NL7101187A - Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing - Google Patents

Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing

Info

Publication number
NL7101187A
NL7101187A NL7101187A NL7101187A NL7101187A NL 7101187 A NL7101187 A NL 7101187A NL 7101187 A NL7101187 A NL 7101187A NL 7101187 A NL7101187 A NL 7101187A NL 7101187 A NL7101187 A NL 7101187A
Authority
NL
Netherlands
Prior art keywords
adding water
amfotericin
washing
dmf
purificn
Prior art date
Application number
NL7101187A
Other versions
NL166852B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to NL7101187A priority Critical patent/NL166852B/en
Publication of NL7101187A publication Critical patent/NL7101187A/en
Publication of NL166852B publication Critical patent/NL166852B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Amfotericin B (I), a macrolide antibiotic used for treating mycosis, is separated and purified by treating a soln. of impure (I) in DMF with a amt. of dist. H2O ca 1/2 that of the DMF, acidifying the mixt. to pH 2-3.6 (pref. with 10% HCl), separating the ppted. impurities, adding an amt. of H2O similar to that of the solvent, adjusting the pH to 6.5-7.0/pref. with 10% NaOH soln.) washing with aqs. n-propanol (pref. 50% conc.) and acetone and drying. The product has a specific activity of >750 mu g/mg. and an ash content of 0.5%.
NL7101187A 1971-01-29 1971-01-29 METHOD FOR RECOVERING PURE AMPHOTERICIN B AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION NL166852B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7101187A NL166852B (en) 1971-01-29 1971-01-29 METHOD FOR RECOVERING PURE AMPHOTERICIN B AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7101187A NL166852B (en) 1971-01-29 1971-01-29 METHOD FOR RECOVERING PURE AMPHOTERICIN B AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION

Publications (2)

Publication Number Publication Date
NL7101187A true NL7101187A (en) 1972-08-01
NL166852B NL166852B (en) 1981-05-15

Family

ID=19812361

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7101187A NL166852B (en) 1971-01-29 1971-01-29 METHOD FOR RECOVERING PURE AMPHOTERICIN B AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION

Country Status (1)

Country Link
NL (1) NL166852B (en)

Also Published As

Publication number Publication date
NL166852B (en) 1981-05-15

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Legal Events

Date Code Title Description
P1 Automatically granted patents, except
RI Patent application has been withdrawn after publication (e.g. due to an opposition)
BI The patent application has been withdrawn
BK Erratum

Free format text: IE NR.10 VAN 1981: RUBR.R:A01K 31/71 MOET ZIJN A61K 31/71