JP2005529155A5 - - Google Patents
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- Publication number
- JP2005529155A5 JP2005529155A5 JP2004506758A JP2004506758A JP2005529155A5 JP 2005529155 A5 JP2005529155 A5 JP 2005529155A5 JP 2004506758 A JP2004506758 A JP 2004506758A JP 2004506758 A JP2004506758 A JP 2004506758A JP 2005529155 A5 JP2005529155 A5 JP 2005529155A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethylcarbamoyloxyphenyl
- ylamino
- pyrimidin
- diethylamino
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- -1 4-fluorobenzenesulfonyl Chemical group 0.000 claims 4
- 102000006495 integrins Human genes 0.000 claims 4
- 108010044426 integrins Proteins 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- XCHMCUCXTAVCLX-UHFFFAOYSA-N 2-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound OC(=O)C(C)C1=CC=C(OC(=O)N(C)C)C=C1 XCHMCUCXTAVCLX-UHFFFAOYSA-N 0.000 claims 1
- UEHGISKTKRLKLO-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(2,4-difluorophenyl)sulfonyl-prop-2-ynylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(CC#C)S(=O)(=O)C1=CC=C(F)C=C1F UEHGISKTKRLKLO-UHFFFAOYSA-N 0.000 claims 1
- YQPPFPAOQXSSBY-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(2,4-difluorophenyl)sulfonylmethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=C(F)C=C1F YQPPFPAOQXSSBY-UHFFFAOYSA-N 0.000 claims 1
- QNBPSKYQBURTTK-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(2-fluorophenyl)sulfonylmethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=CC=C1F QNBPSKYQBURTTK-UHFFFAOYSA-N 0.000 claims 1
- XGZSKLPECGWKPZ-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(3,4-difluorophenyl)sulfonyl-propan-2-ylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(C(C)C)S(=O)(=O)C1=CC=C(F)C(F)=C1 XGZSKLPECGWKPZ-UHFFFAOYSA-N 0.000 claims 1
- QKAALEADKHAZAF-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(3,4-difluorophenyl)sulfonylmethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=C(F)C(F)=C1 QKAALEADKHAZAF-UHFFFAOYSA-N 0.000 claims 1
- NADHCGMMZGXNJU-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(3,5-difluorophenyl)sulfonylmethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC(F)=CC(F)=C1 NADHCGMMZGXNJU-UHFFFAOYSA-N 0.000 claims 1
- PFFXAHQMJBDKHJ-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(3-fluorophenyl)sulfonylmethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=CC(F)=C1 PFFXAHQMJBDKHJ-UHFFFAOYSA-N 0.000 claims 1
- CFDKPPWKFDOSSA-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(4-fluorophenyl)sulfonyl-(2-methylpropyl)amino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(CC(C)C)S(=O)(=O)C1=CC=C(F)C=C1 CFDKPPWKFDOSSA-UHFFFAOYSA-N 0.000 claims 1
- JODSWHRKWYEUDL-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(4-fluorophenyl)sulfonyl-prop-2-ynylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(CC#C)S(=O)(=O)C1=CC=C(F)C=C1 JODSWHRKWYEUDL-UHFFFAOYSA-N 0.000 claims 1
- RAPVDKCWUQBKGG-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(4-fluorophenyl)sulfonyl-propan-2-ylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(C(C)C)S(=O)(=O)C1=CC=C(F)C=C1 RAPVDKCWUQBKGG-UHFFFAOYSA-N 0.000 claims 1
- WWBYAPLJMTZOTK-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[(4-fluorophenyl)sulfonylmethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=C(F)C=C1 WWBYAPLJMTZOTK-UHFFFAOYSA-N 0.000 claims 1
- AIGZEIASVOBQCI-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[2-(2,3-difluorophenyl)sulfonylethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC=CC(F)=C1F AIGZEIASVOBQCI-UHFFFAOYSA-N 0.000 claims 1
- PQYHPONWVXTFQW-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[2-(2,4-difluorophenyl)sulfonylethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC=C(F)C=C1F PQYHPONWVXTFQW-UHFFFAOYSA-N 0.000 claims 1
