JP2008505120A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008505120A5 JP2008505120A5 JP2007519533A JP2007519533A JP2008505120A5 JP 2008505120 A5 JP2008505120 A5 JP 2008505120A5 JP 2007519533 A JP2007519533 A JP 2007519533A JP 2007519533 A JP2007519533 A JP 2007519533A JP 2008505120 A5 JP2008505120 A5 JP 2008505120A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- phenyl
- double bonds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 70
- 125000000217 alkyl group Chemical group 0.000 claims 63
- 150000002367 halogens Chemical class 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 52
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 46
- 125000001424 substituent group Chemical group 0.000 claims 29
- 125000000623 heterocyclic group Chemical group 0.000 claims 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims 22
- 125000005842 heteroatom Chemical group 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 21
- 229910052757 nitrogen Inorganic materials 0.000 claims 20
- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 229910052717 sulfur Inorganic materials 0.000 claims 17
- 125000005843 halogen group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 9
- -1 —C 1 -C 5 alkyl Inorganic materials 0.000 claims 7
- 125000001624 naphthyl group Chemical group 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 2
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 2
- 102100031545 Microsomal triglyceride transfer protein large subunit Human genes 0.000 claims 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010038232 microsomal triglyceride transfer protein Proteins 0.000 claims 2
- 125000003884 phenylalkyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- 101150092476 ABCA1 gene Proteins 0.000 claims 1
- 102000018616 Apolipoproteins B Human genes 0.000 claims 1
- 108010027006 Apolipoproteins B Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 229940122502 Cholesterol absorption inhibitor Drugs 0.000 claims 1
- 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 claims 1
- 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 claims 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 claims 1
- 229930003779 Vitamin B12 Natural products 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 108091022863 bile acid binding Proteins 0.000 claims 1
- 102000030904 bile acid binding Human genes 0.000 claims 1
- 229920000080 bile acid sequestrant Polymers 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 1
- 235000000639 cyanocobalamin Nutrition 0.000 claims 1
- 239000011666 cyanocobalamin Substances 0.000 claims 1
- 229960002104 cyanocobalamin Drugs 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002530 phenolic antioxidant Substances 0.000 claims 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 239000011715 vitamin B12 Substances 0.000 claims 1
- 235000019163 vitamin B12 Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58527404P | 2004-07-02 | 2004-07-02 | |
| US60/585,274 | 2004-07-02 | ||
| US64610305P | 2005-01-21 | 2005-01-21 | |
| US60/646,103 | 2005-01-21 | ||
| PCT/US2005/023775 WO2006014413A1 (en) | 2004-07-02 | 2005-07-01 | Cetp inhibitors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010031195A Division JP4491062B1 (ja) | 2004-07-02 | 2010-02-16 | Ｃｅｔｐ阻害薬 |
| JP2011015653A Division JP5543932B2 (ja) | 2004-07-02 | 2011-01-27 | Ｃｅｔｐ阻害薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505120A JP2008505120A (ja) | 2008-02-21 |
