JP2004115534A5 - - Google Patents
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- Publication number
- JP2004115534A5 JP2004115534A5 JP2003394308A JP2003394308A JP2004115534A5 JP 2004115534 A5 JP2004115534 A5 JP 2004115534A5 JP 2003394308 A JP2003394308 A JP 2003394308A JP 2003394308 A JP2003394308 A JP 2003394308A JP 2004115534 A5 JP2004115534 A5 JP 2004115534A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyclohexylmethyl
- dioxo
- tetrahydro
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 208000028169 periodontal disease Diseases 0.000 claims 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 8
- 229920000847 nonoxynol Polymers 0.000 claims 8
- LERWZBXJAOSNBN-DTQAZKPQSA-N (e)-3-[4-[1,3-bis(cyclohexylmethyl)-2,6-dioxo-7h-purin-8-yl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C1=NC(C(N(CC2CCCCC2)C(=O)N2CC3CCCCC3)=O)=C2N1 LERWZBXJAOSNBN-DTQAZKPQSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- PHPTYNIVTRERGL-CCEZHUSRSA-N (e)-3-[3-[1,3-bis(cyclohexylmethyl)-2,6-dioxo-7h-purin-8-yl]phenyl]prop-2-enoic acid Chemical compound OC(=O)\C=C\C1=CC=CC(C=2NC3=C(C(N(CC4CCCCC4)C(=O)N3CC3CCCCC3)=O)N=2)=C1 PHPTYNIVTRERGL-CCEZHUSRSA-N 0.000 claims 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 claims 2
- -1 cinnamic acid nonaethylene glycol methyl ether ester Chemical class 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000005024 alkenyl aryl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9817623.3A GB9817623D0 (en) | 1998-08-13 | 1998-08-13 | Pharmaceutical compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000564958A Division JP3631961B2 (ja) | 1998-08-13 | 1999-08-11 | フェニルキサンチン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004115534A JP2004115534A (ja) | 2004-04-15 |
| JP2004115534A5 true JP2004115534A5 (enExample) | 2005-05-26 |
Family
ID=10837179
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000564958A Expired - Fee Related JP3631961B2 (ja) | 1998-08-13 | 1999-08-11 | フェニルキサンチン誘導体 |
| JP2003164252A Withdrawn JP2004137251A (ja) | 1998-08-13 | 2003-06-09 | フェニルキサンチン誘導体 |
| JP2003394308A Pending JP2004115534A (ja) | 1998-08-13 | 2003-11-25 | フェニルキサンチン誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000564958A Expired - Fee Related JP3631961B2 (ja) | 1998-08-13 | 1999-08-11 | フェニルキサンチン誘導体 |
| JP2003164252A Withdrawn JP2004137251A (ja) | 1998-08-13 | 2003-06-09 | フェニルキサンチン誘導体 |
Country Status (36)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9703044D0 (en) | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| WO2002040021A2 (en) * | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| WO2002067942A2 (en) * | 2001-02-28 | 2002-09-06 | Smithkline Beecham Corporation | Methods of treating irritable bowel syndrome and functional dyspepsia |
| WO2003017964A1 (en) | 2001-08-24 | 2003-03-06 | Unilever N.V. | Oral composition comprising an alkylhydroxybenzoate |
| ATE520694T1 (de) | 2001-11-09 | 2011-09-15 | Gilead Palo Alto Inc | A2b-adenosinrezeptorantagonisten |
| US6977300B2 (en) | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7125993B2 (en) | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US20040072848A1 (en) * | 2002-02-26 | 2004-04-15 | Huber Brian E | Methods of treating irritable bowel syndrome and functional dyspepsia |
| WO2004009091A1 (en) | 2002-06-17 | 2004-01-29 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
| KR101222364B1 (ko) * | 2003-08-25 | 2013-01-15 | 트로비스 파마슈티칼스 엘엘씨 | 치환된 8-헤테로아릴 크산틴 |
