KR101555658B1 - 재조합 폴리클로날 단백질의 제조 방법 - Google Patents

재조합 폴리클로날 단백질의 제조 방법 Download PDF

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KR101555658B1
KR101555658B1 KR1020097027038A KR20097027038A KR101555658B1 KR 101555658 B1 KR101555658 B1 KR 101555658B1 KR 1020097027038 A KR1020097027038 A KR 1020097027038A KR 20097027038 A KR20097027038 A KR 20097027038A KR 101555658 B1 KR101555658 B1 KR 101555658B1
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polyclonal
cells
cell
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protein
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Korean (ko)
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KR20100017923A (ko
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라르스 소에가아르트 니엘센
디트마르 웨일쿠니
안네 본트가아르트 톨스트럽
핀 비베르그
크리스티안 뮐러
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심포젠 에이/에스
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Non-Volatile Memory (AREA)
KR1020097027038A 2007-05-25 2008-05-21 재조합 폴리클로날 단백질의 제조 방법 Expired - Fee Related KR101555658B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DKPA200700764 2007-05-25
DKPA200700764 2007-05-25
US92470807P 2007-05-29 2007-05-29
US60/924,708 2007-05-29
DKPA200701292 2007-09-07
DKPA200701292 2007-09-07
US96000207P 2007-09-11 2007-09-11
US60/960,002 2007-09-11

Publications (2)

Publication Number Publication Date
KR20100017923A KR20100017923A (ko) 2010-02-16
KR101555658B1 true KR101555658B1 (ko) 2015-09-24

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KR1020097027038A Expired - Fee Related KR101555658B1 (ko) 2007-05-25 2008-05-21 재조합 폴리클로날 단백질의 제조 방법

Country Status (22)

Country Link
US (1) US7910332B2 (enExample)
EP (1) EP2152872B1 (enExample)
JP (2) JP5941616B2 (enExample)
KR (1) KR101555658B1 (enExample)
CN (1) CN101688204B (enExample)
AT (1) ATE481483T1 (enExample)
AU (1) AU2008255383B2 (enExample)
BR (1) BRPI0812091A2 (enExample)
CA (1) CA2683800C (enExample)
CY (1) CY1110939T1 (enExample)
DE (1) DE602008002593D1 (enExample)
DK (1) DK2152872T3 (enExample)
HR (1) HRP20100640T1 (enExample)
IL (1) IL201395A (enExample)
MX (1) MX2009012526A (enExample)
NZ (1) NZ581316A (enExample)
PL (1) PL2152872T3 (enExample)
PT (1) PT2152872E (enExample)
SI (1) SI2152872T1 (enExample)
TW (1) TW200902548A (enExample)
WO (1) WO2008145133A2 (enExample)
ZA (1) ZA200908021B (enExample)

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CA2512647C (en) 2003-01-07 2013-10-08 Symphogen A/S Method for manufacturing recombinant polyclonal proteins
MX2009008908A (es) * 2007-03-01 2009-08-28 Symphogen As Metodo para clonacion de anticuerpos analogos.
NZ581316A (en) * 2007-05-25 2012-02-24 Symphogen As Method for manufacturing a recombinant polyclonal protein
CN101821289A (zh) * 2007-09-07 2010-09-01 西福根有限公司 重组制造抗rsv抗体的方法
CA2713885A1 (en) * 2008-02-01 2009-08-20 Chromocell Corporation Novel cell lines and methods
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
BRPI0910454A2 (pt) * 2008-04-23 2018-03-27 Symphogen As processo para produção de uma proteína policlonal
EP2297331B1 (en) * 2008-05-28 2015-03-25 Bayer HealthCare, LLC Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells
MX2011001930A (es) * 2008-08-29 2011-04-21 Symphogen As Metodo para clonar anticuerpos derivados de aves.
DK2393927T3 (en) 2009-02-09 2015-03-30 Morphosys Ag Preparation of oligoclonal mixtures of antibodies in the individual cells
ES2692379T3 (es) 2010-11-01 2018-12-03 Symphogen A/S Anticuerpos anti-HER3 y composiciones
CA2817751C (en) 2010-11-16 2019-04-30 Excelimmune, Inc. Methods for producing recombinant proteins
CN102558353A (zh) * 2011-12-09 2012-07-11 上海应用技术学院 一种大肠杆菌NrfA基因表达蛋白多克隆抗体及其制备方法
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
WO2013164689A2 (en) 2012-05-02 2013-11-07 Lantto, Johan Humanized pan-her antibody compositions
JP2016514091A (ja) 2013-02-08 2016-05-19 ミスフォールディング ダイアグノスティクス， インコーポレイテッド トランスサイレチン抗体およびその使用
WO2016042412A1 (en) 2014-09-16 2016-03-24 Symphogen A/S Anti-met antibodies and compositions
US12404552B2 (en) * 2015-07-17 2025-09-02 Allele Biotechnology & Pharmaceuticals, Inc. Methods of selecting antibodies and antibody fragments
JP2019501658A (ja) * 2016-01-14 2019-01-24 アントン バウアーＡｎｔｏｎ Ｂａｕｅｒ 生産用細胞株を作製する方法
WO2018073393A2 (en) 2016-10-19 2018-04-26 Cellectis Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
CN110621698B (zh) 2017-04-05 2024-04-12 法国施维雅药厂 靶向pd-1、tim-3及lag-3的组合疗法
MA52945A (fr) 2018-06-22 2021-04-28 Genmab As Procédé de production d'un mélange contrôlé d'au moins deux anticorps différents
CA3118692A1 (en) 2018-11-06 2020-05-14 Alsatech, Inc. Cell-based gene therapy for neurodegenerative diseases
CN109988751A (zh) * 2019-01-15 2019-07-09 济宁学院 一种用于制备抗egfr全人源化单克隆抗体的细胞株构建方法
AU2020264492A1 (en) * 2019-04-30 2021-10-14 Gigagen, Inc. Recombinant polyclonal proteins and methods of use thereof
WO2021058709A1 (en) * 2019-09-27 2021-04-01 Glaxosmithkline Intellectual Property Development Limited Method of predicting production stability of clonal cell lines
CA3177152A1 (en) 2020-06-12 2021-12-16 David Scott Johnson Recombinant polyclonal proteins targeting covid-19 and methods of use thereof
WO2024240634A1 (en) 2023-05-19 2024-11-28 Les Laboratoires Servier Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof

