BRPI0812091A2 - Método para fabricar uma proteína policlonal recombinante - Google Patents
Método para fabricar uma proteína policlonal recombinanteInfo
- Publication number
- BRPI0812091A2 BRPI0812091A2 BRPI0812091-9A2A BRPI0812091A BRPI0812091A2 BR PI0812091 A2 BRPI0812091 A2 BR PI0812091A2 BR PI0812091 A BRPI0812091 A BR PI0812091A BR PI0812091 A2 BRPI0812091 A2 BR PI0812091A2
- Authority
- BR
- Brazil
- Prior art keywords
- collection
- cells
- manufacturing
- recombinant polyclonal
- polyclonal protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Non-Volatile Memory (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200700764 | 2007-05-25 | ||
DKPA200701292 | 2007-09-07 | ||
PCT/DK2008/050116 WO2008145133A2 (en) | 2007-05-25 | 2008-05-21 | Method for manufacturing a recombinant polyclonal protein |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0812091A2 true BRPI0812091A2 (pt) | 2014-10-14 |
Family
ID=39739965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0812091-9A2A BRPI0812091A2 (pt) | 2007-05-25 | 2008-05-21 | Método para fabricar uma proteína policlonal recombinante |
Country Status (23)
Country | Link |
---|---|
US (1) | US7910332B2 (pt) |
EP (1) | EP2152872B1 (pt) |
JP (2) | JP5941616B2 (pt) |
KR (1) | KR101555658B1 (pt) |
CN (1) | CN101688204B (pt) |
AT (1) | ATE481483T1 (pt) |
AU (1) | AU2008255383B2 (pt) |
BR (1) | BRPI0812091A2 (pt) |
CA (1) | CA2683800C (pt) |
CY (1) | CY1110939T1 (pt) |
DE (1) | DE602008002593D1 (pt) |
DK (1) | DK2152872T3 (pt) |
HK (1) | HK1134519A1 (pt) |
HR (1) | HRP20100640T1 (pt) |
IL (1) | IL201395A (pt) |
MX (1) | MX2009012526A (pt) |
NZ (1) | NZ581316A (pt) |
PL (1) | PL2152872T3 (pt) |
PT (1) | PT2152872E (pt) |
SI (1) | SI2152872T1 (pt) |
TW (1) | TW200902548A (pt) |
WO (1) | WO2008145133A2 (pt) |
ZA (1) | ZA200908021B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA05006724A (es) | 2003-01-07 | 2005-09-08 | Symphogen As | Metodo para producir proteinas policlonales recombinantes. |
ES2369946T3 (es) * | 2007-03-01 | 2011-12-09 | Symphogen A/S | Procedimiento para clonación de anticuerpos análogos. |
PL2152872T3 (pl) * | 2007-05-25 | 2011-03-31 | Symphogen As | Sposób wytwarzania rekombinowanego białka poliklonalnego |
RU2010113510A (ru) * | 2007-09-07 | 2011-10-20 | Симфоген А/С (Dk) | Способы рекомбинантной продукции антител против респираторно-цинцитиального вируса (rsv) |
CN101960014B (zh) * | 2008-02-01 | 2013-10-16 | 克罗莫塞尔公司 | 细胞系以及制备和使用其的方法 |
EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
BRPI0910454A2 (pt) * | 2008-04-23 | 2018-03-27 | Symphogen As | processo para produção de uma proteína policlonal |
CN102112622B (zh) * | 2008-05-28 | 2014-12-10 | 拜耳医药保健有限公司 | 用于在表达HBx的哺乳动物细胞中生产重组蛋白的方法和组合物 |
US20100069262A1 (en) * | 2008-08-29 | 2010-03-18 | Symphogen A/S | Method for Cloning Avian-Derived Antibodies |
US8551733B2 (en) | 2009-02-09 | 2013-10-08 | Morphosys Ag | Production of oligoclonal mixtures of immunoglobulins in single cells |
US9217039B2 (en) | 2010-11-01 | 2015-12-22 | Symphogen A/S | Anti-HER3 antibodies and compositions |