| GB0324086D0 (en) * | 2003-10-14 | 2003-11-19 | Glaxo Group Ltd | Process for preparing a co-precipitate of a non-crystalline solid drug substance |
| US20060063828A1 (en) * | 2004-06-28 | 2006-03-23 | Weingarten M D | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
| WO2006091936A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| US7618962B2 (en) * | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
| US7884100B2 (en) * | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| WO2009140517A1 (en) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2010039289A2 (en) | 2008-05-14 | 2010-04-08 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| US20120108614A1 (en) * | 2008-05-14 | 2012-05-03 | Chong Jayhong A | Compounds and compositions for treating chemical warfare agent-induced injuries |
| CA2721851A1 (en) * | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
| CN102260260B (zh) * | 2010-05-24 | 2014-08-06 | 中国科学院上海药物研究所 | 8-苯基黄嘌呤类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| CN102993203B (zh) * | 2011-09-09 | 2015-11-25 | 温州医学院 | 8-苯基黄嘌呤类衍生物的制备及应用 |
| US9502952B2 (en) | 2012-10-12 | 2016-11-22 | Persimmon Technologies, Corp. | Hybrid motor |
| AU2014262547A1 (en) | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| EP2994139B1 (en) | 2013-05-10 | 2019-04-10 | Gilead Apollo, LLC | Acc inhibitors and uses thereof |
| JP6417402B2 (ja) * | 2013-05-10 | 2018-11-07 | ギリアド アポロ， エルエルシー | Ａｃｃ阻害剤及びその使用 |
| JP6417401B2 (ja) * | 2013-05-10 | 2018-11-07 | ギリアド アポロ， エルエルシー | Ａｃｃ阻害剤及びその使用 |
| EP4389749A1 (en) * | 2022-12-20 | 2024-06-26 | invIOs GmbH | Substituted 3,7-dihydro-1h-purine-2,6-diones and use thereof |
| KR20250134087A (ko) | 2022-12-20 | 2025-09-09 | 인비오스 게엠베하 | 치환된 3,7-다이하이드로-1h-퓨린 -2,6-다이온 및 이의 용도 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4442125A (en) * | 1978-06-26 | 1984-04-10 | Oxford Hill, Ltd. | Process for detaching or preventing attachment of microorganisms to a surface |
| GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US5015647A (en) | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
| GB8826595D0 (en) | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| IL100088A (en) | 1990-11-21 | 1995-07-31 | Smithkline Beecham Corp | FNT inhibitor preparations containing histogenic transducts converted at positions 1, 3, and 8 |
| GB9210839D0 (en) | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
| TW252044B (enExample) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| JP2613355B2 (ja) | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| US5840302A (en) * | 1993-11-10 | 1998-11-24 | Bristol-Myers Squibb Company | Treatment of bacterially-induced inflammatory diseases |
| US5395831A (en) | 1994-04-08 | 1995-03-07 | American Home Products Corporation | Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone |
| GB9415529D0 (en) * | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| DE19535504A1 (de) | 1995-09-25 | 1997-03-27 | Bayer Ag | Substituierte Xanthine |
| AU2213697A (en) | 1996-03-18 | 1997-10-10 | Medical Science Systems, Inc. | A method for periodontal disease treatment |
| ES2185837T3 (es) | 1996-06-07 | 2003-05-01 | Hoechst Ag | Utilizacion de derivados de teofilina para el tratamiento y la profilaxis de las enfermedades de choque, nuevos compuestos de xantina y procedimientos para su produccion. |
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| US6096707A (en) * | 1997-07-11 | 2000-08-01 | Biotie Therapies Ltd. | Integrin binding peptide and use thereof |
| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| WO1999043673A1 (en) | 1998-02-26 | 1999-09-02 | Zenyaku Kogyo Kabushiki Kaisha | 1-azaindolizine derivatives |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| AP2002002582A0 (en) | 1999-12-23 | 2002-09-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| US20020006915A1 (en) * | 2000-02-15 | 2002-01-17 | Mack Strong Vivian E. | Use of COX-2 inhibitors to treat sepsis, complications thereof, and EP receptor modulation |
| US6751206B1 (en) | 2000-06-29 | 2004-06-15 | Qualcomm Incorporated | Method and apparatus for beam switching in a wireless communication system |
-
1998
- 1998-08-13 GB GBGB9817623.3A patent/GB9817623D0/en not_active Ceased
-
1999
- 1999-08-10 AR ARP990103999A patent/AR020154A1/es not_active Application Discontinuation
- 1999-08-10 CO CO99050691A patent/CO5130007A1/es unknown
- 1999-08-11 DE DE69914921T patent/DE69914921T2/de not_active Expired - Fee Related
- 1999-08-11 AP APAP/P/2001/002071A patent/AP1408A/en active
- 1999-08-11 IL IL14131899A patent/IL141318A0/xx unknown
- 1999-08-11 PL PL99346055A patent/PL346055A1/xx not_active Application Discontinuation
- 1999-08-11 PT PT99944358T patent/PT1104422E/pt unknown
- 1999-08-11 WO PCT/EP1999/005814 patent/WO2000009507A1/en not_active Ceased
- 1999-08-11 NZ NZ509778A patent/NZ509778A/en unknown
- 1999-08-11 US US09/762,559 patent/US6608069B1/en not_active Expired - Fee Related
- 1999-08-11 CN CNB998119695A patent/CN1149215C/zh not_active Expired - Fee Related
- 1999-08-11 BR BR9913020-3A patent/BR9913020A/pt not_active IP Right Cessation
- 1999-08-11 SI SI9930545T patent/SI1104422T1/xx unknown
- 1999-08-11 YU YU11601A patent/YU11601A/sh unknown
- 1999-08-11 TR TR2001/00448T patent/TR200100448T2/xx unknown
- 1999-08-11 EE EEP200100083A patent/EE04721B1/xx not_active IP Right Cessation
- 1999-08-11 AU AU57323/99A patent/AU775819B2/en not_active Ceased
- 1999-08-11 EP EP99944358A patent/EP1104422B1/en not_active Expired - Lifetime
- 1999-08-11 SK SK222-2001A patent/SK2222001A3/sk unknown
- 1999-08-11 PE PE1999000814A patent/PE20000952A1/es not_active Application Discontinuation
- 1999-08-11 CN CNB031104673A patent/CN1251676C/zh not_active Expired - Fee Related
- 1999-08-11 AT AT99944358T patent/ATE259810T1/de not_active IP Right Cessation
- 1999-08-11 HU HU0103637A patent/HUP0103637A3/hu unknown
- 1999-08-11 ES ES99944358T patent/ES2215399T3/es not_active Expired - Lifetime
- 1999-08-11 ID IDW20010591A patent/ID28723A/id unknown
- 1999-08-11 MY MYPI99003429A patent/MY133393A/en unknown
- 1999-08-11 JP JP2000564958A patent/JP3631961B2/ja not_active Expired - Fee Related
- 1999-08-11 KR KR1020017001799A patent/KR20010085369A/ko not_active Abandoned
- 1999-08-11 DK DK99944358T patent/DK1104422T3/da active
- 1999-08-11 EA EA200100127A patent/EA004139B1/ru unknown
- 1999-08-11 MA MA25728A patent/MA26673A1/fr unknown
- 1999-08-11 CA CA002340350A patent/CA2340350A1/en not_active Abandoned
- 1999-08-12 TW TW088113815A patent/TWI224598B/zh not_active IP Right Cessation
-
2001
- 2001-02-09 IS IS5843A patent/IS5843A/is unknown
- 2001-02-12 NO NO20010715A patent/NO20010715L/no not_active Application Discontinuation
- 2001-02-12 ZA ZA200101186A patent/ZA200101186B/en unknown
-
2002
- 2002-03-26 US US10/106,772 patent/US6770267B2/en not_active Expired - Fee Related
-
2003
- 2003-02-03 US US10/357,751 patent/US20040034020A1/en not_active Abandoned
- 2003-06-09 JP JP2003164252A patent/JP2004137251A/ja not_active Withdrawn
- 2003-11-25 JP JP2003394308A patent/JP2004115534A/ja active Pending
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