ATE119910T1 - Amphotericin b derivate. - Google Patents
Amphotericin b derivate.Info
- Publication number
- ATE119910T1 ATE119910T1 AT89312824T AT89312824T ATE119910T1 AT E119910 T1 ATE119910 T1 AT E119910T1 AT 89312824 T AT89312824 T AT 89312824T AT 89312824 T AT89312824 T AT 89312824T AT E119910 T1 ATE119910 T1 AT E119910T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- amphotericin
- derivatives
- ch2oh
- chem
- Prior art date
Links
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical class O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Photoreceptors In Electrophotography (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888829593A GB8829593D0 (en) | 1988-12-19 | 1988-12-19 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119910T1 true ATE119910T1 (de) | 1995-04-15 |
Family
ID=10648737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89312824T ATE119910T1 (de) | 1988-12-19 | 1989-12-08 | Amphotericin b derivate. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5100876A (de) |
| EP (1) | EP0375222B1 (de) |
| JP (1) | JPH02207093A (de) |
| KR (1) | KR900009677A (de) |
| AT (1) | ATE119910T1 (de) |
| AU (1) | AU614204B2 (de) |
| CA (1) | CA2005134A1 (de) |
| DE (1) | DE68921719T2 (de) |
| DK (1) | DK624989A (de) |
| ES (1) | ES2071667T3 (de) |
| GB (1) | GB8829593D0 (de) |
| IE (1) | IE893956L (de) |
| NZ (1) | NZ231722A (de) |
| PT (1) | PT92540B (de) |
| ZA (1) | ZA899506B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0350164A3 (de) * | 1988-06-13 | 1991-07-24 | Beecham Group Plc | Amphotericin-Derivate |
| GB8829592D0 (en) * | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
| WO1991009047A1 (en) * | 1989-12-08 | 1991-06-27 | Beecham Group Plc | Amphotericin b derivatives, their production and use |
| GB9114949D0 (en) * | 1991-07-11 | 1991-08-28 | Smithkline Beecham Plc | Novel compounds |
| FR2683723B1 (fr) * | 1991-11-14 | 1995-05-19 | Mayoly Spindler Laboratoires | Nouveaux medicaments antiviraux actifs sur le virus vih. |
| GB9200713D0 (en) * | 1992-01-14 | 1992-03-11 | Smithkline Beecham Plc | Novel compounds |
| AU780724B2 (en) | 2000-01-14 | 2005-04-14 | Migenix Inc. | Derivatives of polyene macrolides and preparation and use thereof |
| US9447136B2 (en) | 2012-03-09 | 2016-09-20 | Blirt S.A. | Semisynthetic derivatives of Nystatin A1 |
| JP2015519389A (ja) | 2012-06-15 | 2015-07-09 | ブリート スポルカ アクシヤ | 抗真菌性抗生物質アンフォテリシンｂのｎ−置換第二世代誘導体ならびにそれらの調製および塗布方法 |
| MX378786B (es) * | 2014-06-12 | 2025-03-11 | Shionogi & Co | Derivado de macrólido de polieno. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2173632A1 (en) * | 1971-02-04 | 1973-10-12 | Le N Iss | Purificn of amfotericin b - in dmf soln by adding water acidifying filtering adding water,making alkaline and washing |
| US4223130A (en) * | 1978-09-28 | 1980-09-16 | Schering Corporation | Antibiotic 67-121, a polyene antifungal antibiotic produced by Actinoplanes caeruleus |
| US4235993A (en) * | 1979-02-21 | 1980-11-25 | E. R. Squibb & Sons, Inc. | N-Benzylideneamphotericin B, its methyl ester and process for making water-soluble salts thereof |
| EP0350164A3 (de) * | 1988-06-13 | 1991-07-24 | Beecham Group Plc | Amphotericin-Derivate |
| GB8829592D0 (en) * | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
-
1988
- 1988-12-19 GB GB888829593A patent/GB8829593D0/en active Pending
-
1989
- 1989-12-08 DE DE68921719T patent/DE68921719T2/de not_active Expired - Lifetime
- 1989-12-08 EP EP89312824A patent/EP0375222B1/de not_active Expired - Lifetime
- 1989-12-08 ES ES89312824T patent/ES2071667T3/es not_active Expired - Lifetime
