DE68921719D1 - Amphotericin B Derivate. - Google Patents

Amphotericin B Derivate.

Info

Publication number
DE68921719D1
DE68921719D1 DE68921719T DE68921719T DE68921719D1 DE 68921719 D1 DE68921719 D1 DE 68921719D1 DE 68921719 T DE68921719 T DE 68921719T DE 68921719 T DE68921719 T DE 68921719T DE 68921719 D1 DE68921719 D1 DE 68921719D1
Authority
DE
Germany
Prior art keywords
hydrogen
amphotericin
derivatives
ch2oh
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68921719T
Other languages
English (en)
Other versions
DE68921719T2 (de
Inventor
Michael John Beecham Ph Driver
William S Beecham P Maclachlan
Andrew William Beecham Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE68921719D1 publication Critical patent/DE68921719D1/de
Publication of DE68921719T2 publication Critical patent/DE68921719T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
  • Furan Compounds (AREA)
DE68921719T 1988-12-19 1989-12-08 Amphotericin B Derivate. Expired - Lifetime DE68921719T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888829593A GB8829593D0 (en) 1988-12-19 1988-12-19 Novel compounds

Publications (2)

Publication Number Publication Date
DE68921719D1 true DE68921719D1 (de) 1995-04-20
DE68921719T2 DE68921719T2 (de) 1995-07-13

Family

ID=10648737

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921719T Expired - Lifetime DE68921719T2 (de) 1988-12-19 1989-12-08 Amphotericin B Derivate.

Country Status (15)

Country Link
US (1) US5100876A (de)
EP (1) EP0375222B1 (de)
JP (1) JPH02207093A (de)
KR (1) KR900009677A (de)
AT (1) ATE119910T1 (de)
AU (1) AU614204B2 (de)
CA (1) CA2005134A1 (de)
DE (1) DE68921719T2 (de)
DK (1) DK624989A (de)
ES (1) ES2071667T3 (de)
GB (1) GB8829593D0 (de)
IE (1) IE893956L (de)
NZ (1) NZ231722A (de)
PT (1) PT92540B (de)
ZA (1) ZA899506B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350164A3 (de) * 1988-06-13 1991-07-24 Beecham Group Plc Amphotericin-Derivate
GB8829592D0 (en) * 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
WO1991009047A1 (en) * 1989-12-08 1991-06-27 Beecham Group Plc Amphotericin b derivatives, their production and use
GB9114949D0 (en) * 1991-07-11 1991-08-28 Smithkline Beecham Plc Novel compounds
FR2683723B1 (fr) * 1991-11-14 1995-05-19 Mayoly Spindler Laboratoires Nouveaux medicaments antiviraux actifs sur le virus vih.
GB9200713D0 (en) * 1992-01-14 1992-03-11 Smithkline Beecham Plc Novel compounds
JP2003519662A (ja) 2000-01-14 2003-06-24 イントラバイオティクス ファーマシューティカルズ，インコーポレイテッド ポリエン・マクロライド誘導体並びにその製法及び使用
WO2013132014A1 (en) 2012-03-09 2013-09-12 Blirt S.A. Semisynthetic derivatives of nystatin a1
JP2015519389A (ja) 2012-06-15 2015-07-09 ブリート スポルカ アクシヤ 抗真菌性抗生物質アンフォテリシンｂのｎ−置換第二世代誘導体ならびにそれらの調製および塗布方法
CA2951516C (en) * 2014-06-12 2019-04-02 Shionogi & Co., Ltd. Polyene macrolide derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2173632A1 (en) * 1971-02-04 1973-10-12 Le N Iss Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing
US4223130A (en) * 1978-09-28 1980-09-16 Schering Corporation Antibiotic 67-121, a polyene antifungal antibiotic produced by Actinoplanes caeruleus
US4235993A (en) * 1979-02-21 1980-11-25 E. R. Squibb & Sons, Inc. N-Benzylideneamphotericin B, its methyl ester and process for making water-soluble salts thereof
EP0350164A3 (de) * 1988-06-13 1991-07-24 Beecham Group Plc Amphotericin-Derivate
GB8829592D0 (en) * 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
NZ231722A (en) 1992-04-28
ZA899506B (en) 1991-08-28
AU614204B2 (en) 1991-08-22
EP0375222B1 (de) 1995-03-15
PT92540B (pt) 1995-08-09
AU4617089A (en) 1990-06-21
IE893956L (en) 1990-06-19
DK624989D0 (da) 1989-12-11
US5100876A (en) 1992-03-31
EP0375222A2 (de) 1990-06-27
DK624989A (da) 1990-06-20
CA2005134A1 (en) 1990-06-19
DE68921719T2 (de) 1995-07-13
ATE119910T1 (de) 1995-04-15
PT92540A (pt) 1990-06-29
JPH02207093A (ja) 1990-08-16
GB8829593D0 (en) 1989-02-08
ES2071667T3 (es) 1995-07-01
KR900009677A (ko) 1990-07-05
EP0375222A3 (de) 1991-05-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition