JP2006505628A5 - - Google Patents
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- JP2006505628A5 JP2006505628A5 JP2005506111A JP2005506111A JP2006505628A5 JP 2006505628 A5 JP2006505628 A5 JP 2006505628A5 JP 2005506111 A JP2005506111 A JP 2005506111A JP 2005506111 A JP2005506111 A JP 2005506111A JP 2006505628 A5 JP2006505628 A5 JP 2006505628A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- composition according
- hsf
- protein
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000002163 immunogen Effects 0.000 claims 57
- 239000012528 membrane Substances 0.000 claims 24
- 238000002360 preparation method Methods 0.000 claims 24
- 239000012634 fragment Substances 0.000 claims 23
- 101710123608 HSF-like protein Proteins 0.000 claims 21
- 101000812705 Gallus gallus Endoplasmin Proteins 0.000 claims 20
- 102000010912 Transferrin-Binding Proteins Human genes 0.000 claims 20
- 230000000890 antigenic effect Effects 0.000 claims 16
- 108010031133 Transferrin-Binding Protein A Proteins 0.000 claims 14
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims 14
- 230000001580 bacterial effect Effects 0.000 claims 9
- 241000894006 Bacteria Species 0.000 claims 8
- 241000588653 Neisseria Species 0.000 claims 7
- 241000588650 Neisseria meningitidis Species 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 241000606768 Haemophilus influenzae Species 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 241000588655 Moraxella catarrhalis Species 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 4
- 229940047650 haemophilus influenzae Drugs 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 claims 3
- 101710116435 Outer membrane protein Proteins 0.000 claims 3
- 230000036039 immunity Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 150000002482 oligosaccharides Chemical class 0.000 claims 3
- 238000011144 upstream manufacturing Methods 0.000 claims 3
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims 2
- 101100241886 Neisseria meningitidis oatWY gene Proteins 0.000 claims 2
- 101100203230 Neisseria meningitidis serogroup B (strain MC58) siaA gene Proteins 0.000 claims 2
- 101100021843 Shigella flexneri lpxM1 gene Proteins 0.000 claims 2
- 101100021844 Shigella flexneri lpxM2 gene Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 101150060640 lpxM gene Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 101150019075 neuA gene Proteins 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000228212 Aspergillus Species 0.000 claims 1
- 101100329455 Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) crtC gene Proteins 0.000 claims 1
- 206010061190 Haemophilus infection Diseases 0.000 claims 1
- 206010062204 Moraxella infection Diseases 0.000 claims 1
- 241001174901 Neisseria meningitidis alpha275 Species 0.000 claims 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 claims 1
- 241001573069 Neisseria meningitidis serogroup Y Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 208000002352 blister Diseases 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 101150059761 ctrA gene Proteins 0.000 claims 1
- 101150056963 ctrB gene Proteins 0.000 claims 1
- 101150117300 ctrC gene Proteins 0.000 claims 1
- 101150055828 ctrD gene Proteins 0.000 claims 1
- 230000004665 defense response Effects 0.000 claims 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 101150054232 pyrG gene Proteins 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 101150057501 synA gene Proteins 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0218051.1 | 2002-08-02 | ||
| GB0218036A GB0218036D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine |
| GB0218051A GB0218051D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
| GB0218037A GB0218037D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
| GB0218035A GB0218035D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
| GB0218037.0 | 2002-08-02 | ||
| GB0218036.2 | 2002-08-02 | ||
| GB0218035.4 | 2002-08-02 | ||
| GB0220197.8 | 2002-08-30 | ||
| GBGB0220197.8A GB0220197D0 (en) | 2002-08-30 | 2002-08-30 | Refolding method |
| GB0220199.4 | 2002-08-30 | ||
| GBGB0220199.4A GB0220199D0 (en) | 2002-08-30 | 2002-08-30 | Mutant protein and refolding method |
| GB0225524.8 | 2002-11-01 | ||
| GB0225531A GB0225531D0 (en) | 2002-11-01 | 2002-11-01 | Vaccine |
| GB0225531.3 | 2002-11-01 | ||
| GB0225524A GB0225524D0 (en) | 2002-11-01 | 2002-11-01 | Vaccine composition |
| GB0230168A GB0230168D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine composition |
| GB0230164.6 | 2002-12-24 | ||
| GB0230168.7 | 2002-12-24 | ||
| GB0230170A GB0230170D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine |
| GB0230170.3 | 2002-12-24 | ||
| GB0230164A GB0230164D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine composition |
| GB0305028.3 | 2003-03-05 | ||
| GB0305028A GB0305028D0 (en) | 2003-03-05 | 2003-03-05 | Vaccine |
