JP2011504721A5 - - Google Patents
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- Publication number
- JP2011504721A5 JP2011504721A5 JP2010509679A JP2010509679A JP2011504721A5 JP 2011504721 A5 JP2011504721 A5 JP 2011504721A5 JP 2010509679 A JP2010509679 A JP 2010509679A JP 2010509679 A JP2010509679 A JP 2010509679A JP 2011504721 A5 JP2011504721 A5 JP 2011504721A5
- Authority
- JP
- Japan
- Prior art keywords
- polyclonal
- cells
- protein
- cell line
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 59
- 238000000034 method Methods 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 27
- 108090000623 proteins and genes Proteins 0.000 claims 27
- 239000013604 expression vector Substances 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000001890 transfection Methods 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700764 | 2007-05-25 | ||
| DKPA200700764 | 2007-05-25 | ||
| US92470807P | 2007-05-29 | 2007-05-29 | |
| US60/924,708 | 2007-05-29 | ||
| DKPA200701292 | 2007-09-07 | ||
| DKPA200701292 | 2007-09-07 | ||
| US96000207P | 2007-09-11 | 2007-09-11 | |
| US60/960,002 | 2007-09-11 | ||
| PCT/DK2008/050116 WO2008145133A2 (en) | 2007-05-25 | 2008-05-21 | Method for manufacturing a recombinant polyclonal protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191912A Division JP2015037411A (ja) | 2007-05-25 | 2014-09-19 | 組み換えポリクローナルタンパク質を製造する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011504721A JP2011504721A (ja) | 2011-02-17 |
| JP2011504721A5 true JP2011504721A5 (enExample) | 2011-07-07 |
| JP5941616B2 JP5941616B2 (ja) | 2016-06-29 |
Family
ID=39739965
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509679A Expired - Fee Related JP5941616B2 (ja) | 2007-05-25 | 2008-05-21 | 組み換えポリクローナルタンパク質を製造する方法 |
| JP2014191912A Pending JP2015037411A (ja) | 2007-05-25 | 2014-09-19 | 組み換えポリクローナルタンパク質を製造する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191912A Pending JP2015037411A (ja) | 2007-05-25 | 2014-09-19 | 組み換えポリクローナルタンパク質を製造する方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7910332B2 (enExample) |
| EP (1) | EP2152872B1 (enExample) |
| JP (2) | JP5941616B2 (enExample) |
| KR (1) | KR101555658B1 (enExample) |
| CN (1) | CN101688204B (enExample) |
| AT (1) | ATE481483T1 (enExample) |
| AU (1) | AU2008255383B2 (enExample) |
| BR (1) | BRPI0812091A2 (enExample) |
| CA (1) | CA2683800C (enExample) |
| CY (1) | CY1110939T1 (enExample) |
| DE (1) | DE602008002593D1 (enExample) |
| DK (1) | DK2152872T3 (enExample) |
| HR (1) | HRP20100640T1 (enExample) |
| IL (1) | IL201395A (enExample) |
| MX (1) | MX2009012526A (enExample) |
| NZ (1) | NZ581316A (enExample) |
| PL (1) | PL2152872T3 (enExample) |
| PT (1) | PT2152872E (enExample) |
| SI (1) | SI2152872T1 (enExample) |
| TW (1) | TW200902548A (enExample) |
| WO (1) | WO2008145133A2 (enExample) |
| ZA (1) | ZA200908021B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2512647C (en) | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
| MX2009008908A (es) * | 2007-03-01 | 2009-08-28 | Symphogen As | Metodo para clonacion de anticuerpos analogos. |
| NZ581316A (en) * | 2007-05-25 | 2012-02-24 | Symphogen As | Method for manufacturing a recombinant polyclonal protein |
| CN101821289A (zh) * | 2007-09-07 | 2010-09-01 | 西福根有限公司 | 重组制造抗rsv抗体的方法 |
| CA2713885A1 (en) * | 2008-02-01 | 2009-08-20 | Chromocell Corporation | Novel cell lines and methods |
| EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
| BRPI0910454A2 (pt) * | 2008-04-23 | 2018-03-27 | Symphogen As | processo para produção de uma proteína policlonal |
| EP2297331B1 (en) * | 2008-05-28 | 2015-03-25 | Bayer HealthCare, LLC | Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells |
| MX2011001930A (es) * | 2008-08-29 | 2011-04-21 | Symphogen As | Metodo para clonar anticuerpos derivados de aves. |
| DK2393927T3 (en) | 2009-02-09 | 2015-03-30 | Morphosys Ag | Preparation of oligoclonal mixtures of antibodies in the individual cells |
| ES2692379T3 (es) | 2010-11-01 | 2018-12-03 | Symphogen A/S | Anticuerpos anti-HER3 y composiciones |
| CA2817751C (en) | 2010-11-16 | 2019-04-30 | Excelimmune, Inc. | Methods for producing recombinant proteins |
| CN102558353A (zh) * | 2011-12-09 | 2012-07-11 | 上海应用技术学院 | 一种大肠杆菌NrfA基因表达蛋白多克隆抗体及其制备方法 |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| WO2013164689A2 (en) | 2012-05-02 | 2013-11-07 | Lantto, Johan | Humanized pan-her antibody compositions |
| JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス, インコーポレイテッド | トランスサイレチン抗体およびその使用 |
| WO2016042412A1 (en) | 2014-09-16 | 2016-03-24 | Symphogen A/S | Anti-met antibodies and compositions |
| US12404552B2 (en) * | 2015-07-17 | 2025-09-02 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods of selecting antibodies and antibody fragments |
| JP2019501658A (ja) * | 2016-01-14 | 2019-01-24 | アントン バウアーAnton Bauer | 生産用細胞株を作製する方法 |
| WO2018073393A2 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
| CN110621698B (zh) | 2017-04-05 | 2024-04-12 | 法国施维雅药厂 | 靶向pd-1、tim-3及lag-3的组合疗法 |
| MA52945A (fr) | 2018-06-22 | 2021-04-28 | Genmab As | Procédé de production d'un mélange contrôlé d'au moins deux anticorps différents |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| CN109988751A (zh) * | 2019-01-15 | 2019-07-09 | 济宁学院 | 一种用于制备抗egfr全人源化单克隆抗体的细胞株构建方法 |
| AU2020264492A1 (en) * | 2019-04-30 | 2021-10-14 | Gigagen, Inc. | Recombinant polyclonal proteins and methods of use thereof |
| WO2021058709A1 (en) * | 2019-09-27 | 2021-04-01 | Glaxosmithkline Intellectual Property Development Limited | Method of predicting production stability of clonal cell lines |
| CA3177152A1 (en) | 2020-06-12 | 2021-12-16 | David Scott Johnson | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| WO2024240634A1 (en) | 2023-05-19 | 2024-11-28 | Les Laboratoires Servier | Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016074A1 (en) | 1990-04-19 | 1991-10-31 | Medimmune, Inc. | Administration of monoclonal antibodies against respiratory viruses |
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| WO2001094571A1 (fr) * | 2000-06-08 | 2001-12-13 | Mitsubishi Pharma Corporation | Vecteur d'expression permettant le criblage de cellules a haute expression de proteine de recombinaison, transformant a haute expression de proteine de recombinaison, et leur utilisation |
| US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
| SI1523496T1 (sl) * | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| US20040115814A1 (en) * | 2002-09-30 | 2004-06-17 | Protein Design Labs, Inc. | Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes |
| CN100383244C (zh) * | 2003-01-07 | 2008-04-23 | 西福根有限公司 | 用于生产重组多克隆蛋白质的方法 |
| CA2512647C (en) * | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
| US20060275766A1 (en) | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| BRPI0513706A (pt) * | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| RU2426795C2 (ru) * | 2004-07-20 | 2011-08-20 | Симфоген А/С | Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| NZ581316A (en) * | 2007-05-25 | 2012-02-24 | Symphogen As | Method for manufacturing a recombinant polyclonal protein |
-
2008
- 2008-05-21 NZ NZ581316A patent/NZ581316A/en not_active IP Right Cessation
- 2008-05-21 AT AT08748815T patent/ATE481483T1/de active
- 2008-05-21 AU AU2008255383A patent/AU2008255383B2/en not_active Ceased
- 2008-05-21 MX MX2009012526A patent/MX2009012526A/es active IP Right Grant
- 2008-05-21 BR BRPI0812091-9A2A patent/BRPI0812091A2/pt not_active Application Discontinuation
- 2008-05-21 SI SI200830107T patent/SI2152872T1/sl unknown
- 2008-05-21 CN CN2008800174383A patent/CN101688204B/zh not_active Expired - Fee Related
- 2008-05-21 DK DK08748815.1T patent/DK2152872T3/da active
- 2008-05-21 PT PT08748815T patent/PT2152872E/pt unknown
- 2008-05-21 WO PCT/DK2008/050116 patent/WO2008145133A2/en not_active Ceased
- 2008-05-21 JP JP2010509679A patent/JP5941616B2/ja not_active Expired - Fee Related
- 2008-05-21 DE DE602008002593T patent/DE602008002593D1/de active Active
- 2008-05-21 PL PL08748815T patent/PL2152872T3/pl unknown
- 2008-05-21 HR HR20100640T patent/HRP20100640T1/hr unknown
- 2008-05-21 EP EP08748815A patent/EP2152872B1/en not_active Not-in-force
- 2008-05-21 KR KR1020097027038A patent/KR101555658B1/ko not_active Expired - Fee Related
- 2008-05-21 CA CA2683800A patent/CA2683800C/en not_active Expired - Fee Related
- 2008-05-23 TW TW097119118A patent/TW200902548A/zh unknown
- 2008-05-23 US US12/153,809 patent/US7910332B2/en not_active Expired - Fee Related
-
2009
- 2009-10-11 IL IL201395A patent/IL201395A/en active IP Right Grant
- 2009-11-13 ZA ZA2009/08021A patent/ZA200908021B/en unknown
-
2010
- 2010-11-24 CY CY20101101058T patent/CY1110939T1/el unknown
-
2014
- 2014-09-19 JP JP2014191912A patent/JP2015037411A/ja active Pending
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