JP2007512243A5 - - Google Patents
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- JP2007512243A5 JP2007512243A5 JP2006538514A JP2006538514A JP2007512243A5 JP 2007512243 A5 JP2007512243 A5 JP 2007512243A5 JP 2006538514 A JP2006538514 A JP 2006538514A JP 2006538514 A JP2006538514 A JP 2006538514A JP 2007512243 A5 JP2007512243 A5 JP 2007512243A5
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- 108010002350 Interleukin-2 Proteins 0.000 claims 131
- 102000000588 Interleukin-2 Human genes 0.000 claims 131
- 230000003442 weekly effect Effects 0.000 claims 77
- 239000000427 antigen Substances 0.000 claims 46
- 102000036639 antigens Human genes 0.000 claims 46
- 108091007433 antigens Proteins 0.000 claims 46
- 230000027455 binding Effects 0.000 claims 46
- 239000012634 fragment Substances 0.000 claims 46
- 239000005557 antagonist Substances 0.000 claims 26
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 208000003950 B-cell lymphoma Diseases 0.000 claims 10
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 7
- 210000004408 hybridoma Anatomy 0.000 claims 7
- 229950004563 lucatumumab Drugs 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 6
- 206010025323 Lymphomas Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000003325 follicular Effects 0.000 claims 4
- 201000003444 follicular lymphoma Diseases 0.000 claims 4
- 238000007918 intramuscular administration Methods 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
- 238000007920 subcutaneous administration Methods 0.000 claims 4
- 108010063916 CD40 Antigens Proteins 0.000 claims 3
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 2
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 2
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 206010053574 Immunoblastic lymphoma Diseases 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 2
- 201000003791 MALT lymphoma Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000033766 Prolymphocytic Leukemia Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 238000012875 competitive assay Methods 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims 2
- 208000021173 high grade B-cell lymphoma Diseases 0.000 claims 2
- 208000026876 intravascular large B-cell lymphoma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 208000025113 myeloid leukemia Diseases 0.000 claims 2
- 210000005170 neoplastic cell Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 210000004180 plasmocyte Anatomy 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 230000002195 synergetic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000001270 agonistic effect Effects 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51733703P | 2003-11-04 | 2003-11-04 | |
| US60/517,337 | 2003-11-04 | ||
| US52557903P | 2003-11-26 | 2003-11-26 | |
| US60/525,579 | 2003-11-26 | ||
| US56571004P | 2004-04-27 | 2004-04-27 | |
| US60/565,710 | 2004-04-27 | ||
| PCT/US2004/036958 WO2005044294A2 (en) | 2003-11-04 | 2004-11-04 | Method of therapy for cancers expressing the cd40 antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011033969A Division JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007512243A JP2007512243A (ja) | 2007-05-17 |
| JP2007512243A5 true JP2007512243A5 (enExample) | 2007-12-13 |
| JP4765039B2 JP4765039B2 (ja) | 2011-09-07 |
Family
ID=34577667
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538540A Expired - Lifetime JP5019881B2 (ja) | 2003-11-04 | 2004-11-04 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2006538514A Expired - Fee Related JP4765039B2 (ja) | 2003-11-04 | 2004-11-04 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2006538513A Expired - Lifetime JP4746552B2 (ja) | 2003-11-04 | 2004-11-04 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
| JP2010277537A Withdrawn JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2011033969A Withdrawn JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2011040922A Withdrawn JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538540A Expired - Lifetime JP5019881B2 (ja) | 2003-11-04 | 2004-11-04 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538513A Expired - Lifetime JP4746552B2 (ja) | 2003-11-04 | 2004-11-04 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