- KBVXEABVOVICFP-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[2-(3,4-difluorophenyl)sulfonylethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC=C(F)C(F)=C1 KBVXEABVOVICFP-UHFFFAOYSA-N 0.000 claims 1
- FQXLXEDBFFIHNX-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[2-(3,5-difluorophenyl)sulfonylethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC(F)=CC(F)=C1 FQXLXEDBFFIHNX-UHFFFAOYSA-N 0.000 claims 1
- KGSLYLUBNSUZQN-UHFFFAOYSA-N 2-[[2-(diethylamino)-5-[2-(4-fluorophenyl)sulfonylethylamino]pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC=C(F)C=C1 KGSLYLUBNSUZQN-UHFFFAOYSA-N 0.000 claims 1
- XCPNGIQSOZEOOZ-UHFFFAOYSA-N 2-[[5-(benzenesulfonylmethylamino)-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=CC=C1 XCPNGIQSOZEOOZ-UHFFFAOYSA-N 0.000 claims 1
- BMCDGJILQKTGDV-UHFFFAOYSA-N 2-[[5-[(3,4-dichlorophenyl)sulfonylmethylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=C(Cl)C(Cl)=C1 BMCDGJILQKTGDV-UHFFFAOYSA-N 0.000 claims 1
- FPIRQHBDFYJJDM-UHFFFAOYSA-N 2-[[5-[(3,5-dichlorophenyl)sulfonylmethylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 FPIRQHBDFYJJDM-UHFFFAOYSA-N 0.000 claims 1
- BBTTXCPSXDESDD-UHFFFAOYSA-N 2-[[5-[(4-chlorophenyl)sulfonyl-propan-2-ylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(C(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1 BBTTXCPSXDESDD-UHFFFAOYSA-N 0.000 claims 1
- IQIAJOUTZIBYET-UHFFFAOYSA-N 2-[[5-[(4-chlorophenyl)sulfonylmethylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCS(=O)(=O)C1=CC=C(Cl)C=C1 IQIAJOUTZIBYET-UHFFFAOYSA-N 0.000 claims 1
- MAZNQIVGHXAJRX-UHFFFAOYSA-N 2-[[5-[2-(3,5-dichlorophenyl)sulfonylethylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 MAZNQIVGHXAJRX-UHFFFAOYSA-N 0.000 claims 1
- QBKUKQMAGFTCQA-UHFFFAOYSA-N 2-[[5-[2-(4-chlorophenyl)sulfonylethylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1NCCS(=O)(=O)C1=CC=C(Cl)C=C1 QBKUKQMAGFTCQA-UHFFFAOYSA-N 0.000 claims 1
- IKXAHYJACJXEFL-UHFFFAOYSA-N 2-[[5-[butyl-(4-fluorophenyl)sulfonylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1S(=O)(=O)N(CCCC)C1=CN=C(N(CC)CC)N=C1NC(C(O)=O)CC1=CC=C(OC(=O)N(C)C)C=C1 IKXAHYJACJXEFL-UHFFFAOYSA-N 0.000 claims 1
- MIOUNZYFTCIBLP-UHFFFAOYSA-N 2-[[5-[cyclopropylmethyl-(4-fluorophenyl)sulfonylamino]-2-(diethylamino)pyrimidin-4-yl]amino]-3-[4-(dimethylcarbamoyloxy)phenyl]propanoic acid Chemical compound C=1C=C(OC(=O)N(C)C)C=CC=1CC(C(O)=O)NC1=NC(N(CC)CC)=NC=C1N(S(=O)(=O)C=1C=CC(F)=CC=1)CC1CC1 MIOUNZYFTCIBLP-UHFFFAOYSA-N 0.000 claims 1
- 125000006325 2-propenyl amino group Chemical group [H]C([H])=C([H])C([H])([H])N([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38324402P | 2002-05-24 | 2002-05-24 | |
| PCT/US2003/017150 WO2003099231A2 (en) | 2002-05-24 | 2003-05-27 | Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005529155A JP2005529155A (ja) | 2005-09-29 |
| JP2005529155A5 true JP2005529155A5 (enExample) | 2006-07-13 |
| JP4413135B2 JP4413135B2 (ja) | 2010-02-10 |
Family
ID=29584533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506758A Expired - Fee Related JP4413135B2 (ja) | 2002-05-24 | 2003-05-27 | α４インテグリンによって媒介される白血球接着を阻害するヘテロアリール化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7335663B2 (enExample) |
| EP (1) | EP1507533B1 (enExample) |
| JP (1) | JP4413135B2 (enExample) |
| CN (1) | CN1311829C (enExample) |
| AT (1) | ATE464298T1 (enExample) |
| AU (1) | AU2003237302B8 (enExample) |
| BR (1) | BR0309619A (enExample) |
| CA (1) | CA2480756A1 (enExample) |
| DE (1) | DE60332109D1 (enExample) |
| EA (1) | EA008180B1 (enExample) |
| IL (1) | IL164323A (enExample) |
| MX (1) | MXPA04011657A (enExample) |
| NO (1) | NO20045276L (enExample) |
| NZ (1) | NZ535723A (enExample) |
| TW (1) | TW200307671A (enExample) |
| WO (1) | WO2003099231A2 (enExample) |
