AR020154A1 - Derivados de glicol de xantinas, composiciones farmaceuticas, uso en la manufactura de medicamentos, metodos de tratamiento y proceso de preparacion - Google Patents
Derivados de glicol de xantinas, composiciones farmaceuticas, uso en la manufactura de medicamentos, metodos de tratamiento y proceso de preparacionInfo
- Publication number
- AR020154A1 AR020154A1 ARP990103999A ARP990103999A AR020154A1 AR 020154 A1 AR020154 A1 AR 020154A1 AR P990103999 A ARP990103999 A AR P990103999A AR P990103999 A ARP990103999 A AR P990103999A AR 020154 A1 AR020154 A1 AR 020154A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- substituted
- cycloalkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Se describen compuestos de la formula (1), donde: Z representa un cicloalquilo de 5 o 6 miembros, arilo, cicloalquilo substituido, o arilo substituido,dicho cicloalquilo, arilo, cicloalquilo substituido, o arilo substituido contienen opcionalmenteun o o más heteroátomos seleccionados de O, N o S;R1 representa hidrogeno o metilo; R2 representa hidrogeno, alquilo C1-12, arilo o aralquilo; k representa 0 o 1; n representa un numero entero de 1 a 50;X representa -O-, -N(H)-, -N(alquilo C1-6)-N(ciclo alquilo C3-8)-, -N(alquilo C1-8)(cicloalquilo C3-8), -N[(CH2CH2O)m(alquilo C1-12), arilo o aralquilo)],-CH2O-, -CH2NH-, CH2N(alquilo C1-6)-, -CH2N(cicloalquilo C3-8)-, o -alquilo C1-12-; m representa 0-12; Q representa (-CH2)p, (-CH=CH-)p, (-C:::C-)p ,(-(O)p1CH2-)p o (-CH2(O)p1)p en donde p y p1 independientemente representan un numero entero de 0 a 4; y e y independientemente representan numerosenteros de 0 a 10; R3 representa H, alquilo C1-12 de cadena recta o ramificada(opcionalmente sustitui do por fenilo, fenilo -CO-, CN, -CO alquilo C1-3-CO2alquilo C1-3, o que contiene uno o más átomos O en la cadena alquilo); alquenilo de cadena recta o ramificada C1-6 (opcionalmente substituido por fenilo,fenilo -CO, CN, -CO-alquilo C1-3, -CO2 alquil o C1-3, o que contiene uno o más átomos O en la cadena alquilo); alquenilo de cadena recta o ramificada conC1-6 o un grupo -alquilo C1-3-NR8R9, en donde R8 y R9 son independientemente H, alquilo C1-3 o juntos forman ungrupo heterocíclico con 5 o 6 m iembros, quecontiene opcionalmente otros heteroátomos seleccionados de O, N o S; R4 y R5 independientemente representan: cicloalquilo C3-8, alquilo C1-6 de cadena recta oramificada, hidrogeno, alquenilo C2-6 de cadenarecta o ramificada, arilo o aril o substituido; grupo heterocíclico o grupo heterocíclico substituido, queincluye heteroarilo y grupos heteroarilo substituidos; R6 y R7 independientemente representan O o S; con la condicion de que cuando: y e yambos representen1, k representa 1, p1 representa 0, R2 representa H o Me, R3 representa H, X representa O o NH, y Z representa fenilo; R4 y R5 ambos no representan ciclohexilo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9817623.3A GB9817623D0 (en) | 1998-08-13 | 1998-08-13 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020154A1 true AR020154A1 (es) | 2002-04-10 |
Family
ID=10837179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990103999A AR020154A1 (es) | 1998-08-13 | 1999-08-10 | Derivados de glicol de xantinas, composiciones farmaceuticas, uso en la manufactura de medicamentos, metodos de tratamiento y proceso de preparacion |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US6608069B1 (es) |
| EP (1) | EP1104422B1 (es) |
| JP (3) | JP3631961B2 (es) |
| KR (1) | KR20010085369A (es) |
| CN (2) | CN1251676C (es) |
| AP (1) | AP1408A (es) |
| AR (1) | AR020154A1 (es) |
| AT (1) | ATE259810T1 (es) |
| AU (1) | AU775819B2 (es) |
| BR (1) | BR9913020A (es) |
| CA (1) | CA2340350A1 (es) |
| CO (1) | CO5130007A1 (es) |
| DE (1) | DE69914921T2 (es) |
| DK (1) | DK1104422T3 (es) |
| EA (1) | EA004139B1 (es) |
| EE (1) | EE04721B1 (es) |
| ES (1) | ES2215399T3 (es) |
| GB (1) | GB9817623D0 (es) |
| HK (1) | HK1035195A1 (es) |
| HU (1) | HUP0103637A3 (es) |
| ID (1) | ID28723A (es) |
| IL (1) | IL141318A0 (es) |
| IS (1) | IS5843A (es) |
| MA (1) | MA26673A1 (es) |
| MY (1) | MY133393A (es) |
| NO (1) | NO20010715L (es) |
| NZ (1) | NZ509778A (es) |
| PE (1) | PE20000952A1 (es) |
| PL (1) | PL346055A1 (es) |
| PT (1) | PT1104422E (es) |
| SI (1) | SI1104422T1 (es) |
