JP2004531270A5 - - Google Patents

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Publication number
JP2004531270A5
JP2004531270A5 JP2003507235A JP2003507235A JP2004531270A5 JP 2004531270 A5 JP2004531270 A5 JP 2004531270A5 JP 2003507235 A JP2003507235 A JP 2003507235A JP 2003507235 A JP2003507235 A JP 2003507235A JP 2004531270 A5 JP2004531270 A5 JP 2004531270A5
Authority
JP
Japan
Prior art keywords
monoclonal antibody
antibody
kda
antigen
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003507235A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004531270A (ja
JP4455876B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/019646 external-priority patent/WO2003000848A2/en
Publication of JP2004531270A publication Critical patent/JP2004531270A/ja
Publication of JP2004531270A5 publication Critical patent/JP2004531270A5/ja
Application granted granted Critical
Publication of JP4455876B2 publication Critical patent/JP4455876B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003507235A 2001-06-22 2002-06-21 肝移植細胞、アッセイ法、およびその使用法 Expired - Fee Related JP4455876B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30053501P 2001-06-22 2001-06-22
PCT/US2002/019646 WO2003000848A2 (en) 2001-06-22 2002-06-21 Liver engrafting cells, assays, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009090608A Division JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

Publications (3)

Publication Number Publication Date
JP2004531270A JP2004531270A (ja) 2004-10-14
JP2004531270A5 true JP2004531270A5 (enExample) 2006-01-05
JP4455876B2 JP4455876B2 (ja) 2010-04-21

Family

ID=23159503

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003507235A Expired - Fee Related JP4455876B2 (ja) 2001-06-22 2002-06-21 肝移植細胞、アッセイ法、およびその使用法
JP2009090608A Withdrawn JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009090608A Withdrawn JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

Country Status (11)

Country Link
US (3) US7211404B2 (enExample)
EP (3) EP1956078A3 (enExample)
JP (2) JP4455876B2 (enExample)
CN (2) CN101974480A (enExample)
AT (1) ATE371018T1 (enExample)
AU (1) AU2002315392B2 (enExample)
CA (1) CA2451637C (enExample)
DE (1) DE60221987T2 (enExample)
DK (1) DK1406998T3 (enExample)
ES (1) ES2292772T3 (enExample)
WO (1) WO2003000848A2 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US7838292B1 (en) * 2001-03-29 2010-11-23 University Of Louisville Research Foundation, Inc. Methods for obtaining adult human olfactory progenitor cells
AU2002315392B2 (en) 2001-06-22 2008-01-24 Boco Silicon Valley, Inc. Liver engrafting cells, assays, and uses thereof
US7780993B2 (en) * 2001-09-07 2010-08-24 Yeda Research And Development Co. Ltd. Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
US20040136972A1 (en) * 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
CA2469204A1 (en) * 2001-12-07 2003-06-19 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
IL165425A0 (en) * 2004-11-28 2006-01-15 Yeda Res & Dev Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
KR20060031809A (ko) * 2003-06-09 2006-04-13 더 리젠츠 오브 더 유니버시티 오브 미시간 암 치료 및 진단용 조성물 및 방법
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
JP2007526455A (ja) * 2004-02-03 2007-09-13 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法
WO2006019162A1 (ja) * 2004-08-20 2006-02-23 Daiichi Pure Chemicals Co., Ltd. 薬物のヒトにおける肝代謝及び肝機能を予測する方法
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
WO2006138275A2 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
PT2500360E (pt) 2005-10-31 2015-10-15 Oncomed Pharm Inc Composições e métodos para diagnóstico e tratamento do cancro
AU2006308847C1 (en) * 2005-10-31 2012-05-10 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
US7723477B2 (en) * 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2007071339A1 (en) 2005-12-21 2007-06-28 Universite Catholique De Louvain Isolated liver stem cells
WO2008121102A2 (en) * 2006-02-21 2008-10-09 The Regents Of The University Of Michigan Hedgehog signaling pathway antagonist cancer treatment
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
KR101472519B1 (ko) * 2007-06-05 2014-12-29 오레곤 헬스 앤드 사이언스 유니버시티 In vivo에서 인간 간세포 증식 방법
SG183067A1 (en) * 2007-07-20 2012-08-30 Cellartis Ab A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts derived stem cells
US8241898B2 (en) * 2007-12-10 2012-08-14 The Board Of Trustees Of The Leland Stanford Junior University Regenerative dot cells
WO2009111778A2 (en) * 2008-03-07 2009-09-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph nodes as a site for regeneration
MX2011003183A (es) 2008-09-26 2011-04-21 Oncomed Pharm Inc Agentes que se unen a receptor encrespado y usos de los mismos.
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt拮抗劑及治療和篩選方法
JPWO2011102532A1 (ja) * 2010-02-16 2013-06-17 国立大学法人九州大学 誘導肝細胞
KR20130043102A (ko) 2010-04-01 2013-04-29 온코메드 파마슈티칼스, 인크. 프리즐드-결합 작용제 및 그의 용도
HK1212216A1 (en) 2012-10-23 2016-06-10 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
HK1211887A1 (en) 2013-02-04 2016-06-03 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
DK3016665T3 (da) 2013-07-05 2019-11-25 Univ Catholique Louvain Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
JP6672603B2 (ja) * 2015-03-27 2020-03-25 株式会社豊田中央研究所 物質と細胞との間の作用の評価方法
TWI810145B (zh) 2015-06-23 2023-08-01 杰克森實驗室 具有病患衍生之異種移植物之非hla配對的人源化nsg小鼠模式
CN110869032B (zh) 2017-02-17 2024-08-23 匹兹堡大学联邦系统高等教育 脂肪相关淋巴簇作为多种组织的移植、组织再生、器官发生和功能的位点
WO2019210279A1 (en) * 2018-04-27 2019-10-31 The Regents Of The University Of California De novo formation of the biliary system by hepatocyte transdifferentiation
CN116249769A (zh) * 2020-04-17 2023-06-09 昆士兰医学研究所理事会 功能增强的免疫细胞
WO2023060186A1 (en) * 2021-10-07 2023-04-13 Hepatx Corporation Methods of tracking donor cells in a recipient
IL314153A (en) 2022-01-07 2024-09-01 Integriculture Inc Methods for growing liver-derived cells in culture and a culture system containing liver-derived cells

