DE60332109D1 - Heteroaryl-verbindungen zur hemmung der durch alpha-4-integrine vermittelten leukozytenadhäsion - Google Patents

Heteroaryl-verbindungen zur hemmung der durch alpha-4-integrine vermittelten leukozytenadhäsion

Info

Publication number
DE60332109D1
DE60332109D1 DE60332109T DE60332109T DE60332109D1 DE 60332109 D1 DE60332109 D1 DE 60332109D1 DE 60332109 T DE60332109 T DE 60332109T DE 60332109 T DE60332109 T DE 60332109T DE 60332109 D1 DE60332109 D1 DE 60332109D1
Authority
DE
Germany
Prior art keywords
sub
alpha
integrins
compounds
leukocyte adhesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60332109T
Other languages
German (de)
English (en)
Inventor
Andrei W Konradi
Christopher M Semko
Ying-Zi Xu
Frank Stappenbeck
Brian P Stupi
Jenifer Smith
Eugene D Thorsett
Michael A Pleiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Application granted granted Critical
Publication of DE60332109D1 publication Critical patent/DE60332109D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60332109T 2002-05-24 2003-05-27 Heteroaryl-verbindungen zur hemmung der durch alpha-4-integrine vermittelten leukozytenadhäsion Expired - Lifetime DE60332109D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38324402P 2002-05-24 2002-05-24
PCT/US2003/017150 WO2003099231A2 (en) 2002-05-24 2003-05-27 Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins

Publications (1)

Publication Number Publication Date
DE60332109D1 true DE60332109D1 (de) 2010-05-27

Family

ID=29584533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60332109T Expired - Lifetime DE60332109D1 (de) 2002-05-24 2003-05-27 Heteroaryl-verbindungen zur hemmung der durch alpha-4-integrine vermittelten leukozytenadhäsion

Country Status (17)

Country Link
US (2) US7008949B2 (enExample)
EP (1) EP1507533B1 (enExample)
JP (1) JP4413135B2 (enExample)
CN (1) CN1311829C (enExample)
AT (1) ATE464298T1 (enExample)
AU (1) AU2003237302B8 (enExample)
BR (1) BR0309619A (enExample)
CA (1) CA2480756A1 (enExample)
DE (1) DE60332109D1 (enExample)
EA (1) EA008180B1 (enExample)
IL (1) IL164323A (enExample)
MX (1) MXPA04011657A (enExample)
NO (1) NO20045276L (enExample)
NZ (1) NZ535723A (enExample)
TW (1) TW200307671A (enExample)
WO (1) WO2003099231A2 (enExample)
ZA (1) ZA200407944B (enExample)

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TWI389904B (zh) * 2006-02-27 2013-03-21 Elan Pharm Inc 抑制由ｖｌａ-４所調節的白血球黏附之嘧啶磺醯胺化合物
US8410115B2 (en) * 2006-02-28 2013-04-02 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
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KR102630416B1 (ko) 2018-10-30 2024-02-01 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
JP7189368B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド アルファ４ベータ７インテグリンの阻害のための化合物
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
CN111197057B (zh) * 2018-11-19 2024-04-19 中国科学院分子细胞科学卓越创新中心 调控免疫细胞迁移的组合物和方法
CN114222730B (zh) 2019-08-14 2024-09-10 吉利德科学公司 用于抑制α4β7整合素的化合物

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Also Published As

Publication number Publication date
JP4413135B2 (ja) 2010-02-10
CN1311829C (zh) 2007-04-25
AU2003237302A1 (en) 2003-12-12
IL164323A0 (en) 2005-12-18
EP1507533A4 (en) 2007-05-23
NZ535723A (en) 2005-08-26
WO2003099231A2 (en) 2003-12-04
AU2003237302B2 (en) 2008-03-06
EA200401561A1 (ru) 2005-06-30
CA2480756A1 (en) 2003-12-04
EP1507533A2 (en) 2005-02-23
BR0309619A (pt) 2005-06-28
US7008949B2 (en) 2006-03-07
US20050130999A1 (en) 2005-06-16
TW200307671A (en) 2003-12-16
US20040142954A1 (en) 2004-07-22
EP1507533B1 (en) 2010-04-14
AU2003237302B8 (en) 2008-04-03
CN1652789A (zh) 2005-08-10
ATE464298T1 (de) 2010-04-15
EA008180B1 (ru) 2007-04-27
NO20045276L (no) 2004-12-01
IL164323A (en) 2010-02-17
JP2005529155A (ja) 2005-09-29
US7335663B2 (en) 2008-02-26
WO2003099231A3 (en) 2004-01-22
ZA200407944B (en) 2006-07-26
MXPA04011657A (es) 2005-08-18

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