JP2005527628A5 - - Google Patents
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- Publication number
- JP2005527628A5 JP2005527628A5 JP2004507466A JP2004507466A JP2005527628A5 JP 2005527628 A5 JP2005527628 A5 JP 2005527628A5 JP 2004507466 A JP2004507466 A JP 2004507466A JP 2004507466 A JP2004507466 A JP 2004507466A JP 2005527628 A5 JP2005527628 A5 JP 2005527628A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidin
- diethylamino
- phenylalanine
- ylcarbonyloxy
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 229960005190 phenylalanine Drugs 0.000 claims 19
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 19
- 201000010099 disease Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000002393 azetidinyl group Chemical group 0.000 claims 8
- 230000001404 mediated effect Effects 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000003386 piperidinyl group Chemical group 0.000 claims 8
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 108010044426 integrins Proteins 0.000 claims 4
- 102000006495 integrins Human genes 0.000 claims 4
- -1 2,5-dihydropyrrol-1-yl Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38302002P | 2002-05-24 | 2002-05-24 | |
| PCT/US2003/016804 WO2003099809A1 (en) | 2002-05-24 | 2003-05-27 | HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY α4 INTEGRINS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005527628A JP2005527628A (ja) | 2005-09-15 |
| JP2005527628A5 true JP2005527628A5 (enExample) | 2006-07-06 |
| JP4469715B2 JP4469715B2 (ja) | 2010-05-26 |
Family
ID=29584493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004507466A Expired - Fee Related JP4469715B2 (ja) | 2002-05-24 | 2003-05-27 | α４インテグリンにより媒介される白血球接着を阻害する複素環化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7135477B2 (enExample) |
| EP (1) | EP1507775B1 (enExample) |
| JP (1) | JP4469715B2 (enExample) |
| KR (1) | KR100978832B1 (enExample) |
| CN (1) | CN1314682C (enExample) |
| AT (1) | ATE419243T1 (enExample) |
| AU (1) | AU2003240823C1 (enExample) |
| BR (1) | BR0308881A (enExample) |
| CA (1) | CA2481926C (enExample) |
| DE (1) | DE60325583D1 (enExample) |
| DK (1) | DK1507775T3 (enExample) |
| EA (1) | EA008256B1 (enExample) |
| EC (1) | ECSP045425A (enExample) |
| ES (1) | ES2320436T3 (enExample) |
| IL (2) | IL164225A0 (enExample) |
| MX (1) | MXPA04010995A (enExample) |
| NO (1) | NO329933B1 (enExample) |
| NZ (1) | NZ535504A (enExample) |
| TW (1) | TWI281470B (enExample) |
| UA (1) | UA76339C2 (enExample) |
| WO (1) | WO2003099809A1 (enExample) |
| ZA (1) | ZA200407590B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1045157A1 (zh) * | 1999-01-22 | 2002-11-15 | 依兰制药公司 | 抑制vla-4介导的白细胞粘着的化合物 |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| US20050074451A1 (en) * | 2003-06-25 | 2005-04-07 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
| WO2005111020A2 (en) * | 2004-04-30 | 2005-11-24 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by vla-4 |
| CA2573245C (en) * | 2004-07-08 | 2013-10-01 | Elan Pharmaceuticals, Inc. | Multivalent vla-4 antagonists comprising polymer moieties |
| BRPI0611285A2 (pt) * | 2005-05-20 | 2010-08-31 | Elan Pharm Inc | derivados de imidazolona fenilalanina |
| ZA200803016B (en) | 2005-09-29 | 2009-10-28 | Elan Pharmaceuticals Inc Wyeth | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| ATE493405T1 (de) | 2005-09-29 | 2011-01-15 | Elan Pharm Inc | Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren |
| EA017110B1 (ru) * | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
| US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
| KR20080104343A (ko) * | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
| CA2708262A1 (en) * | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
| EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
| MX2010011724A (es) * | 2008-04-29 | 2010-11-30 | Nsab Af Neurosearch Sweden Ab | Moduladores de neurotransmision de dopamina. |
| SG10201401836RA (en) * | 2009-04-27 | 2014-10-30 | Elan Pharm Inc | Pyridinone antagonists of alpha-4 integrins |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| BR112012017014B1 (pt) | 2010-01-11 | 2021-07-20 | Biogen Ma Inc | Métodos para detecção de anticorpos de vírus jc |
| HUE061244T2 (hu) | 2011-05-31 | 2023-06-28 | Biogen Ma Inc | A PML kockázat értékelésének módszere |
| JP6080521B2 (ja) * | 2012-11-30 | 2017-02-15 | インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | 広域分散医療情報ネットワークのデータ管理機構 |
| EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHOD FOR ASSESSING A PML RISK |
| HK1244806A1 (zh) * | 2015-12-30 | 2018-08-17 | Saint Louis University | 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物 |
| DK3873884T3 (da) | 2018-10-30 | 2025-02-17 | Gilead Sciences Inc | 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme |
| ES2987796T3 (es) | 2018-10-30 | 2024-11-18 | Gilead Sciences Inc | Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
| CN109541237A (zh) * | 2018-12-28 | 2019-03-29 | 吴江近岸蛋白质科技有限公司 | 纤维连接蛋白的生物学活性测定方法 |
| AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
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| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| HK1045157A1 (zh) * | 1999-01-22 | 2002-11-15 | 依兰制药公司 | 抑制vla-4介导的白细胞粘着的化合物 |
| WO2000043369A1 (en) * | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
| PE20020384A1 (es) | 2000-07-21 | 2002-05-28 | Schering Corp | PEPTIDOS COMO INHIBIDORES DE LA PROTEASA SERINA NS3/NS4a DEL VIRUS DE LA HEPATITIS C |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
-
2003
- 2003-05-26 TW TW092114183A patent/TWI281470B/zh not_active IP Right Cessation
- 2003-05-27 BR BR0308881-2A patent/BR0308881A/pt active Search and Examination
- 2003-05-27 DK DK03731419T patent/DK1507775T3/da active
- 2003-05-27 ZA ZA200407590A patent/ZA200407590B/en unknown
- 2003-05-27 KR KR1020047018173A patent/KR100978832B1/ko not_active Expired - Fee Related
- 2003-05-27 EA EA200401562A patent/EA008256B1/ru not_active IP Right Cessation
- 2003-05-27 CN CNB038115484A patent/CN1314682C/zh not_active Expired - Fee Related
- 2003-05-27 CA CA2481926A patent/CA2481926C/en not_active Expired - Fee Related
- 2003-05-27 US US10/494,790 patent/US7135477B2/en not_active Expired - Fee Related
- 2003-05-27 WO PCT/US2003/016804 patent/WO2003099809A1/en not_active Ceased
- 2003-05-27 MX MXPA04010995A patent/MXPA04010995A/es active IP Right Grant
- 2003-05-27 JP JP2004507466A patent/JP4469715B2/ja not_active Expired - Fee Related
- 2003-05-27 DE DE60325583T patent/DE60325583D1/de not_active Expired - Lifetime
- 2003-05-27 UA UA20041008397A patent/UA76339C2/uk unknown
- 2003-05-27 NZ NZ535504A patent/NZ535504A/en not_active IP Right Cessation
- 2003-05-27 EP EP03731419A patent/EP1507775B1/en not_active Expired - Lifetime
- 2003-05-27 ES ES03731419T patent/ES2320436T3/es not_active Expired - Lifetime
- 2003-05-27 IL IL16422503A patent/IL164225A0/xx unknown
- 2003-05-27 AT AT03731419T patent/ATE419243T1/de not_active IP Right Cessation
- 2003-05-27 US US10/447,308 patent/US7026328B2/en not_active Expired - Fee Related
- 2003-05-27 AU AU2003240823A patent/AU2003240823C1/en not_active Ceased
-
2004
- 2004-09-17 NO NO20043900A patent/NO329933B1/no not_active IP Right Cessation
- 2004-09-22 IL IL164225A patent/IL164225A/en not_active IP Right Cessation
- 2004-10-11 EC EC2004005425A patent/ECSP045425A/es unknown
-
2006
- 2006-09-26 US US11/527,901 patent/US7427628B2/en not_active Expired - Fee Related
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