- 1989-12-08 AT AT89312824T patent/ATE119910T1/de not_active IP Right Cessation
- 1989-12-11 CA CA002005134A patent/CA2005134A1/en not_active Abandoned
- 1989-12-11 US US07/448,551 patent/US5100876A/en not_active Expired - Lifetime
- 1989-12-11 AU AU46170/89A patent/AU614204B2/en not_active Ceased
- 1989-12-11 IE IE893956A patent/IE893956L/xx unknown
- 1989-12-11 PT PT92540A patent/PT92540B/pt not_active IP Right Cessation
- 1989-12-11 DK DK624989A patent/DK624989A/da not_active Application Discontinuation
- 1989-12-12 JP JP1320748A patent/JPH02207093A/ja active Pending
- 1989-12-12 NZ NZ231722A patent/NZ231722A/en unknown
- 1989-12-12 KR KR1019890018391A patent/KR900009677A/ko not_active Withdrawn
- 1989-12-13 ZA ZA899506A patent/ZA899506B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR900009677A (ko) | 1990-07-05 |
| PT92540B (pt) | 1995-08-09 |
| CA2005134A1 (en) | 1990-06-19 |
| PT92540A (pt) | 1990-06-29 |
| ES2071667T3 (es) | 1995-07-01 |
| IE893956L (en) | 1990-06-19 |
| AU4617089A (en) | 1990-06-21 |
| GB8829593D0 (en) | 1989-02-08 |
| ZA899506B (en) | 1991-08-28 |
| EP0375222B1 (de) | 1995-03-15 |
| EP0375222A2 (de) | 1990-06-27 |
| EP0375222A3 (de) | 1991-05-29 |
| DK624989A (da) | 1990-06-20 |
| DK624989D0 (da) | 1989-12-11 |
| NZ231722A (en) | 1992-04-28 |
| US5100876A (en) | 1992-03-31 |
| DE68921719T2 (de) | 1995-07-13 |
| AU614204B2 (en) | 1991-08-22 |
| DE68921719D1 (de) | 1995-04-20 |
| JPH02207093A (ja) | 1990-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW330202B (en) | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | |
| FI890689A0 (fi) | 3-alkenyl-1-azabicyklo-/3.2.0/ -hept-2-en-2-karboxylsyrafoereningar. | |
| NO903438L (no) | Fremgangsmaate for fremstilling av tiazolderivater. | |
| DE69010139D1 (de) | Haarkräftigungsmittel. | |
| FI881985A0 (fi) | Foerfarande foer framstaellning av terapeutiskt verkande (s,s,s)-isomerer av substituerade acylderivat av 1,2,3,4-tetrahydroisokinolin-3-karboxylsyror. | |
| ES2185635T3 (es) | Derivados de benzamida y su uso como antagonistas de vasopresina. | |
| SE9604786D0 (sv) | New compounds | |
| FI872864A0 (fi) | Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi | |
| ATE107306T1 (de) | 3-pyrrolidinylthio-1-azabicyclo (3.2.0)hept-2-en- 2-carbonsäure-verbindungen. | |
| PT1153924E (pt) | 1,3-oxatiolanos substituidos com propriedades anti-virais | |
| AP9801378A0 (en) | 9-amino-3- keto erythromycin derivatives. | |
| DE68901153D1 (de) | Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung. | |
| ES2058749T3 (es) | Derivados 2-aminopirimidinona. | |
| ES2189941T3 (es) | Derivados de nucleosidos aciclicos. | |
| AU614204B2 (en) | 16-hydroxymethyl amphotericin b derivatives | |
| NO933611L (no) | Anti-tumor- og anti-psoriatiske midler | |
| NO812355L (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater | |
| UA42733C2 (uk) | Похідні біснафталіміду та їх фармацевтично прийнятні кислотно-адитивні солі, фармацевтична композиція з цитотоксичною активністю, яка їх містить | |
| IS4725A (is) | Afleiður amidíns og ísóþíóþvagefnis er hindra nítrítoxíðsyntasa | |
| ATE13765T1 (de) | 2-(1,4-benzodioxan-2-ylalkyl)-imidazole, deren herstellung und sie enthaltende pharmazeutische mittel. | |
| DE3666223D1 (en) | Anticonvulsant agents | |
| FI895139A0 (fi) | Pyrrolidinderivat. | |
| GR3007498T3 (de) | ||
| FI921475A0 (fi) | 1,4-dihydro-4-oxo-3-kinolinderivat som selektivt toxiska antibakteriella aemenn hos daeggdjur. | |
| DK0952157T3 (da) | 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |