JP2006515520A5 - - Google Patents
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- JP2006515520A5 JP2006515520A5 JP2006500508A JP2006500508A JP2006515520A5 JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5 JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- collection
- library
- polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 74
- 238000000034 method Methods 0.000 claims 59
- 150000007523 nucleic acids Chemical group 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 31
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 239000013598 vector Substances 0.000 claims 16
- 238000004519 manufacturing process Methods 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091026890 Coding region Proteins 0.000 claims 6
- 238000012216 screening Methods 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
- 102000018120 Recombinases Human genes 0.000 claims 5
- 108010091086 Recombinases Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 238000002823 phage display Methods 0.000 claims 2
- 238000002702 ribosome display Methods 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43840303P | 2003-01-07 | 2003-01-07 | |
| DKPA200300008 | 2003-01-07 | ||
| US47601803P | 2003-06-05 | 2003-06-05 | |
| PCT/DK2004/000001 WO2004061104A2 (en) | 2003-01-07 | 2004-01-07 | Method for manufacturing recombinant polyclonal proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Division JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515520A JP2006515520A (ja) | 2006-06-01 |
| JP2006515520A5 true JP2006515520A5 (enExample) | 2007-01-11 |
| JP4589914B2 JP4589914B2 (ja) | 2010-12-01 |
Family
ID=32718469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500508A Expired - Fee Related JP4589914B2 (ja) | 2003-01-07 | 2004-01-07 | 組換え型ポリクローナルタンパク質の製造方法 |
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9163232B2 (enExample) |
| EP (2) | EP1762617A1 (enExample) |
| JP (2) | JP4589914B2 (enExample) |
| KR (1) | KR101024443B1 (enExample) |
| AT (1) | ATE338816T1 (enExample) |
| AU (1) | AU2004203727C1 (enExample) |
| BR (1) | BRPI0406678A (enExample) |
| CA (1) | CA2512647C (enExample) |
| DE (1) | DE602004002275T2 (enExample) |
| DK (1) | DK1583830T3 (enExample) |
| EA (1) | EA013225B1 (enExample) |
| ES (1) | ES2273202T3 (enExample) |
| IL (1) | IL169101A (enExample) |
| MX (1) | MXPA05006724A (enExample) |
| NZ (1) | NZ541458A (enExample) |
| PT (1) | PT1583830E (enExample) |
| SI (1) | SI1583830T1 (enExample) |
| WO (1) | WO2004061104A2 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1523496T1 (sl) | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| CA2512647C (en) | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| BRPI0513706A (pt) * | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| RU2426795C2 (ru) | 2004-07-20 | 2011-08-20 | Симфоген А/С | Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии |
| US8815583B2 (en) | 2005-06-24 | 2014-08-26 | Enteris Biopharma, Inc. | Cell lines for expressing enzyme useful in the preparation of amidated products |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| FR2910490B1 (fr) * | 2006-12-20 | 2012-10-26 | Lab Francais Du Fractionnement | Lignee cellulaire a forte activite transcriptionnelle pour la production de proteines, notamment therapeutiques |
| US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| MX2009008908A (es) | 2007-03-01 | 2009-08-28 | Symphogen As | Metodo para clonacion de anticuerpos analogos. |
| PL2132229T3 (pl) | 2007-03-01 | 2016-12-30 | Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórka | |
| CN101679513A (zh) | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
| NZ581316A (en) * | 2007-05-25 | 2012-02-24 | Symphogen As | Method for manufacturing a recombinant polyclonal protein |
| BRPI0816094A2 (pt) | 2007-08-30 | 2015-03-03 | Daiichi Sankyo Co Ltd | Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo. |
| EP2725035A1 (en) | 2007-10-02 | 2014-04-30 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| HUE025262T2 (en) | 2007-10-11 | 2016-02-29 | Daiichi Sankyo Co Ltd | Antibody targeting osteoclast-linked Siglec-15 protein |
| BRPI0910454A2 (pt) * | 2008-04-23 | 2018-03-27 | Symphogen As | processo para produção de uma proteína policlonal |
| EP2331577B1 (en) | 2008-08-29 | 2017-06-07 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| MX2011001930A (es) * | 2008-08-29 | 2011-04-21 | Symphogen As | Metodo para clonar anticuerpos derivados de aves. |
| CN106317224B (zh) | 2009-04-09 | 2020-05-12 | 第一三共株式会社 | 抗-Siglec-15抗体 |
| NZ599315A (en) | 2009-10-15 | 2014-05-30 | Avaxia Biologics Inc | Antibody therapeutics with local activity in the digestive tract |
| CN103282495B (zh) | 2010-10-29 | 2017-06-09 | 第一三共株式会社 | 新的抗dr5抗体 |
| ES2692379T3 (es) | 2010-11-01 | 2018-12-03 | Symphogen A/S | Anticuerpos anti-HER3 y composiciones |
| CA2817751C (en) | 2010-11-16 | 2019-04-30 | Excelimmune, Inc. | Methods for producing recombinant proteins |
| LT2703486T (lt) | 2011-04-25 | 2018-05-25 | Daiichi Sankyo Company, Limited | Anti-b7-h3 antikūnas |
| EP3816284A1 (en) | 2011-12-22 | 2021-05-05 | F. Hoffmann-La Roche AG | Expression vector for antibody production in eukaryotic cells |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| AU2013241002A1 (en) | 2012-03-30 | 2014-10-09 | Daiichi Sankyo Company,Limited | Novel anti-siglec-15 antibody |
| KR20150003170A (ko) | 2012-03-30 | 2015-01-08 | 다이이찌 산쿄 가부시키가이샤 | ＣＤＲ 개변 항 Ｓｉｇｌｅｃ-15 항체 |
| CA2870126C (en) | 2012-04-09 | 2020-10-27 | Daiichi Sankyo Company, Limited | Anti-fgfr2 antibody |
| ES2743399T3 (es) | 2012-04-20 | 2020-02-19 | Merus Nv | Métodos y medios para la producción de moléculas heterodiméricas similares a Ig |
| MX356749B (es) | 2012-04-27 | 2018-06-12 | Daiichi Sankyo Co Ltd | Anticuerpo anti-homologo 4 de roundabout (robo4). |
| WO2013164689A2 (en) | 2012-05-02 | 2013-11-07 | Lantto, Johan | Humanized pan-her antibody compositions |
| JP2015163047A (ja) * | 2012-06-20 | 2015-09-10 | 国立大学法人 東京大学 | タンパク質の迅速改良法 |
| CN104736174B (zh) | 2012-07-06 | 2019-06-14 | 根马布私人有限公司 | 具有三重突变的二聚体蛋白质 |
| US10358492B2 (en) | 2012-09-27 | 2019-07-23 | Merus N.V. | Bispecific IgG antibodies as T cell engagers |
| JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス， インコーポレイテッド | トランスサイレチン抗体およびその使用 |
| EP3061818B1 (en) | 2013-09-30 | 2020-12-16 | Daiichi Sankyo Company, Limited | Anti-lps o11 antibody |
| ES2768618T3 (es) | 2013-10-08 | 2020-06-23 | Daiichi Sankyo Co Ltd | Combinación de anticuerpo anti-FGFR2 y otro agente |
| WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
| SG11201607109QA (en) | 2014-02-28 | 2016-09-29 | Merus Nv | Antibodies that bind egfr and erbb3 |
| SI3110849T1 (sl) | 2014-02-28 | 2021-01-29 | Merus N.V. | Protitelo, ki veže ERBB-2 in ERBB-3 |
| WO2016042412A1 (en) | 2014-09-16 | 2016-03-24 | Symphogen A/S | Anti-met antibodies and compositions |
| EP3273994B1 (en) | 2015-03-27 | 2021-12-01 | University of Southern California | Car t-cell therapy directed to lhr for the treatment of solid tumors |
| CN107847601A (zh) | 2015-06-04 | 2018-03-27 | 南加利福尼亚大学 | Lym‑1和lym‑2靶向的car细胞免疫疗法 |
| EP3345928B1 (en) | 2015-07-10 | 2020-06-24 | Merus N.V. | Human cd3 binding antibody |
| JP7054924B2 (ja) | 2015-09-23 | 2022-04-15 | サイトイミューン セラピューティクス， インコーポレイテッド | 免疫療法のためのｆｌｔ３指向ｃａｒ細胞 |
| JP6878283B2 (ja) | 2015-09-24 | 2021-05-26 | 第一三共株式会社 | 抗ｇａｒｐ抗体 |
| BR112018008068A2 (en) | 2015-10-23 | 2018-11-13 | Merus N.V. | binding molecules that inhibit cancer growth |
| CA3025162A1 (en) | 2016-05-26 | 2017-11-30 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| EP4606383A3 (en) | 2016-12-22 | 2025-12-17 | Daiichi Sankyo Company, Limited | Anti-cd3 antibody and molecules comprising the antibody |
| SG11201907321TA (en) | 2017-02-07 | 2019-09-27 | Daiichi Sankyo Co Ltd | Anti-gprc5d antibody and molecule comprising the antibody |
| TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗ｇｐｒ２０抗體、其製造方法及其應用 |
| CA3058343A1 (en) | 2017-03-31 | 2018-10-04 | Merus N.V. | Erbb-2 and erbb-3 binding bispecific antibodies for use in the treatment of cells that have an nrg1 fusion gene |
| CN110621698B (zh) | 2017-04-05 | 2024-04-12 | 法国施维雅药厂 | 靶向pd-1、tim-3及lag-3的组合疗法 |
| US12195551B2 (en) | 2017-05-17 | 2025-01-14 | Merus N.V. | Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer |
| US20200115446A1 (en) | 2017-06-30 | 2020-04-16 | National University Corporation Hokkaido University | Pediatric osteoporosis drug that does not cause growth disorder |
| JP7271424B2 (ja) | 2017-07-27 | 2023-05-11 | 第一三共株式会社 | 抗ｃｄ１４７抗体 |
| HUE071182T2 (hu) | 2017-08-09 | 2025-08-28 | Merus Nv | EGFR és CMET kötõ antitestek |
| CN111447952A (zh) | 2017-10-05 | 2020-07-24 | 第一三共株式会社 | 用于细胞毒性t细胞耗竭的组合物 |