CA2817751C (en) * | 2010-11-16 | 2019-04-30 | Excelimmune, Inc. | Methods for producing recombinant proteins |
CN102558353A (zh) * | 2011-12-09 | 2012-07-11 | 上海应用技术学院 | 一种大肠杆菌NrfA基因表达蛋白多克隆抗体及其制备方法 |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
AU2013255537B2 (en) | 2012-05-02 | 2018-02-15 | Symphogen A/S | Humanized pan-her antibody compositions |
EP2953970A4 (en) | 2013-02-08 | 2016-06-29 | Misfolding Diagnostics Inc | TRANSTYRETIN ANTIBODIES AND USES THEREOF |
US10450376B2 (en) | 2014-09-16 | 2019-10-22 | Symphogen A/S | Anti-MET antibodies and compositions |
US20170044608A1 (en) * | 2015-07-17 | 2017-02-16 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods of selecting antibodies and antibody fragments |
KR20180096793A (ko) * | 2016-01-14 | 2018-08-29 | 안톤 바우어 | 생산 세포주를 제조하는 방법 |
WO2018073393A2 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
EA201992350A1 (ru) | 2017-04-05 | 2020-03-23 | Симфоген А/С | Комбинированные лекарственные средства, нацеленные на pd-1, tim-3 и lag-3 |
SG11202012713RA (en) | 2018-06-22 | 2021-01-28 | Genmab As | Method for producing a controlled mixture of two or more different antibodies |
CN109988751A (zh) * | 2019-01-15 | 2019-07-09 | 济宁学院 | 一种用于制备抗egfr全人源化单克隆抗体的细胞株构建方法 |
EP4283295A3 (en) * | 2019-04-30 | 2024-03-06 | Gigagen, Inc. | Recombinant polyclonal proteins and methods of use thereof |
WO2021058709A1 (en) * | 2019-09-27 | 2021-04-01 | Glaxosmithkline Intellectual Property Development Limited | Method of predicting production stability of clonal cell lines |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0530216A4 (en) | 1990-04-19 | 1993-06-30 | Medimmune, Inc. | Administration of monoclonal antibodies against respiratory viruses |
GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
US20040038392A1 (en) * | 2000-06-08 | 2004-02-26 | Tatsurou Shibui | Expression vector enabling screening of cells with high expression of recombinant protein, transformant with high expression of recombinant protein and utilization thereof |
US6849259B2 (en) * | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
CA2965865C (en) * | 2002-07-18 | 2021-10-19 | Merus N.V. | Recombinant production of mixtures of antibodies |
WO2004029284A2 (en) * | 2002-09-30 | 2004-04-08 | Protein Design Labs, Inc. | Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes |
CN100383244C (zh) * | 2003-01-07 | 2008-04-23 | 西福根有限公司 | 用于生产重组多克隆蛋白质的方法 |
MXPA05006724A (es) * | 2003-01-07 | 2005-09-08 | Symphogen As | Metodo para producir proteinas policlonales recombinantes. |
US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
EA014182B1 (ru) * | 2004-07-20 | 2010-10-29 | Симфоген А/С | КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ |
ES2332524T3 (es) * | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
EP2314619A1 (en) | 2005-12-05 | 2011-04-27 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
US20100040606A1 (en) | 2006-03-06 | 2010-02-18 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
PL2152872T3 (pl) * | 2007-05-25 | 2011-03-31 | Symphogen As | Sposób wytwarzania rekombinowanego białka poliklonalnego |
-
2008
- 2008-05-21 PL PL08748815T patent/PL2152872T3/pl unknown
- 2008-05-21 CA CA2683800A patent/CA2683800C/en not_active Expired - Fee Related
- 2008-05-21 NZ NZ581316A patent/NZ581316A/en not_active IP Right Cessation
- 2008-05-21 DK DK08748815.1T patent/DK2152872T3/da active
- 2008-05-21 JP JP2010509679A patent/JP5941616B2/ja not_active Expired - Fee Related
- 2008-05-21 MX MX2009012526A patent/MX2009012526A/es active IP Right Grant
- 2008-05-21 PT PT08748815T patent/PT2152872E/pt unknown
- 2008-05-21 KR KR1020097027038A patent/KR101555658B1/ko active IP Right Grant
- 2008-05-21 EP EP08748815A patent/EP2152872B1/en not_active Not-in-force
- 2008-05-21 AU AU2008255383A patent/AU2008255383B2/en not_active Ceased
- 2008-05-21 CN CN2008800174383A patent/CN101688204B/zh not_active Expired - Fee Related
- 2008-05-21 WO PCT/DK2008/050116 patent/WO2008145133A2/en active Application Filing
- 2008-05-21 AT AT08748815T patent/ATE481483T1/de active
- 2008-05-21 BR BRPI0812091-9A2A patent/BRPI0812091A2/pt not_active Application Discontinuation
- 2008-05-21 DE DE602008002593T patent/DE602008002593D1/de active Active
- 2008-05-21 SI SI200830107T patent/SI2152872T1/sl unknown
- 2008-05-23 TW TW097119118A patent/TW200902548A/zh unknown
- 2008-05-23 US US12/153,809 patent/US7910332B2/en not_active Expired - Fee Related
-
2009
- 2009-10-11 IL IL201395A patent/IL201395A/en active IP Right Grant
- 2009-11-13 ZA ZA2009/08021A patent/ZA200908021B/en unknown
-
2010
- 2010-03-09 HK HK10102454.3A patent/HK1134519A1/xx not_active IP Right Cessation
- 2010-11-24 CY CY20101101058T patent/CY1110939T1/el unknown
- 2010-11-24 HR HR20100640T patent/HRP20100640T1/hr unknown
-
2014
- 2014-09-19 JP JP2014191912A patent/JP2015037411A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2008145133A3 (en) | 2009-02-05 |
IL201395A (en) | 2015-09-24 |
US20090111142A1 (en) | 2009-04-30 |
HRP20100640T1 (hr) | 2010-12-31 |
CA2683800A1 (en) | 2008-12-04 |
PT2152872E (pt) | 2010-11-17 |
KR101555658B1 (ko) | 2015-09-24 |
JP2015037411A (ja) | 2015-02-26 |
DE602008002593D1 (de) | 2010-10-28 |
TW200902548A (en) | 2009-01-16 |
DK2152872T3 (da) | 2010-12-06 |
IL201395A0 (en) | 2011-08-01 |
WO2008145133A2 (en) | 2008-12-04 |
PL2152872T3 (pl) | 2011-03-31 |
JP5941616B2 (ja) | 2016-06-29 |
KR20100017923A (ko) | 2010-02-16 |
AU2008255383B2 (en) | 2012-11-01 |
ATE481483T1 (de) | 2010-10-15 |
JP2011504721A (ja) | 2011-02-17 |
CN101688204A (zh) | 2010-03-31 |
CN101688204B (zh) | 2013-07-03 |
HK1134519A1 (en) | 2010-04-30 |
SI2152872T1 (sl) | 2011-01-31 |
NZ581316A (en) | 2012-02-24 |
EP2152872B1 (en) | 2010-09-15 |
EP2152872A2 (en) | 2010-02-17 |
MX2009012526A (es) | 2009-12-09 |
CY1110939T1 (el) | 2015-06-10 |
ZA200908021B (en) | 2010-11-24 |
AU2008255383A1 (en) | 2008-12-04 |
US7910332B2 (en) | 2011-03-22 |
CA2683800C (en) | 2015-03-17 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |