JP2008543339A5 - - Google Patents
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- JP2008543339A5 JP2008543339A5 JP2008518360A JP2008518360A JP2008543339A5 JP 2008543339 A5 JP2008543339 A5 JP 2008543339A5 JP 2008518360 A JP2008518360 A JP 2008518360A JP 2008518360 A JP2008518360 A JP 2008518360A JP 2008543339 A5 JP2008543339 A5 JP 2008543339A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- chain variable
- variable region
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 38
- 210000003719 b-lymphocyte Anatomy 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 210000004881 tumor cell Anatomy 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 7
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 6
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 6
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 6
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 6
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 101100383038 Homo sapiens CD19 gene Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69253105P | 2005-06-20 | 2005-06-20 | |
| US60/692,531 | 2005-06-20 | ||
| US74895605P | 2005-12-08 | 2005-12-08 | |
| US60/748,956 | 2005-12-08 | ||
| US80408306P | 2006-06-06 | 2006-06-06 | |
| US60/804,083 | 2006-06-06 | ||
| PCT/US2006/024183 WO2007002223A2 (en) | 2005-06-20 | 2006-06-20 | Cd19 antibodies and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543339A JP2008543339A (ja) | 2008-12-04 |
| JP2008543339A5 true JP2008543339A5 (enExample) | 2009-07-23 |
| JP5215180B2 JP5215180B2 (ja) | 2013-06-19 |
Family
ID=37459434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518360A Active JP5215180B2 (ja) | 2005-06-20 | 2006-06-20 | Ｃｄ１９抗体およびその使用法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8097703B2 (enExample) |
| EP (1) | EP1899379B1 (enExample) |
| JP (1) | JP5215180B2 (enExample) |
| KR (1) | KR20080032097A (enExample) |
| AU (1) | AU2006262232A1 (enExample) |
| BR (1) | BRPI0613279A8 (enExample) |
| CA (1) | CA2611814A1 (enExample) |
| EA (1) | EA200800094A1 (enExample) |
| HR (1) | HRP20080028A2 (enExample) |
| IL (1) | IL188088A0 (enExample) |
| MX (1) | MX2007015944A (enExample) |
| NO (1) | NO20080362L (enExample) |
| WO (1) | WO2007002223A2 (enExample) |
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-
2006
- 2006-06-20 KR KR1020087001276A patent/KR20080032097A/ko not_active Ceased
- 2006-06-20 AU AU2006262232A patent/AU2006262232A1/en not_active Abandoned
- 2006-06-20 HR HR20080028A patent/HRP20080028A2/xx not_active Application Discontinuation
- 2006-06-20 CA CA002611814A patent/CA2611814A1/en not_active Abandoned
- 2006-06-20 BR BRPI0613279A patent/BRPI0613279A8/pt not_active Application Discontinuation
- 2006-06-20 EA EA200800094A patent/EA200800094A1/ru unknown
- 2006-06-20 WO PCT/US2006/024183 patent/WO2007002223A2/en not_active Ceased
- 2006-06-20 JP JP2008518360A patent/JP5215180B2/ja active Active
- 2006-06-20 MX MX2007015944A patent/MX2007015944A/es not_active Application Discontinuation
- 2006-06-20 US US11/917,750 patent/US8097703B2/en active Active
- 2006-06-20 EP EP06785284.8A patent/EP1899379B1/en active Active
-
2007
- 2007-12-12 IL IL188088A patent/IL188088A0/en unknown
-
2008
- 2008-01-18 NO NO20080362A patent/NO20080362L/no not_active Application Discontinuation
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