| AU2018383600B2 (en) | 2017-12-11 | 2025-10-02 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| CN111836643A (zh) | 2018-03-05 | 2020-10-27 | 学校法人埼玉医科大学 | 用于治疗或预防异位骨化的药物组合物 |
| JP6790307B2 (ja) | 2018-05-31 | 2020-11-25 | 第一三共株式会社 | 抗ヒトｔｌｒ７抗体 |
| MA52945A (fr) | 2018-06-22 | 2021-04-28 | Genmab As | Procédé de production d'un mélange contrôlé d'au moins deux anticorps différents |
| CN112673023B (zh) | 2018-07-10 | 2023-09-12 | 国立大学法人神户大学 | 抗SIRPα抗体 |
| TWI846717B (zh) | 2018-07-27 | 2024-07-01 | 日商第一三共股份有限公司 | 辨識抗體-藥物結合物之藥物部位的蛋白質 |
| SG11202103334YA (en) * | 2018-10-26 | 2021-05-28 | Hoffmann La Roche | Multispecific antibody screening method using recombinase mediated cassette exchange |
| WO2021020282A1 (ja) | 2019-07-26 | 2021-02-04 | 学校法人埼玉医科大学 | Ａｌｋ２／ａｃｖｒ１の細胞外領域を認識する抗体 |
| WO2021079958A1 (ja) | 2019-10-25 | 2021-04-29 | 第一三共株式会社 | 抗ｇａｒｐ抗体と免疫調節剤の組み合わせ |
| WO2021136835A1 (en) | 2019-12-31 | 2021-07-08 | Antagonis | Compositions and methods for the prevention of s. aureus infection |
| CA3177152A1 (en) | 2020-06-12 | 2021-12-16 | David Scott Johnson | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| WO2022031834A1 (en) | 2020-08-05 | 2022-02-10 | Gigagen, Inc. | Recombinant polyclonal proteins targeting zika and methods of use thereof |
| US11975066B2 (en) | 2020-08-31 | 2024-05-07 | SAB Biotherapeutics, Inc. | Ungulate-derived polyclonal immunoglobulin specific for coronavirus protein and uses thereof |
| WO2024240634A1 (en) | 2023-05-19 | 2024-11-28 | Les Laboratoires Servier | Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof |
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| US155114A (en) * | 1874-09-15 | Improvement in methods of laying and forming cast-iron pipes | ||
| CA1293460C (en) * | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
| WO1991016074A1 (en) | 1990-04-19 | 1991-10-31 | Medimmune, Inc. | Administration of monoclonal antibodies against respiratory viruses |
| GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
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| DK1231268T3 (da) * | 1994-01-31 | 2005-11-21 | Univ Boston | Polyklonale antistofbiblioteker |
| US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
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| EP1337631A2 (en) * | 2000-11-28 | 2003-08-27 | Applied Molecular Evolution, Inc. | Eukaryotic expression libraries based on double lox recombination and methods of use |
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| CA2512647C (en) | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
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| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| AR047440A1 (es) | 2004-01-21 | 2006-01-18 | Novozymes As | Produccion de un anticuerpo monoclonal en un hongo heterocarion o una celula huesped fungal |
| BRPI0513706A (pt) | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| RU2426795C2 (ru) | 2004-07-20 | 2011-08-20 | Симфоген А/С | Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| TW200846362A (en) | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| NZ581316A (en) | 2007-05-25 | 2012-02-24 | Symphogen As | Method for manufacturing a recombinant polyclonal protein |
-
2004
- 2004-01-07 CA CA2512647A patent/CA2512647C/en not_active Expired - Fee Related
- 2004-01-07 PT PT04700438T patent/PT1583830E/pt unknown
- 2004-01-07 AU AU2004203727A patent/AU2004203727C1/en not_active Ceased
- 2004-01-07 EP EP06018504A patent/EP1762617A1/en not_active Withdrawn
- 2004-01-07 DK DK04700438T patent/DK1583830T3/da active
- 2004-01-07 AT AT04700438T patent/ATE338816T1/de active
- 2004-01-07 NZ NZ541458A patent/NZ541458A/en not_active IP Right Cessation
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- 2004-01-07 JP JP2006500508A patent/JP4589914B2/ja not_active Expired - Fee Related
- 2004-01-07 WO PCT/DK2004/000001 patent/WO2004061104A2/en not_active Ceased
- 2004-01-07 SI SI200430074T patent/SI1583830T1/sl unknown
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- 2004-01-07 MX MXPA05006724A patent/MXPA05006724A/es active IP Right Grant
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2005
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2008
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2010
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