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
EP0597964A4 (en) 1991-08-07 1994-11-30 Einstein Coll Med PROLIFERATION OF HEPATOCYTE PRECURSORS.
CA2146747C (en) * 1992-10-09 2006-12-19 Brian A. Naughton Liver reserve cells
US5459037A (en) 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
WO1995013697A1 (en) 1993-11-19 1995-05-26 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Hepatoblasts and method of isolating same
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
CA2223492A1 (en) 1995-06-06 1996-12-12 The Whitehead Institute For Biomedical Research Isolation of mammalian hematopoietic stem cells
WO1996040875A1 (en) * 1995-06-07 1996-12-19 Novartis Ag Methods for obtaining compositions enriched for hematopoietic stem cells and antibodies for use therein
US5776683A (en) 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
US6046036A (en) * 1996-10-25 2000-04-04 Advanced Research And Technology Institute DNA sequences encoding fusions of DNA repair proteins and uses thereof
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6242666B1 (en) * 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
ES2295012T3 (es) 1999-02-12 2008-04-16 Stemcells California, Inc. Poblaciones enriquecidas de celulas del sistema nervioso central.
US6468794B1 (en) 1999-02-12 2002-10-22 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
ES2367005T3 (es) 2000-10-03 2011-10-27 University Of North Carolina Métodos de aislamiento de células progenitoras hepáticas bipotentes.
EP1559777A1 (en) 2001-04-24 2005-08-03 Hokkaido Technology Licensing Office Co., Ltd. Process for maturating small heptocyte-rich colonies into liver tissue
AU2002315392B2 (en) * 2001-06-22 2008-01-24 Boco Silicon Valley, Inc. Liver engrafting cells, assays, and uses thereof
US8707400B2 (en) 2007-01-22 2014-04-22 Apple Inc. System and method for implementing an extended authentication and authorization credential store

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