| JP2010277537A Withdrawn JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗ｃｄ４０モノクローナル抗体およびそれらを使用するための方法 |
| JP2011033969A Withdrawn JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Ｃｄ４０抗原を発現する癌に対する治療方法。 |
| JP2011040922A Withdrawn JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗ｃｄ４０抗体の使用 |
Country Status (22)
| Country | Link |
|---|---|
| EP (6) | EP1682180B1 (enExample) |
| JP (6) | JP5019881B2 (enExample) |
| KR (2) | KR101125127B1 (enExample) |
| CN (2) | CN1905897B (enExample) |
| AT (3) | ATE476448T1 (enExample) |
| AU (3) | AU2004287482B2 (enExample) |
| CA (3) | CA2544949C (enExample) |
| CY (3) | CY1110231T1 (enExample) |
| DE (3) | DE602004028505D1 (enExample) |
| DK (4) | DK1694360T3 (enExample) |
| EC (2) | ECSP066607A (enExample) |
| ES (3) | ES2435410T3 (enExample) |
| HR (2) | HRP20100066T1 (enExample) |
| IL (1) | IL175225A (enExample) |
| MA (1) | MA28331A1 (enExample) |
| PL (4) | PL1682180T3 (enExample) |
| PT (4) | PT1682180E (enExample) |
| RS (2) | RS51230B (enExample) |
| SG (1) | SG148143A1 (enExample) |
| SI (3) | SI1694360T1 (enExample) |
| WO (3) | WO2005044854A2 (enExample) |
| ZA (1) | ZA200604419B (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| SI1694360T1 (sl) * | 2003-11-04 | 2010-12-31 | Novartis Vaccines & Diagnostic | Uporaba antagonističnih anti-CD40 protiteles za zdravljenje avtoimunskih in vnetnih bolezni in zavrnitve transplantata organa |
| WO2005044307A2 (en) * | 2003-11-04 | 2005-05-19 | Chiron Corporation | Methods of therapy for b cell-related cancers |
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| US20050281815A1 (en) * | 2004-02-26 | 2005-12-22 | Dani Eshel | CD40 splice variants and their uses |
| WO2006125117A2 (en) * | 2005-05-18 | 2006-11-23 | Novartis Ag | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
| US8337851B2 (en) * | 2005-05-18 | 2012-12-25 | Novartis Ag | Methods of monitoring the efficacy of anti-CD40 antibodies in treating a subject for a CD40-expressing cancer |
| JP2008543839A (ja) | 2005-06-14 | 2008-12-04 | アムジェン インコーポレーテッド | 自己緩衝タンパク質製剤 |
| CA2628105A1 (en) * | 2005-11-01 | 2007-05-10 | Novartis Ag | Uses of anti-cd40 antibodies |
| AU2006308860B2 (en) * | 2005-11-01 | 2012-01-12 | Novartis Ag | Uses of anti-CD40 antibodies |
| CA2628703C (en) | 2005-11-30 | 2019-10-29 | Abbott Laboratories | Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
| US9127251B2 (en) | 2005-12-09 | 2015-09-08 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of antibody producing cells |
| WO2007067032A1 (en) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| BRPI0710826A2 (pt) * | 2006-04-21 | 2011-08-23 | Novartis Ag | composições farmacêuticas de anticorpo anti-cd40 antagonista |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2129401B8 (en) * | 2006-12-21 | 2020-01-15 | Amgen Inc. | Stable buffered formulations containing polypeptides |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| CA2692165A1 (en) | 2007-06-25 | 2008-12-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| KR101620642B1 (ko) | 2007-11-07 | 2016-05-12 | 제넨테크, 인크. | 항-ｃｄ４０ 항체를 사용한 치료에 대한 ｂ-세포 림프종의 반응성 평가를 위한 방법 및 조성물 |
| MX2010005099A (es) * | 2007-11-09 | 2010-05-27 | Novartis Ag | Usos de anticuerpos anti-cd40. |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| ES2605228T3 (es) | 2009-04-18 | 2017-03-13 | Genentech, Inc. | Métodos para evaluar la capacidad de respuesta de un linfoma de células B al tratamiento con anticuerpos anti-CD40 |
| EP2454283B1 (en) | 2009-07-15 | 2018-03-14 | AIMM Therapeutics B.V. | Means and methods for producing high affinity antibodies |
| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
| WO2012024187A1 (en) | 2010-08-14 | 2012-02-23 | Abbott Laboratories | Amyloid-beta binding proteins |
| PE20141162A1 (es) | 2010-11-04 | 2014-09-18 | Boehringer Ingelheim Int | Anticuerpos anti-il-23 |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| AU2016201742B2 (en) * | 2010-11-15 | 2017-11-02 | Novartis Ag | Silent Fc variants of anti-CD40 antibodies |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| ES2626671T3 (es) | 2010-12-02 | 2017-07-25 | Aimm Therapeutics B.V. | Medios y métodos para producir anticuerpos de alta afinidad |
| US9125893B2 (en) | 2011-02-17 | 2015-09-08 | Kyowa Hakko Kirin Co., Ltd. | Highly concentrated anti-CD40 antibody pharmaceutical preparation |
| US9713636B2 (en) * | 2011-02-28 | 2017-07-25 | Napajen Pharma, Inc. | Nucleic acid/polysaccharide complex |
| WO2012125569A2 (en) | 2011-03-11 | 2012-09-20 | Beth Israel Deaconess Medical Center, Inc. | Anti-cd40 antibodies and uses thereof |
| TWI598363B (zh) * | 2011-04-21 | 2017-09-11 | 必治妥美雅史谷比公司 | 拮抗ｃｄ４０之抗體多肽 |
| HK1198689A1 (en) | 2011-10-25 | 2015-05-29 | Prothena Biosciences Limited | Antibody formulations and methods |
| KR102057742B1 (ko) * | 2011-11-17 | 2019-12-19 | 군드람 정 | 의학적 용도를 위한 이중특이성 항체 |
| KR102124758B1 (ko) * | 2012-05-03 | 2020-06-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 항-ｉｌ-23ｐ19 항체 |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| CN104918957B (zh) * | 2012-10-30 | 2018-11-16 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
| ES2649991T3 (es) | 2012-11-19 | 2018-01-16 | Baliopharm Ag | Anticuerpo biespecífico recombinante que se une a CD20 y CD95 |
| WO2014200349A1 (en) * | 2013-06-13 | 2014-12-18 | Fast Forward Pharmaceutical B.V. | Cd40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an tgr5-receptor agonist, an fxr agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis. |
| DK3099709T3 (da) | 2014-01-31 | 2020-02-03 | Aimm Therapeutics Bv | Midler og fremgangsmåder til fremstilling af stabile antistoffer |
| US10435475B2 (en) | 2014-03-07 | 2019-10-08 | Bristol-Myers Squibb Company | Method of using antibody polypeptides that antagonize CD40 to treat IBD |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| CN108025068A (zh) * | 2014-03-12 | 2018-05-11 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns的疾病和损伤 |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| CN114081946A (zh) | 2014-03-12 | 2022-02-25 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
| BR112016018813A2 (pt) * | 2014-03-19 | 2017-10-10 | Bristol Myers Squibb Co | métodos para tratar rejeição de transplante usando um anticorpo de domínio direcionado contra cd40l |
| WO2016014775A1 (en) | 2014-07-24 | 2016-01-28 | Boehringer Ingelheim International Gmbh | Biomarkers useful in the treatment of il-23a related diseases |
| US11111284B2 (en) | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing |
| UA123624C2 (uk) | 2014-09-03 | 2021-05-05 | Бьорінґер Інґельхайм Інтернаціональ Ґмбх | Сполука, специфічна до іл-23а та фнп-альфа, та її застосування |
| KR102656470B1 (ko) | 2014-12-10 | 2024-04-09 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기 |
| SG11201705728RA (en) | 2015-02-04 | 2017-08-30 | Boehringer Ingelheim Int | Methods of treating inflammatory diseases |
| UY36692A (es) | 2015-05-29 | 2016-12-30 | Abbvie Inc | Anticuerpos anti-cd40 y usos de los mismos |
| DK3334747T5 (da) | 2015-08-13 | 2024-10-07 | Amgen Inc | Ladet dybdefiltrering af antigenbindende proteiner |
| SI3307322T1 (sl) | 2015-09-04 | 2021-08-31 | Primatope Therapeutics Inc. | Humanizirana protitelesa proti CD40 in njihove uporabe |
| MA43053A (fr) * | 2015-09-30 | 2018-08-08 | Janssen Biotech Inc | Anticorps antagonistes se liant spécifiquement au cd40 humain et procédés d'utilisation |
| MX393066B (es) | 2016-04-18 | 2025-03-24 | Celldex Therapeutics Inc | Anticuerpos agonistas que se unen a cd40 humana y usos de los mismos. |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| MX2018015853A (es) | 2016-07-14 | 2019-08-21 | Genmab As | Anticuerpos multiespecificos frente a los grupos de diferenciacion 40 y 137 (cd40 y cd137). |
| JP7257971B6 (ja) * | 2017-06-01 | 2023-07-24 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 抗ｃｄ４０抗体、その抗原結合フラグメント、およびその医学的使用 |
| KR102198998B1 (ko) * | 2017-06-01 | 2021-01-07 | 서울대학교 산학협력단 | 신규한 항-ｃｄ40 항체 및 이의 용도 |
| MX2020001525A (es) | 2017-08-24 | 2020-03-20 | Novo Nordisk As | Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos. |
| AU2019213045B2 (en) * | 2018-01-29 | 2023-08-10 | The Regents Of The University Of California | Therapies and methods to treat TLR2-mediated diseases and disorders |
| WO2019156565A1 (en) * | 2018-02-12 | 2019-08-15 | Fast Forward Pharmaceuticals B.V. | Improved antagonistic anti-human cd40 monoclonal antibodies |
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