JP2006515520A5 - - Google Patents
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- JP2006515520A5 JP2006515520A5 JP2006500508A JP2006500508A JP2006515520A5 JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5 JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006500508 A JP2006500508 A JP 2006500508A JP 2006515520 A5 JP2006515520 A5 JP 2006515520A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- collection
- library
- polyclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 74
- 238000000034 method Methods 0.000 claims 59
- 150000007523 nucleic acids Chemical group 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 31
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 239000013598 vector Substances 0.000 claims 16
- 238000004519 manufacturing process Methods 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 9
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091026890 Coding region Proteins 0.000 claims 6
- 238000012216 screening Methods 0.000 claims 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
- 102000018120 Recombinases Human genes 0.000 claims 5
- 108010091086 Recombinases Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 238000002823 phage display Methods 0.000 claims 2
- 238000002702 ribosome display Methods 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43840303P | 2003-01-07 | 2003-01-07 | |
| DKPA200300008 | 2003-01-07 | ||
| US47601803P | 2003-06-05 | 2003-06-05 | |
| PCT/DK2004/000001 WO2004061104A2 (en) | 2003-01-07 | 2004-01-07 | Method for manufacturing recombinant polyclonal proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Division JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515520A JP2006515520A (ja) | 2006-06-01 |
| JP2006515520A5 true JP2006515520A5 (enExample) | 2007-01-11 |
| JP4589914B2 JP4589914B2 (ja) | 2010-12-01 |
Family
ID=32718469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500508A Expired - Fee Related JP4589914B2 (ja) | 2003-01-07 | 2004-01-07 | 組換え型ポリクローナルタンパク質の製造方法 |
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010155716A Pending JP2010268806A (ja) | 2003-01-07 | 2010-07-08 | 組換え型ポリクローナルタンパク質の製造方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9163232B2 (enExample) |
| EP (2) | EP1583830B1 (enExample) |
| JP (2) | JP4589914B2 (enExample) |
| KR (1) | KR101024443B1 (enExample) |
| AT (1) | ATE338816T1 (enExample) |
| AU (1) | AU2004203727C1 (enExample) |
| BR (1) | BRPI0406678A (enExample) |
| CA (1) | CA2512647C (enExample) |
| DE (1) | DE602004002275T2 (enExample) |
| DK (1) | DK1583830T3 (enExample) |
| EA (1) | EA013225B1 (enExample) |
| ES (1) | ES2273202T3 (enExample) |
| IL (1) | IL169101A (enExample) |
| MX (1) | MXPA05006724A (enExample) |
| NZ (1) | NZ541458A (enExample) |
| PT (1) | PT1583830E (enExample) |
| SI (1) | SI1583830T1 (enExample) |
| WO (1) | WO2004061104A2 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| EA013225B1 (ru) | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| JP4926054B2 (ja) * | 2004-07-20 | 2012-05-09 | シムフォゲン・アクティーゼルスカブ | 抗−ＲｈＤ組換えポリクローナル抗体及び製造方法 |
| ES2332524T3 (es) | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| EP1907561B1 (en) * | 2005-06-24 | 2013-08-28 | Unigene Laboratories, Inc. | Cell lines for expressing enzyme useful in the preparation of amidated products |
| WO2007065433A2 (en) | 2005-12-05 | 2007-06-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| US20100040606A1 (en) * | 2006-03-06 | 2010-02-18 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| FR2910490B1 (fr) * | 2006-12-20 | 2012-10-26 | Lab Francais Du Fractionnement | Lignee cellulaire a forte activite transcriptionnelle pour la production de proteines, notamment therapeutiques |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| WO2008097926A2 (en) * | 2007-02-02 | 2008-08-14 | Yale University | Transient transfection with rna |
| TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| NZ578851A (en) | 2007-03-01 | 2011-09-30 | Symphogen As | Method for cloning cognate antibodies |
| CA2678628A1 (en) * | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
| BRPI0812091A2 (pt) | 2007-05-25 | 2014-10-14 | Symphogen As | Método para fabricar uma proteína policlonal recombinante |
| WO2009028639A1 (ja) | 2007-08-30 | 2009-03-05 | Daiichi Sankyo Company, Limited | 抗ｅｐｈａ２抗体 |
| WO2009046168A1 (en) | 2007-10-02 | 2009-04-09 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| CN108130327A (zh) | 2007-10-11 | 2018-06-08 | 第三共株式会社 | 靶向破骨细胞相关蛋白Siglec-15的抗体 |
| RU2010147652A (ru) * | 2008-04-23 | 2012-05-27 | Симфоген А/С (Dk) | Способы производства поликлонального белка |
| CA2735020A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
| MX2011001927A (es) | 2008-08-29 | 2011-04-21 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| EP2377932B1 (en) | 2009-04-09 | 2020-11-18 | Daiichi Sankyo Company, Limited | ANTI-Siglec-15 ANTIBODY |
| AU2010306563B2 (en) | 2009-10-15 | 2013-11-28 | Circle 33, Llc | Antibody therapeutics with local activity in the digestive tract |
| BR112013010574A2 (pt) | 2010-10-29 | 2016-08-09 | Daiichi Sankyo Co Ltd | anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo |
| WO2012059857A2 (en) | 2010-11-01 | 2012-05-10 | Symphogen A/S | Pan-her antibody composition |
| JP6092782B2 (ja) * | 2010-11-16 | 2017-03-08 | エクセリミューン， インコーポレイテッド | 組換えタンパク質の製造方法 |
| EP2703486B1 (en) | 2011-04-25 | 2018-03-07 | Daiichi Sankyo Company, Limited | Anti-b7-h3 antibody |
| CN107881196A (zh) | 2011-12-22 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 表达载体组织、新的生产用细胞产生方法及其在重组产生多肽中的用途 |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US9464133B2 (en) | 2012-03-30 | 2016-10-11 | Daiichi Sankyo Company, Limited | CDR-modified anti-Siglec-15 antibody |
| JPWO2013147212A1 (ja) | 2012-03-30 | 2015-12-14 | 第一三共株式会社 | 新規抗Ｓｉｇｌｅｃ−１５抗体 |
| AU2013247645B2 (en) | 2012-04-09 | 2019-02-14 | Daiichi Sankyo Company, Limited | Anti-FGFR2 antibody |
| WO2013157953A1 (en) | 2012-04-20 | 2013-10-24 | Merus B.V. | Methods and means for the production of ig-like molecules |
| IN2014DN07799A (enExample) | 2012-04-27 | 2015-05-15 | Daiichi Sankyo Co Ltd | |
| HK1202431A1 (en) | 2012-05-02 | 2015-10-02 | Symphogen A/S | Humanized pan-her antibody compositions |
| JP2015163047A (ja) * | 2012-06-20 | 2015-09-10 | 国立大学法人 東京大学 | タンパク質の迅速改良法 |
| WO2014006217A1 (en) | 2012-07-06 | 2014-01-09 | Genmab B.V. | Dimeric protein with triple mutations |
| BR112015006824A2 (pt) | 2012-09-27 | 2017-07-04 | Merus B V | anticorpo igg biespecífico, método para produzir um anticorpo igg biespecífico, anticorpo, composição farmacêutica e uso de um anticorpo igg biespecífico |
| JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス， インコーポレイテッド | トランスサイレチン抗体およびその使用 |
