JP6268097B2 - 固形腫瘍治療のための併用薬物療法 - Google Patents
固形腫瘍治療のための併用薬物療法 Download PDFInfo
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Description
本出願は、2011年11月11日に出願した米国仮特許出願第61/558,732号の優先権を主張し、その内容の全体は参照することにより本明細書の一部をなすものとする。
以下の用語は、当該技術分野においてよく認識された意味を有すると考えられる。しかし、本発明の説明を容易にする目的で以下の定義を記述する。
ガニツマブ(G)とエベロリムス(E)の2剤組み合わせについて、この薬剤の組み合わせの安全性と忍容性のプロファイルをより良く理解するために、拡張コホートにより追跡された最大耐用量/推奨第II相用量を評価した。
1. King, E.R.ら(2011) Recent Pat Anticancer Drug Discov。
2. Tolcher, A.W.ら(2009) J. Clin. Oncol. 27:5800−5807。
3. Schmelzle, T.ら(2000) Cell 103:253−262。
4. O’Reilly, K.E.ら(2006) Cancer Res. 66:1500−1508。
5. Wan, X.ら(2007) Oncogene 26:1932−1940。
Claims (37)
- 治療有効量のIGF1R阻害剤を含有する組成物と、mTOR阻害剤を含有する組成物とを含んでなる、対象における非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍を治療するための組み合わせ医薬品であって、前記IGF1R阻害剤を含有する組成物と前記mTOR阻害剤を含有する組成物とが同じ製剤中にある、または、前記IGF1R阻害剤を含有する組成物と前記mTOR阻害剤を含有する組成物とが異なる製剤中にあり、前記IGF1R阻害剤が抗体を含み、前記抗体がガニツマブであり、前記mTOR阻害剤がエベロリムスを含む、組み合わせ医薬品。
- 前記IGF1R阻害剤を含有する組成物および前記mTOR阻害剤を含有する組成物が、同じ経路によって前記対象に同時投与される、請求項1に記載の組み合わせ医薬品。
- 前記IGF1R阻害剤を含有する組成物および前記mTOR阻害剤を含有する組成物が、異なる経路によって前記対象に同時投与される、請求項1に記載の組み合わせ医薬品。
- 前記対象へ前記IGF1R阻害剤を含有する組成物および前記mTOR阻害剤を含有する組成物が同時に投与される、請求項1〜3のいずれか1項に記載の組み合わせ医薬品。
- 前記対象へ前記IGF1R阻害剤を含有する組成物および前記mTOR阻害剤を含有する組成物が順次的に投与される、請求項1〜3のいずれか1項に記載の組み合わせ医薬品。
- 前記IGF1R阻害剤が約0.1mg/kgから約20mg/kgの量で投与される、請求項1〜5のいずれか1項に記載の組み合わせ医薬品。
- 前記IGF1R阻害剤が約5mg/kgから約15mg/kgの量で投与される、請求項1〜5のいずれか1項に記載の組み合わせ医薬品。
- 前記IGF1R阻害剤が12mg/kgの量で投与される、請求項1〜5のいずれか1項に記載の組み合わせ医薬品。
- 前記IGF1R阻害剤が20mg/kgの量で投与される、請求項1〜5のいずれか1項に記載の組み合わせ医薬品。
- 前記mTOR阻害剤が約0.1mgから約10mgの量で投与される、請求項1〜9のいずれか1項に記載の組み合わせ医薬品。
- 前記mTOR阻害剤が約2mgから約8mgの量で投与される、請求項1〜9のいずれか1項に記載の組み合わせ医薬品。
- 前記mTOR阻害剤が5mgの量で投与される、請求項1〜11のいずれか1項に記載の組み合わせ医薬品。
- 前記IGF1R阻害剤が、週に1回、2週間に1回、3週間に1回、4週間に1回、およびこれらの組み合わせからなる群から選択される様式で投与される、請求項1〜12のいずれか1項に記載の組み合わせ医薬品。
- 前記mTOR阻害剤が、毎日、週に6日、週に5日、週に4日、週に3日、週に2日、週に1日、またはこれらの組み合わせからなる群から選択される様式で投与される、請求項1〜12のいずれか1項に記載の組み合わせ医薬品。
- 放射線、細胞毒性剤、化学療法剤、抗がん剤およびそれらの組み合わせからなる群から選択される追加治療の少なくとも1つを治療有効量で前記対象に投与するステップをさらに含む請求項1〜14のいずれか1項に記載の組み合わせ医薬品。