| ZA (1) | ZA200407944B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE455106T1 (de) * | 1999-01-22 | 2010-01-15 | Elan Pharm Inc | Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen |
| TW200509930A (en) * | 2003-06-25 | 2005-03-16 | Elan Pharm Inc | Methods and compositions for treating rheumatoid arthritis |
| EP1725542A1 (en) * | 2004-03-10 | 2006-11-29 | Merck & Co., Inc. | Vla-4 antagonists |
| MX2007000228A (es) * | 2004-07-08 | 2007-03-30 | Elan Pharm Inc | Antagonistas de vla-4 multivalentes que comprenden porsiones de polietilenglicol. |
| WO2006023396A2 (en) * | 2004-08-16 | 2006-03-02 | Merck & Co., Inc. | Vla-4 antagonists |
| AU2006297180A1 (en) | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| WO2007041270A1 (en) * | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| EP1996559A1 (en) | 2006-02-27 | 2008-12-03 | Elan Pharmaceuticals Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
| HUE047230T2 (hu) * | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
| WO2007100763A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| EP4582099A3 (en) * | 2006-03-03 | 2025-10-01 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| CA2708262A1 (en) | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
| CA2760151A1 (en) * | 2009-04-27 | 2010-11-04 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
| EP4152004B9 (en) | 2010-01-11 | 2025-04-09 | Biogen MA Inc. | Assay for jc virus antibodies |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| US8343706B2 (en) | 2010-01-25 | 2013-01-01 | International Business Machines Corporation | Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same |
| LT3575792T (lt) | 2011-05-31 | 2023-03-10 | Biogen Ma Inc. | Pdl rizikos vertinimo būdas |
| WO2014193804A1 (en) | 2013-05-28 | 2014-12-04 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| ES3003232T3 (en) | 2018-10-30 | 2025-03-10 | Gilead Sciences Inc | Compounds for inhibition of alpha4beta7 integrin |
| ES2987796T3 (es) | 2018-10-30 | 2024-11-18 | Gilead Sciences Inc | Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias |
| CN112969687B (zh) | 2018-10-30 | 2024-08-23 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| CN111197057B (zh) * | 2018-11-19 | 2024-04-19 | 中国科学院分子细胞科学卓越创新中心 | 调控免疫细胞迁移的组合物和方法 |
| CN114222730B (zh) | 2019-08-14 | 2024-09-10 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
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-
2003
- 2003-05-26 TW TW092114184A patent/TW200307671A/zh unknown
- 2003-05-27 AU AU2003237302A patent/AU2003237302B8/en not_active Ceased
- 2003-05-27 WO PCT/US2003/017150 patent/WO2003099231A2/en not_active Ceased
- 2003-05-27 EP EP03736768A patent/EP1507533B1/en not_active Expired - Lifetime
- 2003-05-27 EA EA200401561A patent/EA008180B1/ru not_active IP Right Cessation
- 2003-05-27 AT AT03736768T patent/ATE464298T1/de not_active IP Right Cessation
- 2003-05-27 JP JP2004506758A patent/JP4413135B2/ja not_active Expired - Fee Related
- 2003-05-27 CN CNB038112582A patent/CN1311829C/zh not_active Expired - Fee Related
- 2003-05-27 DE DE60332109T patent/DE60332109D1/de not_active Expired - Lifetime
- 2003-05-27 MX MXPA04011657A patent/MXPA04011657A/es active IP Right Grant
- 2003-05-27 US US10/494,788 patent/US7335663B2/en not_active Expired - Fee Related
- 2003-05-27 US US10/447,208 patent/US7008949B2/en not_active Expired - Fee Related
- 2003-05-27 CA CA002480756A patent/CA2480756A1/en not_active Abandoned
- 2003-05-27 BR BR0309619-0A patent/BR0309619A/pt not_active IP Right Cessation
- 2003-05-27 NZ NZ535723A patent/NZ535723A/en unknown
-
2004
- 2004-09-28 IL IL164323A patent/IL164323A/en not_active IP Right Cessation
- 2004-10-01 ZA ZA200407944A patent/ZA200407944B/en unknown
- 2004-12-01 NO NO20045276A patent/NO20045276L/no not_active Application Discontinuation
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