| JP2008505120A5 true JP2008505120A5 (cg-RX-API-DMAC7.html) | 2010-06-24 |
| JP4695139B2 JP4695139B2 (ja) | 2011-06-08 |
Family
ID=35045145
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519533A Expired - Fee Related JP4695139B2 (ja) | 2004-07-02 | 2005-07-01 | Ｃｅｔｐ阻害薬 |
| JP2010031195A Expired - Fee Related JP4491062B1 (ja) | 2004-07-02 | 2010-02-16 | Ｃｅｔｐ阻害薬 |
| JP2011015653A Expired - Fee Related JP5543932B2 (ja) | 2004-07-02 | 2011-01-27 | Ｃｅｔｐ阻害薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010031195A Expired - Fee Related JP4491062B1 (ja) | 2004-07-02 | 2010-02-16 | Ｃｅｔｐ阻害薬 |
| JP2011015653A Expired - Fee Related JP5543932B2 (ja) | 2004-07-02 | 2011-01-27 | Ｃｅｔｐ阻害薬 |
Country Status (37)
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7270971B2 (en) * | 2003-10-16 | 2007-09-18 | Merck & Co., Inc. | Fluorescence assay for measuring the rate of cholesterol ester transfer |
| DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| JP5112307B2 (ja) * | 2005-07-01 | 2013-01-09 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｅｔｐ阻害剤を合成するための方法 |
| US8486983B2 (en) | 2005-12-05 | 2013-07-16 | Merck Sharp & Dohme Corp. | Self-emulsifying formulations of CETP inhibitors |
| TW200732313A (en) | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
| AU2006335110B2 (en) * | 2005-12-30 | 2011-04-14 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| US8865707B2 (en) * | 2005-12-30 | 2014-10-21 | Merck Sharp & Dohme Corp. | Cholesteryl ester transfer protein inhibitors |
| US7910592B2 (en) * | 2005-12-30 | 2011-03-22 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| EP2029560B1 (en) * | 2005-12-30 | 2013-04-24 | Merck Sharp & Dohme Corp. | 1,3-oxazolidin-2-one derivatives useeful as cetp inhibitors |
| WO2007092642A2 (en) * | 2006-02-09 | 2007-08-16 | Merck & Co., Inc. | Polymer formulations of cetp inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| WO2007136672A2 (en) * | 2006-05-19 | 2007-11-29 | Merck & Co., Inc. | Synthesis of a biaryl synthetic intermediate |
| WO2008082567A1 (en) * | 2006-12-29 | 2008-07-10 | Merck & Co., Inc. | Process for synthesizing a cetp inhibitor |
| DK2114971T3 (en) | 2007-01-26 | 2015-08-31 | Kaneq Pharma Inc | Fused aromatic PTB-1B inhibitors |
| US8759383B2 (en) | 2007-03-16 | 2014-06-24 | Concert Pharmaceuticals, Inc. | Inhibitors of cholesterol ester transfer protein |
| US8338458B2 (en) | 2007-05-07 | 2012-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fused aromatic compounds having anti-diabetic activity |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| AU2008266954A1 (en) * | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | CETP inhibitors derived from benzoxazole arylamides |
| EP2170059B1 (en) * | 2007-06-20 | 2014-11-19 | Merck Sharp & Dohme Corp. | Cetp inhibitors derived from benzoxazole arylamides |
| AU2008266957A1 (en) * | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | CETP inhibitors derived from benzoxazole arylamides |
| JP5431316B2 (ja) | 2007-07-02 | 2014-03-05 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｃｒ２受容体アンタゴニストとしてのイミダゾール誘導体 |
| ES2395081T3 (es) * | 2007-07-26 | 2013-02-08 | Vitae Pharmaceuticals, Inc. | Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 |
| AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| EP2229368A1 (en) | 2007-12-11 | 2010-09-22 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (ja) * | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター |
| JP5491416B2 (ja) | 2008-02-01 | 2014-05-14 | パンミラ ファーマシューティカルズ，エルエルシー． | プロスタグランジンｄ２受容体のｎ，ｎ−２置換アミノアルキルビフェニルアンタゴニスト |
| EP2245002A4 (en) * | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
| CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| US8242145B2 (en) | 2008-02-14 | 2012-08-14 | Panmira Pharmaceuticals, Llc | Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors |
| JP5730021B2 (ja) * | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体 |
| EP2245022A4 (en) | 2008-02-25 | 2012-02-22 | Panmira Pharmaceuticals Llc | ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| EP2274287B1 (en) * | 2008-03-18 | 2016-03-09 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| EP2268611A2 (en) | 2008-04-02 | 2011-01-05 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
| CL2009001058A1 (es) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
| TW200946520A (en) | 2008-05-01 | 2009-11-16 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8063088B2 (en) * | 2008-06-11 | 2011-11-22 | Hoffmann-La Roche Inc. | Imidazolidine derivatives |
| EP2324018B1 (en) | 2008-07-25 | 2013-09-04 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| JP5390610B2 (ja) | 2008-07-25 | 2014-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| DE102008049675A1 (de) | 2008-09-30 | 2010-04-01 | Markus Dr. Heinrich | Verfahren zur Herstellung von 3-Aminobiphenylen |
| EP2348859B1 (en) * | 2008-10-01 | 2013-12-04 | Merck Sharp & Dohme Corp. | Prodrugs of oxazolidinone cetp inhibitors |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| US8524748B2 (en) | 2008-10-08 | 2013-09-03 | Panmira Pharmaceuticals, Llc | Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors |
| CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| TW201028414A (en) | 2009-01-16 | 2010-08-01 | Merck Sharp & Dohme | Oxadiazole beta carboline derivatives as antidiabetic compounds |
| WO2010085528A1 (en) | 2009-01-23 | 2010-07-29 | Schering Corporation | Bridged and fused antidiabetic compounds |
| EP2389226B1 (en) | 2009-01-23 | 2013-11-20 | Merck Sharp & Dohme Corp. | Bridged and fused heterocyclic antidiabetic compounds |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| WO2010091176A1 (en) | 2009-02-05 | 2010-08-12 | Schering Corporation | Phthalazine-containing antidiabetic compounds |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| SG178252A1 (en) * | 2009-08-05 | 2012-03-29 | Panmira Pharmaceuticals Llc | Dp2 antagonist and uses thereof |
| JP2011057661A (ja) | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
| WO2011056737A1 (en) | 2009-11-05 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Novel chiral phosphorus ligands |
| CN102695414A (zh) | 2010-01-15 | 2012-09-26 | 默沙东公司 | 作为抗糖尿病化合物的噁二唑β-咔啉衍生物 |
| CA2786314A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2012046681A1 (ja) | 2010-10-04 | 2012-04-12 | 興和株式会社 | 脂質代謝関連ｍＲＮＡの発現抑制剤 |
| JP2013531636A (ja) | 2010-05-26 | 2013-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−オキソ−１，２−ジヒドロピリジン−４−イルボロン酸誘導体 |
| EP2397473A1 (en) | 2010-06-14 | 2011-12-21 | LEK Pharmaceuticals d.d. | A stable highly crystalline anacetrapib |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| JP5852662B2 (ja) * | 2010-10-29 | 2016-02-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 環状アミン置換されたオキサゾリジノン系ｃｅｔｐ阻害薬 |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| EP2468735A1 (en) * | 2010-12-23 | 2012-06-27 | LEK Pharmaceuticals d.d. | Synthesis of intermediates for preparing anacetrapib and derivates thereof |
| EP2468736A1 (en) * | 2010-12-23 | 2012-06-27 | LEK Pharmaceuticals d.d. | Synthesis of intermediates for preparing anacetrapib and derivates thereof |
| ES2648788T3 (es) | 2011-01-26 | 2018-01-08 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Método para evaluar el riesgo de un sujeto de tener una enfermedad cardiovascular |
| EP3243385B1 (en) | 2011-02-25 | 2021-01-13 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| AU2012243583B2 (en) | 2011-04-12 | 2015-10-22 | Chong Kun Dang Pharmaceutical Corp. | Cycloalkenyl aryl derivatives for CETP inhibitor |
| WO2013005834A1 (ja) * | 2011-07-07 | 2013-01-10 | 持田製薬株式会社 | 高純度ｅｐａを含有する抗肥満剤 |
| RU2609200C2 (ru) | 2011-07-08 | 2017-01-30 | Новартис Аг | Способ лечения атеросклероза у субъектов с высоким уровнем триглицеридов |
| JO3210B1 (ar) | 2011-10-28 | 2018-03-08 | Merck Sharp & Dohme | مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة |
| EP2773210A4 (en) * | 2011-10-31 | 2015-07-22 | Merck Sharp & Dohme | Process for a cetp inhibitor |
| WO2013064188A1 (en) | 2011-11-03 | 2013-05-10 | Lek Pharmaceuticals D.D. | A stable highly crystalline anacetrapib |
| US20140303198A1 (en) | 2011-11-29 | 2014-10-09 | Kowa Company, Ltd. | Agent for inhibiting expression of npc1l1 and/or lipg mrna and agent for preventing and/or treating obesity |
| JP6108631B2 (ja) | 2011-11-30 | 2017-04-05 | デウン ファーマシューティカル カンパニー リミテッド | 高脂血症を予防または治療するための医薬組成物 |
| WO2013091696A1 (en) * | 2011-12-21 | 2013-06-27 | Lek Pharmaceuticals D.D. | Synthesis of intermediates for preparing anacetrapib and derivatives thereof |
| US9353101B2 (en) | 2012-05-02 | 2016-05-31 | Merck Sharp & Dohme Corp. | Cyclic amine substituted heterocyclic CETP inhibitors |
| MX347400B (es) | 2012-06-29 | 2017-04-18 | Univ Nac Autónoma De México | Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso. |
| CN103958484B (zh) * | 2012-07-19 | 2015-11-25 | 上海恒瑞医药有限公司 | 噁唑烷酮类衍生物、其制备方法及其在医药上的应用 |
| WO2014031465A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydropyran derivatives |
| EP2934518B1 (en) | 2012-12-19 | 2020-02-19 | Merck Sharp & Dohme Corp. | Spirocyclic cetp inhibitors |
| US9376408B2 (en) | 2012-12-20 | 2016-06-28 | Merck Sharp & Dohme Corp. | Therapeutic thiazolidinone compounds |
| WO2014111953A1 (en) * | 2013-01-17 | 2014-07-24 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of anacetrapib and intermediates thereof |
| DK2943474T3 (en) | 2013-01-31 | 2017-08-21 | Chong Kun Dang Pharmaceutical Corp | BIARYL- OR HETEROCYCLIC BIARYL-SUBSTITUTED CYCLOHEXE DERIVATE COMPOUNDS AS CETP INHIBITORS |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| EP3027619B1 (en) | 2013-07-30 | 2019-01-02 | Merck Sharp & Dohme Corp. | Bicyclic ureas and thiadiazolidine-1,1-dioxides as cetp inhibitors |
| US9688630B2 (en) | 2013-10-10 | 2017-06-27 | Merck Sharp & Dohme Corp. | 3,3′-disubstituted indolines as inhibitors of cholesterol ester transfer protein |
| US9663534B2 (en) | 2013-12-17 | 2017-05-30 | Merck Sharp & Dohme Corp. | Fused bicyclic isoxazolines as inhibitors of cholesterol ester transfer protein |
| WO2015106674A1 (zh) * | 2014-01-14 | 2015-07-23 | 杭州普晒医药科技有限公司 | 一种安塞曲匹的晶型及其制备方法、其药物组合物和用途 |
| CN103923030B (zh) * | 2014-03-27 | 2015-07-22 | 汕头经济特区鮀滨制药厂 | 一种安塞曲匹的关键中间体的合成方法 |
| CN103923031A (zh) * | 2014-04-01 | 2014-07-16 | 汕头经济特区鮀滨制药厂 | 一种安塞曲匹的中间体的合成方法 |
| US10011572B2 (en) | 2014-07-29 | 2018-07-03 | Merck Sharp & Dohme Corp. | Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein |
| JP6854752B2 (ja) | 2014-07-30 | 2021-04-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｈｄｌ上昇剤又はｈｄｌ模倣剤を用いた治療に対する応答性を予測するための遺伝マーカー |
| CN104230835B (zh) * | 2014-09-01 | 2017-01-25 | 福建师范大学 | 一种合成n‑苯乙烯基恶唑烷‑2‑酮衍生物的方法 |
| WO2016067194A1 (en) * | 2014-10-27 | 2016-05-06 | Sun Pharmaceutical Industries Limited | Process for the preparation of anacetrapib and an intermediate thereof |
| CN106032362B (zh) * | 2015-03-10 | 2018-06-19 | 湖南千金湘江药业股份有限公司 | 安塞曲匹的制备方法 |
| CA3029109A1 (en) | 2016-06-29 | 2018-01-04 | Orion Corporation | Benzodioxane derivatives and their pharmaceutical use |
| KR101902002B1 (ko) * | 2016-07-19 | 2018-09-27 | 재단법인 대구경북첨단의료산업진흥재단 | Cetp 억제제로서의 옥사졸리딘온 유도체 화합물 |
| JP6945619B2 (ja) * | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Ｎｅｐ阻害剤合成のための新規な方法および中間体 |
| CN106496211A (zh) * | 2016-10-18 | 2017-03-15 | 湖南德魅信息技术有限公司 | 二氟甲基取代的噁唑烷酮化合物及其用途 |
| CN106496154A (zh) * | 2016-10-18 | 2017-03-15 | 湖南德魅信息技术有限公司 | 安塞曲匹的制备方法 |
| CN106749075A (zh) * | 2016-11-24 | 2017-05-31 | 山东新华制药股份有限公司 | 阿那曲波的恶唑烷酮中间体的晶型及其制备方法 |
| WO2019043018A1 (en) | 2017-08-29 | 2019-03-07 | Dalcor Pharma Uk Ltd., Stockport Zug Branch | METHODS OF TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND REDUCING THE RISK OF CARDIOVASCULAR EVENTS |
| JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
| SG11202101086YA (en) | 2018-08-09 | 2021-03-30 | Dalcor Pharma Uk Ltd Leatherhead | Methods for delaying occurrence of new-onset type 2 diabetes and for slowing progression of and treating type 2 diabetes |
| CA3126323A1 (en) | 2019-03-07 | 2020-09-10 | Jean-Claude Tardif | Methods for treating or preventing heart failure and reducing risk of heart failure |
| TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
| EP3999518A2 (en) | 2019-07-19 | 2022-05-25 | Biosynth AG | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| JP7519463B2 (ja) | 2020-05-05 | 2024-07-19 | ヌバレント， インク． | ヘテロ芳香族大環状エーテル化学療法剤 |
| PE20230309A1 (es) | 2020-05-05 | 2023-02-14 | Nuvalent Inc | Agentes quimioterapeuticos de eteres macrociclicos heteroaromaticos |
| WO2022075645A1 (ko) * | 2020-10-08 | 2022-04-14 | 재단법인 대구경북첨단의료산업진흥재단 | Pcsk9 억제제로서 아미노알콜 유도체 및 이를 함유하는 고콜레스테롤 혈증의 예방 또는 치료용 약학적 조성물 |
| WO2023278698A1 (en) * | 2021-06-30 | 2023-01-05 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
| CN118234725A (zh) | 2021-10-01 | 2024-06-21 | 纽威伦特公司 | 杂芳族大环醚化合物的固体形式、药物组合物及制备 |
| WO2025093129A1 (en) | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Treatment and prevention of age-related macular degeneration using a cetp inhibitor |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179442A (en) * | 1975-08-29 | 1979-12-18 | York Hartleben | 4-(Alpha-hydroxy-isopropyl)-5-phenyl-oxazolidin-2-one |
| DE2655369A1 (de) * | 1976-12-03 | 1978-06-08 | Schering Ag | 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung |
| US4851423A (en) | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| WO1988009661A1 (en) * | 1987-06-10 | 1988-12-15 | Pfizer Inc. | Oxazolidin-2-one derivatives as hypoglycemic agents |
