JP4413135B2 - α４インテグリンによって媒介される白血球接着を阻害するヘテロアリール化合物 - Google Patents
α４インテグリンによって媒介される白血球接着を阻害するヘテロアリール化合物 Download PDFInfo
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- JP4413135B2 JP4413135B2 JP2004506758A JP2004506758A JP4413135B2 JP 4413135 B2 JP4413135 B2 JP 4413135B2 JP 2004506758 A JP2004506758 A JP 2004506758A JP 2004506758 A JP2004506758 A JP 2004506758A JP 4413135 B2 JP4413135 B2 JP 4413135B2
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- Prior art keywords
- diethylamino
- ylamino
- pyrimidin
- dimethylcarbamoyloxyphenyl
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/US2003/017150 WO2003099231A2 (en) | 2002-05-24 | 2003-05-27 | Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins |
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| JP2005529155A5 JP2005529155A5 (enExample) | 2006-07-13 |
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| HK1045157A1 (zh) * | 1999-01-22 | 2002-11-15 | 依兰制药公司 | 抑制vla-4介导的白细胞粘着的化合物 |
| US20050074451A1 (en) * | 2003-06-25 | 2005-04-07 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
| JP2007528397A (ja) * | 2004-03-10 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | Ｖｌａ−４アンタゴニスト |
| CA2573245C (en) * | 2004-07-08 | 2013-10-01 | Elan Pharmaceuticals, Inc. | Multivalent vla-4 antagonists comprising polymer moieties |
| WO2006023396A2 (en) * | 2004-08-16 | 2006-03-02 | Merck & Co., Inc. | Vla-4 antagonists |
| ZA200803016B (en) * | 2005-09-29 | 2009-10-28 | Elan Pharmaceuticals Inc Wyeth | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| ATE493405T1 (de) * | 2005-09-29 | 2011-01-15 | Elan Pharm Inc | Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren |
| EA017110B1 (ru) * | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
| US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
| KR20080104343A (ko) * | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
| CA2708262A1 (en) * | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
| SG10201401836RA (en) * | 2009-04-27 | 2014-10-30 | Elan Pharm Inc | Pyridinone antagonists of alpha-4 integrins |
| BR112012017014B1 (pt) | 2010-01-11 | 2021-07-20 | Biogen Ma Inc | Métodos para detecção de anticorpos de vírus jc |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| US8343706B2 (en) | 2010-01-25 | 2013-01-01 | International Business Machines Corporation | Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same |
| HUE061244T2 (hu) | 2011-05-31 | 2023-06-28 | Biogen Ma Inc | A PML kockázat értékelésének módszere |
| EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHOD FOR ASSESSING A PML RISK |
| EP3810085A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| ES2987796T3 (es) | 2018-10-30 | 2024-11-18 | Gilead Sciences Inc | Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias |
| DK3873884T3 (da) | 2018-10-30 | 2025-02-17 | Gilead Sciences Inc | 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
| CN111197057B (zh) * | 2018-11-19 | 2024-04-19 | 中国科学院分子细胞科学卓越创新中心 | 调控免疫细胞迁移的组合物和方法 |
| AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
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-
2003
- 2003-05-26 TW TW092114184A patent/TW200307671A/zh unknown
- 2003-05-27 NZ NZ535723A patent/NZ535723A/en unknown
- 2003-05-27 CA CA002480756A patent/CA2480756A1/en not_active Abandoned
- 2003-05-27 DE DE60332109T patent/DE60332109D1/de not_active Expired - Lifetime
- 2003-05-27 AT AT03736768T patent/ATE464298T1/de not_active IP Right Cessation
- 2003-05-27 BR BR0309619-0A patent/BR0309619A/pt not_active IP Right Cessation
- 2003-05-27 AU AU2003237302A patent/AU2003237302B8/en not_active Ceased
- 2003-05-27 MX MXPA04011657A patent/MXPA04011657A/es active IP Right Grant
- 2003-05-27 EP EP03736768A patent/EP1507533B1/en not_active Expired - Lifetime
- 2003-05-27 US US10/494,788 patent/US7335663B2/en not_active Expired - Fee Related
- 2003-05-27 JP JP2004506758A patent/JP4413135B2/ja not_active Expired - Fee Related
- 2003-05-27 CN CNB038112582A patent/CN1311829C/zh not_active Expired - Fee Related
- 2003-05-27 US US10/447,208 patent/US7008949B2/en not_active Expired - Fee Related
- 2003-05-27 WO PCT/US2003/017150 patent/WO2003099231A2/en not_active Ceased
- 2003-05-27 EA EA200401561A patent/EA008180B1/ru not_active IP Right Cessation
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2004
- 2004-09-28 IL IL164323A patent/IL164323A/en not_active IP Right Cessation
- 2004-10-01 ZA ZA200407944A patent/ZA200407944B/en unknown
- 2004-12-01 NO NO20045276A patent/NO20045276L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20050130999A1 (en) | 2005-06-16 |
| EP1507533A4 (en) | 2007-05-23 |
| EA200401561A1 (ru) | 2005-06-30 |
| AU2003237302B8 (en) | 2008-04-03 |
| IL164323A0 (en) | 2005-12-18 |
| TW200307671A (en) | 2003-12-16 |
| US20040142954A1 (en) | 2004-07-22 |
| ZA200407944B (en) | 2006-07-26 |
| AU2003237302A1 (en) | 2003-12-12 |
| CN1652789A (zh) | 2005-08-10 |
| AU2003237302B2 (en) | 2008-03-06 |
| EP1507533B1 (en) | 2010-04-14 |
| CN1311829C (zh) | 2007-04-25 |
| CA2480756A1 (en) | 2003-12-04 |
| US7008949B2 (en) | 2006-03-07 |
| MXPA04011657A (es) | 2005-08-18 |
| IL164323A (en) | 2010-02-17 |
| EA008180B1 (ru) | 2007-04-27 |
| BR0309619A (pt) | 2005-06-28 |
| NO20045276L (no) | 2004-12-01 |
| WO2003099231A3 (en) | 2004-01-22 |
| JP2005529155A (ja) | 2005-09-29 |
| DE60332109D1 (de) | 2010-05-27 |
| EP1507533A2 (en) | 2005-02-23 |
| ATE464298T1 (de) | 2010-04-15 |
| NZ535723A (en) | 2005-08-26 |
| US7335663B2 (en) | 2008-02-26 |
| WO2003099231A2 (en) | 2003-12-04 |
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