| CA2925897A1 (en) | 2013-09-30 | 2015-04-02 | Daiichi Sankyo Company, Limited | Anti-lps o11 antibody |
| CN105792844B (zh) | 2013-10-08 | 2021-03-02 | 第一三共株式会社 | 抗fgfr2抗体和另一药剂的组合 |
| WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
| DK3805268T3 (da) | 2014-02-28 | 2025-01-20 | Merus Nv | Antistof, der binder erbb-2 og erbb-3 |
| CA2941030C (en) | 2014-02-28 | 2025-05-13 | Merus N.V. | ANTIBODIES THAT BIND TO EGFR AND ERBB3 |
| MX378108B (es) | 2014-09-16 | 2025-03-10 | Servier Lab | Anticuerpos anti-met y composiciones. |
| EP3273994B1 (en) | 2015-03-27 | 2021-12-01 | University of Southern California | Car t-cell therapy directed to lhr for the treatment of solid tumors |
| CA2987992A1 (en) | 2015-06-04 | 2016-12-08 | University Of Southern California | Lym-1 and lym-2 targeted car cell immunotherapy |
| WO2017010874A1 (en) | 2015-07-10 | 2017-01-19 | Merus N.V. | Human cd3 binding antibody |
| JP7054924B2 (ja) | 2015-09-23 | 2022-04-15 | サイトイミューン セラピューティクス， インコーポレイテッド | 免疫療法のためのｆｌｔ３指向ｃａｒ細胞 |
| CN110922481A (zh) | 2015-09-24 | 2020-03-27 | 第一三共株式会社 | 抗garp抗体 |
| JP7296728B2 (ja) | 2015-10-23 | 2023-06-23 | メルス ナムローゼ フェンノートシャップ | 癌の成長を抑制する結合分子 |
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| CA3025162A1 (en) * | 2016-05-26 | 2017-11-30 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| CN118126180A (zh) | 2016-12-22 | 2024-06-04 | 第一三共株式会社 | 抗cd3抗体和包含所述抗体的分子 |
| TW201837174A (zh) | 2017-02-07 | 2018-10-16 | 日商第一三共股份有限公司 | 抗ｇｐｒｃ５ｄ抗體及包含該抗體之分子 |
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| JP7737220B2 (ja) | 2017-03-31 | 2025-09-10 | メルス ナムローゼ フェンノートシャップ | ＮＲＧ１融合遺伝子を有する細胞の処置における使用のためのＥｒｂＢ－２及びＥｒｂＢ３結合二重特異性抗体 |
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| US20200115446A1 (en) | 2017-06-30 | 2020-04-16 | National University Corporation Hokkaido University | Pediatric osteoporosis drug that does not cause growth disorder |
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| CN111836643A (zh) | 2018-03-05 | 2020-10-27 | 学校法人埼玉医科大学 | 用于治疗或预防异位骨化的药物组合物 |
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| EP3831853A4 (en) | 2018-07-27 | 2022-06-01 | Daiichi Sankyo Company, Limited | ANTIBODY-DRUG CONJUGATE PROTEIN-RECOGNIZING DRUG UNIT |
| KR102559149B1 (ko) * | 2018-10-26 | 2023-07-24 | 에프. 호프만-라 로슈 아게 | 재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법 |
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| EP4008350A4 (en) | 2019-07-26 | 2023-06-14 | Saitama Medical University | ANTIBODY RECOGNIZING THE EXTRACELLULAR REGION OF ALK2/ACVR1 |
| CN114630679A (zh) | 2019-10-25 | 2022-06-14 | 第一三共株式会社 | 抗garp抗体和免疫调节剂的组合 |
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| JP2007535913A (ja) | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| ES2332524T3 (es) | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| JP4926054B2 (ja) | 2004-07-20 | 2012-05-09 | シムフォゲン・アクティーゼルスカブ | 抗−ＲｈＤ組換えポリクローナル抗体及び製造方法 |
| WO2007065433A2 (en) | 2005-12-05 | 2007-06-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| US20100040606A1 (en) | 2006-03-06 | 2010-02-18 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| TW200846362A (en) | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
| BRPI0812091A2 (pt) | 2007-05-25 | 2014-10-14 | Symphogen As | Método para fabricar uma proteína policlonal recombinante |
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2004
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