FR2173632A1 - Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing - Google Patents

Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing

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Publication number
FR2173632A1
FR2173632A1 FR7103762A FR7103762A FR2173632A1 FR 2173632 A1 FR2173632 A1 FR 2173632A1 FR 7103762 A FR7103762 A FR 7103762A FR 7103762 A FR7103762 A FR 7103762A FR 2173632 A1 FR2173632 A1 FR 2173632A1
Authority
FR
France
Prior art keywords
adding water
amfotericin
washing
dmf
purificn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7103762A
Other languages
French (fr)
Other versions
FR2173632B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LE N ISS
Original Assignee
LE N ISS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LE N ISS filed Critical LE N ISS
Priority to FR7103762A priority Critical patent/FR2173632A1/en
Publication of FR2173632A1 publication Critical patent/FR2173632A1/en
Application granted granted Critical
Publication of FR2173632B1 publication Critical patent/FR2173632B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Amfotericin B (I), a macrolide antibiotic used for treating mycosis, is separated and purified by treating a soln. of impure (I) in DMF with a amt. of dist. H2O ca 1/2 that of the DMF, acidifying the mixt. to pH 2-3.6 (pref. with 10% HCl), separating the ppted. impurities, adding an amt. of H2O similar to that of the solvent, adjusting the pH to 6.5-7.0/pref. with 10% NaOH soln.) washing with aqs. n-propanol (pref. 50% conc.) and acetone and drying. The product has a specific activity of >750 mu g/mg. and an ash content of 0.5%.
FR7103762A 1971-02-04 1971-02-04 Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing Granted FR2173632A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7103762A FR2173632A1 (en) 1971-02-04 1971-02-04 Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7103762A FR2173632A1 (en) 1971-02-04 1971-02-04 Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing

Publications (2)

Publication Number Publication Date
FR2173632A1 true FR2173632A1 (en) 1973-10-12
FR2173632B1 FR2173632B1 (en) 1975-04-18

Family

ID=9071392

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7103762A Granted FR2173632A1 (en) 1971-02-04 1971-02-04 Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing

Country Status (1)

Country Link
FR (1) FR2173632A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330706A1 (en) * 1988-02-29 1989-09-06 E.R. Squibb & Sons, Inc. Method for forming amphotericin B crystals in fermentation broth
EP0350164A2 (en) * 1988-06-13 1990-01-10 Beecham Group Plc Amphotericin derivatives
EP0375222A2 (en) * 1988-12-19 1990-06-27 Beecham Group Plc Amphotericin B derivatives
EP0375223A2 (en) * 1988-12-19 1990-06-27 Beecham Group Plc Novel compounds
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
WO1991009047A1 (en) * 1989-12-08 1991-06-27 Beecham Group Plc Amphotericin b derivatives, their production and use
FR2657260A1 (en) * 1987-10-27 1991-07-26 Squibb & Sons Inc PROCESS AND COMPOSITION FOR PURIFYING AMPHOTERICIN B.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE543959A (en) *

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE543959A (en) *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2657260A1 (en) * 1987-10-27 1991-07-26 Squibb & Sons Inc PROCESS AND COMPOSITION FOR PURIFYING AMPHOTERICIN B.
EP0330706A1 (en) * 1988-02-29 1989-09-06 E.R. Squibb & Sons, Inc. Method for forming amphotericin B crystals in fermentation broth
EP0350164A3 (en) * 1988-06-13 1991-07-24 Beecham Group Plc Amphotericin derivatives
EP0350164A2 (en) * 1988-06-13 1990-01-10 Beecham Group Plc Amphotericin derivatives
EP0375223A2 (en) * 1988-12-19 1990-06-27 Beecham Group Plc Novel compounds
EP0375223A3 (en) * 1988-12-19 1991-07-03 Beecham Group Plc Novel compounds
EP0375222A3 (en) * 1988-12-19 1991-05-29 Beecham Group Plc Amphotericin B derivatives
EP0375222A2 (en) * 1988-12-19 1990-06-27 Beecham Group Plc Amphotericin B derivatives
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
EP0431874A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Novel compounds
WO1991009047A1 (en) * 1989-12-08 1991-06-27 Beecham Group Plc Amphotericin b derivatives, their production and use
US5204330A (en) * 1989-12-08 1993-04-20 Beecham Group P.L.C. Antifungal compounds
US6284736B1 (en) 1989-12-08 2001-09-04 Beecham Group, Plc Amphotericin derivatives

Also Published As

Publication number Publication date
FR2173632B1 (en) 1975-04-18

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Legal Events

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