| PCT/EP2003/008567 WO2004014419A1 (en) | 2002-08-02 | 2003-07-31 | Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006505628A JP2006505628A (ja) | 2006-02-16 |
| JP2006505628A5 true JP2006505628A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2006-09-14 |
| JP5409986B2 JP5409986B2 (ja) | 2014-02-05 |
Family
ID=31722002
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506111A Expired - Fee Related JP5409986B2 (ja) | 2002-08-02 | 2003-07-31 | グラム陰性細菌由来のトランスフェリン結合タンパク質およびＨｓｆを含んでなるワクチン組成物 |
| JP2005506112A Expired - Fee Related JP4740738B2 (ja) | 2002-08-02 | 2003-07-31 | ワクチン |
| JP2005506113A Pending JP2006500963A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2005506114A Pending JP2006506467A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2010237357A Expired - Fee Related JP5414651B2 (ja) | 2002-08-02 | 2010-10-22 | ワクチン組成物 |
| JP2011047056A Pending JP2011142916A (ja) | 2002-08-02 | 2011-03-04 | ワクチン |
| JP2012026928A Expired - Fee Related JP5789203B2 (ja) | 2002-08-02 | 2012-02-10 | ワクチン組成物 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506112A Expired - Fee Related JP4740738B2 (ja) | 2002-08-02 | 2003-07-31 | ワクチン |
| JP2005506113A Pending JP2006500963A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2005506114A Pending JP2006506467A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2010237357A Expired - Fee Related JP5414651B2 (ja) | 2002-08-02 | 2010-10-22 | ワクチン組成物 |
| JP2011047056A Pending JP2011142916A (ja) | 2002-08-02 | 2011-03-04 | ワクチン |
| JP2012026928A Expired - Fee Related JP5789203B2 (ja) | 2002-08-02 | 2012-02-10 | ワクチン組成物 |
Country Status (25)
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
| US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| ES2397918T3 (es) | 1999-04-30 | 2013-03-12 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos Neisseriales conservados |
| DK2270173T3 (en) * | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisserial combination compositions |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| CN1796404A (zh) | 1999-10-29 | 2006-07-05 | 启龙有限公司 | 奈瑟球菌的抗原性肽 |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| JP2003523208A (ja) * | 2000-01-25 | 2003-08-05 | ザ ユニバーシティ オブ クイーンズランド | 髄膜炎菌表面抗原ＮｈｈＡの保存領域を含むタンパク質 |
| CN1201011C (zh) | 2000-02-28 | 2005-05-11 | 启龙股份公司 | 奈瑟球菌蛋白质的异源表达 |
| AU2001280883A1 (en) | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| US20050232936A1 (en) | 2001-07-27 | 2005-10-20 | Chiron Corporation | Meningococcus adhesins nada, app and orf 40 |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| SI1524993T1 (sl) * | 2002-08-02 | 2013-07-31 | Glaxosmithkline Biologicals S.A. | Neisserijski vakcinski sestavki, ki obsegajo kombinacijo antigenov |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| CN1809380B (zh) * | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP2338333B1 (en) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylation methods and proteins/peptides produced by the methods |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| ATE520709T1 (de) | 2003-09-19 | 2011-09-15 | Epitopix Llc | Campylobacter-polypeptide und verwendungsverfahren |
| NZ546430A (en) | 2003-10-02 | 2009-04-30 | Novartis Vaccines & Diagnostic | Liquid vaccines for multiple meningococcal serogroups |
| GB0323709D0 (en) * | 2003-10-09 | 2003-11-12 | Health Prot Agency | Modified whole cell,cell extract and omv-based vaccines |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| CA2550927A1 (en) * | 2003-12-23 | 2005-07-14 | Glaxosmithkline Biologicals S.A. | A gram negative bacterium with reduced lps level in the outer membrane and use thereof for treating gram negative bacterial infection |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| CN1997392B (zh) * | 2004-05-11 | 2011-06-01 | 荷兰健康、福利与体育部部长代表的荷兰国 | 作为佐剂的脑膜炎奈瑟氏菌lgtB LOS |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| EP3061461A1 (en) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| GB0428381D0 (en) * | 2004-12-24 | 2005-02-02 | Isis Innovation | Vaccine |
| MX2007008229A (es) | 2005-01-10 | 2007-09-11 | Neose Technologies Inc | Factor estimulador de colonias de granulocitos glicopegilado. |
| CA2595163A1 (en) * | 2005-01-21 | 2006-07-27 | Epitopix, Llc | Yersinia peptides grown in media comprising 2,2'-dipyridyl, compositions and kits thereof |
| DK2682126T3 (en) * | 2005-01-27 | 2017-02-27 | Children's Hospital & Res Center At Oakland | GNA1870-based vesicle vaccines for broad-spectrum protection against diseases caused by Neisseria meningitidis |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| BRPI0612654B8 (pt) | 2005-06-27 | 2021-05-25 | Glaxosmithkline Biologicals Sa | método para conjugar um sacarídeo a uma proteína, e, conjugado sacarídeo-proteína |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US7955817B2 (en) | 2005-09-02 | 2011-06-07 | Glaxosmithkline Biologicals S.A. | Vaccine protection assay |