Citations (1)

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WO2004029284A3 (en) 2002-09-30 2005-05-12 Protein Design Labs Inc Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes

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WO1991016074A1 (en) 1990-04-19 1991-10-31 Medimmune, Inc. Administration of monoclonal antibodies against respiratory viruses
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
WO2001094571A1 (fr) * 2000-06-08 2001-12-13 Mitsubishi Pharma Corporation Vecteur d'expression permettant le criblage de cellules a haute expression de proteine de recombinaison, transformant a haute expression de proteine de recombinaison, et leur utilisation
US6849259B2 (en) 2000-06-16 2005-02-01 Symphogen A/S Polyclonal antibody composition for treating allergy
SI1523496T1 (sl) * 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
CN100383244C (zh) * 2003-01-07 2008-04-23 西福根有限公司 用于生产重组多克隆蛋白质的方法
CA2512647C (en) * 2003-01-07 2013-10-08 Symphogen A/S Method for manufacturing recombinant polyclonal proteins
US20060275766A1 (en) 2003-01-07 2006-12-07 Haurum John S Method for manufacturing recombinant polyclonal proteins
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
BRPI0513706A (pt) * 2004-07-20 2008-05-13 Symphogen As anticorpo policlonal recombinante anti-rhesus d e métodos de produção
RU2426795C2 (ru) * 2004-07-20 2011-08-20 Симфоген А/С Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии
JP2009518320A (ja) 2005-12-05 2009-05-07 シュムフォウエン アクティーゼルスカブ 抗オルトポックスウイルス組換えポリクローナル抗体
KR20080113223A (ko) 2006-03-06 2008-12-29 심포젠 에이/에스 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체
NZ581316A (en) * 2007-05-25 2012-02-24 Symphogen As Method for manufacturing a recombinant polyclonal protein

Patent Citations (1)

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Publication number Publication date
AU2008255383B2 (en) 2012-11-01
BRPI0812091A2 (pt) 2014-10-14
JP2011504721A (ja) 2011-02-17
WO2008145133A3 (en) 2009-02-05
DE602008002593D1 (de) 2010-10-28
CA2683800A1 (en) 2008-12-04
PT2152872E (pt) 2010-11-17
WO2008145133A2 (en) 2008-12-04
US20090111142A1 (en) 2009-04-30
MX2009012526A (es) 2009-12-09
NZ581316A (en) 2012-02-24
CN101688204B (zh) 2013-07-03
ZA200908021B (en) 2010-11-24
TW200902548A (en) 2009-01-16
CN101688204A (zh) 2010-03-31
HK1134519A1 (en) 2010-04-30
EP2152872A2 (en) 2010-02-17
JP2015037411A (ja) 2015-02-26
CY1110939T1 (el) 2015-06-10
PL2152872T3 (pl) 2011-03-31
ATE481483T1 (de) 2010-10-15
JP5941616B2 (ja) 2016-06-29
SI2152872T1 (sl) 2011-01-31
IL201395A (en) 2015-09-24
DK2152872T3 (da) 2010-12-06
KR20100017923A (ko) 2010-02-16
US7910332B2 (en) 2011-03-22
EP2152872B1 (en) 2010-09-15
AU2008255383A1 (en) 2008-12-04
CA2683800C (en) 2015-03-17
HRP20100640T1 (hr) 2010-12-31
IL201395A0 (en) 2011-08-01

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