| DE69329106T2 (de) * | 1992-04-30 | 2001-03-22 | Taiho Pharmaceutical Co., Ltd. | Oxazolidinderivat und sein pharmazeutisch verträgliches salz |
| US5482971A (en) | 1993-10-01 | 1996-01-09 | American Cyanamid Company | Beta3 -adrenergic agents and their use in pharmaceutical compositions |
| CN1115576A (zh) * | 1993-10-15 | 1996-01-24 | 盐野义制药株式会社 | 具有细胞浆磷脂酶a2抑制活性的噁唑啉酮衍生物 |
| ATE255413T1 (de) * | 1994-04-21 | 2003-12-15 | Schering Ag | Pde iv-inhibitoren zur behandlung der multiplen sklerose |
| FR2729954B1 (fr) * | 1995-01-30 | 1997-08-01 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| ZA961081B (en) * | 1995-02-10 | 1996-10-15 | Schering Ag | Pharmaceutical preparations for tnf inhibition |
| JP2002515014A (ja) * | 1995-05-17 | 2002-05-21 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 殺菌・殺カビ性の環式アミド類 |
| US5612363A (en) | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| NZ310884A (en) | 1995-06-20 | 1999-04-29 | Du Pont | Arthropodicidal and fungicidal cyclic amides |
| US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| US6310095B1 (en) | 1995-11-06 | 2001-10-30 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| WO1997028149A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| WO1998023155A1 (en) | 1996-11-26 | 1998-06-04 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
| DE19704243A1 (de) * | 1997-02-05 | 1998-08-06 | Bayer Ag | Neue 2-Amino-substituierte Pyridine |
| PL336580A1 (en) * | 1997-03-03 | 2000-07-03 | Boehringer Ingelheim Pharma | Fine-molecular compounds useful in treating inflammatory diseases |
| ES2387211T3 (es) | 1997-05-07 | 2012-09-18 | University Of Pittsburgh | Inhibidores de proteínas isoprenil transferass |
| DE19741400A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Benzyl-biphenyle |
| US6239152B1 (en) | 1998-01-23 | 2001-05-29 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| IT1300055B1 (it) | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| HK1052497B (zh) | 1999-09-17 | 2007-03-02 | 千禧药品公司 | 苯甲酸胺和相关的因子xa抑制剂 |
| HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
| US6462063B1 (en) | 2000-02-04 | 2002-10-08 | Fibrogen, Inc. | C-proteinase inhibitors |
| AU4456601A (en) | 2000-03-28 | 2001-10-08 | Nippon Soda Co., Ltd. | Oxa(thia)zolidine derivative and anti-inflammatory drug |
| SK7822003A3 (en) * | 2000-12-21 | 2003-12-02 | Aventis Pharma Gmbh | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism |
| WO2003022824A1 (en) | 2001-09-11 | 2003-03-20 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
| US7235579B2 (en) * | 2001-10-16 | 2007-06-26 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| PT1603553E (pt) | 2003-03-17 | 2012-02-03 | Japan Tobacco Inc | Composições farmacêuticas de inibidores de cetp |
| UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| CN101180288A (zh) | 2005-03-31 | 2008-05-14 | 科学与工业研究会 | 与抗感染药物联用的芳香族取代的戊二烯酸酰胺 |
| EP2029560B1 (en) | 2005-12-30 | 2013-04-24 | Merck Sharp & Dohme Corp. | 1,3-oxazolidin-2-one derivatives useeful as cetp inhibitors |
| US7910592B2 (en) | 2005-12-30 | 2011-03-22 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| AU2006335110B2 (en) | 2005-12-30 | 2011-04-14 | Merck Sharp & Dohme Corp. | CETP inhibitors |
-
2005
- 2005-01-31 DO DO2005000123A patent/DOP2005000123A/es unknown
- 2005-06-23 MY MYPI20052868A patent/MY167430A/en unknown
- 2005-06-26 JO JOP/2005/0091A patent/JO2994B1/ar active
