 2003-09-11 |
US20140135481A1 (en) | 2014-05-15 |
JP2003521219A (ja) | 2003-07-15 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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