CN1311829C - 抑制由α4整合素介导的白细胞粘附的杂芳基化合物 - Google Patents

抑制由α4整合素介导的白细胞粘附的杂芳基化合物 Download PDF

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Publication number
CN1311829C
CN1311829C CNB038112582A CN03811258A CN1311829C CN 1311829 C CN1311829 C CN 1311829C CN B038112582 A CNB038112582 A CN B038112582A CN 03811258 A CN03811258 A CN 03811258A CN 1311829 C CN1311829 C CN 1311829C
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CN
China
Prior art keywords
diethylamino
ylamino
pyrimidin
dimethylcarbamoyloxyphenyl
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB038112582A
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English (en)
Chinese (zh)
Other versions
CN1652789A (zh
Inventor
安德烈·W·康拉迪
克里斯托夫·M·塞姆科
许英姿
弗兰克·斯塔潘贝克
布赖恩·P·斯图皮
珍妮弗·史密斯
尤金·D·托尔塞特
迈克尔·A·普莱斯
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Elan Pharmaceuticals LLC
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Elan Pharmaceuticals LLC
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Publication of CN1652789A publication Critical patent/CN1652789A/zh
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Publication of CN1311829C publication Critical patent/CN1311829C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB038112582A 2002-05-24 2003-05-27 抑制由α4整合素介导的白细胞粘附的杂芳基化合物 Expired - Fee Related CN1311829C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38324402P 2002-05-24 2002-05-24
US60/383,244 2002-05-24

Publications (2)

Publication Number Publication Date
CN1652789A CN1652789A (zh) 2005-08-10
CN1311829C true CN1311829C (zh) 2007-04-25

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ID=29584533

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CNB038112582A Expired - Fee Related CN1311829C (zh) 2002-05-24 2003-05-27 抑制由α4整合素介导的白细胞粘附的杂芳基化合物

Country Status (17)

Country Link
US (2) US7008949B2 (enExample)
EP (1) EP1507533B1 (enExample)
JP (1) JP4413135B2 (enExample)
CN (1) CN1311829C (enExample)
AT (1) ATE464298T1 (enExample)
AU (1) AU2003237302B8 (enExample)
BR (1) BR0309619A (enExample)
CA (1) CA2480756A1 (enExample)
DE (1) DE60332109D1 (enExample)
EA (1) EA008180B1 (enExample)
IL (1) IL164323A (enExample)
MX (1) MXPA04011657A (enExample)
NO (1) NO20045276L (enExample)
NZ (1) NZ535723A (enExample)
TW (1) TW200307671A (enExample)
WO (1) WO2003099231A2 (enExample)
ZA (1) ZA200407944B (enExample)

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US7727996B2 (en) 2005-09-29 2010-06-01 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
CA2624450C (en) * 2005-09-29 2014-02-04 Elan Pharmaceuticals, Inc. Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4
MY151045A (en) 2006-02-27 2014-03-31 Elan Pharm Inc Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
WO2007100770A2 (en) * 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with natalizumab
US8410115B2 (en) * 2006-02-28 2013-04-02 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
RS20080391A (sr) 2006-03-03 2009-07-15 Elan Pharmaceuticals Inc., Postupci lečenja zapaljenskih i autoimunih bolesti natalizumabom
CA2708262A1 (en) * 2007-12-07 2009-06-18 Elan Pharmaceuticals, Inc. Methods and compositions for treating liquid tumors
CN102459179A (zh) * 2009-04-27 2012-05-16 艾伦药物公司 α-4整联蛋白的吡啶酮拮抗剂
RS63744B1 (sr) 2010-01-11 2022-12-30 Biogen Ma Inc Test za antitela protiv jc virusa
US11287423B2 (en) 2010-01-11 2022-03-29 Biogen Ma Inc. Assay for JC virus antibodies
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ES2729945T3 (es) 2011-05-31 2019-11-07 Biogen Ma Inc Procedimiento para valorar el riesgo de LMP
HK1216546A1 (zh) 2013-05-28 2016-11-18 Biogen Ma Inc. 评估pml风险的方法
WO2019246455A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
DK3873884T3 (da) 2018-10-30 2025-02-17 Gilead Sciences Inc 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme
PL3873605T3 (pl) 2018-10-30 2025-03-03 Gilead Sciences, Inc. Związki hamujące integrynę alfa4beta7
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
EP3873897B1 (en) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases
CN111197057B (zh) * 2018-11-19 2024-04-19 中国科学院分子细胞科学卓越创新中心 调控免疫细胞迁移的组合物和方法
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin

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EP1507533B1 (en) 2010-04-14
US7335663B2 (en) 2008-02-26
CA2480756A1 (en) 2003-12-04
US7008949B2 (en) 2006-03-07
AU2003237302A1 (en) 2003-12-12
AU2003237302B8 (en) 2008-04-03
EP1507533A2 (en) 2005-02-23
MXPA04011657A (es) 2005-08-18
NZ535723A (en) 2005-08-26
WO2003099231A3 (en) 2004-01-22
US20040142954A1 (en) 2004-07-22
WO2003099231A2 (en) 2003-12-04
US20050130999A1 (en) 2005-06-16
EA008180B1 (ru) 2007-04-27
BR0309619A (pt) 2005-06-28
DE60332109D1 (de) 2010-05-27
IL164323A (en) 2010-02-17
JP4413135B2 (ja) 2010-02-10
CN1652789A (zh) 2005-08-10
EP1507533A4 (en) 2007-05-23
NO20045276L (no) 2004-12-01
IL164323A0 (en) 2005-12-18
JP2005529155A (ja) 2005-09-29
ATE464298T1 (de) 2010-04-15
ZA200407944B (en) 2006-07-26
TW200307671A (en) 2003-12-16
AU2003237302B2 (en) 2008-03-06
EA200401561A1 (ru) 2005-06-30

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