JP2004531270A5 - - Google Patents

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Publication number
JP2004531270A5
JP2004531270A5 JP2003507235A JP2003507235A JP2004531270A5 JP 2004531270 A5 JP2004531270 A5 JP 2004531270A5 JP 2003507235 A JP2003507235 A JP 2003507235A JP 2003507235 A JP2003507235 A JP 2003507235A JP 2004531270 A5 JP2004531270 A5 JP 2004531270A5
Authority
JP
Japan
Prior art keywords
monoclonal antibody
antibody
kda
antigen
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003507235A
Other languages
English (en)
Japanese (ja)
Other versions
JP4455876B2 (ja
JP2004531270A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/019646 external-priority patent/WO2003000848A2/en
Publication of JP2004531270A publication Critical patent/JP2004531270A/ja
Publication of JP2004531270A5 publication Critical patent/JP2004531270A5/ja
Application granted granted Critical
Publication of JP4455876B2 publication Critical patent/JP4455876B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2003507235A 2001-06-22 2002-06-21 肝移植細胞、アッセイ法、およびその使用法 Expired - Fee Related JP4455876B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30053501P 2001-06-22 2001-06-22
PCT/US2002/019646 WO2003000848A2 (en) 2001-06-22 2002-06-21 Liver engrafting cells, assays, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009090608A Division JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

Publications (3)

Publication Number Publication Date
JP2004531270A JP2004531270A (ja) 2004-10-14
JP2004531270A5 true JP2004531270A5 (enExample) 2006-01-05
JP4455876B2 JP4455876B2 (ja) 2010-04-21

Family

ID=23159503

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003507235A Expired - Fee Related JP4455876B2 (ja) 2001-06-22 2002-06-21 肝移植細胞、アッセイ法、およびその使用法
JP2009090608A Withdrawn JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009090608A Withdrawn JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

Country Status (11)

Country Link
US (3) US7211404B2 (enExample)
EP (3) EP2388330B1 (enExample)
JP (2) JP4455876B2 (enExample)
CN (2) CN101974480A (enExample)
AT (1) ATE371018T1 (enExample)
AU (1) AU2002315392B2 (enExample)
CA (1) CA2451637C (enExample)
DE (1) DE60221987T2 (enExample)
DK (1) DK1406998T3 (enExample)
ES (1) ES2292772T3 (enExample)
WO (1) WO2003000848A2 (enExample)

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US7780993B2 (en) * 2001-09-07 2010-08-24 Yeda Research And Development Co. Ltd. Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
US20040136972A1 (en) * 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
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US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
AU2005209909B8 (en) * 2004-02-03 2009-01-15 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
JP4854509B2 (ja) * 2004-08-20 2012-01-18 積水メディカル株式会社 薬物のヒトにおける肝代謝及び肝機能を予測する方法
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1945754B1 (en) * 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7723477B2 (en) * 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP2500360B1 (en) 2005-10-31 2015-08-05 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
CA2634510C (en) 2005-12-21 2018-01-09 Universite Catholique De Louvain Isolated liver stem cells
WO2008121102A2 (en) * 2006-02-21 2008-10-09 The Regents Of The University Of Michigan Hedgehog signaling pathway antagonist cancer treatment
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
CA2689591A1 (en) * 2007-06-05 2008-12-11 Oregon Health & Science University Method of expanding human hepatocytes in vivo
CA2693481A1 (en) * 2007-07-20 2009-01-29 Cellartis Ab A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts derived stem cells
US8241898B2 (en) * 2007-12-10 2012-08-14 The Board Of Trustees Of The Leland Stanford Junior University Regenerative dot cells
US9125891B2 (en) * 2008-03-07 2015-09-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph nodes as a site for regeneration
EP2331136B1 (en) 2008-09-26 2018-01-10 OncoMed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
WO2011102532A1 (ja) * 2010-02-16 2011-08-25 国立大学法人九州大学 誘導肝細胞
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
JP6474394B2 (ja) 2013-07-05 2019-02-27 ユニベルシテ カトリック ドゥ ルーベン ヒト成体肝臓幹細胞由来の馴化培地および肝臓障害の治療におけるその使用
JP6672603B2 (ja) * 2015-03-27 2020-03-25 株式会社豊田中央研究所 物質と細胞との間の作用の評価方法
TWI810145B (zh) * 2015-06-23 2023-08-01 杰克森實驗室 具有病患衍生之異種移植物之非ｈｌａ配對的人源化ｎｓｇ小鼠模式
IL268389B2 (en) 2017-02-17 2024-06-01 Univ Pittsburgh Commonwealth Sys Higher Education Adipose-associated lymphoid aggregates as a site for transplantation, tissue regeneration, organ generation, and a role for multiple tissues
WO2019210279A1 (en) * 2018-04-27 2019-10-31 The Regents Of The University Of California De novo formation of the biliary system by hepatocyte transdifferentiation
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ATE371018T1 (de) * 2001-06-22 2007-09-15 Stemcells Inc Le-zellen (liver engrafting cells), assays und verwendungen davon
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