| SK (1) | SK2222001A3 (es) |
| TR (1) | TR200100448T2 (es) |
| TW (1) | TWI224598B (es) |
| WO (1) | WO2000009507A1 (es) |
| YU (1) | YU11601A (es) |
| ZA (1) | ZA200101186B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9703044D0 (en) | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| WO2002040021A2 (en) * | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| JP2004523559A (ja) * | 2001-02-28 | 2004-08-05 | スミスクライン ビーチャム コーポレーション | 過敏性腸症候群および機能性胃腸症の治療方法 |
| EP1418882A1 (en) | 2001-08-24 | 2004-05-19 | Unilever N.V. | Oral composition comprising an alkylhydroxybenzoate |
| US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US6977300B2 (en) | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US7125993B2 (en) | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| PT1444233E (pt) | 2001-11-09 | 2011-09-29 | Gilead Palo Alto Inc | Antagonistas de receptor de adenosina a2b |
| US20040072848A1 (en) * | 2002-02-26 | 2004-04-15 | Huber Brian E | Methods of treating irritable bowel syndrome and functional dyspepsia |
| AU2003231805A1 (en) | 2002-06-17 | 2004-02-09 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
| US7342006B2 (en) * | 2003-08-25 | 2008-03-11 | Adenosine Therapeutics, Llc | Substituted 8-heteroaryl xanthines |
| GB0324086D0 (en) * | 2003-10-14 | 2003-11-19 | Glaxo Group Ltd | Process for preparing a co-precipitate of a non-crystalline solid drug substance |
| WO2006004903A2 (en) * | 2004-06-28 | 2006-01-12 | Atherogenics, Inc. | 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
| US7618962B2 (en) * | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
| WO2006091936A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| US7884100B2 (en) * | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US8318728B2 (en) | 2008-05-14 | 2012-11-27 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| US20120108614A1 (en) * | 2008-05-14 | 2012-05-03 | Chong Jayhong A | Compounds and compositions for treating chemical warfare agent-induced injuries |
| WO2009140517A1 (en) * | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
| BRPI0909614A2 (pt) * | 2008-05-30 | 2015-09-22 | Hoffmann La Roche | "composto, composição farmacêutica, método de tratamento de um transtorno hiperproliferativo em um mamífero, processo para a preparação de uma composição farmacêutica, método para a inibição ou modulação da atividade de quinase de lipídio em um mamífero, kit para o tratamento de condição mediada por pi3k e método de preparação de um composto da fórmula |
| CN102260260B (zh) * | 2010-05-24 | 2014-08-06 | 中国科学院上海药物研究所 | 8-苯基黄嘌呤类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| CN102993203B (zh) * | 2011-09-09 | 2015-11-25 | 温州医学院 | 8-苯基黄嘌呤类衍生物的制备及应用 |
| US9502952B2 (en) | 2012-10-12 | 2016-11-22 | Persimmon Technologies, Corp. | Hybrid motor |
| KR20160005365A (ko) | 2013-05-10 | 2016-01-14 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
| KR20160006762A (ko) | 2013-05-10 | 2016-01-19 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
| US9765089B2 (en) * | 2013-05-10 | 2017-09-19 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| WO2014182943A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4442125A (en) * | 1978-06-26 | 1984-04-10 | Oxford Hill, Ltd. | Process for detaching or preventing attachment of microorganisms to a surface |
| GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US5015647A (en) | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
| GB8826595D0 (en) | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| IL100088A (en) | 1990-11-21 | 1995-07-31 | Smithkline Beecham Corp | FNT inhibitor preparations containing histogenic transducts converted at positions 1, 3, and 8 |
| GB9210839D0 (en) | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
| TW252044B (es) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| JP2613355B2 (ja) | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| JPH09511220A (ja) * | 1993-11-10 | 1997-11-11 | ブリストル‐マイヤーズ スクイブ カンパニー | バクテリアによって誘発される炎症性疾患の治療 |
| US5395831A (en) | 1994-04-08 | 1995-03-07 | American Home Products Corporation | Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone |
| GB9415529D0 (en) | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| DE19535504A1 (de) | 1995-09-25 | 1997-03-27 | Bayer Ag | Substituierte Xanthine |
