JP2004510752A5 - - Google Patents
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- JP2004510752A5 JP2004510752A5 JP2002532304A JP2002532304A JP2004510752A5 JP 2004510752 A5 JP2004510752 A5 JP 2004510752A5 JP 2002532304 A JP2002532304 A JP 2002532304A JP 2002532304 A JP2002532304 A JP 2002532304A JP 2004510752 A5 JP2004510752 A5 JP 2004510752A5
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- JP
- Japan
- Prior art keywords
- cells
- antibody
- monoclonal antibody
- fragment
- malignant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 98
- 239000012634 fragment Substances 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 67
- 230000003211 malignant effect Effects 0.000 claims description 34
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 29
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 108010063916 CD40 Antigens Proteins 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 16
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 8
- 208000017604 Hodgkin disease Diseases 0.000 claims description 8
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 8
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 8
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 8
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 8
- 208000034578 Multiple myelomas Diseases 0.000 claims description 8
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 8
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 8
- 239000000556 agonist Substances 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 239000005557 antagonist Substances 0.000 claims description 8
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 238000010494 dissociation reaction Methods 0.000 claims description 8
- 208000021173 high grade B-cell lymphoma Diseases 0.000 claims description 8
- 210000004408 hybridoma Anatomy 0.000 claims description 8
- 208000025113 myeloid leukemia Diseases 0.000 claims description 8
- 230000035755 proliferation Effects 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 230000004797 therapeutic response Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 4
- 230000005593 dissociations Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 description 53
- 230000001154 acute effect Effects 0.000 description 4
- 208000032839 leukemia Diseases 0.000 description 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23755600P | 2000-10-02 | 2000-10-02 | |
| PCT/US2001/030963 WO2002028481A2 (en) | 2000-10-02 | 2001-10-02 | Methods of therapy for b-cell malignancies using antagonist anti-cd40 antibodies |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007305086A Division JP2008074870A (ja) | 2000-10-02 | 2007-11-26 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2008220544A Division JP4838831B2 (ja) | 2000-10-02 | 2008-08-28 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510752A JP2004510752A (ja) | 2004-04-08 |
| JP2004510752A5 true JP2004510752A5 (enExample) | 2005-12-22 |
| JP4202127B2 JP4202127B2 (ja) | 2008-12-24 |
Family
ID=22894238
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532486A Expired - Lifetime JP4271440B2 (ja) | 2000-10-02 | 2001-10-02 | ヒト抗ｃｄ４０抗体 |
| JP2002532304A Expired - Fee Related JP4202127B2 (ja) | 2000-10-02 | 2001-10-02 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2007299859A Pending JP2008156339A (ja) | 2000-10-02 | 2007-11-19 | ヒト抗ｃｄ４０抗体 |
| JP2007305086A Pending JP2008074870A (ja) | 2000-10-02 | 2007-11-26 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2008220544A Expired - Fee Related JP4838831B2 (ja) | 2000-10-02 | 2008-08-28 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2009143746A Pending JP2009201523A (ja) | 2000-10-02 | 2009-06-16 | ヒト抗ｃｄ４０抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002532486A Expired - Lifetime JP4271440B2 (ja) | 2000-10-02 | 2001-10-02 | ヒト抗ｃｄ４０抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007299859A Pending JP2008156339A (ja) | 2000-10-02 | 2007-11-19 | ヒト抗ｃｄ４０抗体 |
| JP2007305086A Pending JP2008074870A (ja) | 2000-10-02 | 2007-11-26 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2008220544A Expired - Fee Related JP4838831B2 (ja) | 2000-10-02 | 2008-08-28 | アンタゴニスト抗ｃｄ４０抗体を用いるｂ細胞悪性腫瘍の治療方法 |
| JP2009143746A Pending JP2009201523A (ja) | 2000-10-02 | 2009-06-16 | ヒト抗ｃｄ４０抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US7288252B2 (enExample) |
| EP (3) | EP1717251B1 (enExample) |
| JP (6) | JP4271440B2 (enExample) |
| AT (3) | ATE327004T1 (enExample) |
| AU (4) | AU2001296507A1 (enExample) |
| CA (2) | CA2424296A1 (enExample) |
| DE (2) | DE60119945T2 (enExample) |
| ES (1) | ES2357051T3 (enExample) |
| PT (1) | PT1326896E (enExample) |
| WO (4) | WO2002028480A2 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
| JP4271440B2 (ja) * | 2000-10-02 | 2009-06-03 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | ヒト抗ｃｄ４０抗体 |