| JP5047969B2 (ja) * | 2005-09-05 | 2012-10-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌特異的抗血清に対する血清殺菌アッセイ |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| CA2632434A1 (en) * | 2005-12-06 | 2007-06-14 | Universita Degli Studi Di Padova | Methods and compositions relating to adhesins as adjuvants |
| SI1962899T1 (sl) | 2005-12-22 | 2011-11-30 | Glaxosmithkline Biolog Sa | Pnevmokokna polisaharidna konjugatna vakcina |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| CU23549A1 (es) * | 2005-12-29 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Composiciones farmacéuticas que contienen la proteína nma0939 |
| EP2476433A1 (en) | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| CA2654706A1 (en) * | 2006-06-12 | 2007-12-21 | Nathalie Devos | Neisseria meningitidis lipooligosaccharide vaccine |
| WO2008011633A2 (en) | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| CA2662064A1 (en) | 2006-09-07 | 2008-03-13 | Glaxosmithkline Biologicals S.A. | Method of producing a combination polivirus vaccine |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
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| PL2144923T3 (pl) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Sposoby leczenia z użyciem glikopegilowanego G-CSF |
| CN101778859B (zh) | 2007-06-12 | 2014-03-26 | 诺和诺德公司 | 改良的用于生产核苷酸糖的方法 |
| ES2626662T3 (es) | 2007-06-26 | 2017-07-25 | Glaxosmithkline Biologicals S.A. | Vacuna que comprende conjugados de polisacárido capsular de Streptococcus pneumoniae |
| WO2009038889A1 (en) * | 2007-08-02 | 2009-03-26 | Children's Hospital And Research Center At Oakland | Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
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| CN101951949B (zh) | 2007-10-19 | 2013-10-02 | 诺华股份有限公司 | 脑膜炎球菌疫苗制剂 |
| ES2532946T3 (es) | 2008-02-21 | 2015-04-06 | Novartis Ag | Polipéptidos PUfH meningocócicos |
| CA2715465C (en) | 2008-02-27 | 2017-03-21 | Novo Nordisk A/S | Conjugated factor viii molecules |
| CN102015651B (zh) | 2008-03-03 | 2014-12-31 | Irm责任有限公司 | 作为tlr活性调节剂的化合物和组合物 |
| RU2477145C2 (ru) | 2008-05-30 | 2013-03-10 | ДЗЕ Ю.Эс.Эй., ЭС РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТАРИ ОФ ДЗЕ АРМИ, ОН БЕХАФ ОФ УОЛТЕР РИД АРМИ | Мультивалентная вакцина из нативных везикул наружной мембраны менингококков, способы ее получения и применения |
| KR101042541B1 (ko) * | 2008-07-25 | 2011-06-17 | 한국생명공학연구원 | 외막소체를 생산하는 재조합 ｇ（－） 박테리아 및 이를이용한 다가항원이 실린 외막소체의 제조방법 |
| US20110182981A1 (en) * | 2008-08-25 | 2011-07-28 | Peixuan Zhu | Gonococcal vaccines |
| GB0816447D0 (en) | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| EP2367568A2 (en) | 2008-12-17 | 2011-09-28 | Novartis AG | Meningococcal vaccines including hemoglobin receptor |
| CN101759781B (zh) * | 2008-12-25 | 2013-04-03 | 上海市第六人民医院 | 一种细菌表层黏附蛋白及其用途 |
| ES2537426T3 (es) | 2008-12-25 | 2015-06-08 | The Chemo-Sero-Therapeutic Research Institute | Vacuna recombinante para la rinitis infecciosa aviar y método para producirla |
| EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| AU2010227219B2 (en) | 2009-03-24 | 2014-02-27 | Glaxosmithkline Biologicals S.A. | Adjuvanting meningococcal factor H binding protein |
| US20120064103A1 (en) | 2009-03-24 | 2012-03-15 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| AU2010227221B2 (en) * | 2009-03-24 | 2015-01-22 | Novartis Ag | Combinations including pneumococcal serotype 14 saccharide |
| EP2430151B1 (fr) | 2009-05-14 | 2014-06-18 | Sanofi Pasteur | Vaccin meningocoque a base de lipooligosaccharide (los) provenant de souches modifiees de neisseria meningitidis d'immunotype l6 |
| EP2429576A1 (fr) * | 2009-05-14 | 2012-03-21 | Sanofi Pasteur | Vaccin meningocoque a base de lipooligosaccharide (los) et de proteine de neisseria meningitidis |
| WO2010130896A2 (fr) | 2009-05-14 | 2010-11-18 | Sanofi Pasteur | Procédé pour adjuver le lipopolysaccharide (lps) des bactéries à gram-négatif |
| JP5536765B2 (ja) * | 2009-05-20 | 2014-07-02 | 国立大学法人鳥取大学 | 部分糖鎖エピトープを用いた、病原性ナイセリア属細菌感染の検出方法およびそれら細菌に対するワクチン |
| WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| BR112012004275A2 (pt) | 2009-08-27 | 2016-11-16 | Novartis Ag | polipeptídios híbridos incluindo sequências meningocócicas de fhbp |
| CA2772103A1 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| CN102480932B (zh) | 2009-09-01 | 2015-01-14 | 阿昂梅迪克斯公司 | 源于肠道共生细菌的细胞外小泡及利用其的疫苗、备选药物筛选方法 |
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2004
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2005
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2010
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2012
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2013
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2015
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2016
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