- 12mg/kgのガニツマブが隔週、および5mgのエベロリムスが毎週5回、前記対象に投与される請求項1〜8および10〜15のいずれか1項に記載の組み合わせ医薬品。
- 前記非小細胞肺がんが腺がんである、請求項1〜16のいずれか1項に記載の組み合わせ医薬品。
- 前記非小細胞肺がんが扁平上皮がんである、請求項1〜16のいずれか1項に記載の組み合わせ医薬品。
- 前記非小細胞肺がんが大細胞がんである、請求項1〜16のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも2週間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも4週間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも8週間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも3カ月間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも4カ月間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも6カ月間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも9カ月間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 少なくとも1年間投与されるものである、請求項1〜19のいずれか1項に記載の組み合わせ医薬品。
- 対象における固形腫瘍疾患を治療する組み合わせ医薬品であって、前記固形腫瘍疾患が非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍であり、12mg/kgのガニツマブが隔週、および5mgのエベロリムスが毎日、前記対象に投与される組み合わせ医薬品。
- 対象における固形腫瘍疾患を治療する組み合わせ医薬品であって、前記固形腫瘍疾患が非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍であり、12mg/kgのガニツマブが隔週、および5mgのエベロリムスが週に5日、前記対象に投与される組み合わせ医薬品。
- 対象における固形腫瘍疾患を治療する組み合わせ医薬品であって、前記固形腫瘍疾患が非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍であり、12mg/kgのガニツマブが隔週、および5mgのエベロリムスが週に3日、前記対象に投与される組み合わせ医薬品。
- 前記NSCLCが腺がんである、請求項28〜30のいずれか1項に記載の組み合わせ医薬品。
- 前記NSCLCが扁平上皮がんである、請求項28〜30のいずれか1項に記載の組み合わせ医薬品。
- 前記NSCLCが大細胞がんである、請求項28〜30のいずれか1項に記載の組み合わせ医薬品。
- IGF1R阻害剤を含有する組成物およびmTOR阻害剤を含有する組成物を製薬学的に許容される担体中に含む組み合わせ医薬品であって、前記IGF1R阻害剤が抗体を含み、前記抗体がガニツマブであり、前記mTOR阻害剤がエベロリムスを含む、請求項1〜33のいずれか1項に記載の組み合わせ医薬品。
- IGF1R阻害剤およびmTOR阻害剤、ならびに対象における非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍を治療するための方法として、IGF1R阻害剤およびmTOR阻害剤の対象への併用治療を使用することを指示する印刷された使用説明書を含む容器を含むキットであって、前記IGF1R阻害剤が抗体を含み、前記抗体がガニツマブであり、前記mTOR阻害剤がエベロリムスを含む、非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍を治療するためのキット。
- 滅菌希釈剤をさらに含む請求項35に記載のキット。
- 治療有効量のIGF1R阻害剤を含み、mTOR阻害剤と組み合わせて使用される、非小細胞肺がん(NSCLC)、神経内分泌腫瘍、胸腺腫または線維性腫瘍を治療するための医薬組成物であって、前記IGF1R阻害剤と前記mTOR阻害剤とが同じ製剤中にある、または、前記IGF1R阻害剤と前記mTOR阻害剤とが異なる製剤中にあり、前記IGF1R阻害剤が抗体を含み、前記抗体がガニツマブであり、前記mTOR阻害剤がエベロリムスを含む、医薬組成物。
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |