CY1114463T1 - Κλωνος κυτταρου που παραγει fsh - Google Patents

Κλωνος κυτταρου που παραγει fsh

Info

Publication number
CY1114463T1
CY1114463T1 CY20131100874T CY131100874T CY1114463T1 CY 1114463 T1 CY1114463 T1 CY 1114463T1 CY 20131100874 T CY20131100874 T CY 20131100874T CY 131100874 T CY131100874 T CY 131100874T CY 1114463 T1 CY1114463 T1 CY 1114463T1
Authority
CY
Cyprus
Prior art keywords
nucleic acid
cell
present
recombinant
relates
Prior art date
Application number
CY20131100874T
Other languages
English (en)
Inventor
Stefan Arnold
Nanni Jelinek
Original Assignee
Biogenerix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenerix Ag filed Critical Biogenerix Ag
Publication of CY1114463T1 publication Critical patent/CY1114463T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε μόρια νουκλεϊνικού οξέος που περιλαμβάνουν αλληλουχία νουκλεϊνικού οξέος που κωδικοποιεί την α- και την β-άλυσο της ανθρώπινης ορμόνης διέγερσης ωοθυλακίου (FSΗ), αντιστοίχως, η οποία έχει τροποποιηθεί σε σχέση προς την χρήση κωδικονίου σε CΗΟ κύτταρα. Η παρούσα εφεύρεση περαιτέρω αφορά ένα ανασυνδυασμένο μόριο νουκλεϊνικού οξέος που περιλαμβάνει τέτοιες αλληλουχίες νουκλεϊνικού οξέος και κύτταρα-ξενιστές που περιέχουν τέτοια ανασυνδυασμένα μόρια νουκλεϊνικού οξέος, καθώς επίσης χρήση αυτών στην παρασκευή ανασυνδυασμένης ανθρώπινης FSΗ. Τελικά, η παρούσα εφεύρεση επίσης αφορά σε μια μέθοδο παρασκευής κυττάρων ξενιστών που εκφράζουν ανθρώπινη ορμόνη διέγερσης ωοθυλακίου με μεταμόλυνση κυττάρων σε καλλιέργεια εναιωρήματος υπό συνθήκες άνευ ορού με το ανασυνδυασμένο μόριο νουκλεϊνικού οξέος της παρούσας εφεύρεσης.
CY20131100874T 2007-06-28 2013-10-09 Κλωνος κυτταρου που παραγει fsh CY1114463T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07111257 2007-06-28
EP08774439.7A EP2170942B1 (en) 2007-06-28 2008-06-27 Fsh producing cell clone

Publications (1)

Publication Number Publication Date
CY1114463T1 true CY1114463T1 (el) 2016-10-05

Family

ID=39745099

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100874T CY1114463T1 (el) 2007-06-28 2013-10-09 Κλωνος κυτταρου που παραγει fsh

Country Status (24)

Country Link
US (1) US8318457B2 (el)
EP (2) EP2170942B1 (el)
JP (1) JP5570980B2 (el)
KR (1) KR101522217B1 (el)
CN (1) CN101720332B (el)
AU (1) AU2008267138B9 (el)
BR (1) BRPI0813913B1 (el)
CA (1) CA2690844C (el)
CY (1) CY1114463T1 (el)
DK (1) DK2170942T3 (el)
EA (1) EA022993B1 (el)
ES (1) ES2432183T3 (el)
HK (1) HK1140782A1 (el)
HR (1) HRP20130921T1 (el)
IL (1) IL202280A (el)
MX (1) MX2010000385A (el)
NZ (1) NZ581702A (el)
PL (1) PL2170942T3 (el)
PT (1) PT2170942E (el)
RS (1) RS52976B (el)
SI (1) SI2170942T1 (el)
UA (1) UA103598C2 (el)
WO (1) WO2009000913A1 (el)
ZA (1) ZA200908168B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01337B (me) 2008-02-08 2013-12-20 Biogenerix Ag Tečni preparat fsh
KR101761168B1 (ko) 2009-04-01 2017-07-25 바이오제너릭스 게엠베하 재조합 ｆｓｈ 정제 방법
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
US9657310B2 (en) * 2012-04-27 2017-05-23 Jcr Pharmaceuticals Co., Ltd. Expression vector
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN105462909B (zh) * 2015-12-31 2019-09-27 哈药集团技术中心 一种高效表达人促卵泡激素的cho细胞的培养方法
CN107460206B (zh) * 2017-09-11 2020-05-01 深圳市深研生物科技有限公司 人fsh的重组表达载体、重组细胞株及重组人fsh的制备方法
CN111349154A (zh) * 2018-12-21 2020-06-30 江苏众红生物工程创药研究院有限公司 一种重组人促卵泡激素及其制备方法和药物应用
CN110812366B (zh) * 2019-11-18 2023-11-17 珠海丽凡达生物技术有限公司 一种可用于激素补充的mRNA药物及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
CA2018676C (en) 1989-06-20 2003-05-06 Christie A. Kelton Novel heteropolymeric protein production methods
US6183987B1 (en) 1995-02-17 2001-02-06 Stichting Institut Voor Dierhouderij En Diergezonheld Production of biologically active recombinant bovine follicle stimulation hormone (rec bFSH) in the baculovirus expression system
IL122732A0 (en) 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
AU776823B2 (en) 1998-07-23 2004-09-23 Ares Trading S.A. FSH and FSH variant formulations, products and methods
JP4574865B2 (ja) 1999-04-16 2010-11-04 インスチチュート マッソーネ エス．エイ． 高度に精製されたゴナドトロピン組成物およびそれらの製造方法
WO2001058493A1 (en) 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
US20020127652A1 (en) 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
EP1546329A4 (en) * 2002-09-13 2006-07-12 Univ Queensland GENE EXPRESSION SYSTEM BASED ON CODON TRANSLATION EFFICIENCY
KR100533794B1 (ko) * 2003-10-02 2005-12-07 주식회사 프로젠 인간 난포자극 호르몬을 대량으로 생산하는 방법
UA90664C2 (ru) 2003-12-22 2010-05-25 Ейрес Трейдінг С.А. Способ очистки fsh
EP1809663B1 (en) 2004-11-09 2008-09-17 Ares Trading S.A. Method for purifying fsh
TWI369401B (en) * 2005-07-05 2012-08-01 Ares Trading Sa Serum-free culture medium for the production of recombinant gonadotropins
US20070281883A1 (en) 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish

Also Published As

Publication number Publication date
AU2008267138B9 (en) 2014-06-05
EA022993B1 (ru) 2016-04-29
IL202280A0 (en) 2010-06-16
US8318457B2 (en) 2012-11-27
MX2010000385A (es) 2010-03-29
SI2170942T1 (sl) 2013-12-31
KR20100051632A (ko) 2010-05-17
AU2008267138B2 (en) 2014-01-16
KR101522217B1 (ko) 2015-05-21
BRPI0813913A8 (pt) 2018-02-14
EP2492280A1 (en) 2012-08-29
CN101720332A (zh) 2010-06-02
PT2170942E (pt) 2013-10-22
US20120034655A1 (en) 2012-02-09
HRP20130921T1 (hr) 2013-11-08
RS52976B (en) 2014-02-28
CA2690844C (en) 2016-05-17
BRPI0813913B1 (pt) 2022-04-19
UA103598C2 (uk) 2013-11-11
JP5570980B2 (ja) 2014-08-13
IL202280A (en) 2014-12-31
WO2009000913A1 (en) 2008-12-31
CA2690844A1 (en) 2008-12-31
EA201070071A1 (ru) 2010-10-29
AU2008267138A1 (en) 2008-12-31
PL2170942T3 (pl) 2013-12-31
NZ581702A (en) 2011-10-28
ZA200908168B (en) 2010-07-28
EP2170942B1 (en) 2013-07-31
JP2010531148A (ja) 2010-09-24
HK1140782A1 (en) 2010-10-22
CN101720332B (zh) 2014-08-13
EP2170942A1 (en) 2010-04-07
DK2170942T3 (da) 2013-11-04
ES2432183T3 (es) 2013-12-02
BRPI0813913A2 (pt) 2014-12-30

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