BR0309619A - Compostos de heteroarila os quais inibem a adesão de leucócitos mediada por integrinas (alfa)4 - Google Patents

Compostos de heteroarila os quais inibem a adesão de leucócitos mediada por integrinas (alfa)4

Info

Publication number
BR0309619A
BR0309619A BR0309619-0A BR0309619A BR0309619A BR 0309619 A BR0309619 A BR 0309619A BR 0309619 A BR0309619 A BR 0309619A BR 0309619 A BR0309619 A BR 0309619A
Authority
BR
Brazil
Prior art keywords
sub
alpha
compounds
leukocyte adhesion
integrin
Prior art date
Application number
BR0309619-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Andrei W Konradi
Christopher M Semko
Ying-Zi Xu
Brian P Stupi
Eugene D Thorsett
Frank Stappenbeck
Jenifer Smith
Michael A Pleiss
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of BR0309619A publication Critical patent/BR0309619A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR0309619-0A 2002-05-24 2003-05-27 Compostos de heteroarila os quais inibem a adesão de leucócitos mediada por integrinas (alfa)4 BR0309619A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38324402P 2002-05-24 2002-05-24
PCT/US2003/017150 WO2003099231A2 (en) 2002-05-24 2003-05-27 Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins

Publications (1)

Publication Number Publication Date
BR0309619A true BR0309619A (pt) 2005-06-28

Family

ID=29584533

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309619-0A BR0309619A (pt) 2002-05-24 2003-05-27 Compostos de heteroarila os quais inibem a adesão de leucócitos mediada por integrinas (alfa)4

Country Status (17)

Country Link
US (2) US7335663B2 (enExample)
EP (1) EP1507533B1 (enExample)
JP (1) JP4413135B2 (enExample)
CN (1) CN1311829C (enExample)
AT (1) ATE464298T1 (enExample)
AU (1) AU2003237302B8 (enExample)
BR (1) BR0309619A (enExample)
CA (1) CA2480756A1 (enExample)
DE (1) DE60332109D1 (enExample)
EA (1) EA008180B1 (enExample)
IL (1) IL164323A (enExample)
MX (1) MXPA04011657A (enExample)
NO (1) NO20045276L (enExample)
NZ (1) NZ535723A (enExample)
TW (1) TW200307671A (enExample)
WO (1) WO2003099231A2 (enExample)
ZA (1) ZA200407944B (enExample)

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MX2007000228A (es) * 2004-07-08 2007-03-30 Elan Pharm Inc Antagonistas de vla-4 multivalentes que comprenden porsiones de polietilenglicol.
WO2006023396A2 (en) * 2004-08-16 2006-03-02 Merck & Co., Inc. Vla-4 antagonists
AU2006297180A1 (en) 2005-09-29 2007-04-12 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
WO2007041270A1 (en) * 2005-09-29 2007-04-12 Elan Pharmaceuticals, Inc. Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4
EP1996559A1 (en) 2006-02-27 2008-12-03 Elan Pharmaceuticals Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
HUE047230T2 (hu) * 2006-02-28 2020-04-28 Biogen Ma Inc Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei
WO2007100763A2 (en) * 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
EP4582099A3 (en) * 2006-03-03 2025-10-01 Biogen MA Inc. Methods of treating inflammatory and autoimmune diseases with natalizumab
CA2708262A1 (en) 2007-12-07 2009-06-18 Elan Pharmaceuticals, Inc. Methods and compositions for treating liquid tumors
CA2760151A1 (en) * 2009-04-27 2010-11-04 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
EP4152004B9 (en) 2010-01-11 2025-04-09 Biogen MA Inc. Assay for jc virus antibodies
US11287423B2 (en) 2010-01-11 2022-03-29 Biogen Ma Inc. Assay for JC virus antibodies
US8343706B2 (en) 2010-01-25 2013-01-01 International Business Machines Corporation Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
LT3575792T (lt) 2011-05-31 2023-03-10 Biogen Ma Inc. Pdl rizikos vertinimo būdas
WO2014193804A1 (en) 2013-05-28 2014-12-04 Biogen Idec Ma Inc. Method of assessing risk of pml
WO2019246455A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
ES3003232T3 (en) 2018-10-30 2025-03-10 Gilead Sciences Inc Compounds for inhibition of alpha4beta7 integrin
ES2987796T3 (es) 2018-10-30 2024-11-18 Gilead Sciences Inc Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias
CN112969687B (zh) 2018-10-30 2024-08-23 吉利德科学公司 作为α4β7整合素抑制剂的喹啉衍生物
CA3114240C (en) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
CN111197057B (zh) * 2018-11-19 2024-04-19 中国科学院分子细胞科学卓越创新中心 调控免疫细胞迁移的组合物和方法
CN114222730B (zh) 2019-08-14 2024-09-10 吉利德科学公司 用于抑制α4β7整合素的化合物

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Also Published As

Publication number Publication date
IL164323A0 (en) 2005-12-18
MXPA04011657A (es) 2005-08-18
US7008949B2 (en) 2006-03-07
US20050130999A1 (en) 2005-06-16
ATE464298T1 (de) 2010-04-15
CN1652789A (zh) 2005-08-10
AU2003237302A1 (en) 2003-12-12
AU2003237302B2 (en) 2008-03-06
EA200401561A1 (ru) 2005-06-30
EP1507533B1 (en) 2010-04-14
US7335663B2 (en) 2008-02-26
CA2480756A1 (en) 2003-12-04
EP1507533A2 (en) 2005-02-23
NZ535723A (en) 2005-08-26
EA008180B1 (ru) 2007-04-27
AU2003237302B8 (en) 2008-04-03
DE60332109D1 (de) 2010-05-27
TW200307671A (en) 2003-12-16
CN1311829C (zh) 2007-04-25
US20040142954A1 (en) 2004-07-22
JP4413135B2 (ja) 2010-02-10
WO2003099231A3 (en) 2004-01-22
NO20045276L (no) 2004-12-01
JP2005529155A (ja) 2005-09-29
IL164323A (en) 2010-02-17
ZA200407944B (en) 2006-07-26
EP1507533A4 (en) 2007-05-23
WO2003099231A2 (en) 2003-12-04

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012.