- 2005-06-28 GT GT200500175A patent/GT200500175A/es unknown
- 2005-06-30 PE PE2005000763A patent/PE20060525A1/es active IP Right Grant
- 2005-06-30 TW TW094122197A patent/TWI299991B/zh not_active IP Right Cessation
- 2005-06-30 PA PA20058638101A patent/PA8638101A1/es unknown
- 2005-07-01 GE GEAP20059837A patent/GEP20094694B/en unknown
- 2005-07-01 NZ NZ552061A patent/NZ552061A/en not_active IP Right Cessation
- 2005-07-01 CN CN201110245074.8A patent/CN102311401B/zh not_active Expired - Fee Related
- 2005-07-01 CN CN201410720703.1A patent/CN104447603A/zh active Pending
- 2005-07-01 PL PL05771445T patent/PL1765793T3/pl unknown
- 2005-07-01 RS RS20120497A patent/RS52563B/sr unknown
- 2005-07-01 JP JP2007519533A patent/JP4695139B2/ja not_active Expired - Fee Related
- 2005-07-01 SI SI200531643T patent/SI1765793T1/sl unknown
- 2005-07-01 WO PCT/US2005/023546 patent/WO2006014357A1/en not_active Ceased
- 2005-07-01 EP EP11184420A patent/EP2415759A1/en not_active Withdrawn
- 2005-07-01 EA EA200700259A patent/EA011130B1/ru not_active IP Right Cessation
- 2005-07-01 CN CN201110245073.3A patent/CN102304096B/zh not_active Expired - Fee Related
- 2005-07-01 SV SV2005002160A patent/SV2007002160A/es unknown
- 2005-07-01 US US11/173,295 patent/US7652049B2/en active Active
- 2005-07-01 MX MX2007000035A patent/MX2007000035A/es active IP Right Grant
- 2005-07-01 DK DK05771445.3T patent/DK1765793T3/da active
- 2005-07-01 WO PCT/US2005/023775 patent/WO2006014413A1/en not_active Ceased
- 2005-07-01 US US11/631,821 patent/US20080119476A1/en not_active Abandoned
- 2005-07-01 AR ARP050102755A patent/AR049956A1/es not_active Application Discontinuation
- 2005-07-01 CN CN201410720701.2A patent/CN104557757A/zh active Pending
- 2005-07-01 ES ES05771445T patent/ES2393721T3/es not_active Expired - Lifetime
- 2005-07-01 AU AU2005270058A patent/AU2005270058B2/en not_active Ceased
- 2005-07-01 CA CA2570717A patent/CA2570717C/en not_active Expired - Fee Related
- 2005-07-01 BR BRPI0512910-9A patent/BRPI0512910A/pt not_active Application Discontinuation
- 2005-07-01 HR HRP20120993TT patent/HRP20120993T1/hr unknown
- 2005-07-01 EP EP05771445A patent/EP1765793B1/en not_active Expired - Lifetime
- 2005-07-01 KR KR1020077000039A patent/KR101204336B1/ko not_active Expired - Fee Related
- 2005-07-01 PT PT57714453T patent/PT1765793E/pt unknown
-
2006
- 2006-12-13 CR CR8808A patent/CR8808A/es unknown
- 2006-12-22 NI NI200600322A patent/NI200600322A/es unknown
- 2006-12-28 IL IL180432A patent/IL180432A/en not_active IP Right Cessation
- 2006-12-28 EC EC2006007124A patent/ECSP067124A/es unknown
-
2007
- 2007-01-03 EG EGNA2007000001 patent/EG27138A/xx active
- 2007-02-01 NO NO20070607A patent/NO339808B1/no not_active IP Right Cessation
- 2007-02-01 MA MA29647A patent/MA28780B1/fr unknown
-
2009
- 2009-11-25 US US12/625,783 patent/US8735435B2/en active Active
-
2010
- 2010-02-16 JP JP2010031195A patent/JP4491062B1/ja not_active Expired - Fee Related
-
2011
- 2011-01-27 JP JP2011015653A patent/JP5543932B2/ja not_active Expired - Fee Related
-
2012
- 2012-01-12 IL IL217530A patent/IL217530A0/en unknown
- 2012-07-30 AR ARP120102770A patent/AR087382A2/es unknown
- 2012-12-21 CY CY20121101259T patent/CY1117930T1/el unknown
-
2014
- 2014-04-14 US US14/252,256 patent/US20140221383A1/en not_active Abandoned
-
2015
- 2015-10-05 US US14/875,438 patent/US20160075724A1/en not_active Abandoned