| WO1997034616A1 (en) | 1996-03-18 | 1997-09-25 | Medical Science Systems, Inc. | A method for periodontal disease treatment |
| EP0812844B1 (de) | 1996-06-07 | 2002-10-23 | Hoechst Aktiengesellschaft | Verwendung von Theophyllinderivaten zur Behandlung und Propylaxe von Schockzuständen, neue Xanthinverbindungen und Verfahren zu deren Herstellung |
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| US6096707A (en) * | 1997-07-11 | 2000-08-01 | Biotie Therapies Ltd. | Integrin binding peptide and use thereof |
| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| AU2640999A (en) | 1998-02-26 | 1999-09-15 | Zenyaku Kogyo Kabushiki Kaisha | 1-azaindolizine derivatives |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| IL150368A0 (en) | 1999-12-23 | 2002-12-01 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use |
| US20020006915A1 (en) * | 2000-02-15 | 2002-01-17 | Mack Strong Vivian E. | Use of COX-2 inhibitors to treat sepsis, complications thereof, and EP receptor modulation |
| US6751206B1 (en) | 2000-06-29 | 2004-06-15 | Qualcomm Incorporated | Method and apparatus for beam switching in a wireless communication system |
-
1998
- 1998-08-13 GB GBGB9817623.3A patent/GB9817623D0/en not_active Ceased
-
1999
- 1999-08-10 AR ARP990103999A patent/AR020154A1/es not_active Application Discontinuation
- 1999-08-10 CO CO99050691A patent/CO5130007A1/es unknown
- 1999-08-11 WO PCT/EP1999/005814 patent/WO2000009507A1/en active IP Right Grant
- 1999-08-11 DK DK99944358T patent/DK1104422T3/da active
- 1999-08-11 KR KR1020017001799A patent/KR20010085369A/ko active IP Right Grant
- 1999-08-11 AU AU57323/99A patent/AU775819B2/en not_active Ceased
- 1999-08-11 AP APAP/P/2001/002071A patent/AP1408A/en active
- 1999-08-11 IL IL14131899A patent/IL141318A0/xx unknown
- 1999-08-11 MA MA25728A patent/MA26673A1/fr unknown
- 1999-08-11 CA CA002340350A patent/CA2340350A1/en not_active Abandoned
- 1999-08-11 ID IDW20010591A patent/ID28723A/id unknown
- 1999-08-11 SI SI9930545T patent/SI1104422T1/xx unknown
- 1999-08-11 CN CNB031104673A patent/CN1251676C/zh not_active Expired - Fee Related
- 1999-08-11 JP JP2000564958A patent/JP3631961B2/ja not_active Expired - Fee Related
- 1999-08-11 AT AT99944358T patent/ATE259810T1/de not_active IP Right Cessation
- 1999-08-11 PL PL99346055A patent/PL346055A1/xx not_active Application Discontinuation
- 1999-08-11 DE DE69914921T patent/DE69914921T2/de not_active Expired - Fee Related
- 1999-08-11 TR TR2001/00448T patent/TR200100448T2/xx unknown
- 1999-08-11 CN CNB998119695A patent/CN1149215C/zh not_active Expired - Fee Related
- 1999-08-11 EP EP99944358A patent/EP1104422B1/en not_active Expired - Lifetime
- 1999-08-11 EE EEP200100083A patent/EE04721B1/xx not_active IP Right Cessation
- 1999-08-11 NZ NZ509778A patent/NZ509778A/en unknown
- 1999-08-11 MY MYPI99003429A patent/MY133393A/en unknown
- 1999-08-11 BR BR9913020-3A patent/BR9913020A/pt not_active IP Right Cessation
- 1999-08-11 YU YU11601A patent/YU11601A/sh unknown
- 1999-08-11 EA EA200100127A patent/EA004139B1/ru unknown
- 1999-08-11 ES ES99944358T patent/ES2215399T3/es not_active Expired - Lifetime
- 1999-08-11 PT PT99944358T patent/PT1104422E/pt unknown
- 1999-08-11 SK SK222-2001A patent/SK2222001A3/sk unknown
- 1999-08-11 PE PE1999000814A patent/PE20000952A1/es not_active Application Discontinuation
- 1999-08-11 US US09/762,559 patent/US6608069B1/en not_active Expired - Fee Related
- 1999-08-11 HU HU0103637A patent/HUP0103637A3/hu unknown
- 1999-08-12 TW TW088113815A patent/TWI224598B/zh not_active IP Right Cessation
-
2001
- 2001-02-09 IS IS5843A patent/IS5843A/is unknown
- 2001-02-12 NO NO20010715A patent/NO20010715L/no not_active Application Discontinuation
- 2001-02-12 ZA ZA200101186A patent/ZA200101186B/en unknown
- 2001-08-22 HK HK01105939A patent/HK1035195A1/xx not_active IP Right Cessation
-
2002
- 2002-03-26 US US10/106,772 patent/US6770267B2/en not_active Expired - Fee Related
-
2003
- 2003-02-03 US US10/357,751 patent/US20040034020A1/en not_active Abandoned
- 2003-06-09 JP JP2003164252A patent/JP2004137251A/ja not_active Withdrawn
- 2003-11-25 JP JP2003394308A patent/JP2004115534A/ja active Pending
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