JP2020509763A5 - - Google Patents

Info

Publication number

JP2020509763A5

JP2020509763A5 JP2019549562A JP2019549562A JP2020509763A5 JP 2020509763 A5 JP2020509763 A5 JP 2020509763A5 JP 2019549562 A JP2019549562 A JP 2019549562A JP 2019549562 A JP2019549562 A JP 2019549562A JP 2020509763 A5 JP2020509763 A5 JP 2020509763A5

Authority

JP

Japan

Prior art keywords

nucleic acid

acid construct

host cell

nucleotide sequence

exogenous nucleic

Prior art date

2018-03-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108020004707 nucleic acids Proteins 0.000 claims 35
• 102000039446 nucleic acids Human genes 0.000 claims 35
• 150000007523 nucleic acids Chemical class 0.000 claims 35
• 210000004027 cell Anatomy 0.000 claims 25
• 239000002773 nucleotide Substances 0.000 claims 18
• 125000003729 nucleotide group Chemical group 0.000 claims 18
• 229920001184 polypeptide Polymers 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 8
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 7
• 238000000034 method Methods 0.000 claims 7
• 230000002950 deficient Effects 0.000 claims 6
• 210000000349 chromosome Anatomy 0.000 claims 5
• 239000002609 medium Substances 0.000 claims 5
• 101150116046 PCBD1 gene Proteins 0.000 claims 4
• 101150036331 pah gene Proteins 0.000 claims 4
• 239000006143 cell culture medium Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
• 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 108010069013 Phenylalanine Hydroxylase Proteins 0.000 claims 2
• 102100038223 Phenylalanine-4-hydroxylase Human genes 0.000 claims 2
• 102100029333 Pterin-4-alpha-carbinolamine dehydratase Human genes 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 210000004962 mammalian cell Anatomy 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 108010016842 pterin-4a-carbinolamine dehydratase Proteins 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000699802 Cricetulus griseus Species 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 238000005215 recombination Methods 0.000 claims 1
• 230000006798 recombination Effects 0.000 claims 1
• 108091008146 restriction endonucleases Proteins 0.000 claims 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1