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| US7906492B2 (en) | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| ATE374214T1 (de) | 2001-04-27 | 2007-10-15 | Kirin Brewery | Monoklonaler anti-cd-40-antikörper |
| EP2236172A1 (en) * | 2003-11-04 | 2010-10-06 | Novartis Vaccines and Diagnostics, Inc. | Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers |
| EP2301575A1 (en) * | 2003-11-04 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the CD40 cell-surface antigen |
| DK2149585T3 (da) * | 2003-11-04 | 2013-10-21 | Novartis Vaccines & Diagnostic | Anvendelse af antagonistiske anti-CD40-monoklonale antistoffer |
| PT1682177E (pt) * | 2003-11-04 | 2010-11-29 | Xoma Technology Lt | Utilização de anticorpos antagonistas anti-cd40 para o tratamento da leucemia linfocítica crónica |
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| US8926979B2 (en) | 2005-11-01 | 2015-01-06 | Novartis Ag | Treatment of cancer or pre-malignant conditions using anti-CD40 antibodies |
| US8323644B2 (en) * | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
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| EP2589654A1 (en) | 2006-05-03 | 2013-05-08 | The Regents of the University of Colorado, a body corporate | CD40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| DK2176298T3 (en) | 2007-05-30 | 2018-02-12 | Xencor Inc | Methods and compositions for inhibiting CD32B-expressing cells |
| EP2211902A1 (en) * | 2007-11-09 | 2010-08-04 | Novartis AG | Uses of anti-cd40 antibodies |
| EP2245065A1 (en) | 2008-01-23 | 2010-11-03 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
| WO2010104749A2 (en) | 2009-03-10 | 2010-09-16 | Baylor Research Institute | Antigen presenting cell targeted cancer vaccines |
| CN102770457A (zh) | 2009-03-10 | 2012-11-07 | 贝勒研究院 | 靶向抗原呈递细胞的疫苗 |
| BRPI1009455A2 (pt) | 2009-03-10 | 2016-03-01 | Baylor Res Inst | anticorpos anti-c40 e usos dos mesmos |
| WO2011109280A1 (en) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Methods and compositions to treat immune-mediated disorders |
| ES2993140T3 (en) | 2010-04-02 | 2024-12-23 | Amunix Pharmaceuticals Inc | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
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| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| PL3556774T3 (pl) | 2011-03-11 | 2024-07-01 | Beth Israel Deaconess Medical Center Inc. | Przeciwciała anty-cd40 i ich zastosowania |
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| JP6475631B2 (ja) | 2012-11-19 | 2019-02-27 | バリオファルム・アクチェンゲゼルシャフト | Ｃｄ２０およびｃｄ９５に結合する組換え二重特異性抗体 |
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2001
- 2001-10-02 JP JP2002532486A patent/JP4271440B2/ja not_active Expired - Lifetime
- 2001-10-02 WO PCT/US2001/030961 patent/WO2002028480A2/en not_active Ceased
- 2001-10-02 AU AU2001296507A patent/AU2001296507A1/en not_active Abandoned
- 2001-10-02 WO PCT/US2001/030859 patent/WO2002028905A2/en not_active Ceased
- 2001-10-02 WO PCT/US2001/030857 patent/WO2002028904A2/en not_active Ceased
- 2001-10-02 US US10/380,223 patent/US7288252B2/en not_active Expired - Fee Related
- 2001-10-02 EP EP06005656A patent/EP1717251B1/en not_active Expired - Lifetime
- 2001-10-02 DE DE60119945T patent/DE60119945T2/de not_active Expired - Lifetime
- 2001-10-02 CA CA002424296A patent/CA2424296A1/en not_active Abandoned
- 2001-10-02 AU AU2002211366A patent/AU2002211366A1/en not_active Abandoned
- 2001-10-02 AT AT01977428T patent/ATE327004T1/de not_active IP Right Cessation
- 2001-10-02 EP EP01977428A patent/EP1322383B9/en not_active Expired - Lifetime
- 2001-10-02 JP JP2002532304A patent/JP4202127B2/ja not_active Expired - Fee Related
- 2001-10-02 AT AT06005656T patent/ATE541860T1/de active
- 2001-10-02 WO PCT/US2001/030963 patent/WO2002028481A2/en not_active Ceased
- 2001-10-02 AU AU2001296545A patent/AU2001296545A1/en not_active Abandoned
- 2001-10-02 DE DE60143535T patent/DE60143535D1/de not_active Expired - Lifetime
- 2001-10-02 AT AT01979395T patent/ATE489403T1/de active
- 2001-10-02 CA CA002424749A patent/CA2424749A1/en not_active Abandoned
- 2001-10-02 EP EP01979395A patent/EP1326896B1/en not_active Expired - Lifetime
- 2001-10-02 AU AU2001296547A patent/AU2001296547A1/en not_active Abandoned
- 2001-10-02 ES ES01979395T patent/ES2357051T3/es not_active Expired - Lifetime
- 2001-10-02 PT PT01979395T patent/PT1326896E/pt unknown
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2007
- 2007-08-31 US US11/849,107 patent/US7445780B2/en not_active Expired - Fee Related
- 2007-11-19 JP JP2007299859A patent/JP2008156339A/ja active Pending
- 2007-11-26 JP JP2007305086A patent/JP2008074870A/ja active Pending
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2008
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2009
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